Pharmaceutics Exam II Quizzes, Examples, & Presentation Questions

True statements, about the function of excipients used in tablet formulations include:

-binds promote granulation during the wet granulation process -glidants help to promote the flow of the tablet granulation during manufacture

The following steps involved in hard gelatin capsule shells production?

-dipping -spinning -trimming

Why is Metadate CD preferred over IR formulations of Methylphenidate HCl?

-higher adherence -once a day dosing instead of multiple times per day -less fluctuation of plasma concentration

Hydroxychloroquine's FDA approved indications include which of the following?

-malaria -rheumatoid arthritis -systemic lupus erythematosus

Advantages to the manufacturer for tablet film coating when compared to sugar coating include

-shorter production time -less gross weight -lower incidence in coat chipping

Manufacturing variables that would likely affect the dissolution of a prenisolone tablet in the body include:

-the amount & type of binder added -the amount & type of disintegrant added -the force of compression used during tableting

What are the advantages to using suboxone sublingual films?

-they have increased bioavailability as compared to the SL tablets -they have deter abuse

What purpose does silicon dioxide serve in Anusol-HC?

-viscosity agent -slow dispersion of API in the body -excipient

Which of the following capsules sizes has the largest capacity? 000-5

000

Which of the following best describes the correct length of effectiveness of one Annovera?

1 year

Which capsule size has the smallest capacity? 0-5?

5

Considering this "secret" formula and procedure, the amount of Acetaminophen (in kg) required to produce 1 million tylenol tablets is

500mg/tab x 1,000,000 = 500,000,000mg since 1kg = 1000g = 1,000,000mg 1kg/1,000,000mg x 500,000,000mg = 500kg

A pharmacist receives a prescription for 15mg piroxicam capsules, qty 48. A #1 capsule filled with piroxicam weighs 245mg; a capsule filled with lactose weighs 180mg. How much piroxicam and lactose are required for the prescription? Prepare sufficient powder for 50 capsules (2 extra)

750mg piroxicam + 8.45g lactose 50 x 15mg = 750mg piroxicam Equivalent lactose volume for 15mg of drug per capsule? 180/245 = x/15 x=11mg Required lactose amount per cap 180mg - 11mg = 169lactose/cap Total required lactose amount for 50 cap 169 x 50 = 8.45g lactose required

If the API of 125mg tablet decays by zero-order kinetics with a reaction rate constant kinetic of 0.5mg per hour, what is the amount of intact drug remaining after 3 days (72 hours)?

A = Ao - Kot 125mg - 0.5mg/hr x 72hr 89mg after 3 days

Which of the following statements is NOT TRUE about modified-release drug products?

Advising patients to drink a full glass of alcohol with these medications for better absorption

You are asked to prepare 2 sets of twelve 1g suppositories, Set A and Set B. Set A required 12 suppositories each containing 50mg of Drug X while Set B requires both 50mg of Drug X as well as 300mg of Drug Y in all twelve suppositories. Cocoa butter or Theobroma oil will be used for the base of the suppositories. A) What is the quantity of theobroma oil base is required in each set? B) How much does an individual suppository weigh in each set? NOTE: Displacement values of X & Y are 0.7 and 1.5, respectively. Hint: Make 15 suppositories to account for losses

A) theobroma oil for Set A = 13.9g, for Set B = 10.9g B) Individual suppository in Set A = 0.98g and in Set B = 1.08g A. 15 x 50 = 750mg = 0.75g/0.7g = 1.07g 15 - 1.07 = 13.93g 13.93g + 0.75g = 14.68/15 = 0.98g B. 15 x 50 = 750mg = 0.75g/0.7g = 1.07g 15 x 300 = 4,500 = 4.5g/1.5g = 3 15 - 1.07 - 3 = 10.93g 10.93g + 0.75g + 4.5g = 16.5/15 = 1.1g

What is the mechanism of action of Nurtec?

Calcitonin-gene related peptide receptor antagonist

Iron oxide yellow

Colorant

The ingredients "titanium oxide" and "yellow ferric oxide" act as _________ in the formulation of Avigan tablets

Colorants

Which of the following characteristics/effects of Danazol is correct?

Effect on pituitary gland, which results in reduced FSH and LH production

Which formulation method is used to produce Cleocin Ovules?

Fusion molding

Which method involves dissolving the API into a melted base and then transferring the ingredients into molds? (Anusol-HC)

Fusion molding

What is the role of talc in the formulation of Danazol hard capsules?

Improve powder flow properties (glidant)

Drug is bound to a resin & released due to changes in pH

Ion Exchange

Which of these is the primary reason for why it is possible for Vyvanse to have a chewable dosage form?

It is not metabolized into its active form until after it is absorbed by the gut

Drug compressed into tabs with insoluble polymer

Matrix Diffusion

Drug is compressed into tabs with slowing soluble polymer

Matrix Dissolution

Which statement is true about Avigan?

No change in bioavailabilty between capsule and tablet formulation

Titanium dioxide

Opacifier

Drug compressed into tabs with semipermeable membrane and laser drilled hole through which drug is transported out by convective flow

Osmotic pumping

What is the point of advice that is TRUE for patients taking Oxecta?

Oxecta should never be stopped abruptly

What is the active pharmaceutical ingredient (API) in Oxecta?

Oxycodone hydrochloride

What is the indication for Dextenza?

Post-op ophthalmic surgery inflammation of the eye & pain

High bloom strength gelatin is used in the manufacturing of?

Soft gelatin capsules & hard gelatin capsules

Which of the following describe proper storage techniques for Annovera?

Store at room temperature

Which of the following is the best option for storage of Suboxone?

Store in dry, room temperature places

What is the therapeutic class of Nurtec?

Treatment of acute migraine

What role does the ingrediant hydrated silica have? (Cleocin Ovules)

Water absorbant

Which method of tablet production is used to make acetaminphen tablets?

Wet granulation

The respective amount of zinc oxide and cocoa butter required to make these 12 suppositories is

ZnO: 3.6g Cocoa butter: 23g Total weight if only cocoa butter used: 12 x 2.0g = 24g NOTE: if density factor = 4.44, 4.44g of drug displaces 1g of suppository base (cocoa butter) Weight of ZnO required is 300mg x 12 = 3600mg = 3.6g How many grams of base 3.6 of drug will displace? 4.44g ZnO/1g cocoa butter = 3.6g ZnO/Xg cocoa butter X = 0.81g = the amount of suppository base displaced by active drug weight of suppository base for this Rx: 24g - 0.81g = 23g

The rectal route of administration of drug may be preferred over the oral route for some systemic-action because

a portion of the absorbed drug does not pass through the liver before entering the systemic circulation

What is the role of the benzalkonium chloride in the preparation of Rhopressa solution?

antibacterial preservative

Which ingredient is essential in the controlled release timing of Lamprene (soft gelatin capule)?

beeswax

Agents that might be used to coat enteric-coated tablets include

cellulose acetate phtalate (CAP)

Consider the basic tablet coating solution formula below: PEG 0.8% w/w

coating & flexibilty -plasticizer

Vyvanse is a Prodrug that metabolized into what 2 metabolites?

d-amphetamine + 1-lysine

What is the ingredient croscarmellose sodium used for in making acetaminophen tablets?

disintegrant

What is the main role of the sugar spheres in Metadate CD capsules?

filler

What is the advantage of Lamprene dosage form (soft gelatin capsule)?

increased bioavailabilty

A major benefit of Rhopressa as an opthalmic solution include all the following EXCEPT?

increased systemic absorption

A satisfactory suppository base must meet all of the following criteria EXCEPT:

it should melt below 30 degrees celsius

In this formula magnesium stearate is used as

lubricant

Consider the basic tablet coating solution formula below: HPMC, 5cps, 7.5% w/w

main coating material -water soluble polymer/film forming

Most commerical vaginal suppository use a base of

polyethylene glycol

What is the use of titanium dioxide in Hydroxychloroquine tablets?

prevent light degredation

The shells of soft gelatin capsules may be made elastic or plastic by the addition of?

sorbitol

What is the purpose of the PEG hydrogel in Dextenza?

vehicle

purified water

vehicle or solvent