LabCE 1

What is the normal myeloid to erythroid (M:E) ratio in the bone marrow? a) 2:1 - 4:1 b) 1:2 - 1:4 c) 3:1 - 5:1 d) 5:1 -10:1

a) 2:1 - 4:1

B lymphocytes and T lymphocytes are derived from: a) Hematopoietic stem cells b) Macrophages or monocytes c) Mucosa-associated lymphoid tissue (MALT) d) Granulocytes

a) Hematopoietic stem cells

The life span of RBCs containing Hemoglobin H is typically: a) Less than 120 days b) 100-120 days c) 120-140 days d) Greater than 140 days

a) Less than 120 days

Which of the following cells are of lymphoid lineage? a) Plasma cell b) Macrophage c) Eosinophil d) Megakaryocyte

a) Plasma cell

Out of the choices below, which set of cells is arranged from least mature to most mature? a) Stem Cell, Rubriblast, Prorubricyte, Rubricyte, Metarubricyte, Reticulocyte, Erythrocyte b) Stem Cell, Prorubricyte, Metarubricyte, Erythrocyte, Rubriblast, Rubricyte, Reticulocyte c) Erythrocyte, Reticulocyte, Metarubricyte, Rubricyte, Prorubricyte, Rubriblast, Stem Cell d) Rubricyte, Rubriblast, Stem Cell, Prorubricyte, Erythrocyte, Reticulocyte, Metarubrictye

a) Stem Cell, Rubriblast, Prorubricyte, Rubricyte, Metarubricyte, Reticulocyte, Erythrocyte

The average bone marrow cellularity in a normal adult (50 years old) is: a) 30 b) 50 c) 65 d) 70

b) 50

Adult (normal) Hemoglobin is made up of the following composition: a) >90% HbA, 1% HbA2, 5% HbF b) >95% HbA, <3.5% HbA2, <1-2% HbF c) <90% HbA, 10% HbA2, 5% HbF d) >90% HbA, 1% HbA2, 5-10% HbF

b) >95% HbA, <3.5% HbA2, <1-2% HbF

Which hormone is produced by the kidney and influences erythrocyte production? a) Growth hormone b) Erythropoietin c) Interleukin 3 d) ALA synthetase

b) Erythropoietin

In which organ or tissue do T-lymphocytes mature? a) Bone marrow b) Thymus c) Lymph nodes d) Spleen

b) Thymus

What is the expected life span of a normal red blood cell? a) 3-4 months b) 1-2 months c) 3-6 weeks d) 1-3 weeks

a) 3-4 months

Which of the following is the proper designation for the pluripotential stem cell that is a precursor for both myeloid and lymphoid cell lines? a) CFU-S b) CFU-GEMM c) G-CSF d) CFU-GM

a) CFU-S

What is the platelet precursor cell found in the bone marrow? a) Megakaryocyte b) Megaloblast c) Myeloblast d) Pronormoblast

a) Megakaryocyte

Which of the following statements is correct regarding bone marrow evaluation? a) Bone marrow cellularity increases with age. b) Bone marrow cellularity is highest in young children compared to adults. c) In a healthy person, the expected myeloid : erythroid ratio is less than 1 (one). d) As we age, the amount of adipose tissue (fat) decreases.

b) Bone marrow cellularity is highest in young children compared to adults.

Which of the following are terms used to describe storage pool iron? a) Hemosiderin and myoglobin b) Ferritin and hemosiderin c) Hemopectin and hemoglobin d) Apoferritin and transferrin

b) Ferritin and hemosiderin

The bone marrow begins producing cells in the _____________ month of fetal life. a) First b) Fourth to Fifth c) Sixth d) Eighth

b) Fourth to Fifth

Which of the following stages of neutrophilic granulocyte cellular development is at the second stage from the least mature stage? a) Band neutrohiil b) Promyelocyte c) Metamyelocyte d) Myeloblast

b) Promyelocyte

Which of the following statements are true for the hematopoietic cords? a) Hematopoietic cells develop at random locations in the marrow cells b) Reticular cells (adventitial cells) provide support for developing hematopoietic cells within the hematopoietic cords c) Lymphocytes are not seen in normal marrow d) Fat cells content of bone marrow decrease with aging

b) Reticular cells (adventitial cells) provide support for developing hematopoietic cells within the hematopoietic cords

Which of these is arranged from least mature to most mature? a) Lymphoblast, lymphocyte, prolymphocyte, stem cell b) Stem cell, lymphoblast, prolymphocyte, lymphocyte c) Stem cell, lymphoblast, lymphocyte, prolymphocyte d) Lymphocyte, prolymphocyte, lymphoblast, stem cell

b) Stem cell, lymphoblast, prolymphocyte, lymphocyte

Which of the following is responsible for the humoral (involving antibody production) immune response: a) Neutrophils b) Basophils c) B lymphocytes d) Monocytes

c) B lymphocytes

What is the normal ratio of erythroid to myeloid cells found in the normal bone marrow? a) 1:1 - 2:1 b) 1:5 c) 1:3 d) 1:10

c) 1:3

Whole blood if composed of approximately: a) 75% formed elements and 25% plasma b) 60% formed elements and 40% plasma c) 45% formed elements and 55% plasma d) 30% formed elements and 70% plasma

c) 45% formed elements and 55% plasma

From the white blood cell values listed below, which is within the normal reference ranges? a) 2,700/mm3 b) 3,800/mm3 c) 5,500/mm3 d) 15,000/mm3

c) 5,500/mm3

What is the composition of the granules associated with basophilic stippling? a) Aggregates of iron b) Aggregates of hemoglobin c) Aggregates of ribosomes d) Aggregates of DNA

c) Aggregates of ribosomes

All of the following are sites of active hematopoiesis in the adult EXCEPT: a) Skull b) Ribs c) Liver d) Pelvis

c) Liver

Which of the following major cellular elements does not develop solely in the bone marrow? a) Monocyte b) Neutrophil c) Lymphocyte d) Macrophage

c) Lymphocyte

What is the precursor of the platelet which is, in most cases, only found in the bone marrow? a) Myeloblast b) Promegakarocyte c) Megakaryocyte d) Erythroblast

c) Megakaryocyte

If greater than 50% lymphocytes were found on the peripheral blood smear of a 5-month-old child you would suspect which of the following conditions? a) Immune deficiency syndrome b) Acute viral infection c) Normal finding d) Infectious hepatitis

c) Normal finding

What is the correct order of erythrocyte maturaton in the bone marrow? (beginning from the most immature) a) Polychromatophilic normoblast? basophilic normoblast? polychromatophilic erythrocyte? orthochromic normoblast? pronormoblast b) Orthochromic normoblast? basophilic normoblast? polychromatophilic normoblast? polychromatophilic erythrocyte? pronormoblast c) Pronormoblast? basophilic normoblast? polychromatophilic normoblast? orthochromic normoblast? polychromatophilic erythrocyte d) Pronormoblast? basophilic normoblast? polychromatophilic erythrocyte? orthochromic normoblast? polychromatophilic normoblast

c) Pronormoblast? basophilic normoblast? polychromatophilic normoblast? orthochromic normoblast? polychromatophilic erythrocyte

All of the following are present in normal bone marrow EXCEPT? a) Siderocyte b) Sideroblast c) Ringed sideroblast d) Hemosiderin

c) Ringed sideroblast

All of the following bones contain active hematopoietic bone marrow in a normal adult, EXCEPT? a) Pelvis b) Sternum c) Tibia d) Vertebrae

c) Tibia

In which of the following situations would a bone marrow aspirate and biopsy be MOST LIKELY recommended to aid in diagnosis? a) Primary evaluation of a hypochromic/microcytic anemia b) Routine screening for hematologic complications c) Part of bone density screening d) Evaluation of unexplained cytopenias

d) Evaluation of unexplained cytopenias

The production of and development of blood cells is called: a) Hemoglobin b) Hematocrit c) Hemostasis d) Hemopoiesis

d) Hemopoiesis

What is the site used MOST frequently in the adult patient when performing a bone marrow biopsy? a) Vertebrae b) Sternum c) Clavicle d) Iliac crest

d) Iliac crest

Erythropoietin is mainly produced in: a) Bone marrow b) Bones c) Lymphocytes d) Kidneys

d) Kidneys

In an adult, hematopoiesis occurs in which of the following listed sites? a) Liver b) Spleen c) Pancreas d) Proximal ends of long bones

d) Proximal ends of long bones

Which white blood cell is found in the largest numbers in the peripheral blood of a normal adult? a) Lymphocyte b) Monocyte c) Basophil d) Segmented neutrophil

d) Segmented neutrophil

The bone marrow becomes the main site of hematopoiesis in the ________ month of gestation. a) First b) Second c) Fourth d) Seventh

d) Seventh

In the process of thrombopoiesis, which is arranged from least mature to most mature? a) Thrombocyte, metamegakarocyte, megakarocyte, promegakarocyte, megakaryoblast, stem cell b) Stem cell, megakaryoblast, megakarocyte, promegakarocyte, thrombocyte, metamegakarocyte c) Megakarocyte, promegakarocyte, megakaryoblast, thrombocyte d) Stem cell, megakaryoblast, promegakarocyte, megakarocyte, thrombocyte

d) Stem cell, megakaryoblast, promegakarocyte, megakarocyte, thrombocyte