Poliomyelitis,muscular dystrophies, and myasthenia gravis

People with subclinical polio

infection might not have symptoms, or mild symptoms may last 72 hours or less.

polio virus

kills the cell and then spreads to infect other cells.

main signs of muscular dystrophy

main sign of muscular dystrophy is progressive muscle weakness.

polio cells

polio virus enters cells and replicates in six to eight hours, yielding 10,000 to 100,000 virus particles per cell.

three basic patterns of polio infection:

subclinical infections, non paralytic, and paralytic.

when symptoms come

time from being infected with the virus to developing symptoms of disease (incubation) ranges from 5 - 35 days(average 7-14 days)

three types of polio virus:

type 1,2,3

Duchenne muscular dystrophy, Becker muscular dystrophy, Myotonic, Facioscapulohumeral (FSHD), Congenital, Limb-girdle

types of muscular dystrophy

polio virus enters

virus enters through the mouth and multiplies in the throat and gastrointestinal tract, then moves into the bloodstream and is carried to the central nervous system where it replicates and destroys the motor neuron cells

how polio enters the body

virus enters through the mouth and nose, multiplies in the throat and intestinal tract, and then is absorbed and spread through the blood and lymph system.

Motor neurons

control the muscles for swallowing, circulation, respiration, and the trunk, arms, and legs.

type 1

Abortive Polio

Signs and symptoms are similar to those of Duchenne muscular dystrophy,milder and progress more slowly.

Becker muscular dystrophy symptoms

Poliomyelitis spreads by...

Contact with infected feces, Contact with infected mucus or phlegm from the nose or mouth, Direct person-to-person contact.

frequently falls, difficulty getting up from a lying or sitting position,trouble running and jumping,waddling gait,walking on toes,large calf muscles,muscle pain and stiffness,and learning disability.

Duchenne muscular dystrophy symptoms

polio cell ratio

For every 200 or so virus particles that encounter a susceptible cell, only one will successfully enter and replicate.

Subclinical infection symptoms

General discomfort or uneasiness,headache,red throat,slight fever,sore throat,vomiting

polio symptoms timing

Most people do not develop symptoms so the risks are:Lack of immunization against polio travel to an area that has experienced a polio outbreak.

type 2

Non-paralytic Polio

when do you breaks happen

Outbreaks happen usually in groups of people who have not been vaccinated.

type 3

Paralytic Polio

Clinical poliomyelitis

affects the central nervous system (brain and spinal cord), and is divided into non paralytic and paralytic forms. It may occur after recovery from a subclinical infection.

type 1 symptoms

Symptoms do not include neurologic symptoms. Mainly gastrointestinal upset and sore throat. polio virus can be isolated from throat washings and stool. Interpretation: polio virus growing in gut and throat lymphatic tissue and has not migrated to the spinal cord or brain.

type 2 symptoms

Symptoms include neurological symptoms: Headache, stiff neck, muscle stiffness and spasms along with other muscular symptoms.

when symptoms come (muscular dystrophies)

Symptoms of the most common variety begin in childhood, primarily in boys. Other types don't surface until adulthood.

type 3 symptoms

all the other symptoms but in addition residual weakness and lingering paralysis of some muscles.

producing antibodies that engage the protein covering of the poliovirus, preventing the virus from interacting with another cell.

Way the human immune system protects itself from polio

Polio virus begins dun dun DUUUNNNNN!!!!!!

When poliovirus encounters the nerve cells, the protruding receptors attach to the virus particle, and infection begins.

MUSCULAR DYSTROPHIES

a group of diseases that cause progressive weakness and loss of muscle mass and abnormal genes (mutations) interfere with the production of proteins needed to form healthy muscle.

Poliomyelitis

a viral disease that can affect nerves and can lead to partial or full paralysis.

Symptoms generally begin in the teens but may not occur until the mid-20s or even later.

about Becker muscular dystrophy

This type affects boys and girls and is apparent at birth or before age 2. Some forms progress slowly and cause only mild disability, while others progress rapidly and cause severe impairment.

about Congenital

half of people with muscular dystrophy have this variety. girls can be carriers and mildly affected, the disease typically affects boys.one-third of boys with Duchenne muscular dystrophy don't have a family history of the disease,possibly because the gene involved may be subject to sudden abnormal change signs+symptoms usually appear around the ages of 2and3.

about Duchenne muscular dystrophy

Muscle weakness typically begins in the face and shoulders. The shoulder blades might stick out like wings when a person with FSHD raises his or her arms. Onset usually occurs in the teenage years but may begin in childhood or as late as age 40.

about Facioscapulohumeral (FSHD)

Hip and shoulder muscles are usually the first affected. People with this type of muscular dystrophy may have difficulty lifting the front part of the foot and so may trip frequently. Onset usually begins in childhood or the teenage years. Some genes are involved in making proteins that protect muscle fibers from damage.

about Limb-girdle

Also known as Steinert's disease, this form is characterized by an inability to relax muscles at will following contractions. Myotonic muscular dystrophy is the most common form of adult-onset muscular dystrophy. Facial and neck muscles are usually the first to be affected

about Myotonic muscular dystrophy