Unit 5 AP Bio

An experiment was performed to determine the mode of inheritance of two mouse genes, one for fur color and one for fur length. It is known that black fur (B�) is dominant over white fur (b�) and that long fur (L�) is dominant over short fur (l�). To determine how the genes are inherited, a cross was performed between two true-breeding mice, one with long black fur and one with short white fur. Their progeny, the F1F1 generation, all had long black fur. Five F1F1 male-female pairs were then crossed with one another. The F2F2 generation phenotypes for each cross are shown in Table·1. Which of the following is the mean number per cross of F2F2 generation offspring that are the result of crossing over?

2.2

Pigeons demonstrate ZW sex determination, such that a ZZ genotype produces a male and a ZW genotype produces a female. The gene for feather color is located on the Z chromosome, and the red allele is dominant over the brown allele. Three crosses between brown male pigeons and red female pigeons were performed, and the results are shown below. Which of the following is the mean number of male offspring produced by the three crosses?

9

Insulin is a hormone produced by some pancreatic cells. Scientists have isolated the DNA sequence that codes for human insulin production. Which of the following best predicts the effect of inserting this gene into the DNA of a bacterial cell?

A recessive mutation on a somatic chromosome

The Russian blue is a rare breed of cat that is susceptible to developing cataracts on the eyes. Scientists hypothesize that this condition is inherited as a result of a mutation. Figure 1 shows a pedigree obtained in a study of cats owned by members of the Russian Blue Club in Sweden. Based on the inheritance pattern shown in Figure 1, which of the following best predicts the nature of the original mutation?

A recessive mutation on a somatic chromosome

An African violet grower observes that genetically identical African violet plants growing near the walls of the greenhouse have white flowers, that plants growing farther away from the walls have pale blue flowers, and that plants growing nearest the center of the greenhouse have dark blue flowers. Which of the following best explains the differences in flower color of the African violets in the greenhouse?

An enzyme responsible for flower color does not fold correctly in cooler temperatures, and the greenhouse is warmest in the center.

Trisomy 21 is a condition in which a child is born with an extra chromosome in pair 21. Researchers assessed the frequency of children born with trisomy 21 by age of the mothers at birth (maternal age) and primary cause of the error leading to trisomy 21. The findings are presented in Figure 1. Based on the data in Figure 1, which of the following is most likely the primary cause of the pattern of frequency of trisomy 21 births in the selected maternal age-groups?

At older maternal ages, the incidence of errors in meiosis during egg production increases, which leads to an increase in nondisjunction.

Figure 1 illustrates processes related to control of transcription and translation in a cell. Which of the following scientific claims is most consistent with the information provided in Figure 1 ?

Different genes may be regulated by the same transcription factor.

Table 1 shows the stage and number of cells and chromosomes per cell at the end of the stage in a 2n=24 2 n = 24 organism. Table 1. Cell and chromosome count during selected phases of meiosis Stage Number of Cells Number of Chromosomes per Cell Prophase I 1 24 Metaphase I 1 24 Anaphase I 1 24 Telophase I 1 24 Beginning of Prophase II 2 12 Which of the following statements correctly describes the chromosomes in each daughter cell at the end of meiosis I?

Each daughter cell contains 12 chromosomes, each composed of two chromatids. Each chromosome is one of a pair of homologous chromosomes from the parent cell, with the other homologue found in the other daughter cell

Histone methyltransferases are a class of enzymes that methylate certain amino acid sequences in histone proteins. A research team found that transcription of gene R� decreases when histone methyltransferase activity is inhibited. Which scientific claim is most consistent with these findings?

Histone methylation opens up chromatin at gene R� so transcription factors can bind to DNADNA more easily.

A model showing two possible arrangements of chromosomes during meiosis is shown in Figure 1. Which of the following questions about genetic diversity could most appropriately be answered by analysis of the model in Figure 1 ?

How does the independent assortment of the two sets of homologous chromosomes increase genetic diversity?

In sweet pea plants, purple flower color is dominant over red flower color and long pollen grain shape is dominant over round pollen grain shape. Two sweet pea plants that are heterozygous for both flower color and pollen grain shape are crossed with one another. A geneticist is surprised to observe that there are far fewer round, purple offspring and long, red offspring than were predicted by the 9:3:3:1 expected phenotypic ratio. Which of the following statements provides the most reasonable prediction to account for the deviation from the expected results?

In sweet pea plants, the gene for flower color and the gene for pollen grain shape are genetically linked.

Australian dragon lizards have a ZW sex-determination system. The male genotype is homogametic (ZZ), and the female genotype is heterogametic (ZW). However, all eggs incubated at temperatures above 32°C tend to develop into females. Which of the following best explains how the development of phenotypic female Australian dragon lizards with a ZZ genotype occurs when incubation temperatures are above 32°C?

Incubation temperatures above 32°C inhibit the genes on the Z chromosome that produce proteins necessary for male development.

During prophase I replicated homologous chromosomes pair up and undergo synapsis. What testable question is generated regarding synapsis and genetic variability by Figure 1 ?

Is the distance between two gene loci related to crossover rate?

Scientists have found that DNA methylation suppresses crossing-over in the fungus Ascobolus immersus. Which of the following questions is most appropriately raised by this specific observation?

Is the level of genetic variation in the gametes related to the amount of DNADNA methylation observed?

Both liver cells and lens cells have the genes for making the proteins albumin and crystalline. However, only liver cells express the blood protein albumin and only lens cells express crystalline, the main protein in the lens of the eye. Both of these genes have enhancer sequences associated with them. The claim that gene regulation results in differential gene expression and influences cellular products (albumin or crystalline) is best supported by evidence in which of the following statements?

Liver cells possess transcriptional activators that are different from those of lens cells.

eiosis begin with a parent cell that is diploid. Which of the following best describes how mitosis and meiosis result in daughter cells with different numbers of chromosomes?

Mitosis produces two identical diploid daughter cells after one round of division. Meiosis produces four haploid daughter cells after two rounds of division.

Figure 1 illustrates the X and Y chromosomes during meiosis I and meiosis II of normal spermatogenesis in a mammal species. If the normal spermatogenesis is disrupted, the gametes can have different chromosomes than expected. Which of the following is the most likely cause of one of the four gametes having two X chromosomes and one having neither an X nor a Y chromosome?

Nondisjunction of the X chromosome during meiosis II

lement found in both aquatic and terrestrial environments. Scientists have found genes that allow bacteria to remove arsenic from their cytoplasm. Arsenic enters cells as arsenate that must be converted to arsenite to leave cells. Figure 1 provides a summary of the arsenic resistance genes found in the operons of three different bacteria. E. coli R773 is found in environments with low arsenic levels. Herminiimonas arsenicoxydans and Ochrobactrum tritici are both found in arsenic‑rich environments. Researchers claim that bacteria that live in environments heavily contaminated with arsenic are more efficient at processing arsenic into arsenite and removing this toxin from their cells. Justify this claim based on the evidence

Responses There are multiple operons controlling the production of proteins that process and remove arsenite from cells in both H. arsenicoxydans and O. tritici. In contrast, E. coli has only one operon devoted to arsenic removal.

A student crosses a pure-breeding line of red-flowered poinsettias with a pure-breeding line of white-flowered poinsettias. The student observes that all the plants in the F1 generation have pink flowers. The student then crosses the F1 plants with one another and records observations about the plants in the F2 generation. The student will use the F2 data to perform a chi-square goodness-of-fit test for a model of incomplete dominance. The setup for the student's chi-square goodness-of-fit test is presented in Table 1. The critical value for a chi-square test with a significance level of p=0.05 and 2 degrees of freedom is 5.99. Which of the following statements best completes the student's chi-square goodness-of-fit test?

The calculated chi-square value is 1.53, and the null hypothesis cannot be rejected.

In fruit flies, purple eyes and ebony body are traits that display autosomal recessive patterns of inheritance. In a genetics experiment, students cross wild-type flies with flies that have purple eyes and ebony bodies. The students observe that all the flies in the F1 generation have normal eyes and a normal body color. The students then allow the F1 flies to mate and produce an F2 generation. The students record observations about the flies in the F2 generation and use the data to perform a chi-square goodness-of-fit test for a model of independent assortment. The setup for the students' chi-square goodness-of-fit test is presented in Table 1. The students choose a significance level of p=0.01. Which of the following statements best completes the next step of the chi-square goodness-of-fit test?

The calculated chi-square value is 10.48, and the critical value is 11.35.

In a strain of tomato plants, short plant height and small fruit size are traits that display autosomal recessive patterns of inheritance. To investigate whether the traits segregate independently, researchers cross a pure-breeding line of tall tomato plants that have large fruits with a pure-breeding line of short tomato plants that have small fruits. The researchers observe that all the plants in the F1 generation are tall and have large fruits. The researchers cross the F1 plants with one another to generate an F2 generation. The researchers record observations for the F2 generation and will use the data to perform a chi-square goodness-of-fit test for a model of independent assortment. The setup for the chi-square goodness-of-fit test is shown in Table 1. The researchers choose a significance level of p=0.05. Which of the following best completes the chi-square goodness-of-fit test?

The calculated chi-square value is 9.24, and the critical value is 7.82. The null hypothesis of independent assortment can be rejected.

A student carries out a genetics experiment with fruit flies to investigate the inheritance pattern of the white eye trait. The student crosses a homozygous white-eyed female with a wild-type male and records observations about the flies in the F1F1 generation. The student plans to use the F1F1 data to perform a chi-square goodness-of-fit test for a model based on an X-linked recessive pattern of inheritance. The student will use one degree of freedom and a significance level of p=0.05�=0.05. The setup for the student's chi-square goodness-of-fit test is presented in Table 1. The student calculates a chi-square value of 0.36. Which of the following statements best completes the student's chi-square goodness-of-fit test?

The critical value is 3.84, and the student cannot reject the null hypothesis.

Saccharomyces cerevisiae is a diploid yeast species that can reproduce either sexually or asexually. An experiment was performed to induce mitotically dividing S. cerevisiae cells in G2 to undergo meiosis. Which of the following best describes the steps these cells will follow to form gametes?

The first division will reduce the number of chromosomes by half for each daughter cell, and the second division will move single chromatids to each daughter cell.

Red-green color blindness in humans is caused by a recessive allele located on the XX chromosome. Figure 1 shows the potential offspring of a female who is red-green color-blind and a male with full-color vision. All of the possible male offspring would be color-blind, and all of the possible female offspring would have full-color vision. If during the production of male gametes an error in meiosis occurred, sperm containing both an XX and a YY chromosome could be produced. How would the extra chromosome affect the male offspring produced by the gamete?

The male offspring would have full-color vision, because of the presence of the extra XX chromosome

In fruit flies, sepia eyes and ebony body are traits that display autosomal recessive patterns of inheritance. To investigate whether the traits are genetically linked, students cross wild-type flies with a line of flies that have sepia eyes and ebony bodies. The students observe that all the flies in the F1 generation have normal eyes and normal bodies. The students allow the flies in the F1 generation to mate and produce an F2 generation. The students then record observations for the flies in the F2 generation and use the data to perform a chi-square goodness-of-fit test for a model of independent assortment. The setup for the chi-square goodness-of-fit test is presented in Table 1. The students calculate a chi-squared value of 92.86 and compare it with a critical value of 7.82. Which of the following best completes the chi-square goodness-of-fit test?

The null hypothesis can be rejected, and the students should conclude that the data may have resulted from genetic linkage.

A gene that influences coat color in domestic cats is located on the XX chromosome. A female cat that is heterozygous for the gene (XBXOX�X�) has a calico-colored coat. In a genetics experiment, researchers mate a calico-colored female cat (XBXOX�X�) with an orange-colored male cat (XOYX�Y) to produce an F1F1 generation. The researchers record observations for the cats in the F1F1 generation and plan to use the data to perform a chi-square goodness-of-fit test for a model of XX-linked inheritance. The data for the chi-square goodness-of-fit test are presented in Table 1. The researchers calculate a chi-square value of 4.6 and choose a significance level of p=0.05�=0.05. Which of the following statements best completes the chi-square goodness-of-fit test?

The null hypothesis cannot be rejected because the chi-square value is less than the critical value.

In order to determine the effects of age on the accumulation of mitochondrial mutations, mitochondrial DNA samples from young mice (3 months) and old mice (30 months) were observed for mutations. Which of the following is a correct analysis of this data set?

There is an increase in the mean number of mutations for the two age groups of 9.2 mutations per 106 base pairs. This is more critical in female mammals since mitochondria are maternally inherited.

A scientist studying phenotypic variation in a species of butterfly observed that genetically identical caterpillars grown in similar cages but exposed to different colored lights developed into butterflies with differences in wing color and body size, as shown in Table 1. Which of the following best explains the cause of the phenotypic variation observed in the butterflies?

There was differential gene expression of wing color and body size in response to the colors of light the caterpillars were exposed to.

Figure 1 represents a metabolic process involving the regulation of lactose metabolism by E. coli bacteria. Lactose is utilized for energy by E. coli when glucose is not present. Allolactose is an isomer of lactose that is in the environment of these bacteria when lactose is present. The CAP site prevents the binding of RNA polymerase when glucose is present in the environment. The lacZ, lacY, and lacA genes code for proteins needed for lactose metabolism. Which is a scientific claim that is consistent with the information provided and Figure 1?

When bound to the operator, the repressor protein prevents lactose metabolism in E. coli.

Phytochromes are molecules that change light stimuli into chemical signals, and they are thought to target light-activated genes in plants. A study was conducted to determine how certain cell proteins were made in a plant cell using a phytochrome. Figures 1 and 2 represent findings from the study. Use the response models shown in Figures 1 and 2 to justify the claim that phytochromes regulate the transcription of genes leading to the production of certain cellular proteins.

When inactive phytochrome PrPr is activated by red light to become phytochrome PfrPfr, it is transported into the nucleus where it binds to the transcription factor PIF3PIF3 at the promoter. This stimulates transcription, ultimately leading to protein production. Far-red light inactivates the phytochrome, which will turn transcription off by not binding to PIF3PIF3.