Osteoclasts

Cell regions of osteoclasts

ruffled border, clear zone, vesicular region, basal region

Do osteoclasts divide?

No

matrix resorptive surfaces are

etched or scalloped, bare, and have scattered osteoclasts

basolateral and vesicular regions of osteoclasts

exocytosis of digested material

osteoclasts are derived from

hematopoetic stem cells, not mesenchyme

Osteoclast cells are (small or large? single or multinucleated?)

large and multinucleated

Osteoclasts are ______-resorbing cells

matrix

Osteoclasts are involved in ______ which includes 3 things

matrix remodeling, bone growth, fracture repair, and removal of weakened matrix

These can be observed in the bone under _____ as a direct result of their activity

osteoclasts, resorption bay (Howship's lacunae)

ruffled border of osteoclasts

part in direct contact with bone

clear zone of osteoclasts

perimeter of cytoplasm adjacent to the ruffled border showing where the matrix is being resorbed