Genetics Chapter 15

Which of the following would also work as an enhancer for the following bi-directional enhancer? 5' GTTC 3' 3' CAAG 5'

5' GAAC 3' 3' CTTG 5'

Which of the following is the most likely location of an insulator sequence?

Between two genes

Histone acetyltransferases are directly involved in which of the following?

Chemical modification of histones

CpG islands are associated with which of the following?

DNA methylation

DNA that contains actively transcribed genes would most likely contain chromatin in the closed configuration

False

Methylation of DNA bases is one way that regulatory transcription factors may influence gene expression

False

Which of the following structural motifs promotes dimerization?

Leucine zipper

What basal transcription factor is most often affected by regulatory transcription factors?

TFIID

In ChIP-Seq, the DNA fragments to be sequenced are around 150 bp in length. What does this size of DNA represent?

The amount of DNA wrapped around a nucleosome

A particular cell contains all of the standard histones but lacks several histone variants. Which of the following MAY be true of this cell?

The cell will express different sets of genes than other cells in the same organism

A particular gene has a mutation in its NFR that causes it to bing abnormally tightly to histones. What effect would you expect this mutation has on the expression of this gene?

The expression of the gene would be abnormally low or absent

Housekeeping genes are unmethylated and active in most cells

True

Steroid hormones are an example of an effector which regulates transcription factor activity

True

The activity of some transcription factors can be regulated by colvalent modifications

True

When cortisol binds to the glucocorticoid receptor, HSp90 is relased

True

Insulators exert their effects on gene expresssion through histone acetyltransferase, histone deacetylase, and RNA polymerase

false

What activates CREB?

phosphorylation

cAMP is known as a second messenger since the pathway is first activated by a extracellular signaling molecule

true