MODULE 6 (Quality Control)

Equivalence factor for sodium thiosulfate: A. 1 B. 2 C. 3 D. 6 E. 10

A. 1

The filing volume is the volume to be filled with _____ in the container for the purpose of the test: A. Purified water B. water for injection C. 0.02N H2SO4 D. 0.02N NaOH E. NOTA

A. Purified water

Which of the ff. is used to identify peaks in the chromatogram? A. Retention time B. tailing factor C. number of theoretical plates D. width E. AOTA

A. Retention time

This test classifies whether the suspension is flocculated or deflocculated one: A. Sedimentation volume B. Viscosity C. Deliverable volume D. Minimum fill E. Assay

A. Sedimentation volume

Equivalence factor for assay of Pjosphoric Acod, NF: A. 1 B. 2 C. 3 D. 4 E. 10

B. 2

Formes a chelate with divalent and multivalent cations: A. Ammonia B. Ededate ion C. Fluoride ion D. Oxalate ion E. All of the choices

B. Ededate ion

The most widely used chromatographic method in drug analysis is: A) GC ) LLC C) HPLC D) SLC ) TLC

C) HPLC

Chemical analysis, which determines the amount or percentage content of a certain component in a sample: A) Qualitative B) Proximate C) Quantitative D) Gravimetric

C) Quantitative

Equivalence factor for potassium permanganate as an oxidizing agent: A. 2 B. 3 C. 5 D.10 E. 23

C. 5

An inert type of stainless steel used in dissolution apparatus recognized by the USP: A. Type 114 B. Type 239 C. Type 316 D. Type 489 E. All of the choices

C. Type 316

The biological assay for digitalis employs what test animal? A. Rats B. Guinea pigs C. dogs D. Pigeons E. rabbit

D. Pigeons

Dissolution testing should be conducted at this temperature A 37+0.5oC B. 37+2oC C. 37+0.2oC D. 37+2oC. E. 37+0.1oC

A 37+0.5oC

The oxidation number of atomic iodine is: A) +1 B) +2 C) +4 D) +3

A) +1

One twentieth molar solution of sulfuric acid is: A) 0.05 M B) 0.1 M C) 0.005 M D) 0.5 M

A) 0.05 M

How many mL of water is expected from a 20 g Digitalis sample containing 1.5% moisture? A) 0.3 mL B) 30 mL C) 3 mL D) None of the above

A) 0.3 mL

The official USP gravimetric methods are: 1. Assay involving direct ignition 2. Assay involving sublimation 3. Assay involving extraction 4. Assay involving precipitation followed by ignition A) 1, 3 and 4 B) 2, 3 and 4 C) 1, 2 and 4 D) 1, 2 and 3

A) 1, 3 and 4

Calculate the normality of sulfuric acid solution using 22.5mL. The volume of standardized NaOH used in the standardization was 20.70mL, and its normality was 1.1055: A) 1.0171 B) 1.1071 C) 1.0175 D) 1.0711

A) 1.0171

Calculate the normality of sulfuric acid solution using 22.15 mL of it. The volume of NaOh used in the standardization was 20.75 mL and its normality was 1.1055. A) 1.0356 B) 1.3056 C) 1.0035 D) 1.0030

A) 1.0356

The following data were obtained after the moisture and total ash content determination of acacia powder: Wt. of empty crucible 52.452 g Wt. of crucible & sample 61.648 g Wt. of crucible & sample after drying to constant wt. 60.502 g Wt. of crucible and residue left after incineration 53.006g Moisture content in grams: A) 1.146 B) 1.144 C) 1.164 D) 1.166

A) 1.146

The residue after incineration of a drug was 0.1185 g from a sample of 7.0 g. The percentage of ash is: A) 1.56 B) 2.56 C) 2.0 D) 1.55

A) 1.56

Content uniformity test is conducted in: A) 10 tablets B) 15 tablets C) 20 tablets D) 30 tablets

A) 10 tablets

The concentration of official diluted alcohol is: A) 10% B) 50% C) 80% D) 70%

A) 10%

Compute for the iodine value of corn oil 0.2048g dissolved in 10 mL chloroform and 25 mL iodobromide TS was added, mixed and allowed to stand for one hour. Thirty mL of KI TS and 100 mL distilled water were added and titrated with 10 mL of 0.1065 N sodium thiosulfate. The volume of sodium thiosulfate consumed in the blank was 25.7. I is equal to 126.9. A) 103.61 B) 103.16 C) 101.36 D) 103.66

A) 103.61

If a 0.4600g of potassium iodide (KI) yielded a 0.715g of silver iodide precipitate by gravimetric assay, what would be the percentage purity of KI? At.wt.: Ag = 107.87; K = 39.1; I = 126/9 A) 110.90 B) 110.89 C) 45.08 D) 109.90

A) 110.90

How many samples should be tested if a batch consists of 120 bottles of paracetamol suspension when the square root method is used? A) 12 B) 11 C) 10 D) 9

A) 12

Calculate the water content of an antibiotic powder using 350mg sample. The water equivalence factor (F) of the Karl Fischer reagent is 4.6 and the volume of the reagent used was 9.2 mL. The % of water content is: A) 12.09% B) 1.21% C) 12.11% D) A and B

A) 12.09%

Find the acid value of a sample weighing 1.230 g that consumes 30.0 mL pf 0.110 N NaOH to bring about the end point using KOH in the titration: A) 150.54 mg/g B) 157.72 mg/g C) 109.18 mg/g D) 124.41 mg/g

A) 150.54 mg/g

An accurately measured sample of hydrogen peroxide 2.00g was dissolved in a mixture of 20mL water and 20mL and 20mL diluted sulfuric acid and was then titrated with 0.100N potassium permanganate consuming 30.0mL to reach the end point. Compute for the percentage of peroxide (MW = 34) A) 2.55% B) 5.1% C) 2.5% D) None of the above

A) 2.55%

An accurately measured sample of hydrogen peroxide 2g was dissolved in a mixture of 20mL water and 20mL diluted sulfuric acid and was titrated with 0.1N potassium permanganate consuming 30mL to reach the endpoint. Compute for the percentage of hydrogen peroxide (MW=34): A) 2.55% B) 5.1% C) 2.5% D) 5.5%

A) 2.55%

If a 0.2250g of sodium bicarbonate (96.5% NaHCO3) is titrated with 0.1165N sulfuric acid. What volume of the acid is required to reach the end point? At.Wt. of Na = 23; H = 1.0; C = 12; O = 16 A) 22.19mL B) 21.98mL C) 21.20mL D) 21.22mL

A) 22.19mL

Twenty tablets of ascorbic acid weighed 4.2500g and a powdered sample of 0.3075g was titrated consuming 21.5mL of 0.1085N Iodine solution. Each mL of 0.1N Iodine is equivalent to 8.80mg of ascorbic acid. What is the amount of ascorbic acid per dose of two tablets? A) 283.72 mg B) 141.86 mg C) 283.22 mg D) A and C

A) 283.72 mg

A sample of Magnesia Magma weighing 12.35g was dissolved in 50mL of 1.0340N sulfuric acid and titrated until end point is reached consuming 24.6mL of 1.1255N sodium hydroxide solution. The percentage of MgO content is: At.Wt. of Mg = 24.3: O = 16 A) 3.92 B) 4.0 C) 3.85 D) 3.91

A) 3.92

The recommended maximum limit for overage of vitamins is: A) 30% B) 10% C) 90% D) None of the above

A) 30%

Compute for the angle of repose of the sample powder using fixed funnel method if the height and diameter obtained was 5 cm and 13 cm respectively. A) 37.57o B) 36.57o C) 35.75o D) 36o

A) 37.57o

Content uniformity test is to be performed for all products whose active ingredient is: A) 50 mg or less B) 130 - 134 mg C) 130 mg or less D) 324 mg or more

A) 50 mg or less

Content uniformity is to be performed for all tablets whose active ingredients are: A) 50mg or less B) 100mg or less C) 50mg or more D) None of the above

A) 50mg or less

In phenol content determination of a volatile oil, the layer in the graduated neck of the Cassia flask reached 2.7mL obtained from a sample of 10mL after treatment with KOH solution. The percentage of oil is: A) 73% B) 69% C) 7.3% D) 27%

A) 73%

Calculate the calcium carbonate content of a sample of chalk weighing 0.2545g and consuming 16.7 mL of 0.1150 M EDTA. At. Wt. Of Ca = 40.08 A) 75.52% B) 75.50% C) 37.76% D) 37.78%

A) 75.52%

What would be the aldehyde content of peppermint oil if the sample used was 15mL and the insoluble portion as read in the graduated neck of the Cassia flask was 2.2mL. The percentage of aldehyde content is: A) 85.33 B) 83.33 C) 84.30 D) 14.67

A) 85.33

If a 0.3800 g sample of sodium sulfate yielded 0.55 g of barium sulfate precipitate by gravimetric assay, what would be the percentage purity of sodium sulfate? At.wt.: Ba = 173.3; S = 32.06; Na = 23; O = 16 A) 88.11 B) 99.94 C) 99.15 D) 88.51

A) 88.11

The titer value of 1.0mL of 0.1N ceric sulfate for arsenic trioxide (MW = 197.94) A) 9.496 mg B) 197.84 mg C) 9.892 mg D) 14.838 mg

A) 9.496 mg

The period of stability of a preparation is the time from the date of manufacture of the formulation until its chemical or biological activity is not less than ___ of labeled potency: A) 90% B) 95% C) 93% D) 99%

A) 90%

A sample of 0.1350 g of As2O3 was assayed iodimetrically using 23.4 mL of 0.1055N Iodine solution. The percentage purity of the sample is: At.wt. of As = 74.92; O = 16 A) 90.44 B) 90.23 C) 89.00 D) 90.54

A) 90.44

A sample of 0.1350g of arsenic trioxide (As2O3) was assayed iodimetrically using 23.4mL of 0.1055N iodine solution. The percentage purity of the sample is: A) 90.44 B) 89.10 C) 90.54 D) 90.23

A) 90.44

Silica from the soil that is left after treatment of the ash with diluted HCl is the: A) Acid-insoluble ash B) Sulfated ash C) Residue on ignition D) Loss on ignition

A) Acid-insoluble ash

The measurement of a base of a given sample by titration with a standard acid is: A) Acidimetry B) Compleximetry C) Alkalimetry D) Redox

A) Acidimetry

The measurement of a weak base in nonaqueous medium of a given sample by titration with standard perchloric acid: A) Acidimetry B) Alkalimetry C) Compleximetry D) Redoc titration

A) Acidimetry

The bisulfite method is used in the assay of volatile oils to determine: A) Aldehyde content B) Acid content C) Ester content D) Sulfur content

A) Aldehyde content

Inspection stations are placed in the following areas, except: A) Analytical laboratory B) Manufacturing area C) Warehouse D) Packaging area

A) Analytical laboratory

Drug substances that are withheld from distribution until batch certification from BFAD has been received: A) Antibiotics B) Antineoplastics C) Vitamins D) All of the above

A) Antibiotics

The assay procedures in volumetric precipitation were introduced by the following scientists, except: A) Arrhenius B) Mohr C) Fajan D) Volhard

A) Arrhenius

Which of the following is a reducing agent? A) Ascorbic acid B) KMNO4 C) Iodine D) Hydrochloric acid

A) Ascorbic acid

Which of the following substances is assayed by residual alkalimetric analysis? A) Aspirin B) Sodium hydroxide C) Hydrochloric acid D) Zinc oxide

A) Aspirin

The First-In First-Out Policy must always be observed to: A) Assures that the oldest stock is used first B) Prevents contamination and mix-ups of materials C) Contains the information regarding the activity of the active ingredient D) All of the above

A) Assures that the oldest stock is used first

Trace minerals in a multivitamin preparation can be assayed faster by: A) Atomic Absorption Spectrophotometer B) UV-Vis Spectrophotometer C) Gas Liquid Chromatography D) High Pressure Liquid Chromatography

A) Atomic Absorption Spectrophotometer

A ____ is a specific amount produced according to a single manufacturing order during a single period of production. A) Batch B) Lot C) Component D) None of the above

A) Batch

The crude fiber of a drug usually consist of: A) Cellulose B) Cholesterol C) Phytosterol D) None of the above

A) Cellulose

The unsaponified matter present in animal fat is: A) Cholesterol B) Phytosterol C) Lard D) Wax

A) Cholesterol

In column chromatography, the resulting patterns with several bands is called: A) Chromatogram B) Eluate C) Spectrum D) Band E) A and C

A) Chromatogram

Acetylene and aldehyde group present in a compound that absorbs radiant energy are called: A) Chromophore B) Inactive C) Inert D) B and C

A) Chromophore

Efficiency of HEPA filters is assessed using: A) DOP test B) Water attack test C) Carr's index D) Bubble point test

A) DOP test

The pharmaceutical excipient, which affects the disintegration of a tablet is: A) Disintegrant B) Lubricant C) Filler D) Colorant

A) Disintegrant

Most of the official drugs containing calcium and zinc are assayed by: A) EDTA method B) Gravimetry C) Nonaqueous titrimetry D) Acidimetry

A) EDTA method

The terms used when equivalent amounts of each reactant have reacted are the following, except: A) End point B) Equivalence point C) Stoichiometric pont D) Theoretical point

A) End point

Stoichiometric point in titration means that: A) Equivalent amounts of the titrant and analyte have reacted. B) Normality or molarity of the reactants are the same. C) End point in titration has been reached D) A and C

A) Equivalent amounts of the titrant and analyte have reacted.

Fats are: A) Esters of glycerin and fatty acid B) Polypeptides C) Compounds of glycerol, fatty acid. Phosphoric acid and choline D) Steroids with one or more hydroxyl groups E) Esters of fatty acids with high molecular weight alcohol

A) Esters of glycerin and fatty acid

The soluble constituents of crude drug in a certain solvent: A) Extractive B) Ash C) Crude fiber D) Phytosterol

A) Extractive

Cause of quality variation due to men: A) Fatigue due to overwork B) Requires high salary C) Resourceful at work D) B and C

A) Fatigue due to overwork

An instrument in spectrometry using the filter as radiant energy device: A) Filter photometer B) Infrared spectrometer C) UV - Vis spectrometer D) Flame photometer

A) Filter photometer

To control finished products in the warehouse of a company, the distribution practice is: A) First-in first-out B) Samples needed C) Ratio and proportion D) A and B

A) First-in first-out

The calcium and sodium content of the blood can be determined by: A) Flame spectrometry B) Nephelometry C) Colorimetry D) Turbidimetry

A) Flame spectrometry

Complex inorganic compounds that are used to determine the end point in titration: A) Indicators B) Standard solutions C) Precipitating agents D) None of the above

A) Indicators

Malic acid present in cherry juice may be determined by: A) Indirect permanganate oxidation method B) Direct permanganate oxidation method C) Alkalimetry D) Acidimetry

A) Indirect permanganate oxidation method

Using a sampling plan by military standard 105 D, the sample size required is obtained from: A) Master table B) Ratio and proportion C) Samples needed D) A and B

A) Master table

When a strong acid is titrated against a weak base, the indicator is: A) Methyl red B) Phenolphthalein C) Methyl orange D) Crystal violet

A) Methyl red

Constant weight in analytical procedures of drying means that consecutive weighing after heating and cooling do not differ by: A) More than 0.25mg B) More than 0.50mg C) More than 0.255mg D) Not more than 0.75mg

A) More than 0.25mg

A chelate must always contain a/an: A) Multivalent metal B) Ethylenediamine group C) Amine group D) Triple bond

A) Multivalent metal

To find the mEq factor of an oxidizing agent, divide the molecular weight by: A) No. of electrons gained B) No. of electrons lost C) Valence D) Replaceable hydrogen

A) No. of electrons gained

A concentration expression referring to the number of equivalents of solute per liter of solution is: A) Normality B) Molarity C) Molality D) Formality

A) Normality

The most effective chemical substance in removing stains of potassium permanganate: A) Oxalic acid B) Sodium thiosulfate C) Chalk D) Vinegar

A) Oxalic acid

Iodometry is an indirect analysis of: A) Oxidizing agents B) Reducing agents C) Acids D) Bases

A) Oxidizing agents

The purity and strength of chemicals and drugs official in the USP/NF is usually expressed in terms of: A) Percentage B) g/mL C) mg/mL D) g/L

A) Percentage

Safety and toxicity tests are conducted for: A) Plastic tubings B) Solutions in vial C) Tablets D) Oral liquids

A) Plastic tubings

The instrument used in measuring the optical activity of a sample: A) Polarimeter B) Refractometer C) Spectrometer D) Flame photometer

A) Polarimeter

The study of the optical activity of a substance is: A) Polarimetry B) Refractometry C) Spectrophotometry D) Potentiometry

A) Polarimetry

This is the method of analysis based on the measurement of current resulting from the electrolysis of an electroactive species at a given electrode potential under controlled condition: A) Potentiometry B) Polarimetry C) Polarography D) Refractometry E) pH measurement

A) Potentiometry

A solution of known concentration used to standardize another solution is: A) Primary standard B) Dilute solution C) Secondary standard D) B ans C

A) Primary standard

A spectrophotometer differs from a colorimeter because it consists of: A) Prism B) Lamp house C) Cell compartment D) Optical scale

A) Prism

To assure stability of the product until expiry date, the label should indicate: A) Proper storage B) Proper dosage C) Proper color D) Proper drug administration

A) Proper storage

Limulus ameobocyte lysate (LAL) assay method is applicable in the determination of: A) Pyrogens B) Chemical impurities C) Microorganisms D) All of the above

A) Pyrogens

This is the sum of all tests performed to determine the conformance of the product to specifications: A) Quality control B) Quality Assurance C) CGMP D) A and B

A) Quality control

In the assay of ascorbic acid by iodimetry, it acts as: A) Reducing agent B) Oxidizing agent C) Buffer D) Neutral agent

A) Reducing agent

Nephelometry is based on the measurement of light that is: A) Refelected B) Absorbed C) Transmitted D) Adsorbed by the particles of a suspension

A) Refelected

A similar preparation in spectrometry refers to: A) Reference standard and sample identically made B) Reference standard greater than sample C) Sample greater than reference standard D) All of the above

A) Reference standard and sample identically made

In gas chromatography, the result of the assay is expressed in: A) Retention on the column B) Rf value C) Volume of gas used D) Adsorbent E) A and C

A) Retention on the column

The process of removing an appropriate number of items from a population in order to make interferences to the entire population is called: A) Sampling B) Inspection C) Statistic D) None of the above

A) Sampling

A ______ is a definite working rule regarding N, n and c. A) Sampling plan B) QC analysis C) Risk D) Chart

A) Sampling plan

The material used to make the cell holder for infrared analysis are, except: A) Sodium bromide B) Potassium bromide C) Sodium chloride D) Potassium chloride

A) Sodium bromide

A person who determines the presence of pyrogens and microorganisms of a pharmaceutical product is performing: A) Special method B) Identification test C) Pharmaceutical assaying D) Pharmacopoeial test

A) Special method

The QC manager is in charge of the following sections, except: A) Specification and assay development B) Analytical testing laboratory C) Research and development studies D) Biological testing

A) Specification and assay development

The process by which the exact concentration of a solution is determined is: A) Standardization B) Neutralization C) Redox D) Acidimetry

A) Standardization

In the microbial assay of antibiotics, the microorganism used for Penicillin G is: A) Staphylococcus aureus B) Pseudomonas aeruginosa C) Escherichia coli D) Bacillus subtilis

A) Staphylococcus aureus

To identify the place where materials have to be stored in a material warehouse, a _____ is pasted on the container of the material. A) Sticker B) Label C) Ribbon D) None of the above

A) Sticker

Turbidimetric and nephelometric methods of assay are applied to: A) Suspensions B) Solutions C) Colored samples D) A and B

A) Suspensions

The experimental way of determining when equivalent amounts of reactants have reacted together is: A) Titration B) Stoichiometric point C) Standardization D) Equivalence point

A) Titration

The purpose of using a combination of indicators is: A) To attain a sharp end point B) To facilitate reaction C) To attain a complete reaction D) A and B

A) To attain a sharp end point

The masking agent used in the assay of Mg with EDTA in the presence of Al is: A) Triethanolamine B) Thioglycol C) Potassium cyanide D) Ammonium fluoride

A) Triethanolamine

In microbial assay, the instrumental method used to prepare the inoculum is: A) Turbidimetry B) Nephelometry C) Chromatography D) A and B

A) Turbidimetry

Radiant energy required in the analysis of drugs under Fluorometry is in: A) UV region B) Visible region C) IR region D) A and B

A) UV region

Gas chromatography is used in the separation of: A) Volatile liquids B) Amino acid C) Carbohydrates D) Lipids E) Carboxylic acid

A) Volatile liquids

USP requires not less than 2.5g and not more than 3.5g of hydrogen peroxide /100 parts. Does the sample conforms with the standard requirement? A) Yes B) No C) Maybe D) Cannot be determined

A) Yes

All of the following are optical devices or instruments, except: A) pH meter B) Spectrophotometer C) Colorimeter D) Flame photometer

A) pH meter

For measurement of viscosity, the temperature of the substance should be held to within A. +0.1 B. + 0.2 C. 0.3+ D. +0.4 E. +0.5

A. +0.1

Koppeschaar's Solution: A. 0.1N Bromine VS B. Chlorine Water C. 0.1N Iodine VS D. Phosphoric Acid E. Ammonium Phosphomolybdate TS

A. 0.1N Bromine VS

Calculate for Rf value given the following data: Distance travelled by solvent=8.7cm Distance travelled by solute=3.2cm A. 0.37 B. 2.72 C. 27.84 D. 0.63 E. 5.95

A. 0.37

What is the pH of a 0.400M HNO3 solution? A. 0.40 B. 2.05 C. 0.60 D. 4.12 E. 1.67

A. 0.40

A sample of sodium bicarbonate powder weighs 5.6424g. The powder was transferred to a graduated cylinder and its volume was 8.5mL. the graduated cylinder was tapped repeatedly following USP guidelines and the volume of the powder after tapping was 4.2 mL. what is the hausner ratio of the powder? A. 0.49 B. 2.00 C. 2.25 D. 6.35 E. 35.7

A. 0.49

Initially, how many samples are required for minimum fil? A. 10 B. 15 C. 20 D. 30 E. AOTA

A. 10

Referring to item # 70, the extraction solutions are analyzed by titration. How many trials are required? A. 2 B. 3 C. 4 D. 5 E. 6

A. 2

An unknown sample of a soluble sulphate weighing 1.8000g yielded 0.9000g of barium sulphate. Calculate the % sulfur present in the unknown. (MW of barium sulfate=233.40g/mol, MW of sulfur=32.06g/mol). A. 6.87% B.7.28% C. 13.74% D. 3.43% E. 14.56%

A. 6.87%

A parameter that denotes the nearness of the experimental dta of the true value: A. Accuracy B. Deviation between trials C. Precision D. Ruggedness E. B and C

A. Accuracy

Alcoholic hydroxyl groups present in fatty acids is estimated using what fat constant? A. Acetyl value B. Acid value C. Unsaponifiable matter D. Iodine value E. Ester value

A. Acetyl value

Measures the free fatty acid present in a given sample of fats of fixed oil: A. Acid Value B. Ester Value C. Crude Fiber D. Iodine Value E. Unsaponifiable Matter

A. Acid Value

Azeotropic distillation is utilized in the USP for determination of ______ of pharmaceutical articles: A. Alcohol content B. Aflatoxins C. Bacterial endotoxins D. Water content E. Steroid content

A. Alcohol content

Suitable backtitrant for titration involving the use of excess silver nitrate VS: A. Ammonium thiosulfate VS B. Sodium tetraphenylboron VS C. Lithium methoxide VS D. Potassium Ferrocyanide VS E. Ceric Sulfate VS

A. Ammonium thiosulfate VS

Stability projection for shelf life of pharmaceuticals are commonly based on ______ equation: A. Arrhenius equation B. Clausius-Clapeyron equation C. Dieterici equation D. Henderson-Hasselbalch equation E. Van Deemter equation

A. Arrhenius equation

Represent the inorganic salts naturally occurring in the drug and adhering to it, but may also include inorganic matter added for the purpose of adulteration. A. Ash content B. Crude fiber C. Loss on ignition D. Water content E. Unsaponifiable matter

A. Ash content

The law which relates the power of the incident and transmitted beams to the thickness and concentration of solution containing the absorbing chemical species: A. Beer-Lambert's law B. fick's law C. Nernst's law D. Snell's law E. hess' law

A. Beer-Lambert's law

This refers to the ratio of the mass of an untapped powder sample and its volume including the contribution of the interparticulate void volume: A. Bulk density B. Tapped density C. Angle of response D. Hausner's ratio E. NOTA

A. Bulk density

In the assay of Rochelle's salt, the compound formed after ignition prior to titration is: A. Carbonate B. Oxide C. Bicarbonate and carbonate D. Carbon E. Tartaric Acid

A. Carbonate

primary interference present during alkalimetric titration: A. Carbonate B. Metal ions C. Organic matter D. Saliva E. Halides

A. Carbonate

Given the ff. Ksp values for the ff. sulfides, rank the ff. insoluble sulfides according to increase solubitliy: MnS= 3.0 x 10 -14 CdS= 8.0 x 10-28 Cos = 4.0 x 10-21 A. CdS>Cos> Mns B. CdS<Cos< Mns C. CdS>MnS>CoS D. CoS< CdS < MnS E. None of the choices

A. CdS>Cos> Mns

Titrimetric assay for ferrous salts employ what method? A. Cerimetry B. Acidimetry C. Iodometry D. Precipitimetry E. Gravimetry

A. Cerimetry

Sterile filling facilities are usually: A. Class100 B. Class1000 C. Class10000 D. Class100000 E. Class1000000

A. Class100

An example of drying oil: A. Cod liver oil D. Sesame oil B. Olive oil E. Lard C. Coconut oil

A. Cod liver oil

A synthetic contaminant often used to test high efficiency filters is composed of atomized droplets of hot di-octyl-phthalate. This test refers to: A. DOP testing B. Leak testing C. HC emery D. Two flow testing E. Scan testing

A. DOP testing

A tightly closed container of suitable size and design that maintains an atmosphere of low moisture content by means of appropriate drying agents: A. Desiccator B. Muffle furnace C. Oven D. Glass stoppered bottle

A. Desiccator

Assay involves an acidimetric type of titration: A. Determination of total alkalinity of NaOH B. Phosphomolybdate assay for phosphates C. Assay of Precipitated Sulfur using oxygen flask combustion D. Assay of Cupric Sulfate E. Assay of Zinc Chloride

A. Determination of total alkalinity of NaOH

delayed release tablet can also be called A. Enteric coated tablet B. Avid resistant tablet C. SIF resistant tablet D. SGF resistant tab E. 0.1N HCl resistant

A. Enteric coated tablet

The weight of a substance chemically equivalent to 1mL of a standard solution: A. Equivalent weight B. Titer C. Molecular weight D. Mole E. Calibration standard

A. Equivalent weigh

Powders with an angle of repose equivalent to 30o is said to have A. Excellent flow property B. Good flow property C. Fair flow property D. Poor flow property E. Very poor flow property

A. Excellent flow property

A specific gravity bottle that has a thermometer stopper and a capillary overflow tube: A. Geissler pycnometer B. Pycnometer C. hygrometer D. Lovi's beads E. Saccharometer

A. Geissler pycnometer

Method in Iodine Value determination which employs the use of Iodobromide Ts as source of iodine: A. Hanus method B. Hubl's method C. Wij's method D. Karl Fischer method E. Winkler method

A. Hanus method

This Raw Material Quality Control test entails addition if silver nitrate to a HCl acid standard. A. Limit test for Chloride B. limit test for sulfates C. limit test for sulfides D. litim test for chlorates E. limit test for acetates

A. Limit test for Chloride

This test is an indication of crystal habit, presence of polymorphic form etc.: A. Optical microscopy B. particle size distribution estimation C. viscosity D. Minimum fill E. Deliverable volume

A. Optical microscopy

A type of redox reaction that leads to n increase in positive valence of a chemical species: A. Oxidation C. Reduction E. Decomposition D. Combustion E. Displacement

A. Oxidation

Appropriate indicator for a strong acid-weak base titration: A. Phenolphthalein B. Methyl red C. Eriochrome black T D. Diphenylamine E. Starch

A. Phenolphthalein

This official ID test entails comparison of retention factor. A. Thin layer chromatography B.UV C. IR D.GC E. NMR

A. Thin layer chromatography

This test determines whether the dose in a batch of units is uniform and it the dosage form can deliver the right amount of dose in each patient A. Weight variation B. Assay E. Moist content D. Hardness E. Disintegration

A. Weight variation

Saponifying agent used for the analysis of volatile oils and fixed oils: A. alcohol KOH VS B. NaOH VS C. strong ammonia solution D. A and B E. A, B and C

A. alcohol KOH VS

Assay which involves back titration: A. alkalimetric determination of esters B. Total alkalinity of fixed alkalis C. Determination of chloride by fajan's method D. EDTA titration of zinc ion E. Determination of peroxide by permanganate method

A. alkalimetric determination of esters

Assayed by precipitation as calcium oxalate, conversion to oxalic acid and titrating with acidified permanganate: A. cherry juice for malic acid B. sodium nitrite C. titanium dioxide D. Selenium sulfide E. hydrogen peroxide topical solution

A. cherry juice for malic acid

Oxidizers and organic peroxides fall under class: A. class5 B. class6 C. class7 D. class8 E. class9

A. class5

This is the zone/part of room where filling of sterile products or other sterile processes take place: A. critical area B. Controled area C. assimilated Area D. Think-tank area E. filling area

A. critical area

This type of airflow is used when low airborne concentrations of particles or bacteria are present: A. critical area B. Controlled area C. assimilated Area D. Think-tank area E. filling area

A. critical area

A glass container intended to provide protection form light should meet requirement of what test? A. light transmission test B. Arsenic test C. Light deflection test D. light absorption/ionization test E. Absorption

A. light transmission test

The ff. are dissolution media employed in the comparative dissolution profile testing for bioequivalence, except: A. pH 1.2 buffer B. pH 4.5 buffer C. pH 6.8 buffer D. pH 7.5 buffer E. NOTA

A. pH 1.2 buffer

During an in-process control testing, the following data were obtained from loss on drying test: Wt. of sample before drying 1.146 g Wt. of tare & sample after drying 25.653 g Wt. of tare 24.632 g What is the weight of moisture lost? A) 1.021 g B) 0.125 g C) 1.125 g D) 0.021 g

B) 0.125 g

Compute for the Rf value of a substance if the substance traveled by the solvent is 12.5 cm and the distance traveled by the sample is 7.5 cm: A) 0.70 B) 0.60 C) 1.67 D) 1.66

B) 0.60

In the standardization of HCl using pure anhydrous sodium carbonate as primary standard and methyl orange as indicator, 1.0mL HCl was found to be equivalent to 0.05g of sodium carbonate (MW = 106). The normality of HCl is: A) 1.0 N B) 0.94 N C) 0.4716 N D) None of the above

B) 0.94 N

Calculate the water content of streptomycin powder weighing 4.20g as sample. The water equivalence factor (F) of the Karl Fischer reagent was found to be 5.1 and the volume consumed was 11.50. The % of water is: A) 1.39 B) 1.40 C) 1.41 D) 13.96

B) 1.40

The following data were obtained after the moisture and total ash content determination of acacia powder: Wt. of empty crucible 52.452 g Wt. of crucible & sample 61.648 g Wt. of crucible & sample after drying to constant wt. 60.502 g Wt. of crucible and residue left after incineration 53.006g Percent moisture: A) 12.64% B) 12.46% C) 12.45% D) 12.54%

B) 12.46%

What would be the accepted weight range of tablets weighing 130mg? A) 123.5 - 136.5 mg B) 120.25 - 139.75 mg C) 117 - 123 mg D) 120.9 - 139.1 mg

B) 120.25 - 139.75 mg

This is the acceptable tablet hardness range of chewable tablets: A) 4 - 10 kg B) 2 - 3 kg C) 5 - 8 kg D) 2 - 8 kg

B) 2 - 3 kg

The molecular weight of NaOH is 40. How many grams of NaOH pellets are needed to make 500mL of 1.5N solution? A) 20 B) 30 C) 40 D) 60

B) 30

The gram equivalent weight of potassium permanganate (MW = 158.03) is: A) 29.60 B) 31.60 C) 158.03 D) 79.01

B) 31.60

In the assay of ZnO (MW = 81.38), each mL of 1N of H2SO4 is equivalent to ____ of ZnO. A) 81.38 mg B) 40.69 mg C) 27.13 mg D) 20.34 mg

B) 40.69 mg

If 1mL of HCl is equivalent to 1.5mL of 0.5N NaOH, the volume of the alkali that would be consumed by 30mL of acid is: A) 4.5mL B) 45mL C) 20mL D) 30mL

B) 45mL

If a sample is beeswax is found to have an acid number of 15.5 and a saponification value of 71.2, the ester value of the sample is: A) 86.7 B) 55.7 C) 90 D) None of the above

B) 55.7

The temperature for ignition described as dull red heat is: A) 500 - 1000 oC B) 550 - 700 oC C) 500 - 750 oC D) 300 - 450 oC

B) 550 - 700 oC

The following data were obtained after the moisture and total ash content determination of acacia powder: Wt. of empty crucible 52.452 g Wt. of crucible & sample 61.648 g Wt. of crucible & sample after drying to constant wt. 60.502 g Wt. of crucible and residue left after incineration 53.006g Percent total ash: A) 6.20% B) 6.02% C) 6.22% D) 6.92%

B) 6.02%

An sample of sodium sulfate weighing 1.800g yielded 0.900g of barium sulfate (MW = 233.25). Calculate the percentage of sulfur ( AW = 32.06) in the sample. A) 12.18% B) 6.870% C) 27.48% D) 30.44%

B) 6.870%

Calculate the calcium carbonate content of a sample of chalk weighing 0.2545g and consuming 16.67mL of 0.1150M of EDTA solution in titration. At.Wt of Ca = 40.08; C = 12; O = 16. The percentage of CaCO3 is: A) 75.52 B) 75.50 C) 37.76 D) 37.78

B) 75.50

Potency of a 100mg tablet at the expiry date: A) 95mg B) 90mg C) 105mg D) 110mg

B) 90mg

The reading that must be obtained in a spectrophotometer: A) Concentration error B) Absorbance C) Retention D) Angular rotation

B) Absorbance

The Karl Fischer reagent used for moisture content determination consists of the following except: A) Pyridine B) Acetone C) Sulfur dioxide D) Iodine

B) Acetone

A buret with a glass stopcock can be used for: A) Alcohols B) Acids C) Bases D) Salts

B) Acids

Determination of iodine value of oils depends on: A) Substitution with iodine for the hydrogen in the fatty acid B) Addition of iodine at the double bond of the fatty acid C) Oxidation of the fatty acid by iodide D) All of the above

B) Addition of iodine at the double bond of the fatty acid

Neutralization reactions in titrimetric methods of analysis may be: A) Precipitimetry B) Alkalimetry C) Compleximetry D) A and C

B) Alkalimetry

Residual method titration with EDTA is applicable to what metal ion: A) Calcium B) Aluminum C) Zinc D) Magnesium

B) Aluminum

A plot of absorbance against concentration of a standard drawn in straight line is: A) Charle's B) Beer's C) Lambert's D) B and C

B) Beer's

One of the fundamental laws in spectrophotometry is: A) Law of Mass Action B) Beer's Law C) Boyle's Law D) Newton's law

B) Beer's Law

The assay of the aldehyde content of volatile oils may be done by: A) Extraction B) Bisulfite method C) Bobcock method D) Gravimetric method

B) Bisulfite method

A combining molecule containing one or more groups that donate electrons will form ____ with a metal. A) Complex B) Chelate C) Sequestering agent D) Masking agent

B) Chelate

The apparatus used to keep samples free from moisture is: A) Oven B) Dessicator C) Furnace D) A and C

B) Dessicator

A type of titration where the first titrant is added in excees with the sample and the second titrant reacts with the added excess is: A) Back B) Direct C) Residual D) A and C

B) Direct

The end point in iodimetry using starch TS as indicator is: A) Blue color B) Disappearance of blue color C) Greenish blue color D) A or C

B) Disappearance of blue color

Amount of dissolved drug can be determined by: A) Analytical balance B) Dissolution tester C) Brookefield viscometer D) DOP spray

B) Dissolution tester

The titrant most commonly used for direct compleximetry titration is: A) Zinc sulfate B) EDTA C) AgNO3 D) HclO4

B) EDTA

Hexane is the best solvent for extracting: A) Resins B) Fats C) Volatile oils D) Acids

B) Fats

Volatile oils are complex compounds composed of the following, except: A) Phenols B) Fatty acids C) Hydrocarbons D) Aldehydes

B) Fatty acids

The pH of a solution is usually measured by using: A) Platinum electrode B) Glass electrode C) Mercury electrode D) Calomel electrode

B) Glass electrode

Analysis wherein the constituents of a sample are separated and then the product is weighed: A) Volumetric B) Gravimetric C) Special method D) Gasometric

B) Gravimetric

The indicator for EDTA direct titration of calcium carbonate: A) Thymol blue B) Hydroxynaphthol blue C) Methyl red D) Methylene blue

B) Hydroxynaphthol blue

______ is the comparing of attributes and dimensions of a product against a standard to find out if the product is within the prescribed limit. A) Sampling B) Inspection C) Analysis D) Action

B) Inspection

Which of the following is an oxidizing agent? A) Ascorbic acid B) KMNO4 C) Sodium thiosulfate D) Sodium nitrite

B) KMNO4

The stationary phase used in gas chromatography is: A) Gas B) Liquid C) Substrate D) Cellulose E) Chromatogram

B) Liquid

One batch can be broken into several: A) Ingredients B) Lots C) Components D) None of the above

B) Lots

A term in compleximetry used to indicate a determination of a metal in the presence of another metal is: A) Redox B) Masking C) Linking D) Complexing

B) Masking

In IR spectrometry, the finger print region is: A) Near IR B) Medium IR C) Far IR D) A and B

B) Medium IR

The method of assay for Vitamin B12 and calcium pantothenate is by: A) Iodimetry B) Microbial-turbidimetric method C) Fluorometry D) Redox titration

B) Microbial-turbidimetric method

The name of the originator who introduced the use of 0.1N silver nitrate as the titrant and potassium chromate TS as the indicator in volumetric precipitation of chlorides is: A) Volhard B) Mohr C) Fajan D) Beer

B) Mohr

This is the primary cause of product instability and involves the addition of oxygen or the removal of hydrogen: A) Incompatibility B) Oxidation-Reducation C) Hydrolysis D) Racemization E) Decarboxylation

B) Oxidation-Reducation

Ceric sulfate is a/an: A) Precipitating agent B) Oxidizing agent C) Reducing agent D) Complexing agent

B) Oxidizing agent

The reagent that loses the electron/s in a redox reaction is the: A) Substance that decreases in oxidation number B) Oxidizing agent C) Reducing agent D) Substance reduced

B) Oxidizing agent

In gravimetric analysis, when the process used in extraction to obtain the original constituent, this method belongs to: A) Chemical B) Physical C) Precipitation D) Any of the above

B) Physical

Materials to be sampled include the following, except: A) Final products B) Records C) Intermediate products D) Raw materials

B) Records

In spectrophotometry procedure for assay, aside from the sample or unknown, this is also required: A) Raw material of the sample B) Reference C) Dosage form D) A and C

B) Reference

The type of ash where sulfuric acid is used to whiten the ash is: A) Acid-insoluble ash B) Sulfated ash C) Loss on ignition D) Residue on ignition

B) Sulfated ash

The acid necessary for permanganate titrations is: A) Acetic acid B) Sulfuric acid C) Hydrochloric acid D) Nitric acid

B) Sulfuric acid

The separation of the components of an organic dye mixture is accomplished by using: A) PC B) TLC C) HPLC D) GC E) Any of the above

B) TLC

Expression of concentration in volumetric solutions, except: A) Normality B) Titer C) Molarity D) Molality

B) Titer

Water attack test is used in this type of glass container: A) Type I B) Type II C) Type III D) Type III

B) Type II

Assay of atropine in Belladonna is an example of: A) Proximate assay B) Ultimate assay C) Both A and B D) Neither A nor B

B) Ultimate assay

The end point in the water content determination using Karl Fischer reagent is determined by: A) Use of chemical indicator B) Use of potentiometer or volumeter C) Use of spectrometer D) A or B

B) Use of potentiometer or volumeter

Potentiometry finds application in: A) Biologic assay B) pH determination C) Qualitative analysis D) A and B

B) pH determination

The volume(mL) of 0.02N H2SO4 for treated soda lime glass with a volume of 80mL should not exceed: A. 0.2 B. 0.7 C. 0.9 D. 1.0 E. 1.2

B. 0.7

Extemporaneously compounded 10% potassium chloride should be used within _______ when stored at cold temperatures: A. 7days B. 14days C. 30days D. 60days E. 120days

B. 14days

How many gram-atom of iodine is liberated by one of sodium hypochlorite in the assay of sodium hypochlorite solution? A. 1 B. 2 C. 4 D. 10 E. 46

B. 2

What is the pH of a 0.1M solution of acetic acid? (Ka=1.75x10-5): A. 5.00 B. 2.88 C. 4.76 D. 7.00 E. 9.24

B. 2.88

If a 1.2500 g sample of Zinc oxide, 95.0% ZnO, were treated with 50.00% ml of 1.1230 N sulphuric acid in the casual way, what volume of 0.9765 N sodium hydroxide would be required in the back titration? (MW of ZnO= 81.38 g/mol). A. 42.54 mL B. 27.48 mL C. 12.47 mL D. 2.27 mL E. 0.00mL

B. 27.48 mL

Disintegration testing should be conducted at this temperature A 37+0.5oC B. 37+2oC C. 37+0.2oC D. 37+2oC E. 37+0.1oC

B. 37+2oC

The water content of an 875.4mg samle of dried neem leaves was determined with a moisture analyzer. What is the % w/w H2o in the leaves if the final mass was found to be 545.8mg? A 1.60% B. 37.85% C. 62.35% D. 98.40% E. 5.42%

B. 37.85%

EDTA titration using dithizone TS as indicator should be conducted at what pH? A. 2 B. 4.6 C. 7 D. 10 E. 13

B. 4.6

Based on the previous problem, the volume(mL) of the test liquid necessary for one titration should be: A. 25.0 B. 50.0 C. 100 D. 125 E. 130

B. 50.0

Temperature equivalent of dull-red heat: A. 500-550oC B. 550-700oC C. 800-1000C D. 1000-1200oC E. 1200-1600oC (*o means degrees*)

B. 550-700oC

6 ampoules were filled with medium up to height of the shoulder and the volumes were found to be in 8.21mL, 8.24mL, 8.21mL, 8.25mL, 8.23mL and 8.25mL. The filling volume for the particular ampoule lot is: A. 8.1mL B. 8.2mL C. 8.3mL D. 8.4mL E. 8.5mL

B. 8.2mL

A 1.4500g sample of liquefied phenol was dissolved in enough water to make 1000mL. A 30mL sample of the solution was treated with 30mL of 0.1 N Bromine Vs and HCL. The mixture was treated with potassium iodide and titrated with 7.38mL of 0.1N sodium Thiosulfate VS. It was also found that 21mL of 0.1N Sodium thiosulfate VS was required in the titration of the iodine liberated when 20mL of 0.1N bromine VS was treated with KI and HCL. Calculate the % phenol in the sample. (MW phenol=94.11g/mol) A. 29.00% B. 86.99% C. 8.70% D. 65.56% E. 13.33%

B. 86.99%

USP definition of negligible: A. A quantity of not exceeding 0.25 mg B. A quantity of not exceeding 0.50 mg C. A quantity of not exceeding 2.5 mg D. A quantity of not exceeding 5.0 mg E. None of the choices

B. A quantity of not exceeding 0.50 mg

the direct or residual titrimetric determination of organic or inorganic acids using an accurately measured volume of base: A. Acidimetry B. Alkalimetry C. Potentiometric titration D. Precipitimetry E. Oxidimetry

B. Alkalimetry

In iodometric titration, what should be the color be the color of the solution prior to the addition of Stratch TS? A. Intense brown B. Amber C. Green D. Colorless E. Intense blue

B. Amber

Powder fineness can be blassified using this method. A. Optical Microscopy B. Analytical Seiving C. Moisture content D. Sedimentation E. Strokes

B. Analytical Seiving

The following tests cannot be done by ignition: A. Moisture content determination B. Ash content determination C Extractives D. A and B E. A, B and C

B. Ash content determination

Method II of water determination involves A. tartration B. Azeotropic distillation C. Gravimetry D. stoichiometry E. NOTA

B. Azeotropic distillation

It is a test to detect or quantify endotoxin from Gram negative bacteria using amoebocyte lysate from horshoe crab. A. Leaker's test B. Bacterial endotoxin test C. Light transmission test D. Surface contamination test E. Flow through test

B. Bacterial endotoxin test

pH-adjusting agent used in EDTA titrations using Dithizone TS as indicator: A. 3N HCL B. CH3COOH-CH3COONa buffer C. NH3-NH4Cl buffer D. 1N NaOH E. Any of the choices

B. CH3COOH-CH3COONa buffer

Assay of volatile oil which involves bisulfate addition method: A. Olive oil B. Caraway oil C. Lemon oil D. Peppermint spirit E. Clove oil

B. Caraway oil

In ash content determination, incomplete combustion leads to formation of: A. Carbon dioxide B. Carbon E. Carbonate ion D. Carbonyl E. Carbide

B. Carbon

Preferred titrant for the analysis of ferrous salts in mixtures that contain excipient or diluents that have a reducing action on permanganate: A. Silver nitrate VS B. Ceric sulfate VS C. Sodium thiosulfate VS D. Disodium EDTA VS E. Hydrochloric acid VS

B. Ceric sulfate VS

Gonad-stimulating principle of placental origin prepared from the urine of pregnant women: A. Estrogen B. Chorionic gonodotropin C. Human growth hormone D. Vasopressin E. Progesterone

B. Chorionic gonodotropin

This is a room or area where the product is formulated, filled and sealed: A. critical area B. Controlled area C. assimilated Area D. Think-tank area E. filling area

B. Controlled area

Residue consisting chiefly of cellulose that remains undissolved after successive treatment with boiling acid and alkali: A. Total ash B. Crude Fiber C. Sulfated Ash D. Unsaponifiable Matter E. Looss on Drying

B. Crude Fiber

Elastomeric closures are assayed by: A. Agar diffusion test B. Cylinder plate method C. Bacterial endotoxins test D. Elution test E. leaker test

B. Cylinder plate method

Efficiency of separation could be increased with: A. Increase in plate height B. Decrease in plate height C. decrease in plate count D. Decrease in pressure E. increasing in tailing

B. Decrease in plate height

It measures the ability of a HEPA filter to remove fine particles A. Arrestance B. Efficiency C. Integrity D. Adsorption E. interference

B. Efficiency

Appropriate laboratory apparatus for carrying out ignition: A. Oven B. Electric furnace C. Biosafety cabinet D. Fume hood E. Hot plate

B. Electric furnace

A polarity scale of solvent arranged according to increasing eluting power: A. Electromotive series B. Eluotropic series C. Irving-Williams scale D. pH scale E. Partition coefficient

B. Eluotropic series

This date limits the time during whick the product may be dispensed or used. A. Manufacturing date B. Expiration date C Use date D. Choices B and C E. NOTA

B. Expiration date

Powders with compressibility index of 18% and has a hausner's ratio of 1:20 has a/an A. Passable flow character B. Fair flow character C. Good flow character D. Excellent Flow character E. NOTA

B. Fair flow character

Volhard Method in volumetric precipitation involves the use of what indicator? A. Eosin TS B. Ferric Ammonium Sulfate TS C. Phenolphthalein TS D. Potassium Chromate TS E. Orthophenanthroline TS

B. Ferric Ammonium Sulfate TS

Most popular indicator electrode for pH determinations that involves the exchange of hydrogen ions on its surface: A. Standard Hydrogen Electrode B. Glass electrode C. Fluoride electrode D. Quinhydrone electrode E. Calomel electrode

B. Glass electrode

In the official assay, Boric Acid, NF acts as a strong monobasic acid due to the addition of what sugar alcohol: A. Erythritol B. Glycerol C. Mannitol D. Sorbitol E. Xylitol

B. Glycerol

In what case/s will addition of nitrobenzene be unnecessary in Volhard analysis? I. Determination of chloride II. Determination of bromide III. Determination of iodide A. I only B. II and III C. I and II D. III only E. I, II and III

B. II and III

Plane polarized light is produced by what type of optical lens? A. Echelette grating B. Iceland spar C. Oil immersion objective D. LASER E. Concave lens

B. Iceland spar

Actual indicating species in the assay of Hydrogen Peroxide Topical Solution: A. Free iodine extracted by chloroform B. Intense purple color of permanganate ion C. Blue color of starch-iodo complex D. Use of Diphenylamine TS as indicator E. None of the choices

B. Intense purple color of permanganate ion C. Blue color of starch-iodo complex (duwa ang naka highlight sa choices)

Several acids, dissolved in a solvent, are completely ionized. The solvent can be classified as a ______ solvent: A. Differentiating B. Leveling C. Protogenic D. Protophilic E. Aprotic

B. Leveling

An instrument that produces ions the substance under investigation, separates them according to m/z (charge to mass) ratio, and records the relative abundance of each ionic species present: A. NMR B. MS C. FTIR D. HPLC E. Fluorimeter

B. MS

A solution that contains methanol, iodine. Sulphur dioxide, and pyridine: A. Wij's rgt. B. Mayer's rgt. C.Karl fischer rgt. D. Koppeschaar's Solution E. Deniges' rgt.

B. Mayer's rgt.

Method I of measuring bulk density A. Measurement in a graduated cylinder B. Measurement in a volumeter C. Measurement in a tachometer D. Measurement in a manometer E. Measurement in a rheometer

B. Measurement in a volumeter

This test is intended is to determine the temperature at which the semisolid melts and therefore indicates proper storage and application: A. Loss on drying B. Melting range C. solubility D. thickness E. Friability

B. Melting range

This test is designed to limit to a level considered to be unobjectionable the number and size of discrete metal particles that may occur in ophthalmic ointments: A. Sterility B. Metal particles in ophthalmic ointment C. Microbial count D. pH E. Arsenic release

B. Metal particles in ophthalmic ointment

This method of determining particulate matter in injections utilizes a binocular microscope: A. Method 1 B. Method 2 C. Method 3 D. Method 4 E. NOTA

B. Method 2

This hardness tester is based on compressing tablets between two jaws via a spring gauge and screw A. Erweka B. Monsanto E. Pfizer D. Strong-Cobb E. Varian

B. Monsanto

Extrction using two immiscible solvents using a separatory funnel is governed by _______: A. Le Chatelier's principle B. Nernst's law C. Rf value D. common-ion effect E. Law of entropy

B. Nernst's law

Kjeldahl method: A. Water content deretmination B. Nitrogen content determination C. Oxygen flask combustion D. Nonaqueous titration E. Specific gravity determination

B. Nitrogen content determination

This type of airflow is used where particle sizes are relatively large. A. Unidirectional Airflow B. Non-unidirectional airflow C. down flow D. up flow E. NOTA

B. Non-unidirectional airflow

Measurement where the sample is diverted from the manufacturing process, and maybe returned to the process stream. A. At-line B. On-line C. In-line D. Off-line E. NOTA

B. On-line

A nicol prism is an intergral part of what instrument? A. Refractometer B. Polarimeter C. HPLC D. IR spectrometer E. Analytic balance

B. Polarimeter

A piece of soft rubber tubing fitted to the end of a glass rod. It is used to loosen from the walls of the containing vessel adhering particles that are not removable by a stream of water from the wash bottle: A. Erlenmeyer flask B. Policeman C. Spatula D. stirring rod E. Watchglass

B. Policeman

This type of pressure must be maintained to ensure airflows from the cleanest space to less clean space: A. Negative pressure B. Positive pressure C. Intermittent pressure D. slight pressure E. isobaric pressure

B. Positive pressure

Starch TS is a satisfactory indicator for what volumetric solution? A. HCl VS B. Potassium Iodate VS C. Cerric sulfate VS D. Sodium Thiosulfate VS E. Silver nitrate VS

B. Potassium Iodate VS

Titrations involving oxidation of sugar alcohols involve the use of what oxidizing agent? A. Ammonium thiocyanate B. Potassium periodate C. Potassium permanganate D. Oxalic acid E. Sodium thiosulfate

B. Potassium periodate

Insufficient sulphuric acid added to the analyte solution during permanganate titration will: A. Will turn the solution intense purple B. Promote formation of a brown precipitate C. Will discharge the color of permanganate ion D. Promote completion of the reaction E. Will turn the solution green

B. Promote formation of a brown precipitate

Preservative in Starch TS: A. Sodium thiosufate B. Red mercuric iodide C. Saliva D. Carbon disulfide E. Arsenic trioxide

B. Red mercuric iodide

Fat constant that aids in the detection of the presence of glyceridesof acides containing less than 16 or more that 18 carbon atoms: A. Acid value B. Saponification value C. Ester value D. Reichert-Messl number E. Polenske value

B. Saponification value

For ampoules the filling volume is the volume up to the height of the ____: A. Neck B. Shoulder C. Tip D. Vent E. NOTA

B. Shoulder

Potassium biphthalate is a primary standard used for standardization of ______: A. Sulfuric Acid VS B. Sodium Hydroxide VS C. Ammonium Thiocyanate VS D. Potassium Permanganate VS E. Disodium Edetate VS

B. Sodium Hydroxide VS

Reagent that provides a blanket of inert atmosphere during iodometric determination: A. HCl B. Sodium bicarbonate C. Sodium carbonate D. Strach TS E. KI

B. Sodium bicarbonate

Passage of fluid or solution through a sterilizing grade membrane to produce a sterile effluent A. Terminal sterilization B. Sterilization by filtration C. Aseptic processing D. Disinfection E. NOTA

B. Sterilization by filtration

Type of reaction that is involved for compounding such as aniline and resorcinol; assayed by bromination: A. Rearrangement B. Substitution C. Elimination D. Free radical formation E. Condensation

B. Substitution

Diazotization assay is used for analysis of what class of analytes? A. Mercaptans B. Sulfonamides C. Alkaloids D. Cyanides E. Volatile oils

B. Sulfonamides

Faulty calibration of laboratory apparatus can result in what type of error? A. Systematic, methodic error B. Systematic, instrumental error C. Indeterminate, personal error D. Indeterminate, absolute error E. Gross

B. Systematic, instrumental error

The official measure of peak symmetry in HPLC is: A. retention time B. Tailing factor C. number of theoretical plates D. width E. AOTA

B. Tailing factor

Purpose of potassium iodide in preparation of Iodine VS: A. To protect iodine from microbial degradation B. To permit dissolution of iodine in water C. As an Antioxidant D. A and B E. A, B and C

B. To permit dissolution of iodine in water

Glassware employed in method II of water content determination in USP: A. Soxhlet apparatus B. Toluene moisture apparatus C. Clavenger apparatus D. Babcock bottle E. Reflux condenser

B. Toluene moisture apparatus

An acetylization flask is used in the determination of: A. Total ester content of peppermint oil B. Total menthol content of peppermint oil C. Carvone content of caraway oil D. Benzaldehyde E. Clove oil

B. Total menthol content of peppermint oil

It is an indirect measure if inorganic molecules present in pharmaceutical waters measured as carbon. A. Total inorganic Carbon B. Total organic carbon C. Organic Carbon D. Choices B and C E. NOTA

B. Total organic carbon

Weight Variation method can be applkied to the ff. dosage forms EXCEPT: A. Liquid filled soft capsule B. Transdermal system C. Singe unit for inhalation D. Sterile solid with no added active substance E. Hard gelatin capsule

B. Transdermal system

An analyst performed powdered glass test. The volume of 0.02N H2SO4 consumed for trials 1 and 2 were found to be 0.70mL and 0.75mL, respectively, and corrected for a blank. The general description of the container should be: A. Highly resistant, borosilicate glass B. Treated soda-lime glass C. soda lime glass D. General- purpose soda-lime glass E. NOTA

B. Treated soda-lime glass

Calcium pantothenate assay employs what method? A. Refractometry B. Turbidimetry C. HPLC D. NMR E. Potentiometric

B. Turbidimetry

Spectrometric method tha measures the amount of light scattered by a suspension: A. Spectophotometry B. Turbidimetry C. Nephelometry D. Colorimetry E. Flame photometry

B. Turbidimetry

This test will determine whether a suspension will not settle out rapidly in the container, will become fluid on shaking, and will remain so long enough for a dose to be dispensed: A. Sedimentation volume B. Viscosity C. Deliverable volume D. Minimum fill E. Assay

B. Viscosity

This test is intended for type 1 containers for aqueous parenteral preparation: A. powedered glass test B. arsenic release C. water attack test D. surface glass test E. NOTA

B. arsenic release

This refers to the contamination of a starting material, intermediate product, or finished product with another starting material or product during manufacture. A. mixed-ups B. cross contamination C. Sanitation D. Scale up E. AOTA

B. cross contamination

This Raw Material Quality Control test entails addition of barium chloride to a sulfuric acid __ standard. A. Limit test for Chloride B. limit test for sulfates C. limit test for sulfides D. limit test for chlorates E. limit test for acetates

B. limit test for sulfates

It is designed to limit to a level considered to be objectionable the number and size of discrete metal particles that may occur in ophthalmic ointments. A. particle size distribution B. metal particles C. minimum fill D. deliverable volume E. NOTA

B. metal particles

Explosives can be identified by what color of placards? A. red B. orange C. green D. yellow E. blue

B. orange

Determine the %w/w of alakaloids present in the belladonna leaf ( calculated as atropine) if 15 ml of 0.0210 N sulfuric acid was added to the extracted alkaloids and 7.30 ml of 0.0198 N sodium hydroxide was required for the residual titration. The weight of the powder of Belladona leaf was 10.21 g. in that reaction, 2 moles of atropine consume 1 mole of sulfuric acid during titration. (MW of atropine= 239.8 g/mol). A. 0.966% B.0.483% C. 0.242% D. 96.60% E. 24.20%

B.0.483%

calculate the NaHCO3 content of a 1.2500g sample of a mixture containing sodium carbonate and sodium bicarbonate requiring 13.80mL of 0.5250N HCL on titration to phenolphthalein endpoint and an additional 16.30mL on further titration to a methyl orange endpoint.(MW NaHCO3=84.01g/mol) A. 61.4% B.8.82% C. 17.64% D. 30.7% E. 70.22%

B.8.82%

The following data were obtained after the moisture and total ash content determination of acacia powder: Wt. of empty crucible 52.452 g Wt. of crucible & sample 61.648 g Wt. of crucible & sample after drying to constant wt. 60.502 g Wt. of crucible and residue left after incineration 53.006g Total ash content in grams: A) 0.545 B) 0.555 C) 0.554 D) 0.445

C) 0.554

How many grams of drug are required to make 500 mL of 25.0% solution? A) 30.0 g B) 50.0 g C) 125 g D) 130 g

C) 125 g

In using spectrophotometer to measure the concentration of a sample, the following data were obtained: absorbance of the standard solution = 0.39; absorbance of the sample solution = 0.42; concentration of the standard = 15mcg. The concentration of the sample is: A) 16.15 mcg B) 17.5 mcg C) 15.75 mcg D) 16.0 mcg

C) 15.75 mcg

The gram equivalent of Magnesium oxide (MW = 40.30) is: A) 0.0403 B) 0.0215 C) 21.15 D) 0.4030

C) 21.15

Calculate the amount of caffeine extracted from coffee beans using 1.0215g of the sample. The volume of 0.0252N H2SO4 added to the extract was 25.4 mL, the excess titrated by 21.75 mL of 0.02115N NaOH. Each mL of 0.02 N H2SO4 is equivalent to 3.8858 mg of caffeine (C9H10O2). The percentage of caffeine is: A) 3.40 B) 3.50 C) 3.42 D) 3.60

C) 3.42

Compute for the percentage loss on ignition of magnesium sulfate hydrated using 3.20 g sample yielding a residue of 2.15g. The loss is: A) 33.81% B) 32.98% C) 32.81 D) 32.75%

C) 32.81

Disintegration test is done at this temperature: A) 36.5 - 37.5 oC B) 36 - 37 oC C) 35 - 39 oC D) 37 oC

C) 35 - 39 oC

A sample of potassium dichromate (K2Cr2O7) weighing 1.5650g was assayed iodometrically using 26.6mL of 0.1120N sodium thiosulfate. Each mL of 0.1N sodium thiosulfate is equivalent to 49.03mg of K2Cr2O7. The percentage purity of the sample is: A) 93.50 B) 95.33 C) 93.33 D) 93.40

C) 93.33

In gas chromatography, the result in the chromatogram is in terms of: A) Retention on the column B) Retention of time/volume C) A and B D) Volume of sample injected in the column

C) A and B

In paper chromatography, the data needed to compute for Rf value: A) Distance traveled by the solute B) Distance traveled by the solvent C) A and B D) Distance traveled by the blank

C) A and B

The expiration date is: A) The direct application and interpretation of the knowledge gained from the stability testing. B) Used to limit the period during which a preparation may be expected to have its labeled potency, provided it has been stored as directed. C) A and B are correct D) A and B are incorrect

C) A and B are correct

Way to obtain the gram equivalent of a substance (GEW) is: A) Based on the replaceable H+ ion B) Based on the valence of the cation C) A or B D) Based on atomic weight

C) A or B

The following are the basic principles behind chromatographic separation, except: A) Partition B) Adsorption C) Absorption D) Ion-exchange

C) Absorption

The alcohol content of a volatile oil can be determined by: A) Bisulfite method B) Complexation process C) Acetylization process D) A and C

C) Acetylization process

Acetylation method of analysis in volatile oils is done to determine: A) Phenol B) Aldehyde C) Alcohol D) Ketone

C) Alcohol

The ester value determination of substances is applicable to the following, except: A) Fats B) Volatile oils C) Alcohols D) Fatty oils

C) Alcohols

The functions of Quality Control include the following, except: A) Analytical control B) Inspection control C) Auditing D) A and B

C) Auditing

A water content determination method that uses Xylene tube is: A) Gravimetry B) Karl Fischer titrimetry C) Azeotropic method D) Dew point method

C) Azeotropic method

Residual titration method under EDTA titrations is applied to metal ion: A) Zinc B) Calcium C) Bismuth D) A and C

C) Bismuth

The adsorbent in the thin layer chromatography may be as follows, except: A) Alumina B) Silica gel C) Calcium oxide D) Silica gel G

C) Calcium oxide

The following are characteristics of a product with quality, except: A) Safe B) Acceptable C) Cheap price D) Effective therapeutically

C) Cheap price

The following are optical methods of analysis, except: A) Colorimetry B) Nephelometry C) Chromatography D) Spectrophotometry

C) Chromatography

The term given to the functional group of an organic molecule that absorbs maximum radiation in UV or IR region is: A) Moiety B) Carbonyl C) Chromophore D) Nitrile

C) Chromophore

. The following compounds are assayed by acidimetrically, except: A) Sodium hydroxide B) Caffeine C) Citric acid D) Zinc oxide

C) Citric acid

Color of phenolphthalein in vinegar: A) Pink B) Yellow C) Colorless D) Orange

C) Colorless

The heart of HPLC and GC: A) Pumps B) Injection valve C) Column D) Detectors E) Integrator

C) Column

In column chromatography, the separation of the sample mixture into a series of narrow bands in a column is: A) Chromatogram B) Eluant C) Development D) A and C

C) Development

In column chromatography, the separation of the sample mixture into a series of narrow bands in a column is:.. A) Chromatogram B) Eluant C) Development D) A and C

C) Development

The method of assay for sulfonamides is: A) Acid-base titration B) Gravimetric C) Diazotization with nitrite D) Redox titration

C) Diazotization with nitrite

The type of assay employed in determining the % ZnO in a sample of Zinc White Powder using EDTA as titrant is: A) Volhard's method B) Direct precipitimetry C) Direct compleximetry D) Residual Compleximetry

C) Direct compleximetry

Oils with iodine value above 120 are classified as: A) Non-drying B) Semi-drying C) Drying D) None of the above

C) Drying

Accelerated stability testing is, except: A) Performed at higher temperatures to intensify degradation through time B) Done to determine the shelf life of the product in a short period of time C) Enough proof of shelf life and need not be further validated D) The initial method used to determine a product's shelf life

C) Enough proof of shelf life and need not be further validated

A date limiting the time during which a preparation may be expected to have retained its labeled potency: A) Shelf life B) Audit time C) Expiry date D) Any of the above

C) Expiry date

The following are indicators used for acid-base titrations, except: A) Methyl orange B) Phenolphthalein C) Ferric alum D) Methyl red

C) Ferric alum

The following conditions cause a reaction to go to completion, except: A) Formation of a gas B) Formation of a precipitate C) Formation of soluble products D) Formation of slightly ionized substances

C) Formation of soluble products

The following are methods of determining the end point in precipitimetry, except: A) Use of adsorption indicators B) Cessation of precipitation C) Formation of turbidity D) Appearance of turbidity

C) Formation of turbidity

Assay of NaCl in table salt by precipitation as AgCl, filtration, drying and weighing the residue is classified as: A) Direct precipitimetry B) Volhard's method C) Gravimetry D) Residual precipitimetry

C) Gravimetry

The type of ligand where EDTA belongs; A) Unidentate B) Bidentate C) Hexadentate D) Tridentate

C) Hexadentate

Nuclear Magnetic Resonance (NMR) is used for: A) Radioisotopes B) Irradiation C) Identification of chemicals D) A and B

C) Identification of chemicals

The mobile phase in the gas chromatography is consists of: A) Alcohol-ethyl acetate mixture B) Alcohol-chloroform mixture C) Inert gas D) A and B

C) Inert gas

The ash content of an organic compound is an impurity of: A) Carbon B) Oil C) Inorganic matter D) Volatile component

C) Inorganic matter

A process wherein the sample is made to liberate iodine, which is then titrated with a standard solution of sodium thiosulfate: A) Volumetric titration B) Back titration C) Iodometry D) Iodimetry

C) Iodometry

The law related to spectrometry wherein the power of transmitted light decreases exponentially as the thickness of the solution increases arithmetically is: A) Charle's B) Beer's C) Lambert's D) Henry's

C) Lambert's

A common sampling plan that uses master tables to interpret the results: A) 100% inspection B) Square root system C) Military standard D) A and C

C) Military standard

The unit of wavelength in spectrometry, except: A) Nanometer B) Micron C) Millimeter D) Micrometer

C) Millimeter

Precipitation method using potassium chromate test solution as indicator and silver nitrate standard solution: A) Volhard B) Fajan C) Mohr D) None of the above

C) Mohr

A parenteral is declared to be pyrogenic if the total rise in temperature of the rabbits is: A) Less than 3.3oC in the 8 rabbits B) More than 3.4oC in the 8 rabbits C) More than 3.3oC in the 8 rabbits D) B and C

C) More than 3.3oC in the 8 rabbits

Ferric alum TS is used as indicator in volumetric precipitation method if the titrant is: A) AgNO3 B) BaCl2 C) NH4SCN D) NH4Cl

C) NH4SCN

The Kjeldahl method of analysis is used to determine: A) Fats B) Sugars C) Nitrogen D) Oxygen in organic compounds

C) Nitrogen

To find the milliequivalent factor of a reducing agent, divide its molecular weight by: A) No. of electrons gained B) Valence C) No. of electrons lost D) Replaceable hydrogen

C) No. of electrons lost

Two substances reacting upon reaching the end point must have the same: A) Normality B) Volume C) No. of equivalents D) Weight

C) No. of equivalents

The presence of a cotton fiber in a liquid preparation is considered as a/an: A) Internal defect B) Critical defect C) Ocular defect D) Variable defect

C) Ocular defect

Substances that have the power of rotating the plane polarized light are said to be: A) Light sensitive B) Active constituents C) Optically active D) Dextrorotatory

C) Optically active

Chemical reactions that involves a change in the valence number of reacting substances: A) Neutralization B) Complexation C) Oxidation-reduction D) Precipitation

C) Oxidation-reduction

Caps, bottles, labels and shipping containers are considered as: A) Active components B) Drug products C) Packaging materials D) None of the above

C) Packaging materials

The type of chromatography where the cellulose of the filter paper is used as the adsorbent: A) Column B) Gas C) Paper D) TLC

C) Paper

The indicator used in permanganate titration: A) Methyl orange B) Phenolphthalein C) Permanganate solution D) Methyl red

C) Permanganate solution

An analyst who determines the strength, potency and percentage purity of a drug or pharmaceutical product is performing: A) Special method B) Identification test C) Pharmaceutical assaying D) Pharmacopoeial test

C) Pharmaceutical assaying

A tool for detecting variations in a process: A) Pie chart B) Bar chart C) Quality control chart D) T-chart

C) Quality control chart

Total quality means: A) Production is responsible for quality B) Quality combines strict adherence to standard C) Quality is everybody's business D) All of the above

C) Quality is everybody's business

. Materials to be sampled include the following, except: A) Intermediate products B) Raw materials C) Records D) Final products

C) Records

The index of refraction of a volatile oil can be determined by: A) Spectrophotometer B) Pycnometer C) Refractometer D) Polarimeter

C) Refractometer

The number of mg of KOH needed to neutralize the free acids and saponify the esters in 1g of oil or fat: A) Acid value B) Ester value C) Saponification value D) Iodine value

C) Saponification value

The primary standard used to standardize Karl Fischer reagent is: A) Anhydrous sodium carbonate B) Potassium bipthalate C) Sodium tartrate D) Sodium oxalate

C) Sodium tartrate

To remove stains of iodine, the most effective chemical substance is: A) Calamansi juice B) Hydrogen peroxide C) Sodium thiosulfate D) Sodium hypochlorite

C) Sodium thiosulfate

In normal phase chromatography: A) Stationary phase and mobile phase are both polar B) Stationary phase is nonpolar, mobile phase is polar C) Stationary phase is polar, mobile phase is nonpolar D) Stationary phase and mobile phase are both nonpolar

C) Stationary phase is polar, mobile phase is nonpolar

The acid used in sulfated ash determination of a crude drug is: A) Diluted HCl B) Nitric acid C) Sulfuric acid D) Any of the above

C) Sulfuric acid

This is the weight of the substance chemically equivalent to 1 mL of the standard solution: A) Titrand B) Equivalence point C) Titer D) End point

C) Titer

The most effective way to clean glass apparatus: A) Soaking in detergent B) Rinsing with nitric acid C) Treatment with a solution of sodium chromate in sulfuric acid D) Acetic acid

C) Treatment with a solution of sodium chromate in sulfuric acid

Ways to prepare the sample for Infrared determination, except: A) Use of Mull technique B) Use of potassium bromide pellet C) Use of alcohol as solvent D) Use of liquid petrolatum as solvent

C) Use of alcohol as solvent

This is used for quantitative preparation of a standard solution: A) Pipet B) Graduated cylinder C) Volumetric flask D) Buret

C) Volumetric flask

Adsorption indicators are used in: A) Compleximetry B) Acidimetry C) Volumetric precipitation D) Alkalimetry

C) Volumetric precipitation

Safety or toxicity test for infusion plastic sets is conducted using: A) Rabbits B) Dogs C) White mice D) Guinea pigs

C) White mice

For samples which contain 50-100% of the active constituent, the difference in percent between two determinations should be: A. 0.03-0.05% B. 0.10-0.20% C. 0.20-0.25% D. 0.30-0.45% E. Not more than 3%

C. 0.20-0.25%

The test limit for powdered glass test of highly resistant, borosilicate glass is A. 5.0mL B. 8.5mL C. 1.0mL D. 1.5mL E.1.8mL

C. 1.0mL

EDTA titration of calcium salts requires a pH of __ to ensure to complete reaction. A. 2 B. 4.6 C. 13 D. 14 E. None of the choices

C. 13

In method II of water content determination, the sample should yield about _____ mL of water for accurate readings: A. 5-8mL B. 3-6mL C. 2-4mL D. 1-3mL E. None of the choices

C. 2-4mL

if an air-dried drug containing 10% moisture 2.5% ash calculated ion the basis of the air-dried drug, what percent of ash would the moisture-free drug contain? A. 25% B. 4% C. 2.25% D. 6.25% E. 7.5%

C. 2.25%

Equivalence factor for dichromate ion when it acts as an oxidizing agent: A. 2 B. 3 C. 6 D. 7 E. 10

C. 6

Reciprocating cylinder is also known as: A. Apparatus 1 B. Apparatus 2 C. Apparatus 3 D. Apparatus 4 E. Apparatus 5

C. Apparatus 3

The following dissolution apparatus can be used for the drug release requirement of transdermal delivery system except: A. Apparatus 4 B. Apparatus 5 C. Apparatus 6 D. Apparatus 7 E. Apparatus 8

C. Apparatus 6

Complementary color of yellow: A. Red B. Purple C. Blue D. Yellow-green E. Blue-green

C. Blue

Calibration weights that are used as working standards for calibration, built-in weights for analytical balances, and laboratory weights for routine analytical work: A. Class P or class 4 B. Class s-1 or class 3 C. Class S or class 2 D. class M or class 1 E. none of the choices

C. Class S or class 2

This test provides assurance that oral liquids will, when transferred from the original container, deliver the volume of dosage form that is declared on the label of the article: A. Sedimentation volume B. Viscosity C. Deliverable volume D. Minimum fill E. Assay

C. Deliverable volume

Example/s of product/s where containers of type 1 glass are generally used: A. Oral suspensions B. Hair cream C. Dextrose 5% in water D. Salicylic acid ointment E. AOTA

C. Dextrose 5% in water

Alcohol content determination in the USP involves ______ step to separate the alcohol from the sample matrix followed by determination of _____ to determine its concentration: A. HPLC, viscosity B. Extraction using immiscible solvent, TLC C. Distillation, specific gravity D. Soxhlet extraction, optical rotation E. Acetylization, titration

C. Distillation, specific gravity

This method of determining the type of emulsion utilizes the knowledge that a water soluble dye will dissolve in the aqueous phase of an emulsion while an oil-soluble dye will taken up by the oil phase: A. Dilution Test B. Conductivity test C. Dye-solubility test D. B and C E. NOTA

C. Dye-solubility test

Which of the ff. is an official ID test for Aspirin A. limit of free p-aminophenol B. limit of free salicylic acid C. FECl3 test D. limit for magnesium E. NOTA

C. FECl3 test

Type of ionization in mass spectrometry which involves a high energy beam of neutral atoms, typically Xe or Ar, causing ionization of the sample. This is useful for determination of molecular weight: A. Electron impact B. Chemical ionization C. Fast atom bombardment D. MALDI-TOF E. Electrospray ionization

C. Fast atom bombardment

Sodium and potassium ions are determined by this method which involves the emission of energy of a particular wavelength when diluted solution of a metallic ion is sprayed into a colorless flame. The intensity of the emitted radiation is determined by a suitable spectrometer and compared to the standard: A. Atomic absorption spectroscopy B. Supercritical fluid extraction C. Flame photometry D. Tandem mass spectrometry E. Refractometry

C. Flame photometry

Riboflavin assay: A. HPLC B. TLC C. Fluorimetry D. Turbidimetry E. Colorimetry

C. Fluorimetry

Suitable method of separating highly volatile compounds: A. Chiral chromatography B. Supercritical fluid chromatography C. Gas chromatohraphy D. Medium pressure liquid chromatography E. Medium pressure liquid chromatography

C. Gas chromatohraphy

A nitrometer is employed in: A. Column Chromatography B. Soxhlet extraction C. Gasometric analysis D. NMR E. Polarography

C. Gasometric analysis

A suitable detector for radioactive samples: A. UV detector B. Echelette grating C. Geiger-Muller Counter D. Vanillin reagent E. Iodine vapour

C. Geiger-Muller Counter

A glassware usually used in gravimetric analysis that has a perforated bottom upon which is bedded of asbestos that is used for separation of precipitates by use of suction filtration: A. Aspirator B. Buchner funnel C. Gooch Crucible D. Soxhlet apparatus E. Reflux condenser

C. Gooch Crucible

Acceptable glassware to be used to deliver an exact volume of a certain standard solution to be used for titration: A. Beaker B. Buret C. Graduated cylinder D. Analytical balance E. Volumetric flask

C. Graduated cylinder

What does G stand for in silica gel G? A. Gauss B. Germanium C. Gypsum D. Gall E. Ghrelin

C. Gypsum

In the equation HF + H2O H30 + F-: A. H2O is a base, and HF is its conjugated acid. B. H2O is an acid, and HF is the conjugated base. C. HF is an acid and F is its conjugated base. D. HF is a base and H3O is its conjugated acid. E. HF is a base. And F is its conjugated acid.

C. HF is an acid and F is its conjugated base.

Buffer solution: A. Arrhenius Equation B. Clausius-Clapeyron equation C. Henderson-Hasselbalch equation D. Nernst equation E. Whitney-Noyes equation

C. Henderson-Hasselbalch equation

Suitable precipitate for the determination of mercury content by gravimetric analysis: A. Sodium Sulfate TS B. Ammonia TS C. Hydrogen Sulfide D. Magnesia Mixture E. Barium Chloride

C. Hydrogen Sulfide

Given the following log Kf values for the following metal ion-EDTA complexes, which of the following cannot be titrated successfully with EDTA? I. Ba-EDTA-2 = 7.76 II. Co-EDTA-2 = 16.39 III. V-EDTA = 25.9 IV. Sr-EDTA-2 = 8.63 A. II and III B. I and IV e. I, II, III AND IV C. I only D. III only E. I, II, III AND IV

C. I only

Volumetric solution that is used for analysis of vitamin C raw material according to USP: A. Potassium Arsenite VS B. Sodium Nitrite VS C. Iodine VS D. Dichlorophenol-indophenol VS E. Ceric Sulfate VS

C. Iodine VS

Assay method for Sodium Hypochlorite Solution, USP: A. Acidimetry B. EDTA titration C. Iodometry D. Permanganometry E. Volumetric precipitation

C. Iodometry

Nitrogen content determination of foods and pharmaceuticals involves what method? A. Fajan's method B. Gay-Lussac method C. Kjeldahl method D. Gravimetric method E. Winkler method

C. Kjeldahl method

In potentiometric titration, the equivalence point in the first derivative plot is signified by: A. The steepest part of the curve B. The line that crosses 0 in the x axis C. Maxima or minima of the plot D. Sharp change in pH reading E. Change in color of the solution

C. Maxima or minima of the plot

Method 1 in determining particulate matter in injection involves: A. Light obscuration particle count test B. Sedimentation Test C. Microscopic particle count test D. minimum fill E. Melting range

C. Microscopic particle count test

The use of potassium chromate TS as indicator in Volumetric precipitation is also known as the ______ method: A. Fajan's Method B. Gay-Lussac Method C. Mohr Method D. Dumas Method E. Volhard Method

C. Mohr Method

This test stimulus the physiological conditions of the body and can therefore predict bioavailability as this prerequisite of absorption. A. Weight variation B. Assay C. Moist content D. Hardness E. Disintegration

C. Moist content

In weight variation test for tablets, a 5.0% difference in average tablet weight is accepted for tablets with an average weight of: A. 130 mg or less B. 130 mg to 324 mg C. More than 324 mg D. A and B E. A, B and C

C. More than 324 mg

This type of airflow has a varying velocity and is usually for Class 1000 and 10000, A. Laminar fairflow B. Unidirectional airflow C. Non-uniderectional airflow D. Down flow E. Up flow

C. Non-uniderectional airflow

When organic compound is placed on a very high magnetic field, the protons absorb radiant energy and produce characteristics peaks due to the organic groups associated with the protons: A. UV spectrophotometry B. Colorimetry C. Nuclear Magnetic Resonance D. HPLC E. Polarography

C. Nuclear Magnetic Resonance

Organic precipitant employed for the assay for MgO content of magnesium citrate oral solution: A. Cupferron B. Nitron C. Oxine D. DMG E. Ferroin

C. Oxine

The eye should be at same level as the meniscus to prevent ______: A. Color blindness B. Number bias C. Parallax error D. Calibration error E. Capillary action

C. Parallax error

In pharmaceutical assaying, the official requirement of diluted acids is expressed on __ basis. A. Molarity B. Percent weight in weight C. Percent weight in volume D. Percent volume in volume E. Normality

C. Percent weight in volume

Titanium Dioxide is assayed by what method? A. Alkalimetry B. Iodometry C. Permanganometry D. Gravimetry E. Volumetric pricipitation

C. Permanganometry

Unsaponifiable matter in the plant matter may represent: A. Unsaturated fatty acid B. Paraffin C. Phytosterol D. Silica E. Rancidity

C. Phytosterol

Type of crucible that can withstand high temperature and is suitable for use in ignition of drugs and precipitates: A. Borosilicate Glass B. Sintered crucible C. Porcelain D. B and C E. A, B and C

C. Porcelain

A volumetric Solution that is prepared from a very pure substance and hence do not require standardization step: A. Iodine VS B. Silver Nitrate VS C. Potassium Iodate VS D. Dichlorophenol-Iodophenol VS E. Bromine VS

C. Potassium Iodate VS

A self-indicating volumetric solution: A. Iodine VS B. Ceric sulfate VS C. Potassium permanganate VS D. Ammonium thiocyanate VS E. sodium hydroxide VS

C. Potassium permanganate VS

Orthophenanthroline TS undergoes a color transition from ______ to ______: A. Colorless to pink D. White to black B. Yellow to red E. Blue to yellow C. Red to blue

C. Red to blue

Used to determine the content of inorganic impurities in an organic substance. This involves a procedure to measure the amount of substance not volatilized from a sample when the sample is ignited in the presence of sulfuric acin: A. Total ash B. Loss on drying C. Residue on ignition D. A and C E. A, B and C

C. Residue on ignition

Analyte that is can be assayed by ferric chloride titration: A. Antimony potassium tartrate B. Precipitated sulfur C. Sodium Fluoride D. Titanium Dioxide E. Vanadyl Sulfate

C. Sodium Fluoride

Reducing titrant that is susceptible to bacterial degradation: A. Oxalic Acid VS B. Potassium Permanganate VS C. Sodium Thiosulfate VS D. Ferrous Ammonium Sulfate VS E. Ceric Sulfate VS

C. Sodium Thiosulfate VS

Reagent added during preparation of Sodium Thiosulfate VS that imparts stability to the volumetric solution by acting as an antimicrobial preservative and suppresses acid-catalyzed hydrolysis of the volumetric solution: A. Hydrochloric acid B. Sodium bicarbonate C. Sodium carbonate D. Carbon tetrachloride E. Starch

C. Sodium carbonate

Standard solution that is most susceptible t air oxidation? A. Ferrous ammonium sulphate TS B. Oxalic Acid VS C. Sodium thoisufate VS D. Titanium trichloride E. Potassium arsenite

C. Sodium thoisufate VS

The ff. are official tests employed in semisolid dosage forms, EXCEPT: A. Viscosity B. pH C. Spreadability D. Particle size distribution estimation E. AOTA

C. Spreadability

Reproducibility of data within a series of results is usually reported as: A. Absolute error B. Relative error C. Standard deviation D. t-test E. Q-test

C. Standard deviation

In the absolute scale, viscosity is measured in the poise of centipose. In the kinematic scale, it is measured in the __. A. Poise B. Contipoise C. Stokes D. Newton E. Milinewton

C. Stokes

Tromethamine is a primary standard used for the standardization of what VS? A. Sodium Nitrite VS B. Ammonium Thicyanate VS C. Sulfuric Acid VS D. Silver Nitrate VS E. Perchloric Acid VS

C. Sulfuric Acid VS

The test of weight variation is applicable for the ff. dosage forms, EXCEPT: A. Uncoated tablets B. Film-coated tablets C. Suppositories D. Solution in soft capsule E. Enteric-coated tablets

C. Suppositories

Assay which employs the use of a jones redactor: A. Alkaloid content of opium B. Cherry juice for malic acid C. Titanium dioxide D. Selenium sulfide E. Dimercaprol

C. Titanium dioxide

Purpose of chloroform in the assay of Phenol. USp: A. Serves as extracting indicator for liberated iodine during titration B. To act as co-solvent for the analyte C. To dissolve tribomophenol for clesar observation of endpoint D. all of the choices

C. To dissolve tribomophenol for clesar observation of endpoint

Masking agent that permits the determination of Mg+2 in the presence of Al+3 ions: A. Absolute alcohol B. Ammonium Fluoride C. Triethanolamine D. Potassium Sodium Tartrate E. Nitric acid

C. Triethanolamine

The performance variation test is performed in dissolution apparatus 1 and 2 using A.USP Aspirin Tablet RS B. USP Salicilic acid RS C. USP Prednisone Tablet RS D. USP Chlorpheneramine Maleate Extended Release Tablets RS E. AOTA

C. USP Prednisone Tablet RS

The assay of Opium for % Morphine content is an example of: A. Limit Test B. Trace Constituent Analysis C. Ultimate Assay D. Identification Test E. Proximate Assay

C. Ultimate Assay

It is a property of liquids that is closely related to resistance to flow A. Surface tension B. Rheology C. Viscosity D. Temperature E. Melting Range

C. Viscosity

Assayed residually by EDTA titration: A. Calcium carbonate B. Aluminum hydroxide C. Zinc sulfate D. Acetic acid E. Sodium thiosulfate

C. Zinc sulfate

This test stimulates the flow of a bed of powder or granules in a hopper: A bulk density B. tapped density C. angle response D. Carr's index E. Hausner's ratio

C. angle response

test animal used in pyrogen testing: A. Cat B. Dog C. guinea pig D. Horseshoe crab E. rabbit

C. guinea pig

This Raw Material Quality Control test entails the use if lead acetate paper: A. Limit test for Chloride B. limit test for sulfates C. limit test for sulfides D. litim test for chlorates E. limit test for acetates

C. limit test for sulfides

In HPLC analysis, the official measure of column efficiency is A. Retention time B. tailing factor C. number of theoretical plates D. width E. AOTA

C. number of theoretical plates

the consistency values of semisolid form can be determined using a: A. viscometer B. Spatula C. penetrometer D. mechanical tap density tester E. Rheometer

C. penetrometer

Reagents that are used to prepare Bromine VS: A. Bromine and water B. Bromine and potassium bromide C. potassium bromide and potassium bromate D. Potassium hypoiodite and potassium perbromate E. Potassium bromide and hydrochloric acid

C. potassium bromide and potassium bromate

Color comparison tubes are used for what official C? A. Limit test for chlorides B. color comparison test C. test for readily carbonizable substance D. limit test for sulfates E. NOTA

C. test for readily carbonizable substance

The test limit for powdered glass test of general purpose glass is A. 1.0mL B . 8.5mL C.10mL D. 15mL E. 18mL

C.10mL

Official temperature for determination of specific gravity A. 10oC B.20 oc C.25oc D. 30oc E.35oc

C.25oc

Kb is the equation of colligative property is AKA? A.Cryoscropic constant B.Dissociation constant C.Ebbuliooscopic constant D. Freezing point constant E. nota

C.Ebbuliooscopic constant

The valence number of Mn in KMNO4 is: A) +2 B) +1 C) +5 D) +7

D) +7

In-process specification requires that the percent loss on drying should not exceed 0.65% of the sample weight. Based on the given data below, what is the total amount of moisture? Tare wt. 26.839 g Gross wt. 36.506 g Gross wt. after drying 36.495 g A) 0.237 g B) 0.060 g C) 9.607 g D) 0.011 g

D) 0.011 g

In the assay of acetic acid (MW = 60.05), each mL of 1N NaOH is equivalent to: A) 0.60000g of acetic acid B) 0.00605g of acetic acid C) 0.60050g of acetic acid D) 0.06005g of acetic acid

D) 0.06005g of acetic acid

Calculate percentage of Atropine in Belladonna powder using 10.7 g sample and adding 20 mL of 0.0225N H2SO4 and back titrated with 12.5 mL of 0.0295N NaOH. Each mL of 0.02N H2SO4 is equivalent to 5.788g of Belladona alkaloids in terms of Atropine. A) 5.60% B) 0.56% C) 0.59% D) 0.22%

D) 0.22%

To find the gram equivalent weight of Phosphoric acid, divide its molecular weight by: A) 1 B) 0 C) 2 D) 3

D) 3

The infrared region of the spectrometer used to identify a substance has a wavelength range of: A) 200 - 380 nm B) 380 - 780 nm C) 780 - 3000 nm D) 3 - 15 mm

D) 3 - 15 mm

The operating speed for paddle in a dissolution apparatus is: A) 150 rpm B) 100 rpm C) 200 rpm D) 50 rpm

D) 50 rpm

USP limit for tablet content uniformity: A) 90 - 110% B) 90 - 100% C) 95 - 105% D) 85 - 115%

D) 85 - 115%

Analysis of substances that fluoresce falls under: A) Fluorometry B) Requires UV light C) Absorbance reading is obtained D) A and B

D) A and B

Assay method that determines the presence of pyrogens in injectables: A) Rabbit test B) Limulus amoebocyte lysate test C) White mice test D) A and B

D) A and B

Chromatography can be used to separate compounds that are: A) Colored B) Colorless ) Precipitate D) A and B

D) A and B

Flame spectroscopy procedures may be divided into: A) Flame emission B) Atomic absorption C) Nuclear magnetic resonance D) A and B

D) A and B

In infrared spectrometry, water is not used as solvent for the sample because the water will: A) Absorb IR radiation B) Dissolve the sodium chloride cell holder C) Not dissolve the sample D) A and B

D) A and B

The moisture content of a drug may be: A) Water of hydration B) Water in the absorbed form C) Water of emulsion D) A and B

D) A and B

A type of quality control chart based on the number of defectives found is: A) Go or no-go B) Variable C) Attribute D) A and C

D) A and C

A type of quality control chart based on the number of defectives found is:.. A) Go or no-go B) Variable C) Attribute D) A and C

D) A and C

The chemical factor used in calculation of percent purity of a substance in volumetric analysis: A) mEq weight B) Molarity C) Titer D) A and C

D) A and C

Volatile oils are complex compounds composed of: A) Phenols B) Inorganic salts C) Hydrocarbons D) A and C

D) A and C

In thin layer chromatography, finding the spot of the colorless compound in the chromatogram can be done by: A) Use of sulfuric acid spray to obtain a brown color B) Use of ultraviolet radiation C) Use of carbon tetrachloride spray D) A or B

D) A or B

The concentration of an unknown sample in spectrophotometric procedures can be calculated by: A) Use of Beer's plot B) Use of chemical factor C) Use of mathematical formula using a reference standard data D) A or C

D) A or C

A polarimeter is used whether a substance is: A) Dextrorotatory B) Levorotatory C) Optically active D) All of the above

D) All of the above

A reaction is led to completion by: A) Formation of ash Formation of insoluble acid C) Production of slightly ionized molecules D) All of the above

D) All of the above

Factors that can be manipulated to accelerate instability: A) Temperature B) Moisture C) Light D) All of the above

D) All of the above

Region in an electromagnetic spectrum: A) Visible B) Infrared C) Ultraviolet D) All of the above

D) All of the above

The Quality Control Department is important to: A) Ensure uniform production of high-quality product B) Safeguard public health C) Ensure that minimum standards of the product comply with the BFAD requirements D) All of the above

D) All of the above

The components of a blank used in the assay of a substance are, except: A) Solvent B) Reagent C) Indicator D) Analyte

D) Analyte

The substance being analyzed is the: A) Titrant B) Indicator C) Salt D) Analyte

D) Analyte

The number of retention samples collected by the Quality Control Inspector from the packaging line is: A) Two times the number required for testing B) Three labeled containers C) Not less than two labeled containers D) Any of A and C

D) Any of A and C

Alkaloidal test solutions include: A) Valser's TS B) Warner's TS C) Mayer's TS D) Any of the above

D) Any of the above

Quantitative determinations of alkaloids may be done by: A) Volumetric B) Gravimetric C) Spectrophotometric D) Any of the above

D) Any of the above

In Azeotropic method for water analysis, the solvent that can be used is/are: A) Water B) Toluene C) Xylene D) B and C

D) B and C

In spectrometry, when a test solution is prepared and observed identically with a reference standard, they are: A) Isometric substances B) Similar solutions C) Similar preparations D) B and C

D) B and C

In the Statistical Quality Control, the chart used to measure the variations in the products inspected in the production: A) Variable chart B) P-chart C) Attribute chart D) B and C

D) B and C

Light scattering method of analysis include/s: A) Flourometry B) Turbidimetry C) Nephelometry D) B and C

D) B and C

The type of titration in ultimate assay of alkaloids is: A) Direct B) Residual C) Back D) B and C

D) B and C

Way to separate the constituents in gravimetric analysis: A) Neutralization process B) Physical means C) Chemical means D) B and C

D) B and C

In-process control tablets include the following, except: A) Weight B) Hardness and thickness C) Disintegration D) Bioavailability

D) Bioavailability

In TLC, the separation takes place on a planar surface by: A) Dufferential migration B) Electrostatic force C) Relative solubility D) Capillary action E) Any of the above

D) Capillary action

Cross-examination and mix up can happen in the following situations, except: A) Improperly dispensed components B) Wrong labels C) Improper partitioning of production area D) Components are kept in tightly-sealed containers

D) Components are kept in tightly-sealed containers

Beer's plot in spectrometry is prepared to determine: A) Absorbance of the sample B) Wavelength to be used C) Absorbance of the blank D) Concentration of the sample

D) Concentration of the sample

Beer's plot in spectrometry is prepared to determine: A) Absorbance of the sample B) Wavelength to be used C) Blank D) Concentration of the sample

D) Concentration of the sample

The specific method for water content determination official in the USP/NF, except: A) Karl Fischer method B) Azeotropic method C) Gravimetric method D) Dew point process

D) Dew point process

Acid insoluble ash is the part of the total ash, which is insoluble in: A) Dilute nitric acid B) Acetic acid C) Dilute sulfuric acid D) Dilute hydrochloric acid

D) Dilute hydrochloric acid

The name of originator who introduced the adsorption dyes as an indicator in volumetric precipitation method: A) Volhard B) Charles C) Mohr D) Fajan

D) Fajan

The instrument used to measure sodium and potassium ions quantitatively: A) Colorimeter B) Refractometer C) Spectrophotometer D) Flame photometer

D) Flame photometer

Thiamine is assayed by: A) Refractometry B) Potentiometry C) Colorimetry D) Fluorimetry

D) Fluorimetry

It is the number of complete cycles that pass a given point per second: A) Wavelength B) Spectrum C) Radiant energy D) Frequency

D) Frequency

Sources of quality variations are as follows, except: A) Technician B) Inadequate procedure C) Equipment D) General manager

D) General manager

An organic compound that changes from one color to another at a certain pH is called: A) Test solution B) Standard solution C) Buffer D) Indicator

D) Indicator

Which of the following is not a QC function? A) In-process analysis B) Inspection of container C) Labeling and packaging materials D) Inventory control

D) Inventory control

The substance used to form a film over the precipitated silver chloride particles in Volhard's method is: A) Nitric acid B) Sodium chloride C) Triethanolamine D) Nitrobenzene

D) Nitrobenzene

Materials being controlled by Quality Control, except: A) Active ingredient B) Excipients C) Finished products D) Packages

D) Packages

Which is not considered as a primary packaging component? A) Bottles B) Vials C) Caps D) Packer boxes

D) Packer boxes

The indicator used in the assay of a weak acid reacting with a strong base is: A) Methyl red TS B) Methyl orange TS C) Eriochrome black D) Phenolphthalein TS

D) Phenolphthalein TS

A substance that has a high degree of purity and is used in direct standardization purposes: A) Technical grage B) CP grade C) Any of the answers D) Primary standard

D) Primary standard

. Type of alkaloidal assay where the total alkaloids are determined: A) Ultimate B) Specific C) Extraction D) Proximate

D) Proximate

Assay of Sodium Nitrite is an example of: A) Neutralization B) Precipitation C) Complexation D) Redox method

D) Redox method

The assay of Menadione Sodium Sulfate (Vit. K) uses this method of analysis: A) Gravimetric method B) Acid base titration C) Precipitation method D) Redox titration

D) Redox titration

The primary standard used in the standardization of potassium permanganate is: A) Hydrogen peroxide B) Sulfuric acid C) Potassium dichromate D) Sodium oxalate

D) Sodium oxalate

This determines the shelf life of a product: A) Sampling inspection program B) All of the answers C) Validation program D) Stability testing program

D) Stability testing program

Microbiological assay of antibiotics may be performed by using the following, except: A) Test tube dilution B) Cylinder plate C) Paper disc D) Staining method

D) Staining method

Antibiotics are assayed by: A) UV-Vis Spectrometry B) IR C) NMR D) Turbidimetry E) Fluorimetry

D) Turbidimetry

The iodine value of oils is a quantitative measure of: A) Phenol content B) Saturated fatty acids C) Unsaponifiable matter D) Unsaturated fatty acids

D) Unsaturated fatty acids

The apparatus used to wash down drops of standard solution clinging to the tip of the buret is: A) Bobcock bottle B) Cassia flask C) Acetylization flask D) Wash bottle

D) Wash bottle

The most preferred medium in dissolution testing is: A) Alcohol B) Acetone C) Ether D) Water E) Benzene

D) Water

Karl Fischer electrometric titration is a method used to assay for its: A) Oxygen content B) Nitrogen content C) Carbonate content D) Water content

D) Water content

Calculate the normality factor for 0.1N Sodium Thiosulfate VS given the following data: Weight of Potassium Dichromate=0.2256g Volume of titrant consumed during standardization=34.55mL Volume of titrant consumed during blank determination=0.05mL Molecular Weight of Sodium Thiosulfate=248.19g/mol Molecular Weight of PotassiumDichromate=294.18g/mol A. 1.5801 B. 0.2635 C. 0.6669 D. 1.3337 E. 1.8153

D. 1.3337

Analyte that involves an alkalimetric type of assay: A. Magnesium Sulfate B. Sodium Chloride C. Hydrogen Peroxide Solution D. 2-Phenoxyethanol E. Selenium Sulfide

D. 2-Phenoxyethanol

Solve for the acid number of a 2g sample of cod liver oil which required 4.5mL of 0.02 KOH in the titration.(MW of KOH 56.11g/mol): A. 0.25% B. 2.5% C. 25mg/g D. 2.5mg/g E. 0.25mg/g

D. 2.5mg/g

Samples to be subjected to titration should consume approximately how many mL of titrant such that errors in buret readings and weighing will not be significant? A. 5mL B. 8mL C. 15mL D. 30mL E. 45mL

D. 30mL

Equivalence factor when arsenic trioxide is used for standardization of iodine VS: A. 1 B. 2 C. 3 D. 4 E. 5

D. 4

Buccal tablet should disintegrate within A. 1hr B. 2hr C. 3hr D. 4hr E. 5hr

D. 4hr

Buccal tablet should disintegrate within. A. 1hr B. 2hr C. 3hr D. 4hr E. 5hr

D. 4hr

The acid value of a certain fixed oil is .96 and the ester value is 2.48. What is the saponification number of the sample? A. 0.50 B. 2.48 C. 3.72 D. 7.44 E. 12.30

D. 7.44

If a 10.0mL sample of clove oil yields 1.4mL of residual liquid in a cassia flask, what is the % eugenol content of the sample? A. 14% B. 28% C. 43% D. 86% E. 100%

D. 86%

Assayed for ketone content: A. Caraway oil B. Spearmint oil C. Cinnamon oil D. A and B E. A, B and C

D. A and B

Determination of bulk density of a power can be done using: A. Scott volumeter B. Graduated cylinder C. Viscometer D. A and B E. A, B and C

D. A and B

In the assay of peppermint oil for total ester, the blank determination serves to: A. Account for an absorption if CO2 by the base B. Corrects any alkalinity arising from interaction of the analyte solution with the glass C. Accounts for air-oxidation of analyte which might have occurred D. A and B E. A, B and C

D. A and B

Suitable form of starch for the preparation of Strach TS: A. Arrowroot starch B. Soluble Starch C. Starch with high α-amylose content D. A and B E. A, B and C

D. A and B

Total alkalinity of sodium hydroxideis due to what chemical species? A. Carbonate ion B. hydroxide ion C. Phosphate ion D. A and B E. A, B and C

D. A and B

Vitamins assayed by fluorometric method: A. Thiamine B. Riboflavin C. Cyanocobalamin D. A and B E. A, B and C

D. A and B

Calibration of burets may be done using_: A. Kiehl buret B. Mohr buret C. Ostwals calibrating pipet D. A and C E. A and B

D. A and C

Official methods of demonstrating antimicrobial activity: A. Turbidimetric assay B. Brine shrimp assay C. Cylinder-plate assay D. A and C E. B and C

D. A and C

IR region that is used in the identification of functional groups such as carbonyl, amino and hydroxyl groups, present in an organic compound: A. Fingerprint region B. Radiofrequency region C. Group frequency region D. Absorption spectrum E. Near-IR region

D. Absorption spectrum

This test determines the resistance to water attack of new glasses containers EXCEPT: A. Powdered glass test B. Surface attack test C.Water attack test D. Acidimetry E. NOTA

D. Acidimetry

All of the ff. are used as colorimetric standars, except: A. Ferric chloride CS B. Cupric sulfate CS C. Cobaltous chloride CS D. Calcium Chloride CS E. NOTA

D. Calcium Chloride CS

This is a purified water that has been boiled vigorously for 5 min. or more and allowed to cool while protected from absorption for carbon dioxide from the atmosphere A. Distilled water B. Deionized water C.UV treated water D. Carbon-dioxide free water E. Nitrogen-free water

D. Carbon-dioxide free water

It is a measure of propensity of a powder to be compressed: A. Bulk density B. Tapped Density C. angle of repose D. Carr's index E. AOTA

D. Carr's index

In analytical chemistry, cleaning solution is basically a solution containing: A. Nitric acid B. Joy® C. Sodium phosphate D. Chromic acid E. Liquid Sosa®

D. Chromic acid

A parameter that checks the homogeneity of the active ingredient in tablets and is usually done by assaying a certain number of tablets individually: A. tablet hardness B. Tablet thickness E. Weight variation C. Dissolution D. Content Uniformity E. Weight variation

D. Content Uniformity

Sulfated potash is assayed gravimetrically by converting it to __, which is then weighed. A. Barium sulfate B. Magnesium ammonium phosphate C. Zinc oxide D. Cupric oxide E. Potassium bipthalate

D. Cupric oxide

The reciprocating cylinder, basket apparatus and paddle apparatus are used for what in-vitro test for tablets? A. Assay B. Content Uniformity C. Disintegration D. Dissolution E. Friability

D. Dissolution

Appropriate weighing vessel for liquid samples: A. Beaker B. Weighing bottle C. Watchglass D. Dropper bottle E. Volumetric flask

D. Dropper bottle

Appropriate solvent for resins for extraction purposes; A. Ether B. Water C. Hexane D. Ethanol E. Petroleum Ether

D. Ethanol

This is the heart of a clean room: A. Barometer B. HPLC C. oven D. HEPA filter E. Laminar flow wood

D. HEPA filter

The current official assay for aspirin tablets employs what method? A. Residual alkalimetry B. TLC C. UV spectrophotometry D. HPLC E. bioassay

D. HPLC

This test shows how well a resists chipping ang crumbling when external stresses are applied. A. Weight variation B. Assay C. Moist content D. Hardness E. Disintegration

D. Hardness

An excellent solvent for fats and fatty oils used in the determination of extractive content of a plant sample: A. alcohol B. Diluted alcohol C. Ether D. Hexane E. water

D. Hexane

Sodium tetraphenylboron will quantitavely precipitate: I. Alkaloids II. Quaternary salts III. Silver ions A. I only B. I and II C. II and III D. I,II and III E. I and III

D. I,II and III

For stability testing purposes, the Philippines is categorized in what climatic zone: A. I B. II C. III D. IV E. V

D. IV

Appropriate glassware to be used in the assay of cupric sulfate, USP: A. Beaker B. Buret C. Erlenmeyer flask D. Iodine flask E. Volumetric flask

D. Iodine flask

Fat constant that states the degree of unsaturation in fats and fixed oils: A. Polenske number B. Koettsdorfer number C. Unsaponifiable matter D. Iodine number E. Acetyl number

D. Iodine number

Oxidizing agents are assayed titrimetrically by: A. Acidimetry B. Cerimetry C. Miscellaneous redox D. Iodometry E. Iodimetry

D. Iodometry

This value represents the percentage of test material which is volatilized and driven off under the condition specified: A. Water content Determination B. Ignition to constant weight C. Loss on drying D. Loss on ignition E. Acid insoluble ash

D. Loss on ignition

Method II of measuring bulk density A. Measurement in a graduated cylinder B. Measurement in a volumeter C. Measurement in a tachometer D. Measurement in a manometer E. Measurement in a rheometer

D. Measurement in a manometer

Failure to judge color change sharply during titration can lead to what type of error? A. Interminate error B. Instrumental error C. Methodic error D. Personal error E. Number bias

D. Personal error

Optical rotation is measured using what instrument? A. Refractometer B. ph meter C. HPLC D. Polarimeter E. Spectrophotometer

D. Polarimeter

A carr's index of 27 implies a/an A. Excellent flow B. GOOD flow D. Poor flow E. Very poor flow

D. Poor flow

USP specifies that the standardization of Sodium Hydroxide VS should be done using ______ as standard: A. Hydrochloric Acid VS B. Sodium Carbonate C. Tromethamine D. Potassium Biphthalate E. Potassium Dichromate

D. Potassium Biphthalate

Which of the following volumetric solution should be read using upper meniscus? A. Ceric sulphate B. Ferrous ammonia sulfate VS C. HCl VS D. Potassium permanganate VS E. Sodium nitrite VS

D. Potassium permanganate VS

Alkalimetric assay which involves a preliminary oxidation step via oxygen flask combustion prior to titration. A. Ethyl acetate B. Formaldehyde solution C. Zinc undecylenate D. Precipitated sulfur E. Sodium metabisulfite

D. Precipitated sulfur

A substance of known purity that is used for deyermination of the exact soncentration of a volumetric solution: A. Analyte B. Blak determination C. Equivalence factor D. Primary standard E. Titer value

D. Primary standard

Addition of an excess titrant to permit complete reaction of the analyte with the titrant and then the unreacted excess titrant with another standard solution: A. Blank determination B. Direct titration C. Double titration D. Residual titration E. Displacement titration

D. Residual titration

it refers to the time a certain constituents passes through the HPLC column. A. Retardation factor B. Retardation time C. Retardation factor D. Retention Time. E. NOTA

D. Retention Time

Type of chromatography wherein the mobile phase is polar in nature and the stationary phase is nonpolar in nature: A. Thin layer chromatography B. Ion-exchange chromatography C. Normal phase chromatography D. Reversed-phase chromatography E. Paper chromatography

D. Reversed-phase chromatography

The ff. should be strictly avoided when using analytical sieves, except: A. Oven drying B. Cleaning using liquid stream C. Removal of blockade by brushing D. Rinsing with nitric acid E. Choices C and D

D. Rinsing with nitric acid

Cultute media of fungi: A. V5 agar B. Eosin- Methylene blue media C. Thioglycollate media D. Saboraud's dextrose media E. Soy-bean- casein digest media

D. Saboraud's dextrose media

Extraction of alkaloids could be done by using: A. Clavenger apparatus B. HPLC C. Brine shrimp assay D. Separatory funnel E. Spectrophotometer

D. Separatory funnel

Assayeed by double titration: A. Sodium hydroxide B. Sodium nitrite C. Dibasic sodium phosphate D. Sodium bromide E. Calcium Disodium Edetate

D. Sodium bromide

Method 1 of determining particulate matter in injections cannot be applied to, EXCEPT: A. Emulsions B. Colloids C. Liposomes D. Solutions E. NOTA

D. Solutions

The test for conformity is required for the ff. dosage forms EXCEPT: A. Suppositories B. Transdermal system C. Suspension D. Solutions in soft capsules E. NOTA

D. Solutions in soft capsules

Apparatus used for determination of alcoholsoluble extractives of benzoin: A. Acetylization flask B. Cassia flask C. Babcock bottle D. Soxhlet apparatus E. Clavenger apparatus

D. Soxhlet apparatus

A plot of the absorbance of the analyte vs. wavelength which determines the λmax at which the absorbance of the standard and unknown solutions will be made: A. Beer's plot B. Planck's constant C. Rf value D. Spectral absorbance curve E. None of the choices

D. Spectral absorbance curve

Iodometry is a suitable method for: A. Ascorbic acid B. Mercaptans C. Sulfites D. Sugar alcohol E. Antimony K Tartrate

D. Sugar alcohol

Vitamin b12 activity assay employs what method of analysis? A. fluorimetry B. HPLC C. Colorimetry D. Turbidimetry E. Reverse osmosis

D. Turbidimetry

The performance variation test is performed in dissolution apparatus 1 and 2 using... A.USP Aspirin Tablet RS B. USP Salicilic acid RS C. USP Prednisone Tablet RS D. USP Chlorpheneramine Maleate Extended Release Tablets RSs E. AOTA

D. USP Chlorpheneramine Maleate Extended Release Tablets RS

An aqueous solution composed of potassium iodide and red mercuric iodide used for the detection of alkaloids: A. Dragendorff's reagent B. Hubl's reagent C. Mayer's reagent D. Valser's reagent E. Wagner's reagent

D. Valser's reagent

Volumetric apparatus designed to contain a definite volume of liquid: A. Beaker B. Buret C. Pipet D. Volumetric flask E. B and C

D. Volumetric flask

Stationary phase in paper chromatography: A. Cellulose B. Acetic acid C. Acetonitrile D. Water E. Methanol

D. Water

Acid color of phenol red: A. Colorless B. Red C. Blue D. Yellow E. Green

D. Yellow

Minimum fill is applicable to any of the ff., EXCEPT: A. container with a labeled amount of 60g or less Container with a labeled amount of 150g or less C. container with a labeled amount of 150g D. container with a labeled amount of more than 150g

D. container with a labeled amount of more than 150g

Titrant which involves the formation of iodine monochloride during titration: A. Iodine VS B. Perchloric acid Vs C. Potassium iodate VS D. hydrochloric acid VS E. Sodium Thiosulfate VS

D. hydrochloric acid VS

Examples of in-plane bending vibration of atoms: A. Scissoring and twisting B. Rocking and wagging C. Wagging and twisting D. scissoring and rocking E. All of the items mentioned

D. scissoring and rocking

Energy of a molecule that is NOT involve in spectroscopic studies: A. electronic B. vibrational C. rotational D. translational E. A and B

D. translational

Assayed by iodimetry: A. Iodine Tincture for Iodine Content B. Sodium Thioglycollate C. sodium metabisulfite D. A and B E. A, B and C

E. A, B and C

Official method of water content determination of pharmaceutical samples: A. Azeotropic distillation B. Gravimetric determination C. Karl Fischer method D. A and C E. A, B and C

E. A, B and C

These are the four basic mechanisms in which fibrous air filter remove contamination from airstreams: A. sieving B. impaction C. interception D. Diffusion E. AOTA

E. AOTA

An example of drying agent used in desiccators: A. Anhydrous calcium chloride B. Solid potassium hydroxide C. Phosphorus pentoxide D. Silica gel E. All of the choices

E. All of the choices

Chromatography is useful for: A. Resolution of mixtures into constituents parts B. ID test by comparing the unknown to a standard C. Determination of homogeneity D. Indication of molecular structure E. All of the choices

E. All of the choices

Method of detection for TLC: A. Iodine vapour B. Sulfuric acid C. UV lamp D. Vanillin Reagent E. All of the choices

E. All of the choices

Powder flow testing: A. Angle of repose B. Compressibility index C. Hausner ratio D. Shear cell E. All of the choices

E. All of the choices

Sublingual tablets must disintegrate within: A. 30mins B. 60mins C. 1hour D. 4hours E. As specified in the monograph

E. As specified in the monograph

6. Gravimetric analysis is an appropriate method for: A. Determination of Atropine content of Belladonna leaf B. Assay of Sodium Chloride, USP C. Assay of Zinc Chloride, USP D. Assay of Sodium Nitrite, USP E. Assay of Sulfurated Potash, USP

E. Assay of Sulfurated Potash, USP

What is/are the required immersion fluid/s for coated tablets? A. water B. simulated gastric fluid C. simulated intestinal fluid D. A and B E. B and C

E. B and C

Titrant used for the official assay of ascorbic acid dosage forms: A. Sodium Tetraphenylboron VS B. Iodine VS C. Potassium Hydroxide VS D. Disodium Edelate VS E. Dichlorophenol-Indophenol VS

E. Dichlorophenol-Indophenol VS

This test shows how well a resists chipping ang crumbling when external stresses are applied. A. Weight variation B. Assay C. Moist content D. Hardness E. Disintegration

E. Disintegration

An instrument that measures the durability of tablets to withstand shock and abrasion during transport: A. Hardness tester B. Caliper C. Analytical balance D. Polarimeter E. Friabilator

E. Friabilator

This test determines the consistency of dosage units and if each unit in a batch has a drug substance within a narrow range around the label claim. A. Content uniformity B. Weight variation C. Spreadability D. Solubility E. Minimum fill

E. Minimum fill

Minimum fill can be applied to such articles, EXCEPT: A. creams B. gels C. jellies D. lotion E. NOTA

E. NOTA

The critical test parameter for each dissolution apparatus is true, except: A. Apparatus 1-Rotation speed B. Apparatus 2- Rotation speed C. Apparatus 3-Dip rate D. Apparatus 4- Flow rate of medium E. NOTA

E. NOTA

The following are methods of sieving, EXCEPT: A. Mechanical method- Dry sieving B. Air Entrapment method-Air jet sieving C. Air Entrapment method- sonic sifter sieving D. AOTA E. NOTA

E. NOTA

Acid titrant preferred for hot titrations: A. Percholic acid VS B. HCl VS C. Sulphuric scid VS D. Acetic acid VS E. Nitric acid VS

E. Nitric acid VS

Titrant employed for non-aqueous alkalimetric titration: A. Ammonium Hydroxide B. Hydrochloric Acid VS C. Perchloric Acid in Glacial Acetic Acid VS D. Potassium Hydroxide VS E. Sodium Methoxide VS

E. Sodium Methoxide VS

The microbial assay for niacin and calcium pantothenate employs: A. Lactobacillus plantarum B. Lactobacillus leichmannii C. Pediococcus acidilactici D. Streptococcus pyogenes E. Streptomyces venezuelae

E. Streptomyces venezuelae