CPIA Exam Study Questions

Which of the following activities would place an animal in category E? A. Lethal dose experiments in which animals are allowed to die without intervention. B. Observation studies of normal primate behavior. C. Blood collection from a superficial vessel of a dog. D. Major surgery in which anesthetics and postoperative analgesics are administered.

A. Lethal dose experiments in which animals are allowed to die without intervention.

With regard to conducting official IACUC business, the definition of a quorum is: A. More than fifty percent (a majority) of voting members. B. Fifty percent of voting and non-voting members combined. C. More than fifty percent (a majority) of voting and non-voting members combined. D. Fifty percent of the voting members.

A. More than fifty percent (a majority) of voting members

Which of the following entities are required to release information per the Freedom of Information Act? A. OLAW B. AAALAC C. IACUC D. HSUS

A. OLAW

Under what circumstance is the IV or IC injection of potassium chloride an acceptable euthanasia method? a) When other methods have failed b) When used in combination with a barbiturate c) If a catheter is used d) If the animal is anesthetized

d) If the animal is anesthetized Source: AALAS Learning Library Regulatory and IACUC Compliance Track > US Mandates and Guidelines > Euthanasia of Research Animals: AVMA Guidelines

When there are allegations of concerns on animal care and use, what are recommended steps for the IACUC when investigating the concern: a) the chair convene a meeting of the IACUC b)IO should be notified b) the AV should be involved in the investigation d) suspend research activity e) all the above

e) all the above

Which of the following is not an example of refinement? A. The use of newer surgical techniques that result in less tissue trauma. B. The use of a new analgesic that provides better postoperative pain relief. C. The use of computer modeling software to substitute for animal experiments. D. The use of a new bleeding technique that causes less pain and distress.

C. The use of computer modeling software to substitute for animal experiments.

What is the basis for the pain/distress classification system used by most institutions? A. AAALAC pain/distress categories. B. PHS pain/distress categories. C. USDA pain/distress categories. D. Guide pain/distress categories.

C. USDA pain/distress categories.

According to USDA, failure to correct a significant deficiency in accordance to a specific schedule and plan must be reported to APHIS and any other federal agency within ____days by who_____?

Notify within 15 days by the IACUC through the IO.

True or False. If a facility that receives DoD funds is under USDA investigation, the facility must notify DoD and have a site visit within 30 days of notification.

True

True or False. The Secretary of the Army as Executive Agent develops and issues joint service regulations to implement the Department of Defense Directive number 3216.1.

True

True or False. The non-affiliated member(s) on a DoD IACUC may be a federal employee with demonstrated commitment to the community.

True

True or False: Institution procuring animal must have lawful procedures in place as well as procedures for compliance with animal transportation regulations to include international requirements.

True

Which entity does not require the IACUC to have a scientific member?

USDA Source: Certified Professional IACUC Administrator (CPIA) Study Group - Facebook Post by Molly Greene Haywood on March 6, 2013

What are the two circumstances that you would submit a semiannual report to OLAW?

What are the two circumstances that you would submit a semiannual report to OLAW?

The Executive Agent for the Department of Defense Directive number 3216.1 is the _____ a. Director, Defense Research and Engineering b. Secretary of the Army c. Commander, US Army Veterinary Command d. Inspector General e. Under Secretary of Defense for Acquisition and Technology

b. Secretary of the Army

PHS and AWRs state that all records should be kept for a minimum of: a) indefinate b) 1-2 years c) 3 years d) non of the above

c) 3 years

Confirmation of death is determined by: a) Lack of movement b) Duration of euthanasia procedure c) Cessation of vital signs d) Use of an adjunctive euthanasia method

c) Cessation of vital signs Source: AALAS Learning Library Regulatory and IACUC Compliance Track > US Mandates and Guidelines > Euthanasia of Research Animals: AVMA Guidelines"

USDA Regulations require the following IACUC members: 1. Veterinarian, chair, nonaffiliated 2. Veterinarian, chair, scientist 3. Veterinarian, nonaffiliated, scientist 4. Veterinarian, nonaffiliated, nonscientist

1. Veterinarian, chair, nonaffiliated

Great Southern Agricultural and Technical University has an Animal Welfare Assurance Statement on file with OLAW that covers all PHS funded projects. The University's policy states that all use of live vertebrate animals for teaching and research requires IACUC review and approval. A faculty member contacts the IACUC Chair to report that he demonstrated a blood sampling procedure on a live chicken for a teaching lab, but it was not the blood sampling method described in the IACUC approved protocol for the lab. The IACUC must report this noncompliance to: 1) OLAW 2) USDA 3) The University's IO 4) All of the above

3) The University's IO

PHS Policy requires the following IACUC members: 1. Veterinarian, chair, nonscientist, nonaffiliated 2. Veterinarian, chair, nonaffiliated, scientist 3. Veterinarian, nonaffiliated, scientist, nonscientist 4. Veterinarian, nonaffiliated, nonscientist, statistician

3. Veterinarian, nonaffiliated, scientist, nonscientist

The guide incorporated two must to Diaster Planning and Emergency Prepardness which involved: a) triage plans for personnel and animals b) emergency contacts for all researchers and staff c) plans include satellite facilities d) corrdinated by the institutional official e) provisions on euthanasia The correct answer is: 1. a and e 2. a and d 3. c and e 4. All the above

3. c and e

Which of the following activities would disqualify an animal from USDA category B? A. Blood collection. B. Being placed into new caging. C. Breeding. D. Being observed during quarantine.

A. Blood collection.

Which of the following statements about OLAW's guidance on the use of carbon dioxide as a euthanasia agent is false? A. Carbon dioxide must be supplied only from compressed gas cylinders. B. Chambers should be pre-filled to lessen animal anxiety when placed inside. C. Death must be verified before disposal of the carcass. D. Unintended recovery of animals after CO2 euthanasia must be reported to OLAW.

A. Carbon dioxide must be supplied only from compressed gas cylinders.

All personnel performing animal procedures must be properly trained to do so when? A. By the end of the experiments. B. Before any procedures are performed. C. Before any procedures are performed unless they have doctoral level or medical degrees. D. Before any procedures are performed unless they receive a waiver from their supervisor.

B. Before any procedures are performed.

The proper sequence for a designated member review by the IACUC is: A. Review materials are sent to all voting members, full committee review is not requested by any member, the chairperson assigns one or more IACUC members as designated reviewers. B. Review materials are sent to a quorum of designated reviewers, review results are solicited from designated reviewers, full committee approval of results is requested. C. Review materials are sent to all voting members, a majority of members do not request full committee review, the chairperson assigns one or more IACUC members as designated reviewers. D. Review materials are sent to a quorum of voting members, a majority of a quorum does not request full committee review, the chairperson assigns one or more IACUC members as designated reviewers.

A. Review materials are sent to all voting members, full committee review is not requested by any member, the chairperson assigns one or more IACUC members as designated reviewers.

Which of the following procedures may correctly be applied to Designated Member Review? A. The IACUC Chair appoints one member to do the Designated Member Review. B. The designated member reviewer is authorized to approve, require modifications, or disapprove the proposal. C. All members receive information about the proposal and send their votes to the designated member reviewer for tallying. D. Designated member review may be utilized to review proposals when there is insufficient time to notify the full membership of the proposal details.

A. The IACUC Chair appoints one member to do the Designated Member Review.

True or False. Violation complaints within the DoD can only be reported to the Inspector General.

False

Who is given the authority to decide if a deficiency identified during a semi-annual IACUC evaluation is significant or minor? A. The IACUC and IO together. B. The veterinarian and the IACUC together. C. Only the IACUC. D. Only the IO.

A. The IACUC and IO together.

Which of the following is not an example of reduction? A. The use of a new anesthetic that provides better induction and a shorter recovery period. B. The shared use of tissues by more than one investigator to minimize animal use. C. The use of improved assays that provide better data precision so that fewer animals are needed per group. D. The use of common control groups during simultaneous experiments to limit the number of control animals needed.

A. The use of a new anesthetic that provides better induction and a shorter recovery period.

Which of the following statements about IACUC suspensions of animal activities is false? A. USDA Animal Welfare Act Regulations and PHS Policy allow the chairperson or another IACUC member to suspend an animal activity on behalf of the IACUC. B. Once the IACUC suspends an activity, it must report the suspension to the IO, who must report it to regulatory agencies. C. A majority of a quorum must vote at a convened meeting to suspend an activity. D. An institutional official can suspend an activity without agreement by the IACUC.

A. USDA Animal Welfare Act Regulations and PHS Policy allow the chairperson or another IACUC member to suspend an animal activity on behalf of the IACUC.

Where do you send the USDA annual report?

APHIS AC Regional Director.

According to USDA Regulations, an IACUC may have no more than how many members from any one administrative unit? A. 2 B. 3 C. 4 D. 5

B. 3

What information must be provided in the report for deficiencies identified during the IACUC semi-annual self-evaluation? A. A reasonable and specific plan and schedule for correcting significant deficiencies, and a description of minor deficiencies. B. A reasonable and specific plan for correcting significant and minor deficiencies and a schedule for completing the corrective actions. C. The name and title of the IACUC member who will perform the corrections and the institutional official in charge of verifying the corrections. D. The name and title of institutional support personnel who will provide the corrections and the IACUC members in charge of verifying the corrections.

B. A reasonable and specific plan for correcting significant and minor deficiencies and a schedule for completing the corrective actions.

OLAW recommends which of the following reporting lines within an animal care and use program? A. IACUC reports to the Attending Veterinarian B. Attending Veterinarian reports to the Institutional Official C. Institutional Official reports to the IACUC D. Attending Veterinarian reports to the IACUC

B. Attending Veterinarian reports to the Institutional Official

Which of the following is false concerning prolonged restraint of animals? A. The restraint method used should be the least restrictive possible that will allow achievement of experimental objectives. B. It can be justified as a convenience for the research staff. C. The period of restraint should be the minimum required to achieve experimental objectives. D. It should not be considered a normal method of housing.

B. It can be justified as a convenience for the research staff.

What is a primary mission of the Animal Welfare Information Center (AWIC)? A. Publishes the Animal Welfare Act Regulations and Standards. B. Provides assistance with alternatives and database searches. C. Publishes the Guide for the Care and Use of Laboratory Animals. D. Provides assistance with identifying the best laboratory animal cage washing equipment.

B. Provides assistance with alternatives and database searches.

When reporting an IACUC suspension of an animal activity, the IACUC should: A. Limit disclosure of the facts to the absolute minimum necessary to prevent institutional embarrassment. B. Report the suspension as soon as possible to the regulatory authorities. C. Notify regulatory authorities no later than one year after the suspension. D. Notify regulatory authorities no earlier than 3 months after a suspension to ensure that a complete investigation has occurred.

B. Report the suspension as soon as possible to the regulatory authorities.

Although opinions vary about the level of detail needed in IACUC minutes, a typical standard is that IACUC minutes: A. Should provide as little information as possible to prevent outside observers from understanding how the IACUC operates. B. Should allow an outside observer to verify that deliberations occurred, and understand the outcomes of those deliberations. C. Must be no longer than three pages to satisfy federal paperwork reduction regulations. D. Must include an actual transcript of all conversations that occurred at the meeting, as a minimum.

B. Should allow an outside observer to verify that deliberations occurred, and understand the outcomes of those deliberations.

Which of the following is true of the dog exercise program mandated by the USDA Animal Welfare Act regulations? A. Dogs must be provided additional exercise regardless of the floor area of the cage. B. The IACUC can exempt an animal for scientific reasons. C. The veterinarian cannot exempt an animal, even for medical reasons. D. The veterinarian can exempt an animal for scientific reasons.

B. The IACUC can exempt an animal for scientific

An investigator wishes to use animals in an experiment that involves category B, C, and D activities performed on the same animal. How should the animal be categorized? A. Categories B, C, and D. B. Category B. C. Category C. D. Category D.

D. Category D.

According to the Animal Welfare Act Regulations of the USDA, when conducting a semi-annual evaluation, the IACUC must conduct the evaluation: A. With at least 1 IACUC member and allow participation by any member who wishes to do so. B. With at least 2 IACUC members and allow participation by any member who wishes to do so. C. With a majority of IACUC members present, including the non-affiliated member. D. With all IACUC members present.

B. With at least 2 IACUC members and allow participation by any member who wishes to do so.

Which of the following statements about the use of "alternate" IACUC members is false? A. Alternates should receive IACUC training or orientation like regular IACUC members. B. Alternate members must be designated in advance and not simply as a matter of convenience on short notice. C. Alternate members may vote on an issue even when the regular member is present and votes on the same issue. D. Alternate members would be expected to vote their conscience rather than simply representing the views of the regular member.

C. Alternate members may vote on an issue even when the regular member is present and votes on the same issue.

Which of these IACUC protocol review outcomes are recognized in the USDA Animal Welfare Act Regulations and PHS Policy? A. Approve, conditional approval, and approval pending modifications. B. Approve, require modifications in (to secure approval), and deferred approval. C. Approve, require modifications in (to secure approval), and withhold approval. D. Approve, disapprove, and probationary approval.

C. Approve, require modifications in (to secure approval), and withhold approval

Which of the following is a required member of the IACUC? A. Institutional Official B. Animal Facility Manager C. Individual not otherwise affiliated with the institution D. Representative from a local animal advocacy organization

C. Individual not otherwise affiliated with the institution

What do the Animal Welfare Act Regulations state about IACUC members who report violations to USDA? A. They may be subjected to reprisals if in violation of local IACUC policy. B. They may be subjected to reprisals if contact with USDA is not approved by IACUC Chair. C. It is against the law for anyone to discriminate against them or subject them to reprisals. D. Local institutional policy can discourage them from reporting violations of the regulations to USDA.

C. It is against the law for anyone to discriminate against them or subject them to reprisals.

The three Rs of Russell and Burch stand for what? A. Research, refinement, and recovery. B. Replace, recognize, and recover. C. Replacement, reduction, and refinement. D. Research, results, and review.

C. Replacement, reduction, and refinement.

Notifying investigators of IACUC protocol review outcomes in writing is: A. A common courtesy not required by regulatory authorities. B. Allowed by the USDA Animal Welfare Act Regulations and PHS Policy only after the minutes have been prepared and approved by the IACUC during a convened meeting. C. Required by both the USDA Animal Welfare Act Regulations and PHS Policy. D. Allowed by the USDA Animal Welfare Act Regulations and PHS Policy only after the IO is notified of the review outcome.

C. Required by both the USDA Animal Welfare Act Regulations and PHS Policy.

Which of the following is not typically a function of the IACUC? A. Investigate allegations of animal mistreatment, and suspend approved research if conducted out of compliance. B. Communicate with the Institutional Official in matters pertaining to the animal care and use program. C. Review and score scientific value for animal protocols submitted. D. Review and approve proposed animal research.

C. Review and score scientific value for animal protocols submitted.

Which of the statements below about the responsibility and authority of the Institutional Official (IO) is false? A. The IO must have authority to commit institutional resources in support of the animal care and use program. B. If the IO is not the institution's Chief Executive Officer, then the CEO must delegate IO authority to that person in writing. C. The IO may reinstate an animal activity that was previously suspended by the IACUC. D. The IO may suspend an animal activity that was previously approved by the IACUC.

C. The IO may reinstate an animal activity that was previously suspended by the IACUC.

Which of the statements below about the responsibility and authority of the Institutional Official (IO) is false? A. The IO must have authority to commit institutional resources in support of the animal care and use program. B. The IO must be the institution's Chief Executive Officer or some appointed by him with authority to fund resources. C. The IO may reinstate an animal activity that was previously suspended by the IACUC. D. The IO may suspend an animal activity that was previously approved by the IACUC.

C. The IO may reinstate an animal activity that was previously suspended by the IACUC.

USDA-APHIS Animal Care Resource Policy #12 "Considerations of Alternatives to Painful/Distressful Procedures" states that when a database search is the primary means of considerations to alternatives of painful and distressful procedures, that a narrative should include all of the following except: A. The name of the databases searched B. The date the search was performed C. The specific field of study D. The search strategy (including scientifically relevant terminology) used

C. The specific field of study

Which of the following is not an example of replacement? A. The use of cell culture instead of animals to grow immortal cell lines. B. The use of a kit to assay hormone levels instead of a bioassay involving animals. C. The use of a new analgesic that provides better postoperative pain relief. D. The use of computer modeling software to replace the use of animals in pharmacologic studies.

C. The use of a new analgesic that provides better postoperative pain relief.

Which statement about the Occupational Health and Safety Program is false? A. You should enroll in the local Occupational Health and Safety Program before you begin your work with laboratory animals. B. Typical services include rabies immunizations, TB testing, and tetanus immunizations. C. You may not decline medical treatments provided as part of the Occupational Health and Safety Program. D. Each institution must have an Occupational Health and Safety Program for personnel who have significant contact with laboratory animals.

C. You may not decline medical treatments provided as part of the Occupational Health and Safety Program.

Which of the following should be considered a significant change to an animal use proposal? A. change in departmental affiliation of the principal investigator B. change in start date of study C. change in anesthetic agent D. change in fluid administration

C. change in anesthetic agent

When there is a change in name of institution, or ownership or operation for the research facility how many days do you have to notify the APHIS AC Regional Director of the change?

Notify within 10 days of change in operation.

When conducting the facilities inspection portion of the semi-annual evaluation in compliance with both the USDA Animal Welfare Act Regulations and PHS Policy, the IACUC must include: A. All areas housing animals for more than 24 hours, and laboratories where animal procedures are performed with the exception of laboratories performing only non-survival surgical procedures. B. All areas housing animals for more than 12 hours, and all investigator laboratory and study areas where animal procedures are performed. C. All areas housing animals for more than 24 hours, and all investigator laboratory and study areas where animal procedures are performed. D. All areas housing animals for more than 12 hours, and laboratories where animal procedures are performed with the exception of laboratories performing only non-survival surgical procedures.

D. All areas housing animals for more than 12 hours, and laboratories where animal procedures are performed with the exception of laboratories performing only non-survival surgical procedures.

Which of the following statements concerning confidentiality of IACUC business is false? A. Trade secrets, processes, operations, and style of work may not usually be revealed to outsiders by IACUC members. B. It is against the law for an IACUC member to use information gained during IACUC meetings to his or her financial advantage. C. It is unlawful for any IACUC member to release certain confidential information about the research facility in some situations. D. Confidentiality requirements prohibit IACUC members from reporting violations of the Animal Welfare Act Regulations or PHS Policy.

D. Confidentiality requirements prohibit IACUC members from reporting violations of the Animal Welfare Act Regulations or PHS Policy.

What is required, of the IACUC, by the USDA AWA Regulations regarding alternatives? A. Ensure that the limit on animal use assigned to the institution by the USDA is not exceeded more than once every three years. B. Reduce animal usage by at least 10% per year over a five-year period. C. Reduce animal usage by at least 25% over a five-year period. D. Ensure that the principal investigator has considered alternatives to painful or distressing procedures, and review a written assurance that alternatives are not available.

D. Ensure that the principal investigator has considered alternatives to painful or distressing procedures, and review a written assurance that alternatives are not available.

Which of the following institutions must follow the PHS Policy? A. Institutions that use any animals for research, teaching, or testing. B. Institutions that use vertebrate animals for research, teaching, or testing. C. Institutions that accept USDA research funds. D. Institutions that accept PHS funding.

D. Institutions that accept PHS funding.

Which of the following statements regarding the process of polling IACUC members via email is true? A. Polling via email can be used to achieve a quorum if the IACUC does not have a quorum during a convened meeting. B. Polling via email can be used to obtain IACUC suspension of an animal activity out of compliance. C. Polling via email can be used to obtain IACUC approval of a protocol during a convened meeting. D. Polling via email can be used to allow the IACUC members to call for full committee review when using the designated reviewer system.

D. Polling via email can be used to allow the IACUC members to call for full committee review when using the designated reviewer system.

U.S. Government Principles on the Use of Animals in Research state that: A. Relief of pain should be provided for vertebrate animals except for birds, mice and rats. B. Animals will show evidence of pain if a procedure causes them pain. C. Pain is perceived differently by animals than by humans. D. Procedures that are painful to humans should be assumed to cause pain in animals unless there is evidence to the contrary.

D. Procedures that are painful to humans should be assumed to cause pain in animals unless there is evidence to the contrary.

Which agency requires an annual report of the number of animals used by pain/distress category? A. American Association for Laboratory Animal Science B. Association for Assessment and Accreditation of Laboratory Animal Care C. Office of Laboratory Animal Welfare D. United States Department of Agriculture

D. United States Department of Agriculture

To comply with the USDA Animal Welfare Act Regulations, what is the proper IACUC course of action to follow if a significant deficiency is not corrected according to the plan set forth in the IACUC semi-annual evaluation report? A. Report the situation through the IO to USDA within 6 months. B. Report the situation through the IO to USDA within 3 months. C. Report the situation through the IO to USDA within 30 business days. D. Report the situation through the IO to USDA within 15 business days.

D. Report the situation through the IO to USDA within 15 business days.

Training and instruction of personnel must include guidance in which of the following areas? A. Effective writing of animal use proposals B. Proper use of personal protective equipment C. Appropriate communication with animal activist groups D. Research or testing methods that limit the use of animals

D. Research or testing methods that limit the use of animals

Which of the following activities would disqualify an animal from USDA category D? A. Retroorbital blood collection from a mouse performed under anesthesia. B. Collecting tail snips from adult rodents for genotyping under local or general anesthesia. C. Surgery performed under anesthesia. D. Studies in which animals are allowed to die without pain relief.

D. Studies in which animals are allowed to die without pain relief.

Which of these statements is true concerning the USDA Animal Welfare Act? A. The USDA passed the Animal Welfare Act, and Congress has released regulations to enforce it. B. The USDA stands for United States Department of Assessments. C. The USDA is responsible for enforcing the Animal Withholding Action Act passed by Congress. D. The Animal Welfare Act regulations take precedence over guidelines produced by the Public Health Service, Department of Veterans Affairs, and other government agencies.

D. The Animal Welfare Act regulations take precedence over guidelines produced by the Public Health Service, Department of Veterans Affairs, and other government agencies.

In which of the following circumstances may animal work begin before receipt of IACUC approval? A. It is a continuing study awaiting three year renewal and for which the renewal protocol has been submitted to the IACUC. B. It is a small pilot study on non-AWAR species. C. It is a teaching activity that uses students' personally owned dogs and cats. D. There are no circumstances in which animal work may begin before IACUC approval.

D. There are no circumstances in which animal work may begin before IACUC approval.

Regarding studies with infectious agents in animals, as the BSL and ABSL number increases from 1 to 4, what happens to the containment and safeguard practices? A. They become less important. B. They become less stringent. C. They become more vague. D. They become more stringent.

D. They become more stringent.

True or False. DoD Activities performed or sponsored in foreign countries shall follow all applicable US requirements, as well as regulations and standards of the host country.

True

True or False. The Department of Defense directive indicates that any species may be purchased or used for inflicting wounds from any type of weapon to conduct training in surgical/medical treatment procedures.

False

True or False. DoD organizations/facilities are not required to apply for AAALAC accreditation.

False

What line of authority submits the annual report to OLAW?

The IO

What is the mode of euthanasia action for an overdose of barbiturates? a) Depresses the CNS leading to cardiac arrest b) Over stimulates the CNS causing cardiac arrhythmia c) Causes hypoxia and brain activity ceases d) Paralyzes lungs and breathing ceases

a) Depresses the CNS leading to cardiac arrest Source: AALAS Learning Library Regulatory and IACUC Compliance Track > US Mandates and Guidelines > Euthanasia of Research Animals: AVMA Guidelines"

According to the 8th edition of the Guide each institution must or should have an occupational health program in place consistent with federal, state and local regulations? a) must b) should c) a and b d) none of the above

a) must

The institution's PHS Assurance applies to PHS-funded projects only. An investigator has two IACUC protocols using mice. Protocol A (NIH funded) stipulates that animals will be killed by barbiturate overdose while decapitation would be the method used in Protocol B (private foundation funds). The investigator informs the IACUC Office that his staff mistakenly euthanized a few animals assigned to Protocol B with barbiturate overdose. How should the IACUC respond? a) Suspend the investigator. b) Report to US Department of Agriculture. c) Report to Office of Laboratory Animal Welfare. d) Retrain the investigator and staff.

a) you could suspend, but it's not required, and would probably make people mad at the IACUC. b) reporting noncompliance to the USDA is not required. c) this institution's Assurance applies to PHS funded activities only therefore reporting noncompliance on a project not funded by the PHS is not required. d) probably the best practice to prevent future noncompliance. Source: Certified Professional IACUC Administrator (CPIA) Study Group - Facebook Post by Molly Greene Haywood on February 8, 2013

Which of the following is not required for IACUC membership according to the Ag Guide: a. veterinarian with training or experience in laboratory animal science and medicine b. scientist with training or experience in agricultural animals c. a person whose primary concerns are in an area outside of science d. a person who is not affiliated with the institution

a. veterinarian with training or experience in laboratory animal science and medicine

A reflex movement during the euthanasia procedure indicates that the unconscious animal is still experiencing pain. a) True b) False

b) False Source: AALAS Learning Library Regulatory and IACUC Compliance Track > US Mandates and Guidelines > Euthanasia of Research Animals: AVMA Guidelines"

Which of the following statements regarding physical methods of euthanasia is true? a) There are few aesthetic considerations for this form of euthanasia. b) Physical methods of euthanasia may be the most humane method for relieving pain and suffering in some instances. c) Physical methods of euthanasia always cause more distress for the animal. d) Exsanguination, stunning, and pithing are acceptable physical methods of euthanasia for horses and cattle.

b) Physical methods of euthanasia may be the most humane method for relieving pain and suffering in some instances. Source: AALAS Learning Library Regulatory and IACUC Compliance Track > US Mandates and Guidelines > Euthanasia of Research Animals: AVMA Guidelines"

Which of the following is a definition of euthanasia as described in the AVMA Guidelines? a) The act of killing animals by methods that preserve physiologic function after death b) The act of killing animals by methods that induce rapid unconsciousness and death with minimal pain or distress c) The act of reducing the emotional state of animals under distress d) The act of preparing animals for a surgical or otherwise invasive procedure

b) The act of killing animals by methods that induce rapid unconsciousness and death with minimal pain or distress Feedback: Euthanasia as defined by the Animal Welfare Act (AWA): ""The humane destruction of an animal must be accomplished by a method that produces rapid unconsciousness and subsequent death without evidence of pain or distress, or a method that utilizes anesthesia produced by an agent that causes painless loss of consciousness and subsequent death."" Source: AALAS Learning Library Regulatory and IACUC Compliance Track > US Mandates and Guidelines > Euthanasia of Research Animals: AVMA Guidelines

In special circumstances that may indicate a need to deviate from the AVMA guidelines, what should be the deciding factor? a) The cost of the procedure b) The best interest of the animal c) The decision of the IO d) Expediency of the method

b) The best interest of the animal Source: AALAS Learning Library Regulatory and IACUC Compliance Track > US Mandates and Guidelines > Euthanasia of Research Animals: AVMA Guidelines"

PHS policy states that the OLAW requires assurance renewal every: a) three years b) up to five years c) four years d) depends on the institution and program size

b) up to five years

Which of the following statements is true of barbiturates? a) Barbiturates cause the animal to gasp for air before becoming unconscious indicating some pain and distress. b) These drugs are extremely painful when administered outside the vein. c) Barbiturates break down quickly in the body so that carcasses of animals in which barbiturates were used for anesthesia do not represent a threat to predators which may eat them. d) Pentobarbital is a barbiturate that is not classified as a controlled substance.

b) These drugs are extremely painful when administered outside the vein. Source: AALAS Learning Library Regulatory and IACUC Compliance Track > US Mandates and Guidelines > Euthanasia of Research Animals: AVMA Guidelines

The 8th addition of the guide incorporated new additions to the guide: IACUC, IACUC Training, Personnel Security, Investigating and Reporting Animal Welfare Concerns, Veterinary Clinical Care Management, Drug Storage and Control. According to the Guide, what item not a requirement for IACUC members: a) Formal orientation to the institution's program b) Training by a certified veterinarian on all procedures involving animals c) Training on how to review protocols as well as evaluate the program d) Training on how to inspect facilities and labs where animal use or housing occurs e) Training on legislation, regulations, guidelines, and policies

b) Training by a certified veterinarian on all procedures involving animals

PHS institutional Assurance is approve up to ___ years where as USDA registration is updated every ___ years: a) 3yrs PHS and 5 years USDA b) up to 5 years for PHS and 3 years FOR USDA c) up to 5 years for both d) 3 years for both

b) up to 5 years for PHS and 3 years FOR USDA

Which of the following statements is true about the use of carbon monoxide for euthanasia? a) Acceptable for individual or mass euthanasia of cattle, horses, and other large mammals. b) It is extremely stressful to the animal. c) Death occurs rapidly at concentrations of 4 to 6%. d) This agent is safe to use by human operators.

c) Death occurs rapidly at concentrations of 4 to 6%. Source: AALAS Learning Library Regulatory and IACUC Compliance Track > US Mandates and Guidelines > Euthanasia of Research Animals: AVMA Guidelines

Which is not required when filing a PHS Institutional Assurance: a) dates of facility inspections b) IACUC member roster c) Number of covered species used annually d) Lines of authority e) species housed and average daily inventory by species

c) Number of covered species used annually

If the institution is PHS assured and is not AAALAC accredited, what must be included in the annual report to OLAW? a) The IACUC minutes b) The intituional officals assurance statement c) Semiannual IACUC report d) none of the above

c) Semiannual IACUC report

For which species is an adjunctive method of euthanasia is recommended to make sure that the animal is dead because detection of heartbeat is difficult in these animals? a) Fish b) Amphibians c) Small rodents d) Nonhuman primates

c) Small rodents Source: AALAS Learning Library Regulatory and IACUC Compliance Track > US Mandates and Guidelines > Euthanasia of Research Animals: AVMA Guidelines"

Which of the following statements is true about routes of administration for injectable agents? a. When performing an IP injection, the drug must also contain a neuromuscular blocking agent. b. IV administration produces the slowest loss of consciousness. c. IC injection is acceptable when the animal is either heavily sedated, anesthetized, or comatose. d. IP administration is optimal for irritating euthanasia agents.

c. IC injection is acceptable when the animal is either heavily sedated, anesthetized, or comatose. Source: AALAS Learning Library Regulatory and IACUC Compliance Track > US Mandates and Guidelines > Euthanasia of Research Animals: AVMA Guidelines

For the VA semiannual program review and facility inspection report, which of the following need not be included: a. Date of the review/isnpection b. Names of individuals responsible for corrective actions c. The signatures of the majority of the voting members d. The timeline for the corrective actions e. The reason for the deficiency

c. The signatures of the majority of the voting members

Cervical dislocation should not be performed in rabbits weighing more than: a) 500 g. b) 2 kg. c) 800 g. d) 1 kg.

d) 1 kg. Source: AALAS Learning Library Regulatory and IACUC Compliance Track > US Mandates and Guidelines > Euthanasia of Research Animals: AVMA Guidelines

What is the recommended concentration of carbon monoxide used for euthanasia of small mammals? a) Over 10% b) 8-10% c) 2-3% d) 4-6%

d) 4-6% Source: AALAS Learning Library Regulatory and IACUC Compliance Track > US Mandates and Guidelines > Euthanasia of Research Animals: AVMA Guidelines

Physical methods of euthanasia cause death through destruction of: a) muscular activity in the body. b) afferent pathways from the periphery to the brain. c) chemical pathways in the heart muscle. d) midbrain centers controlling respiratory and cardiac activity

d) midbrain centers controlling respiratory and cardiac activity. Source: AALAS Learning Library Regulatory and IACUC Compliance Track > US Mandates and Guidelines > Euthanasia of Research Animals: AVMA Guidelines

There are three main circumstances for prompt report to PHS, which one of the three circumstances below must be reported promptly to USDA: a) Suspension of an activity by the IACUC b) serious deviation from the Guide (unless previously approved by the IACUC) c) Serious continuing non compliance with PHS Policy d) none of the above

d) none of the above

The Executive Agent designates the Commander of the US Army Veterinary Command, the Director of Veterinary Services Activity, the Director of Defense Research and Engineering and: a. The Chair of the Joint Technical Working Group (JTWG) b. A veterinarian to the Interagency Research Animal Committee c. The office that will perform headquarters-level administrative review of the use of non-human primates. d. None of the above e. All of the above

d. None of the above

According to the Guide, who can conduct Post-Approval Monitoring (PAM)? a) IACUC b) veterinarians c) animal care personnel d) compliance staff e) all the above

e) all the above

According to PHS, awardee institutions shall maintain good recordkeeping. Which one is not a recordkeeping requirement? a) a copy of the Assurance approved by PHS b) minutes of IACUC meetings c) records of accrediting body determinations d) records and proposals and applications and propose significant changes, IACUC reports and recommendations e) records of semiannual IACUC reports to IO (including minority views) d) all the above e) none of the above

e) none of the above

Which of the following are applicable to the Department of Defense: a. Animal Welfare Act; Animal Welfare Regulations b. The Guide for the Care and Use of Laboratory Animals; The Guide for the Care and Use of Agricultural Animals in Agricultural Research and Teaching c. The Lacey Act; Marine Mammal Protection Act; Endangered Species Act; Convention on International Trade in Endangered Species of Wild Fauna and Flora d. A & C e. All of the above

e. All of the above

Programs for medical evaluation preventative medicine include all the following except: a) pre-employment evaluation b) health history c) procedures for reporting and treating injuries and allergies, including bites and accidents d) Zoonosis surveillance e) Institutions must consider confidentiality and other legal factors f) Pre-employment serum samples g) None of the above

g) Nove of the above