Blood Bank Exit Exam
Why is a recipient's antibody screening performed as a component of compatibility testing
Detects red cell alloantibodies
Antibodies to which blood group system show dosage (i.e., are stronger with homozygous expression of the antigen)?
Duffy
Which of the following organizations are involved in the regulation of blood banks?
FDA
Who establishes GMPs
FDA
What method that uses a dextran-acrylamide matrix?
Gel method
Why do granulocyte concentrates that have more than 2 mL of red blood cells require a cross match?
Granulocytes may contain a significant amount of red blood cells because they are obtained from the "buffy coat" layer during apheresis.
The linked HLA genes on each chromosome are inherited as a
Haplotype
What part of the immunoglobulin molecule distinguishes the isotype
Heavy chain
When is the immediate-spin or abbreviated crossmatch an acceptable procedure for the recipient
If no prior or clinically significant antibodies
Most "naturally occurring" ABO system antibodies fall into which immunoglobulin class?
IgM
Why is polyethylene glycol reagent added to the screen or panel?
Increase the avidity of IgG antibodies
Which ABO phenotype selection contains the most H antigen and the least H antigen, respectively, on the red cell's surface?
O because there are no detectable products; A1B has the lowest number of H antigen sites
If an anti-I is suspected in a patient's sample that requires a transfusion, what is the most acceptable course of action?
Prewarming
Best description of the elution technique.
Technique that disassociates IgG antibodies from red cells for further identification
Red cells that phenotype as S-s- are also
The high-frequency antigen U is also absent
Solid-phase red cell adherence used for antibody detection has an advantage over tube testing because
There is a clear end point
Are Lewis system antibodies enhanced by antibodies?
Yes
Does age lower the level of ABO isoagglutinins?
Yes
Prozone
antibody excess
Postzone
antigen excess
MSBOS
maximum surgical blood order schedule
High-titer, low-avidity antibodies typically
react with antigens of high frequency in the population
What percentage does each red cell unit raise the hematocrit by
3%
Which of the following situations is most likely to cause intravascular hemolysis when an incompatible transfusion is given
A or B cells given to O recipients
What substances are found in the saliva of a group A person who also inherited the secretor gene?
A, H
A donor unit with a positive DAT would cause reactions at what phase of the crossmatch?
AHG
A classic case of autoimmune hemolytic anemia can be prevented by?
AHG phase
What characterizes the Donath-Landsteiner antibody?
An IgG auto anti-P
An anti-E was identified in a patient who recently received a transfusion. What other Rh system antibody should be investigated?
Anti-c
When should anti-Sda be suspected?
Antibody reacts with most panel cells and are mixed field and refractile microscopically
