Chapter 6.3

Also in step 2: Internal to the clot, macrophages and neutrophils (two types of leukocytes) clean the wound of

cellular debris. (For more information about blood clotting

Also Step 3: Macrophages within the wound begin to remove the clotted blood. Fibroblasts produce new

collagen fibers in the region

Step 4: Epithelial regeneration of the epidermis occurs due to division of epithelial cells at the edge of the wound. These new epithelial cells migrate over the wound, moving internally to the now superficial remains of the clot (the scab). The connective tissue is replaced by

fibrosis

The skin repair and regeneration process is dependent on the extent of the injury. The wider and deeper the surface affected, the longer it takes for skin to be repaired. Additionally, the area under repair usually is more susceptible to complications due to

fluid loss and infection

As the severity of the damage increases, the repair and regeneration ability of the integument is strained and its return to its original condition becomes much less likely. Some integumentary system components that are not repaired following severe damage to the integument include

hair follicles, exocrine glands, nerves, and the arrector pili muscle cells

Step 3: The cut blood vessels regenerate and grow in the wound. A soft mass deep in the wound becomes granulation tissue, which is a vascular connective tissue that initially forms in a

healing wound

The stages of wound healing: 1 step: Cut of blood vessles initiates bleeding into the wound. the blood brings clotting proteins, and

numerous leuocytes(white blood cells) and antibodies

Step 2: A blood clot forms, temporarily patching the edges of the wound together and acting as a barrier to prevent the entry of

pathogens into the body