Exam 2 Hematology Ch. 7 - Granulocytes & Monocytes - Quiz & Review Questions
An absolute neutrophil is most likely to be associated with a(n): A. Allergic response B. Parasite infection C. Bacterial infection D. Viral infection
Bacterial infection
Which of the following peripheral blood pictures is likely to be seen if elevated levels of GM-CSF persist in the bone marrow? Neutrophilia, eosinophilia Granulocytosis, monocytosis Monocytopenia, granulocytosis Monocytosis, neutropenia
Granulocytosis, monocytosis
Leukocytes migration to the tissues is regulated by leukocyte-endothelial cell recognition that requires: A. Interaction of adhesion molecules and their receptors B. Activation of membrane oxidase C. leukocyte degranulation D. Hematopoietic growth factors
Hematopoietic growth factors
What would be the major effect on the body of a severe monocytopenia? A. Increases risk of parasitic infections B. Increased risk of bacterial infections C. Increased risk of viral infections D. Decreased risk of allergic reactions
Increased risk of bacterial infections
Patients with chronic granulomatous disease lack the ability to produce a neutrophilic respiratory burst and often die of bacterial infections. Which phase of phagocytosis is disrupted? A. Ingestion of bacteria B. Bacterial cell killing C. Neutrophilic granulation D. Bacterial cell recognition
Bacterial cell killing
Which of the following is associated with an increased leukocyte concentration? Older adults, pregnancy Tissue necrosis, whole body irradiation Birth, pregnancy, infection Older adults, birth
Birth, pregnancy, infection
The process by which neutrophils migrate through the VEC into the tissues is known as: Phagocytosis. Opsonization. Diapedesis. Chemotaxis.
Diapedesis.
IL-5 is the cytokine that is required for which cell type to proliferate and terminally differentiate? Basophil Monocyte Neutrophil Eosinophil
Eosinophil
Which cell line is the first line of defense against helminth infections? Eosinophil Lymphocyte Neutrophil Monocyte
Eosinophil
Which of the following terms is used to describe an absolute increase in the number of eosinophils? Lymphocytosis Neutropenia Leukocytosis Eosinophilia
Eosinophilia
All of the following can cause a leukocytosis except: Malignancy Viral infection Exposure to radiation Immune responses
Exposure to radiation
Leukocyte surface markers identify cell lineage and are helpful in differentiating neoplastic hematologic disorders. What is one method used to identify these surface markers? Leukocyte differential Chamber counts Flow cytometry Cytogenetic methods
Flow cytometry
Basophils and mast cells have receptors for which immunoglobin? A. IgA B. IgG C. IgM D. IgE
IgA
The basophil is the least plentiful cell found in the peripheral blood. What can it indicate when it is increased in the blood? Inflammation Infection Allergic reaction Malignancy
Malignancy
If a neutrophil lacked the ability to produce L-selectin, which of its functions or abilities would be disrupted? A. Phagocytosis B. Degranulation C. Cytokine secretion D. Margination
Margination
All of the following precursors are found in the mitotic pool except: Promyelocyte Metamyelocyte Myelocyte Myeloblast
Metamyelocyte
A(n) __________ has cytoplasm with a ground glass appearance while a ___________ contains cytoplasm that is pinkish to clear in color: A. Eosinophil; neutrophil B. Monocyte; lymphocyte C. Lymphocyte; basophil D. Monocyte; neutrophil
Monocyte; neutrophil
What cell lineage is characterized by the presence of CD14 on its surface? Monocytic Lymphocytic Eosinophilic Neutrophilic
Monocytic
An instrument printout shows a WBC count of 4.5 × 109/L with 75% neutrophils. What is the absolute neutrophil count? 4.5 × 10^9/L 3.4 × 10^9/L 3.8 × 10^9/L 1.9 × 10^9/L
3.4 × 10^9/L
Hematological analysis was performed on a 10-day-old baby who appeared to have difficulty breathing and had a temperature of 101.2°F. The WBC was 29.8 × 109/L. This finding represents a(n): Absolute leukocytosis Normal leukocyte count Absolute leukopenia Relative leukopenia
Absolute leukocytosis
Phagocytosis consumes a large amount of energy provided by what process? Erythrophagocytosis Diapedesis Aerobic and/or anaerobic glycolysis Innate immune response
Aerobic and/or anaerobic glycolysis
Leukocytosis can be defined as an increased in: A. Neutrophils, monocytes, and macrophages B. Neutrophils, eosinophils, erythrocytes, and basophils C. Neutrophils, eosinophils, basophils, monocytes, and lymphocytes D. Neutrophils, eosinophils, basophils, monocytes, lymphocytes, and megakaryocyte
Neutrophils, eosinophils, basophils, monocytes, and lymphocytes
Routine hematological analysis was performed on a 1-day-old baby. The WBC count was 21.3 X 10^9/L. This finding represents a(n): A. Normal leukocyte count B. Absolute leukocytosis C. Relative leukopenia D. Absolute leukopenia
Normal leukocyte count
Routine hematological analysis was performed on a 21-year-old adult. The WBC was 8.3 × 109/L. This finding represents a(n): Relative leukopenia Normal leukocyte count Absolute leukocytosis Absolute leukopenia
Normal leukocyte count
Monocytes function in the innate immune response by their ability to ___________ and the function in the adaptive immune response by __________ and ___________. A. Phagocytose; antigen presentation; cytokine secretion B. Degranulate; erythrophagocytosis; diapedesis C. Stimulate T-cells; secretion of IgM; remove helminths D. Secrete cytokines; chemotaxis; degranulation
Phagocytose; antigen presentation; cytokine secretion
What characteristic that is present in promyelocytes morphologically differentiates a promyelocyte from a myeloblast? Pink cytoplasm Loss of nucleoli Primary granules Secondary granules
Primary granules
3. Primary granules first appear in the: A. Myeloblast B. Promyelocyte C. Myelocyte D. Band
Promyelocyte
The information of 20 mcM (μm) in size, round nucleus with lacey chromatin and several nucleoli, deep blue cytoplasm with large bluish-purple granules describes which stage of neutrophil maturation? Myelocyte Promyelocyte Metamyelocyte Band neutrophil
Promyelocyte
The eosinophils primary function is to: A. Protect the host from helminth parasites B. Protect he host form autoimmune destruction C. Secrete cytokines to attract monocytes to the site of infection D. Secrete cytokines to attract lymphocytes to the site of infection
Protect the host from helminth parasites
11. Which of the following leukocytes are most likely to resemble the morphology of a monocyte? A. Neutrophils B. Basophils C. Reactive lymphocytes D. Eosinophils
Reactive lymphocytes
The total WBC count for an adult is 13.1 X 10^9/L with a differential count that reveals 20% eosinophils. This represents a: A. Relative and absolute eosinophilia B. Relative eosinophilia and normal absolute count C. Normal relative count and absolute eosinophilia D. Normal eosinophil count
Relative and absolute eosinophilia
2. The hallmark of differentiating myelocytes from promyelocytes morphologically is the visual identification of what in the myelocytes? A. Primary granules B. Secondary granules C. Loss of nucleoli D. Pink cytoplasm
Secondary granules
An instrument printout shows a normal WBC count with a neutrophil count of 30%. What can be concluded from this? The patient is suffering from an infection. There is a normal neutrophil concentration. The patient has a relative neutropenia. The patient is an infant.
The patient has a relative neutropenia.
All of the following are included in the kill mechanism by neutrophils except: Chemoattraction of neutrophils to infectious agent. The presentation of the infectious agent to a monocyte for phagocytosis. Diapedesis of neutrophils from blood into tissues. The formation of the phagolysosome by the neutrophil.
The presentation of the infectious agent to a monocyte for phagocytosis.
The life span of the neutrophil is spent in three compartments. Which compartment is the primary site of host defense? Thymus Tissues Liver Bone marrow
Tissues
The induction of activation-dependent adhesion events depends on adhesion molecules and their ligands located on the leukocyte and what other cell? Vascular endothelium cell Adipocyte Hepatocyte Macrophage
Vascular endothelium cell
A(n) __________ has purple-black granules that obscure the cytoplasm, whereas a(n) __________ contains granules that orange to red in color. lymphocyte; basophil eosinophil; neutrophil basophil; eosinophil monocyte; lymphocyte
basophil; eosinophil