BioChem 2: Exam 2 quiz questions

Which of the following compounds is nutritionally essential dietary source of arachidonates in humans? A.) Linoleate B.) Eicosapentene C.) Palmitate D.) Asparagine

A.) Linoleate

Deficiency of which of the following compounds can interrupt dTMP biosynthesis? A.) Tetrahydrofolate B.) Tetrahydrobiopterine C.) Tyrosine D.) Arginine

A.) Tetrahydrofolate

In the urea cycle, the second nitrogen of urea enters the cycle in the form of which of the following metabolites? A.) aspartate B.) arginine C.) ornithine D.) glutamine E.) alanine

A.) aspartate

which of the following reaction inactivate thrombroxanes? a.) oxidation of 15 hydroxyl group to a ketone b.) transamination reaction c.) decarboxylation d.) demethylation

a.) oxidation of 15 hydroxyl group to a ketone

Which of the following compounds can release arachidonic acid? a.) thromboxanes b.) some membrane bound phospholipds c.) corticosteroids d.) acetyl-CoA

b.) some membrane bound phospholipds

Eicosanoids are derived from the following precursor: a.) Glycerol b.) Eicosapentanoic acid c.) Arachidonic acid d.) Glutamic acid

c.) Arachidonic acid

What is true about eicosanoids? a.) eicosanoids are 20 carbon straight chain saturated fatty acids b.) eicosanoids are not sensitive to inflammation process c.) all eicosanoids are derived from a 20 carbon polyunsaturated fatty acid d.) eicosanoids are synthesized directly from acetyl-Coa

c.) all eicosanoids are derived from a 20 carbon polyunsaturated fatty acid

What is one of the functions of prostacyclin? a.) constriction of blood vessel b.) formation of thromboxane c.) dilation of blood vessel d.) synthesis of glucocorticoids

c.) dilation of blood vessel

which of the following compounds is nutritionally essential dietary source of arachidonates in humans? a.) Eicosapentene b.) asparagine c.) linoleate d.) palmitate

c.) linoleate

Which of the following compounds can activate phospholipase A2 in order to release the precursor molecule for eicosanoid biosynthesis? a.) Hydroperoxyeicosapentanoic acid b.) Cholesterol c.) Aspirin d.) Histamine

d.) Histamine

which of the following compounds can activate phospholipase A2 in order to release the precursor molecule for eicosanoid biosynthesis a.) Hydroperoxyeicosapentanoic acid b.) cholesterol c.) aspirin d.) histamine

d.) histamine

the conversion of glutamate to an alpha-ketoacid and NH4+ a.) is a reductive deamination b.) is accompanied by ATP hydrolysis catalyzed by the same enzyme c.) does no require any cofactors d.) is catalyzed by glutamate dehydrogenase e.) requires ATP

d.) is catalyzed by glutamate dehydrogenase

What happens when eicosanoids bind to their selective receptors? a.) Adenylate cyclase activities are regulated b.) G proteins pathways are regulated c.) Protein kinase pathways are regulated d.) Calcium-dependent pathway are regulated e.) all of the above

e.) all of the above

the human genetic disease Phenylketonuria (PKU) can result from: a.) production of enzymes containing no phenylalanine b.) inability to catabolize ketone bodies c.) deficiency of protein in the diet d.) inability to synthesize phenylalanine e.) inability to convert phenylalanine to tyrosine

e.) inability to convert phenylalanine to tyrosine

Which of the following functional groups is transferred by S-adenosylmethionine (SAM) to produce epinephrine from norepinephrine? A.) Formyl group (- CHO) B.) Methyl group (- CH3) C.) Sulfhydryl group (-SH) D.) Methenyl group (- CH)

B.) Methyl group (- CH3)

Which nitrogen atom(s) of the tetrahydrofolate (THF) is bound to the one-carbon unit for its transfer to another molecule? Choose the correct pair. A.) N1 and/or N5 B.) N5 and/or N10 C.) N3 and/or N10 D.) N2 and/or N8

B.) N5 and/or N10

Which of the following compounds is needed for the rearrangement of the methyl group of L-methylmalonyl-CoA to form succinyl-CoA? A.) S-adenosylmethionine (SAM) B.) Vitamin B12 C.)Vitamin B6 D.) Biopterin

B.) Vitamin B12

In the urea cycle, the second nitrogen of urea enters the cycle in the form of which of the following metabolites? A.) ornithine B.) aspartate C.) arginine D.) alanine E.) glutamine

B.) aspartate

Glutamate is metabolically converted to α-ketoglutarate and NH4+ by a process described as: A.) deamination. B.) oxidative deamination. C.) reductive deamination. D.) transamination.E.hydrolysis.

B.) oxidative deamination

Which of these directly donates a nitrogen atom for the formation of urea during the urea cycle? A.) Adenine B.) Creatine C.) Aspartate D.) Ornithine E.) Glutamate

C.) Aspartate

Which amino acid(s) is/are metabolites in the urea cycle, but is/are not used as (a) building block(s) of proteins? A.) ornithine B.) citrulline C.) glutamate D.) A and B E.) A, B, and C

D.) A and B

Methyl group can be transferred by: A.) vitamin B12 B.) tetrahydrofolate C.) s-adenosylmethionine D.) all of the above

D.) all of the above

In amino acid catabolism, the first reaction for many amino acids is a(n): A.) oxidative deamination requiring NAD+. B.) hydroxylation requiring NADPH and O2. C.) decarboxylation requiring thiamine pyrophosphate (TPP). D.) transamination requiring pyridoxal phosphate (PLP). E.) reduction requiring pyridoxal phosphate (PLP).

D.) transamination requiring pyridoxal phosphate (PLP)

Which of the following amino acids is/are glucogenic? A.) asparagine B.) methionine C.) valine D.) lysine E.) A, B, and C

E.) A, B, and C

Which substance is not involved in the production of urea from NH4+ via the urea cycle? A.) Ornithine B.) Carbamoyl phosphate C.) ATP D.) Aspartate E.) Malate

E.) Malate

Glutamine synthetase converts _____ to _____, whereas glutamate synthase converts _____ to _____. A.) α-ketoglutarate; glutamine; α-ketoglutarate; glutamate B.) α-ketoglutarate; glutamine; oxaloacetic acid; glutamate C.) asparagine; glutamine; α-ketoglutarate; glutamate D.) formate; glutamine; ammonia; glutamate E.) glutamate; glutamine; α-ketoglutarate; glutamate

E.) glutamate; glutamine; α-ketoglutarate; glutamate

The human genetic disease phenylketonuria (PKU) can result from: A.) inability to synthesize phenylalanine. B.) deficiency of protein in the diet. C.) production of enzymes containing no phenylalanine. D.) inability to catabolize ketone bodies. E.) inability to convert phenylalanine to tyrosine.

E.) inability to convert phenylalanine to tyrosine.

Urea synthesis in mammals takes place primarily in tissues of the: A.) small intestine. B.) skeletal muscle. C.) kidney. D.) brain. E.) liver.

E.) liver.

Glutamine, arginine, and proline: A.) may all be derived from a urea cycle intermediate. B.) may all be derived from a glycolytic intermediate. C.) may all be derived from a Cori cycle intermediate. D.) do not have a common precursor. E.) may all be derived from a citric acid cycle intermediate

E.) may all be derived from a citric acid cycle intermediate

If a person's urine contains unusually high concentrations of urea, which one of the following diets has he or she probably been eating recently? A.) Very very high fat, high carbohydrate, no protein B.) Very high carbohydrate, no protein, no fat C.) Very high fat, very low protein D.) High carbohydrate, very low protein E.) Very low carbohydrate, very high protein

E.Very low carbohydrate, very high prot