Hematology exam 06

The target therapeutic range for an INR in patients with thromboembolic disease is: A. 2 to 3 B. 2 to 2.5 C. 1.5 to 2.5 D. 1 to 2

A. 2 to 3

Patients with the heterozygous form of afibrinogenemia will have plasma levels of fibrinogen in the range of: A. 20 to 100 mg/dL B. 50 to 150 mg/dL C. 100 to 200 mg/dL D. 0 to 20 mg/dL

A. 20 to 100 mg/dL

Coumadin acts in such a way that it: A. Alters the synthesis of vitamin K-dependent factors B. Reduces the circulating level of factor I C. Cleaves carboxyreductase to generate glutami acid D. Reduces the circulating level of factors III and V

A. Alters the synthesis of vitamin K-dependent factors

A patient with DIC will have the following coagulation test results except: A. An increased fibrinogen B. An increased aPTT C. An increased PT/INR D. An increased D-dimer

A. An increased fibrinogen

Which of the following PT results would most likely be seen in a patient who is on Coumadin and is stable? A. Approximately 26 seconds B. Approximately 13 seconds C. Approximately 40 seconds D. Approximately 60 seconds

A. Approximately 26 seconds

Obstetrical complications like retained placenta or abruptio placenta are leading causes of: A. DIC B. ITP C. TTP D. Thrombosis

A. DIC

D-dimers may be elevated in which of the following? A. Deep vein thrombosis B. Sickle cell disease C. Bernard-Soulier syndrome D. Glanzmann's thrombasthenia

A. Deep vein thrombosis

Which of these are byproducts of fibrinolysis? A. Fibrin degradation products and D-dimers B. Fibrinopeptides A and B C. Alpha 2 antiplasmin D. Streptokinase and urokinase

A. Fibrin degradation products and D-dimers

The substrate upon which the coagulation cascade is centered is: A. Fibrinogen B. Thrombin C. Fibrin D. Vitamin K

A. Fibrinogen

Heparin-induced thrombocytopenia (HIT) usually: A. Occurs 5 to 14 days after heparin therapy B. Occurs only in males C. Occurs as a result of protein C deficiency D. Will show an increase in platelets

A. Occurs 5 to 14 days after heparin therapy

Primary hemostasis refers to the process by which: A. The platelet plug is formed B. A cross-linked fibrin clot is formed C. Fibrin degradation products are generated D. None of the above

A. The platelet plug is formed

The reference range for a thrombin time is: A. 100 to 120 seconds B. 11 to 15 seconds C. 40 to 60 seconds D. 20 to 40 seconds

B. 11 to 15 seconds

Factor VIII inhibitors: A. Are corrected with the addition of normal plasma B. Are usually time and temperature dependent C. Are associated with decreased fibrinogen levels D. Are associated with thrombosis

B. Are usually time and temperature dependent

Arterial thrombosis is associated with: A. A deficiency of physiologic inhibitors B. Atherosclerosis C. Impairment of the fibrinolytic system D. Slow blood flow

B. Atherosclerosis

Prothrombin can only be converted to thrombin by the action of factor X, factor V, platelet factor 3, and: A. Factor II B. Calcium C. Phosphorus D.Fibrinogen

B. Calcium

The D-dimer test measures: A. Fibrinogen degradation B. Fibrin deposition C. Fibrinogen deposition D. Fibrin degradation

B. Fibrin deposition

A prolonged thrombin time and a normal reptilase time is indicative of: A. FDPs B. Heparin therapy C. Warfarin therapy D. Aspirin therapy

B. Heparin therapy

All of the following statements are true regarding Coumadin except: A. PT is used to monitor its dosage. B. It needs antithrombin as a cofactor. C. It is a vitamin K antagonist. D. It is not recommended for pregnant and lactating women.

B. It needs antithrombin as a cofactor.

The international normalized ratio (INR) is useful in: A. Monitoring heparin therapy B. Monitoring Coumadin therapy C. The detection of inhibitors D. The detection of coagulation factor deficiencies

B. Monitoring Coumadin therapy

All of the following are naturally occurring thrombin inhibitors except: A. Protein C B. Plasmin C. Prothrombin cofactor II D. AT

B. Plasmin

The reference range for fibrinogen is: A. 600 to 750 mg/dL B. 100 to 200 mg/dL C. 200 to 400 mg/dL D. 400 to 600 mg/dL

C. 200 to 400 mg/dL

Which of the following hematology disorders will likely trigger an episode of DIC? A. Sickle cell disease B. Iron deficiency anemia C. Acute progranulocytic leukemia D. Idiopathic thrombocythemia

C. Acute progranulocytic leukemia

A primary inhibitor of the fibrinolytic system is: A. Protein C B. Antithrombin C. Alpha 2 antiplasmin D. Alpha 2 macroglobulin

C. Alpha 2 antiplasmin

Drug alternatives for patients with heparin-induced thrombocytopenia include: A. Warfarin B. Aspirin C. Danaparoid D. Streptokinase

C. Danaparoid

The best component to use for patients with afibrinogenemia is: A.Tissue plasminogen activator B. Whole blood C. Fresh frozen plasma D. Factor XIII

C. Fresh frozen plasma

Normal levels of fibrin degradation products are removed by the reticuloendothelial system and usually measure: A. Less than 75 µg/mL B. Less than 100 µg/mL C. Less than 40 µg/mL D. Less than 20 µg/mL

C. Less than 40 µg/mL

The lupus anticoagulant is directed against: A. Factor IX B. Factor VIII C. Phospholipids D. Factor X

C. Phospholipids

Plasmin causes the inactivation of factors: A. X, XI, XII, XIII B. V, VII, X, XI C. V, VIII, XI, XII D. VII, VIII, XI, XII

C. V, VIII, XI, XII

Antithrombin inhibits all of the following factors except: A. IX a B. II a C. VII a D. XI a

C. VII a

The process of fibrin degradation is called __________ and is controlled by the enzyme _________. A. fibrinolysis, protease B. fibrination, plasmin C. fibrinolysis, plasmin D. fibrination, protease

C. fibrinolysis, plasmin

Arterial thrombosis is associated with: A. Impairment of the fibrinolytic system B. A deficiency of physiologic inhibitors C. Slow blood flow D. Atherosclerosis

D. Atherosclerosis

An excess of which of the following is indicative of the breakdown of fibrin products within the circulating blood? A. Alpha-2-antiplasmin B. Protein C C. Plasmin D. D-dimers

D. D-dimers

The primary role of plasmin is: A. Platelet aggregation B. Coagulation inhibition C. Prevention of thrombotic events D. Fibrin breakdown

D. Fibrin breakdown

Heparin: A. Inhibits PF3 B. Degrades antithrombin C. Complexes with protein C D. Inhibits thrombin

D. Inhibits thrombin

All of the following statements describe factor V Leiden except: A. Is an inherited disorder. B. It is associated with increased risk of thrombosis. C. It is a cause of activated protein C resistance. D. It is associated with thrombocytopenia.

D. It is associated with thrombocytopenia.

All of the following statements are true regarding Coumadin except: A. It is not recommended for pregnant and lactating women. B. PT is used to monitor its dosage. C. It is a vitamin K antagonist. D. It needs antithrombin as a cofactor.

D. It needs antithrombin as a cofactor.

The most common tests used to detect Lupus anticoagulants include all of the following except: A. aPTT B. Kaolin clotting time C. Dilute Russell viper venom test D. PT/INR

D. PT/INR

Primary fibrinolysis is a disorder closely related to DIC. All of the coagulation profile assays are the same as that for DIC with the exception of the: A. Fibrinogen level, which is decreased B. D-dimer level, which is increased C. PT/INR, which is increased D. Platelet count, which is normal

D. Platelet count, which is normal

What therapy may be used for a patient with hemophilia A who is bleeding and has a low titer of factor VIII inhibitor? A. High-dosage factor VIII concentrate B. Fresh frozen plasma C. Antithrombin concentrate D. Porcine factor VIII

D. Porcine factor VIII

Protein C is activated by which of the following? A. Heparin cofactor II B. Factor VIII a C. Antithrombin D. Protein S

D. Protein S

Heparin therapy is monitored best by performing routine: A. Fibrinogen levels B. Bleeding time tests C. PT/INRs D. anti-factor Xa

D. anti-factor Xa