Proton Pump Inhibitor Therapy Sherpath

Which statement by the nursing student about the mechanism of action of proton pump inhibitors (PPIs) requires further intervention? "PPIs inhibit active parietal cell acid secretion." "They inhibit ATPase that generates gastric acid." "They promote irreversible hydrogen or potassium ATPase inhibition." "PPIs work by blocking histamine2 receptors, which reduces gastric acid secretion."

"PPIs work by blocking histamine2 receptors, which reduces gastric acid secretion."

A patient who is receiving omeprazole has been prescribed clopidogrel following stent placement. Which outcome does a nurse alert the health care provider about resulting from the drug interaction? Increase in activation of clopidogrel Decrease in activation of clopidogrel Increase in activation of omeprazole Decrease in activation of omeprazole

Decrease in activation of clopidogrel

Which dosage and administration protocol would a nurse follow with the administration of intravenous esomeprazole to Ms. Contreras? - If given as an injection, it will be given over 1 minute. - It may be given with other intravenous medications. - If given as an infusion, it will be administered over 10 to 30 minutes. - The freeze-dried powder will be reconstituted with 5 mL of dextrose 5% in water.

If given as an infusion, it will be administered over 10 to 30 minutes.

Which teaching points would a nurse share with a 33-year-old female patient who has been prescribed omeprazole delayed-release capsules for Zollinger-Ellison syndrome? Take omeprazole at least 1 hour before a meal." "Do not crush, chew, split, or open the omeprazole capsule." "You may experience headache and diarrhea with omeprazole." "Avoid alcohol while receiving omeprazole because it will decrease the absorption of the drug." "Use contraception and alert your health care provider if you suspect you are pregnant while taking omeprazole."

"Do not crush, chew, split, or open the omeprazole capsule." "You may experience headache and diarrhea with omeprazole." "Use contraception and alert your health care provider if you suspect you are pregnant while taking omeprazole."

Which statement regarding the pharmacokinetic profile of esomeprazole is inaccurate? "Esomeprazole is well absorbed after oral administration." "The drug is less than 50% protein bound." "Esomeprazole is extensively metabolized in the liver." "The drug undergoes excretion in the urine."

"The drug is less than 50% protein bound."

Which statements are true about the pharmacokinetics of omeprazole and esomeprazole? Select all that apply. - Omeprazole is more protein bound than esomeprazole. - Esomeprazole is metabolized more slowly than omeprazole. - Esomeprazole is excreted in the urine, while omeprazole is excreted in the feces. - Esomeprazole is metabolized in the liver, while omeprazole undergoes biliary metabolism. - Esomeprazole achieves a higher blood level and has longer-lasting effects compared with omeprazole.

- Esomeprazole is metabolized more slowly than omeprazole. - Esomeprazole achieves a higher blood level and has longer-lasting effects compared with omeprazole.

In which time frame would a patient expect to experience effects from esomeprazole? 1 hour 2 hours 4 hours 6 hours

1 Hour

In which time frame would a nurse expect omeprazole to reach its peak concentration?

2 Hours

Which patients would a nurse determine require cautious use of or avoidance of esomeprazole? A 70-year-old Asian patient with hypertension A 73-year-old Caucasian patient with osteoporosis A 29-year-old Hispanic patient who is breastfeeding A 54-year-old Caucasian patient with alcoholic cirrhosis A 38-year-old Hispanic patient with type 2 diabetes mellitus

A 70-year-old Asian patient with hypertension A 73-year-old Caucasian patient with osteoporosis A 29-year-old Hispanic patient who is breastfeeding A 54-year-old Caucasian patient with alcoholic cirrhosis

A 93-year-old patient with gastroesophageal reflux disease (GERD) is prescribed esomeprazole. The patient is immobile in a skilled nursing facility, is frail, and experienced a stroke a year ago. Which adverse effects of esomeprazole will the nurse be concerned about in this patient? Diabetes Dementia Pneumonia Osteoporosis Thyroid dysfunction Hip or vertebral fracture

Dementia Pneumonia Osteoporosis Hip or vertebral fracture

Which drug interaction and outcome does the nurse anticipate will occur in Ms. Contreras with administration of esomeprazole? Digoxin: Increased digoxin exposure Digoxin: Decreased digoxin exposure Ibuprofen: Increased ibuprofen exposure Ibuprofen: Decreased ibuprofen exposure

Digoxin: Increased digoxin exposure

Which medical conditions would a nurse recognize that oral esomeprazole may be used to treat? Gastroesophageal reflux disease (GERD) Crohn disease Duodenal ulcers Nonsteroidal antiinflammatory drug (NSAID)-induced ulcers Zollinger-Ellison syndrome

Gastroesophageal reflux disease (GERD) Duodenal ulcers Nonsteroidal antiinflammatory drug (NSAID)-induced ulcers Zollinger-Ellison syndrome

Which outcome would a nurse anticipate from the drug interaction that may occur in a patient who is receiving diazepam and has been newly prescribed omeprazole? Increase in serum concentration of diazepam Decrease in serum concentration of diazepam Increase in serum concentration of omeprazole Decrease in serum concentration of omeprazole

Increase in serum concentration of diazepam

Which patient parameters would a nurse ensure are assessed before a patient receives oral esomeprazole? Medication history Gastrointestinal (GI) history Risk for and history of osteoporosis Risk for and history of hypertension Risk for and history of hypothyroidism

Medication history Gastrointestinal (GI) history Risk for and history of osteoporosis

Which statement regarding the pharmacodynamic profile of omeprazole is accurate? The onset of action of omeprazole is 2 hours. Omeprazole's duration of action is up to 24 hours. The elimination half-life of omeprazole is 0.5 to 1 hour. The elimination half-life of omeprazole is reduced in patients with liver dysfunction.

The elimination half-life of omeprazole is 0.5 to 1 hour.