Youan Practice Examples Exam II

Under what temperature conditions should Indocin suppositories be stored? A. 2°C to 8°C (36°F to 46°F) B. 8°C to 14°C (46°F to 57°F) C. 0°C to 6°C (32°F to 42°F) D. Below 0°C (32°F)

A; 2°C to 8°C (36°F to 46°F)

Which of the following is the active ingredient of Methylin? a. Methylphenidate HCl b. Aspartame c. Microcrystalline Cellulose d. A and C e. All of the Above

A; Methylphenidate HCl

A pharmacist receives a prescription for 15 mg piroxicam capsules, qty. 48. A #1 capsule filled with piroxicam weighs 245 mg; a capsule filled with lactose weighs 180 mg. How much piroxicam and lactose are required for the prescription? Prepare sufficient powder for 50 capsules (2 extra). A. 15 mg piroxicam + 165 mg lactose B. 750 mg piroxicam + 9.00 g lactose C. 750 mg piroxicam + 8.45g lactose D. 15 mg piroxicam + 230 mg lactose E. None of the above

C; 750 mg piroxicam + 8.45g lactose

If the API of 125 mg tablet decays by zero-order kinetics with a reaction rate constant kinetic of 0.5 mg per hour, what is the amount of intact drug remaining after 3 days (72 hours)? A. 0.89 mg B. 8.9 mg C. 89 mg D. 890 mg

C; 89 mg

What is the active form of Nepafenac? A. Diclofenac B. Ibuprofen C. Amfenac D. NAC (acetylcysteine)

C; Amfenac

Which of the following is not a coating agent used for Rilutek? A. Hypromellose (HPMC) B. Polyethylene Glycol 6000 C. Hypromellose Phthalate (HPMCP) D. Titanium Dioxide

C; Hypromellose Phthalate (HPMCP)

As described in Case Study 1, Decadron is a conventional release tablet. Given that Decadron follows first-order releases kinetics, it can be assumed: a. The rate of drug release is independent of time and constant over time b. The rate of drug release is delayed for a predefined period of time c. The rate of drug release declines exponentially with time d. The rate of drug release increases exponentially with t

C; The rate of drug release declines exponentially with time

Which one of the following statements concerning tablet dissolution is NOT true? A) Disintegration precedes dissolution B) In vivo disintegration is usually a good predictor of dissolution C) Changing a drug's crystalline state may change dissolution rates D) Increasing tablet compression force will increase dissolution E) Micronization of drug powder will decrease dissolution time

D; Increasing tablet compression force will increase dissolution

What is a disadvantage with using direct compression method? A. Fewer steps B. Direct compression excipients possess inherent disintegration properties (microcrystalline cellulose) C. Faster dissolution compared to wet granulation D. Occurrence of unblending due to variability in API and excipients

D; Occurrence of unblending due to variability in API and excipients

Which of the following capsules sizes has the largest capacity? A) 5 B) 4 C) 1 D) 0 E) 000

E; 000

What is a reason why rectal suppository formulation of an NSAID would be preferred for a patient? A. Rectal suppositories offer less therapeutic response than other formulations B. Patient is unconscious C. Patient is alert, aware, and able to swallow pills or capsules D. Patient is experiencing nausea/vomiting E. Both B and D

E; Both B and D

Most commercial vaginal suppositories use a base of A) Beewax B) Cocoa butter C) Glycerin D) glycerinated gelatin E) Polyethylene glycols

E; Polyethylene glycols

Which of the following is not an ingredient(s) in ibuprofen: a. Maltose b. Lactose c. Croscarmellose sodium d. Colloidal silicon dioxide e. Hot Butter f. A and E g. B and C h. None of the Above

F; A and E

Formulation of ibuprofen involves: a. Low shearing mixing b. Pre-formed ingredients c. Wet Mixtures d. Explosions e. A and B are correct f. None of the above

F; none of the above *probably will look at ibuprofen case study and see what the formulation does involve

True statements, about the function of excipients used in tablet formulations include: I. binders promote granulation during the wet granulation process. II. glidants help to promote the flow of the tablet granulation during manufacture. III. lubricants help the patient to swallow the tablets.

I and II

For each of the tablet processing problem listed below, SELECT/MATCH the most likely reason for the condition. A) Excessive moisture in the granulation B) Entrapment of air C) Tablet friability D) Degraded drug E) Tablet hardness

Picking: A Mottling: D Capping: B Sticking: A

DSUVIA can be administered to patients at home. a. True b. False

B; false *not good question

What poor medication storage method will most likely lead to a degradation of Glucophage XR's active pharmaceutical ingredient (Metformin)? A. Leaving the lid off of medication container (metformin is degraded by oxygen) B. Storing medications next to a window C. Placing medication in a locker at work D. Storing medication next to a space heater

A; Leaving the lid off of medication container (metformin is degraded by oxygen) * not aligned w/ learning objectives

The shells of soft gelatin capsules may be made elastic or plastic-like by the addition of A) sorbitol B) povidone C) polyethylene glycol (PEG) D) lactose E) hydroxypropyl methylcellulose (HPMC)

A; sorbitol

Which two ingredients serve as both glidants and anti-adherent agents? A. talc and magnesium stearate B. polyethylene glycol and titanium dioxide C. microcrystalline cellulose and Lactose monohydrate D. croscarmellose sodium and providone (PVP)

A; talc and magnesium stearate

Which patient could use NuvaRing? A) A 35-year-old with a history of smoking B) A 27-year-old with a latex allergy C) A 26-year-old with a history of coronary artery disease D) A 32-year-old who is currently pregnant

B; A 27-year-old with a latex allergy *not well aligned w/ learning objectives

Which of the following is not a pharmacological property of Rilutek? A. Inhibitory effect on glutamate release B. Agonistic effect on Alpha-2 adrenergic receptors to relieve muscle spasticity C. Deactivation of voltage-dependent sodium channels D. Interfere with intracellular events that follow binding of transmitters at excitatory amino acid receptors

B; Agonistic effect on Alpha-2 adrenergic receptors to relieve muscle spasticity *not aligned w/ learning objectives

Which of the following is true about the storage conditions of DSUVIA? a. DSUVIA should be stored at 30 degrees celsius b. DSUVIA should be stored away from light c. DSUVIA can be stored in a bathroom cabinet d. Because light only affects color, it does not matter if DSUVIA is protected from light

B; DSUVIA should be stored away from light

Which of the following statements is not true about Methylin (methylphenidate HCl)? a. It is a central nervous system stimulant. b. It stimulates the reuptake of norepinephrine and dopamine. c. It is used for the treatment of Attention Deficit and Hyperactivity Disorder (ADHD). d. Maltose and aspartame are two ingredients that act as sweeteners. e. It is classified as "class I" in regards to the Biopharmaceutics Classification System.

B; It stimulates the reuptake of norepinephrine and dopamine.

What is the mode of action of Ilevro? A. Penetrates the cornea as an active drug; inhibits COX1 and COX2. B. Penetrates the cornea as a prodrug; activated in the cornea; inhibits COX1 and COX2. C. Penetrates the cornea as a prodrug; absorbed into the bloodstream; activated in the liver; inhibits COX1 and COX2 D. Penetrates the cornea as a prodrug; activated in the cornea; agonizes COX1 and COX2.

B; Penetrates the cornea as a prodrug; activated in the cornea; inhibits COX1 and COX2. *not well aligned w/ learning objectives

What class of antiviral agents does Veklury (Remdesivir) belong to? a. Protease inhibitors b. RNA polymerase inhibitors c. Entry inhibitors d. Uncoating inhibitors

B; RNA polymerase inhibitors *not well aligned w/ learning objectives

What is the MOA of Ondansetron? a. Non-selective 5-HT3 antagonist b. Selective 5-HT3 antagonist c. Selective 5-HT3 agonist d. Non-selective 5-HT3 agonist

B; Selective 5-HT3 antagonist *not good question

Hypromellose 2208 is an ingredient in all Glucophage XR tablets. If this ingredient was removed from the medication what can we expect to change in the therapeutic effect or manufacturing process of Glucophage XR? A. Product would stick to machinery when being manufactured, causing an array of issues. B. The release of Glucophage XR when taken would be less controlled and result in a quicker release of the drug, removing the benefit of being an extended release tablet. C. Product may cake and will struggle to freely flow during manufacturing. D. No therapeutic or manufacturing effect will be noticed.

B; The release of Glucophage XR when taken would be less controlled and result in a quicker release of the drug, removing the benefit of being an extended release tablet. * not aligned w/ learning objectives

Imvexxy should be taken once a day for two weeks, and then after that how many times a week? A.) One B.) Two C.) Three D.) Four

B; Two *not well aligned w/ learning objectives

Dose dumping is a problem in the formulation of A) compressed tablets B) modified-release drug products C) hard gelatin capsules D) soft gelatin capsules E) suppositories

B; modified-release drug products

Does the World Health Organization recommend the usage of Veklury (Remdesivir) to treat COVID-19? a. Yes b. No

B; no *not well aligned w/ learning objectives

Which of the following is NOT a function of the lubricant in a tablet formulation? A) Improving flow properties of granules B) Reducing powder adhesion onto the dies and punches C) Improving tablet wetting in the stomach D) Reducing punch and die wear E) Facilitating tablet ejection from the die

C; Improving tablet wetting in the stomach

How is NuvaRing to be used? A) Worn around the wrist B) Only inserted into the vagina prior to intercourse C) Inserted into the vagina and left in for 21 days

C; Inserted into the vagina and left in for 21 days

Viral transduction enanchers are materials used to increase the amount of gene expression in the target tissue. Which of the following ingredients assists in gene transduction efficiency? A. Sodium phosphate dibasic B. Sodium chloride C. Poloxamer 188 D. Sodium phosphate monobasic

C; Poloxamer 188

What is the role of propylene glycol in Imvexxy? A.) Plasticizer B.) Lubricant C.) Preservative D.) Suppository Base

C; Preservative

Rx Zinc Oxide 300 mg Cocoa Butter qs 6 Direction: If the density displacement factor for zinc oxide is exactly 4.44, and the suppository mold holds 2.0 g of cocoa butter, how much cocoa butter would be required to prepare 12 of the suppositories for this prescription? Question The respective amount of zinc oxide and cocoa butter required to make these 12 suppositories is: A) ZnO: 0.36 grams Cocoa butter: 2.3 grams B) ZnO: 3.6 grams Cocoa butter: 2.3 grams C) ZnO: 0.36 grams Cocoa butter: 23 grams D) ZnO: 3.6 grams Cocoa butter: 23 grams E) ZnO: 3.6 grams Cocoa butter: 24 grams

C; ZnO: 0.36 grams Cocoa butter: 23 grams

The rectal route of administration of drug may be preferred over the oral route for some systemic-action because A) the drug does not have to be absorbed B) absorption is predictable and complete C) a portion of the absorbed drug does not pass through the liver before entering the systemic circulation D) inert binders, diluents, and excipients cannot interfere with absorption E) the dissolution process is avoided.

C; a portion of the absorbed drug does not pass through the liver before entering the systemic circulation

United States Pharmacopeia (USP) tests for ensuring the quality of drug products in tablet form include all of the following EXCEPT. A) disintegration B) dissolution C) hardness and friability D) content uniformity E) weight variation

C; hardness and friability

content uniformity test for tablets is used to ensure which of the following qualities? A) Bioequivalency B) Dissolution C) Potency D) Purity E) Toxicity

C; potency

Which flavoring is used in the ODT tablet? a. Mint b. Orange c. Strawberry d. Ghost Pepper e. Attack Helicopter

C; strawberry

Considering this "secret" formula and procedure, the amount of Acetaminophen (in kg) required to produce 1 million Tylenol tablets is A) 0.5 kg B) 5 kg C) 50 kg D) 500 kg E) 500,000 kg *look at practice questions for picture

D; 500 kg

What does Luxturna use as a vector to carry a functional gene into the affected eye tissue? A. Poxvirus B. Adenovirus C. Retrovirus D. Adeno-associated virus

D; Adeno-associated

Starch is the main disintegrant ingredient in the Decadron tablet formulation. The primary purpose of starch is to: a. Promote particle aggregation/cohesion in liquid state b. Prevent sticking to die and punch c. Facilitate flow of granules from hopper d. Promote break down of particle aggregates

D; Promote break down of particle aggregates

In which solubility class can you find Norvir? a. Class I b. Class II c. Class III d. Class IV

D; class IV

A satisfactory suppository base must meet all of the following criteria EXCEPT A) it should have a narrow melting range B) it should be nonirritating and nonsensitizing C) it should dissolve or disintegrate rapidly in the body cavity D) it should melt below 30 degrees C E) it should be inert

D; it should melt below 30 degrees C

A sweetener that is widely employed in chewable tablet formulas is A) aspartame B) glucose C) lactose D) mannitol E) sucrose

D; mannitol

If a bottle of tablets has an expiration date of "Dec 2021", the pharmacist may continue to dispense the product A) up to 1 year after the expiration date B) only through January 31, 2021 C) only through December 15, 2021 D) only through December 31, 2021

D; only through December 31, 2021

Which of the following is not an available formulation for Norvir? a. Tablet b. Soft gelatin capsules c. Solution d. Suspension

D; suspension

MATCH the lettered formulation design that best describes the mechanism of drug release from each of the following sustained-release drug delivery systems A) Encapsulated dissolution B) Ion-exchange C) Matrix diffusion D) Matrix dissolution E) Osmotic pumping

Drug is bound to a resin and released due to changes in pH: B Drug is compressed into tablets with a slowly soluble polymer: D Drug is compressed into tablets with an insoluble polymer: C Drug is compressed into tablets with semipermeable membrane and a laser drilled hole through which drug is transported out by convective flow: E

Advantages to the manufacturer for tablet film coating when compared to sugar coating include: I. shorter production times II. less gross weight III. lower incidence in coat chipping

I, II, and III

The prime purpose for which of the following types of coating may be to mask the bitter taste of an orally administered drug? I. Enteric II. Film III. Sugar

II and III

Agents that might be used to coat enteric-coated tablets include: I. hydroxypropyl methylcellulose (HPMC) II. carboxymethylcellulose (CMC) III. cellulose acetate phtalate (CAP)

III only

You are asked to prepare 2 sets of twelve 1g suppositories, Set A and Set B. Set A requires 12 suppositories each containing 50mg of Drug X while Set B requires both 50mg of Drug X as well as 300mg of Drug Y in all twelve suppositories. Cocoa butter or Theobroma oil will be used for the base of the suppositories. A) What quantity of theobroma oil base is required in each set? B) How much does an individual suppository weigh in each set? Note: Displacement values of X and Y are 0.7 and 1.5, respectively. Hint: Make 15 suppo. to account for losses.

Theobroma oil for set A = 13.9g, for set B =10.9g Individual suppo in Set A = 0.98g and in set B = 1.08g