genetics multiple choice questions

what is the mutation rate in prokaryotes

10^-6 to 10^-9

what is another name for the replication bubble A. replicon B AT rich sequence C Dna initiator D telomere

A replicon

which of the following is not needed in bacterial transcription A. DNA primers b. NTPS C. sigma factors D. RNA polymerase E. Terminator

A. DNA primers

The correct mode of replication is A. conservative B. semiconservative C. dispersive D. all of the above

B semiconservative

The following is a protein-coding region of the E. coli genome. Watson strand is the coding strand. What is the mRNA product? Watson: 5'-ATGGCATAAAACCCGGTACGGCATG-3' Crick: 3'-TACCGTATTTT GGGCCATGCCGTAC-5' A. 5'-UACCGUAUUUUCCCGGAUGCCGUAC-3' B. 5'-AUGGCAUAAAACCCGGUACGGCAUG-3' C.5'-GUACGGCAUGGCCCAAAAUACGGUA-3' D.5'-CAUGCCGUAGGCCCUUUUAUGCCAU-3' E. None of the above

B. 5'-AUGGCAUAAAACCCGGUACGGCAUG-3'

Which amino acid substitution is responsible for sickle cell disease? A. Glu to Val in α- polypeptide B. Glu to Val in β- polypeptide C. Val to Glu in α- polypeptide D. Val to Glu in β- polypeptide E. Gln to Val in β- polypeptide

B. Glu to Val in β- polypeptide

the key enzyme that replicates the chromosomes ends A. DNA polymerase B. Topiomerase C. A reverse transcriptase D. none of the above

C a reverse transcriptase

DNA replication is A. Multidirectional B. Unidirectional C. Bidirectional C. Both B and C

C bidirectional

Which is a dominant autosomal genetic disease? A. Kartgner syndrome B. Down syndrome C. Huntington disease D. Cystic fibrosis E. Albinism

C. Huntington disease

What is true about PKU? A. PKU is a sex linked trait B. PKU results from the conversion of Tyrosine to Phenylalanine C. PKU can be managed by dietary control. D. Person with PKU are sterile E. All of the above

C. PKU can be managed by dietary control.

which of the following is not true about RNA A. RNA can regulate gene expression B. not all RNA is translated into proteins C. RNA is more stable than DNA

C. RNA is more stable than DNA

telomere is not present in A. humans B. Ameoba C all organisms consisting of a single cell D. all bacteria

D all bacteria

which enzyme has proof reading function A. DNA polymerase III B. DNA polymerase I C. DNA primas D. Both A and B

D both A and B

what macromolecules represent material in most organisms? A. RNA B. carbohydrate C. protein D. DNA

D. DNA

why eukaryotes have multiple replicons A. reduce the time of genome replication B reduce the mutation in the protein coding genes C. select a set of cell type specific replicons D. all of the above

D. all of the above

Which of the following descriptions is true for Lesch-Nyhan syndrome: A.It is resulting from autosomal recessive mutation B. It is a fatal disease found only in female. C. It causes the heart shifted to right. D. It has pleiotropic effects E. All of the above

D. it has pleitrophic effects

What statement is NOT true for bacterial transcription? A. RNA is synthesized from 5' to 3' B. Sigma factor can be reused. C. NTPs are used in transcription D. Promoters are located at the beginning of the coding regions. E. Prokaryotes have only one RNA polymerase.

D. promoters are located at the beginning of coding regions

which does NOT help make DNA more compact A. Histone B. Non-histone C. loop formation D. Single stranded binding proteins

D. single stranded binding proteins

which enzyme replaces RNA primer with dna after elongation? a. rna polymerase b. dna polymerase 1 c. RNA primase d. dna ligase e. dna polymerase III

DNA polymerase I or dna polymerase III

RNA editing occurs in A. Some nuclear RNA B. Mitochondrial RNA C. Chlorplatsts RNA D. Micro RNA In humans E. all of the above

E. all of the above

what is not true about for eukaryotic transcription A. RNA splicing B. More than one RNA polymerase C. capping and poly A tail D. transcription factors E. o-factors

E. o-factors

which is a dominant autosome genetic disease A. Kartgner syndrome B. Down syndrome C. Huntington disease D. Cystic fibrosis E. Albinism

Huntington disease

Which enzyme elongates the new DNA strand starting at an RNA primer? a. dna polymerase III b. dna polymerase I c. DNA ligase d. RNA polymerase

a. dna polymerase III

after the removal of the RNA primers and replacement with DNA nucleotides, the single-stranded nick adjacent to Okazaki fragments is filled through a reaction that involves which enzyme? a. dna primase b. dna ligase c. dna helicase d. RNA polymerase

b. dna ligase

the enzyme activity of a telomerase is best described as a. topiosmerase b. reverse transcriptase c. exonuclease d. polymerase

b. reverse transcriptase

Which kind of enzyme prevents DNA from tangling up by introducing negative supercoils as the replication fork migrates during replication? a. ligase b. topiosmerase c. helicase d. dna polymerase III

b. topiosmerase

replication of nuclear DNA in eukaryotes requires a. pol alpha and delta b. pol epsilon only c. pol alpha only d. pol alpha, delta and epsilon

d. pol alpha, delta, and epsilon

After a region of DNA has been replicated, ______ removes the RNA primers. a. dna helicase b. dna polymerase I c. dna ligase d. dna polymerase III

dna polymerase I or dna polymerase III