Dermatology Pharm PI
Answer: Isotretinoin--What is the Brand Name for Isotretinoin?
Answer: Accutane, Absorica--What is the Generic Name for Accutane, Absorica
Answer: Trifarotene--What is the Brand Name for Trifarotene?
Answer: Akleif--What is the Generic Name for Akleif?
Answer: Adapalene--What is the Brand Name for Adapalene?
Answer: Differin--What is the Generic Name for Differin?
Answer: Calcipotriene--What is the Brand Name for Calcipotriene?
Answer: Dovonex, Calcitrene--What is the Generic Name for Dovonex, Calcitrene?
Answer: Pimecrolimus--What is the Brand Name for Pimecrolimus?
Answer: Elidel--What is the Generic Name for Elidel?
Answer: Crisaborole--What is the Brand Name for Crisaborole?
Answer: Eucrisa--What is the Generic Name for Eucrisa?
Answer: Azelaic Acid--What is the Brand Name for Azelaic Acid?
Answer: Finacea--What is the Generic Name for Finacea
Answer: Metronidazole--What is the Brand Name for Metronidazole?
Answer: Flagyl--What is the Generic Name for Flagyl?
Answer: Ruxolitinib--What is the Brand Name for Ruxolitinib?
Answer: Opzelura--What is the Generic Name for Opzelura?
Answer: Doxycycline--What is the Brand Name for Doxycycline?
Answer: Oracea--What is the Generic Name for Oracea?
Answer: Apremilast--What is the Brand Name for Apremilast?
Answer: Otezla--What is the Generic Name for Otezla?
Answer: Tacrolimus--What is the Brand Name for Tacrolimus?
Answer: Protopic--What is the Generic Name for Protopic?
Answer: Ivermectrin--What is the Brand Name for Ivermectrin?
Answer: Soolantra--What is the Generic Name for Soolantra?
Answer: Deucravacitinib--What is the Brand Name for Deucravacitinib?
Answer: Sotyktu--What is the Generic Name for Sotyktu?
Answer: Tazarotene--What is the Brand Name for Tazarotene?
Answer: Tazorac--What is the Generic Name for Tazorac?
Answer: Minocycline--What is the Brand Name of Minocycline?
Answer: Zilxi--What is Generic Name of Zilxi?
Answer: Roflumilast--What is the Brand Name for Roflumilast?
Answer: Zoryve--What is the Generic Name for Zoryve?
Need 2 forms of contraception
Besides a (-) hCP lab value, what else does the iPLEDGE system require all childbearing-age women need before they can be prescribed Isotretinoin?
Anagen and telogen stages return to normal resulting in resumed hair shedding
If/When we discontinue a pt's use of Minoxidil (Rogaine), what would we expect to happen?
Janus associated kinases 1 and 2
In terms of JAK Inhibitors MOA, what exactly do these drugs inhibit?
Most settings, it is the most commonly used vehicle for topical treatments
In what settings would we use a cream?
Good for drying weepy rashes
In what settings would we use a gel?
Good for covering large surface areas
In what settings would we use a lotion?
Good for moisturizing dry rashes
In what settings would we use an ointment?
If there is no improvement in 4-6 weeks
In what timeframe do we want to re-evaluate pts on a calcineurin inhibitor?
Clobetasol propionate 0.05%
Name a Class 1 topical steroid
Desoximetasone 0.25%
Name a Class 2 topical steroid
Fluocinonide 0.05%
Name a Class 3 topical steroid
Mometasone furoate 0.1%
Name a Class 4 topical steroid
Hydrocortisone valerate 0.2%
Name a Class 5 topical steroid
Triamcinolone acetonide 0.1%
Name a Class 6 topical steroid
Hydrocortisone OTC
Name a Class 7 topical steroid
T
T/F Calcineurin inhibitors are one of several non-steroidal options for dermatologic treatment
F
T/F Higher concentrations of one topical molecule means that it is "stronger" than a lower concentration of a different molecule in the same drug class
T
T/F Isotretinoin (Accutane, Absorica) is a Pregnancy Category X drug
F--the contraindications include both oral and topical forms
T/F Retinoid contraindications are restrictively for oral prescriptions and topical treatments are safe to use in those pts
T
T/F TYK2 Inhibitors share the same black box warning as JAK 2 Inhibitors
T
T/F There is an oral form of PDE4 inhibitors that we can use for plaque psoriasis treatment
T
T/F There is no required ab monitoring while a patient is taking Apremilast (Otezla)
F
T/F We can use Vit D Analogs as a treatment for Vit D deficiency
PMH of malignancy, TB, CBC, CMP, Hep B and C, and lipid panels
What NEEDS to be screened prior to starting a pt on a biologic?
Lupus-Like Reaction
What SE is Minocycline associated with?
Azelaic Acid (Finazea)
What acne rosacea treatment option is safe to use in pregnancy?
Psoriasis and psoriatic arthritis
What are IL-12 and IL-23 Inhibitors indicated for?
Psoriasis and psoriatic arthritis
What are IL-17 Inhibitors indicated for?
Atopic dermatitis
What are IL-4 and IL-13 Inhibitors indicated for?
Transient decreased libido and ED, gynecomastia, and falsely low PSA levels
What are SE to Finasteride (Propecia) use?
Psoriasis, psoriatic arthritis
What are TNF-Inhibitors indicated for?
Combination med of Calcipotriene (Vit D Analog) + Betamethasone (steroid)
What are Taclonex and Enstilar?
Psoriasis, psoriatic arthritis, hidradenitis supprativa, and atopic dermatitis
What are biologics indicated for?
Tacrolimus (Protopic) and Pimecrolimus (Elidel)
What are examples of calcineurin inhibitors?
Roflumilast (Zoryve) and Crisaborole (Eucrisa)
What are examples of topical PDE4 Inhibitors?
Don't drink alcohol, don't donate blood, don't share pills, protect against/avoid sun exposure, stop or decrease some meds b/c of ADR or blood work abnormalities that can result.
What are some "rules" we tell pts when we start them on Isotretinoin?
Dryness, pseudotumor cerebri, hepatotoxicity, pancreatitis, Steven-Johnson Syndrome, depression, suicidality, thrombocytopenia, IBD exacerbations
What are some SE of Isotretinoin use?
Burning and/or stinging at the site of application and increased risk of viral infections (VZV, HSZ)
What are some SE of calcineurin inhibitors?
Increased sun sensitivity, dryness, and irritation
What are some SE with retinoid use?
Skin irritation and hypercalcemia
What are some common SE expected with Vit D Analog use?
Pregnancy and breast feeding women
What are some contraindications for retinoid use?
Adapalene (Differin), Tretinoin, Tazarotene (Tazorac), and Trifarotene (Akleif)
What are some examples of topical retinoids?
Telangiectasias, acne/rosacea, easy shearing of skin, delayed healing
What are some further complications of topical steroid induced skin atrophy?
Metronidazole, Azelaic acid (Finacea), Minocycline (Zilixi), Ivermectrin (Soolantra), Doxycycline (Oracea)
What are some options for acne rosacea treatment?
Clindamycin, Metronidazole, Erythromycin, Sulfacetamide, Dapsone, Minocycline
What are some options for topical antibacterials?
Salicylic Acid and Benzoyl Peroxide
What are some options of OTC anti-microbials that can also be Rx?
Pediatrics, elderly, pregnancies
What are some populations we hold higher precautions for when prescribing topical steroids?
GI upset (especially diarrhea), weight loss, and depression
What are some side effects to PDE4 Inhibitor use?
Plaque psoriasis
What are systemic/oral TYK2 Inhibitors indicated for?
Tetracyclines such as Minocycline or Doxycycline
What are the 1st line options for oral antibiotic treatment of SEVERE popular/pustular acne?
Anti-hypertensive symptoms
What are the SE of Minoxidil (Rogaine) use?
Male androgenetic alopecia and post-menopausal female androgenetic alopecia
What are the indications for Finasteride (Propecia)?
Atopic dermatitis and alopecia areata
What are the indications for systemic/oral JAK Inhibitors?
The thickness of the stratum corneum and the vascularity of the body location
What are the two main factors we take into consideration when choosing a topical steroid?
Treatment of plaque psoriasis and atopic dermatitis
What are topical PDE4 Inhibitors indicated for?
Maintenance therapy for all forms of psoriasis
What are topical Vitamin D analogs predominantly used for?
CBC, CMP, Lipid panel, and hCG for all females at childbearing age
What baseline labs are required for all pts who are prescribed Isotretinoin (Accutane)?
Vanish when they are rubbed in, non-occlusive
What characteristics do creams have?
Jelly-like, not greasy, can be sticky, least occlusive vehicle, dries quickly
What characteristics do gels have?
Pourable liquid, less greasy, less occlusive, may sting
What characteristics do lotions have?
Thick, lubricating, semi-occlusive, greasy, and do not cause stinging sensations
What characteristics do ointments have?
Retinoids
What class of drugs are used to treat comedonal acne?
Atopic dermatitis and vitiligo
What dermatologic conditions are JAK Inhibitors indicated for?
Oral Antibiotics
What do we use to treat SEVERE popular/pustular acne?
Oral retinoids
What do we use to treat severe nodular-cystic refractory acne?
Psoriasis and psoriatic arthritis
What is Apremilast (Otezla) indicated for?
Treatment of atopic dermatitis
What is Crisaborole (Eucrisa) predominantly indicated for?
An oral retinoid
What is Isotretinoin (Accutane, Absorica)?
Treatment of plaque psoriasis
What is Rofumilast (Zoryve) predominantly indicated for?
Androgenetic alopecia in men and women
What is Topical Minoxidil (Rogaine) used for the treatment of?
A retinoid
What is Tretinoin an example of?
If the woman is carrying a male fetus, we may see the med SE affect the fetus
What is a specific caution when we consider Rx a pregnant pt Finasteride (Propecia)?
Ocular Rosacea
What is a specific indication for Doxycycline (Oracea) that only it can cover?
Apremilast (Otezla)
What is an example of a systemic/oral PDE4 Inhibitor?
Deucravacitinib (Sotyktu)
What is an example of a systemic/oral TYK2 Inhibitor?
Ruxolitinib (Opzelura)
What is an example of a topical JAK Inhibitor?
Finasteride (Propecia)
What is an oral therapy option for alopecia treatment?
Metronidazole (Flagyl)
What is our first line treatment option for acne rosacea?
Severe caution due to an increased risk of serious infections, malignancy, major adverse cardiac events, and thrombosis
What is the Black Box Warning associated with JAK Inhibitors?
Predominantly for oral calcineurin inhibitors: there is an increased risk of skin malignancy and lymphoma
What is the Black Box Warning for calcineurin inhibitors?
Binds to vitamin D3 receptors and mimics vitamin D3 which decreases skin cell ability to proliferate, differentiate, and cause inflammation
What is the MOA for Vit D analogs?
Keratolytic action which regulates cell proliferation, reduced follicular plugging, and decreases sebum production
What is the MOA for retinoids?
Blocks the dephosphorylation of NFAT (nuclear factor of activated T-Cells) which blocks the ability of NFAT to enter the nucleus. Therefore, IL-2 is not activated to produce T-Cells
What is the MOA of calcineurin inhibitors?
120-150 mg/kg
What is the accumulation goal for Isotretinoin when taken with a fatty meal?
A mandatory FDA program that allows women of childbearing age to have 7 days after their proven (-) hCG lab to obtain their Isotretinoin script
What is the iPLEDGE system?
1 mg/kg per day
What is the maximum dose of Isotretinoin?
Irreversible skin atrophy
What is the most common side effect with topical steroid use?
Dermal layer
What layer or layers of the skin are affected with topical steroid induced skin atrophy?
Anti-microbials or Anti-inflammatories
What topical is used to treat papular/pustular acne?
Eyes, face, and genitals
Which areas of the body are high in vascularity but have thinner skin?
Acral surfaces of palms and soles
Which areas of the skin have low vascularity but have thicker skin?
