Alpha Drugs SKETCHY (Phantom of the Alpha)

What is the suffix for alpha-1 selective antagonists

-osin (which are the first letters in Opera and singer)

What does the brain-shaped platform in Raul's pit represent?

Alpha 2 agonists affect the CNS (inhibition of sympathetic tone --> reduced BP)

Why is the opera manager dropping his hot cocoa?

Alpha antagonists (eg. phentolamine) can be used to treat cocaine toxicity. Avoid beta blockers due to unopposed alpha vasoconstriction

What does the heart shaped hammer represent?

Alpha blocker induced hypotension causes reflex tachycardia reflex hammer!

What are some side effects of alpha receptor antagonists?

Alpha receptor antagonists can cause orthostatic hypotension Carlotta on tilt table

Why are -osins good for people with both BPH and hypertension?

Because alpha-1 antagonists also lead to vasodilation

The 2nd manager is eating ice cream and has brain freeze! What does this represent?

Brain freeze: catecholamine excess in pheochromoctyoma causes headaches, hypertension, palpitations, sweating Use alpha blockers (eg. phentolamine) preopertatively to control blood pressure

On the pipe, the pressure gauge says urgent! What does this mean?

Clonidine is useful in the treatment of hypertensive urgency

What do the high pressure pipes represent?

Clonidine treats (reduces) hypertension -reduces BP Reduces sympathetic tone

What do the big sleeves on the phantom represent?

Dilated sleeves: phentolamine causes vasodilation (alpha-1 antagonist effect)

Alpha antagonists

Hooray!

What does the phantom of the opera standing on the falling chandelier represent?

Phantom = phentolamine -reversible alpha-1 and alpha-2 receptor antagonist

What does the phantom's phoenix tattoo represent?

Phenoxybenzamine: irreversible alpha 1 and alpha 2 receptor antagonist

The opera singer -osin represents alpha 1 selective antagonist. What is one example?

Prazosin

What does the praying opera singer represent?

Prazosin

What else can clonidine be used for?

Slow perfusion of clonidine can be used to treat ADHD (distracting mirror that is catching Raul's attention)

The opera singer is falling onto a banister on his butt. What does this represent?

The banister is compressing his prostate. Alpha 1 antagonists treat symptoms of BPH (they relax smooth muscle in the urethra and prostate)

There is a marionnete coming out of the mirror (that Raul is looking at). What does this represent?

Tourette's marionnette Alpha-2 agonists (clonidine) are useful in the management of Tourett'es syndrome

What is above the cave, on the stage?

alpha 1 and alpha 2 antagonists (extinguished candles)

The opera singer is holding a single alpha candle that is extinguished. This represents alpha-1 receptor antagonism

fyi

Why is the praying opera singer wearing army/dog tags?

prazosin can be used to treat some symptoms of PTSD

Raul represents....

the alpha 2 agonist, Clonidine (he has a claw weapon with 2 claws, and he has 2 lit alpha candles)