Gastric Juice

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Accounts for 30-50% of the gastric secretions

Cephalic phase

Where does protein digestion begin?

In the stomach because of pepsin

Protects the stomach lining from HCl

Mucus layer

Is made up of the products of mucous, chief, and parietal cells

Gastric juice

Digests lipids

Gastric lipase

Secreted by the chief cells

Gastric lipase

Accounts for 40-50% of the secretions

Gastric phase

In this phase, acid is secreted and it's inhibited when pH reaches 3.0

Gastric phase

A hormone that is secreted by cells near the parietal cells

Somatastatin

2. After pepsinogen is secreted, it then combines with HCl which is secreted from the ________cells

parietal

When the pH reaches ___ in the stomach, the acid stops secreting

1.5

A high pH of __ or more indicates the need for acid

4

Secreted by the mucus cells

A thin mucus layer

A neurotransmitter

Acetylcholine

It's secreted in response to the parasympathetic nervous system in normal conditions

Acetylcholine

Stimulates cells in the pylorus to secrete the hormone gastrin

Acetylcholine

Suppresses somatastatin and allows HCl to be secreted when needed

Acetylcholine

Begins before food reaches the stomach

Cephalic phase

Controlled by the parasympathetic nervous system

Cephalic phase

Controls the psychological influences such as the smelling, thinking or first taste of food

Cephalic phase

3 phases of gastric juice secretion

Cephalic phase, gastric phase, and intestinal phase

1. Secretes pepsinogen

Chief cells

A hormone secreted by the small intestines, and targets the stomach, but inhibits gastric movement

Cholestokinin

CKK

Cholestokinin

When the stomach stretches due to the presence of food which stimulates gastric secretions

Gastric phase

Stimulates gastric juice release

Gastrin

A hormone secreted by the small intestines, but it targets the stomach

Intestinal gastrin

Enhances gastric gland secretions

Intestinal gastrin

3 hormones are secreted in the intestinal phase; they secrete in order, not at the same time

Intestinal gastrin, cholestokinin, and intestinal somatostatin

Accounts for about 5-10% of the secretions

Intestinal phase

Begins when food enters the small intestines

Intestinal phase

A hormone secreted by the small intestines, targets the stomach, but inhibits all gastric juice secretions

Intestinal somatostatin

Helps absorb vitamin B12 into the blood

Intrinsic factor

Is secreted by parietal cells

Intrinsic factor

3. Pepsinogen + HCl =

Pepsin

Breaks down protein

Pepsin

Inhibits

Slows down

Always inhibits something

Somatastatin

Inhibits the secretion of HCl

Somatastatin


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