cell bio test 4 (2018)

bcr-abi

chromosomal translocation

which of the following would be a reasonable threapeutic strategy to inhibit cancer metastasis

overexpress E-cadherin

all the following statements about destruction of cyclins is true except one

ubiquitin targets Cdks

myc

oncogene

Ubiquitin ligase

APC/C

which of the following summary statements is most accurate when describing the role of ATM and ATR kinases

ATM and ATR result in activation of p21 and PUMA respectively

each of the following would inhibit cell progression through the cell cycle except

CAK kinase phosphorylation of the mitotic Cdk/cyclin complex

which of the following forms a dimer that gets displaced from the surface of the mitochondria by EGL-1

CED-4

phosphatase

Cdc14

anaphase to telophase transition

Cdc20

G2-M transition

Cdc25

protease/proteosome

Cdh1

highly invasive cnacer cells usually express less_____a key adhesion moleculeq

E-cadherin

mitogens are added to the medium of cultured human cells that are synchronized in mitosis. the mitogen is washed way after these cells have passed START in the cell cycle. these cells will progress through the cell cycle then arrest in which phase?

G0/G1

Start (restriction point)

G1/S cyclin

which of the following is the correct order of the pathway by which activation of P13-kinase stimulates cell division

PIP3 formation-Akt phosphorylation-Rheb activation TOR activation

cancer cell aneuploidy is most likely directly caused by a defect in which one of the following

RB

which of the following statements about the Rb tumor suppressor protein is correct

Rb binds the transcription factor E2F and thus prevents the cell from entering S phase until a mitogenic signal is received

Metaphase-Anaphase Transition

Sic1

kinase

WEE1

what is the function of E2F

a transcription factor

each of the following statements regarding CD95-stimulated programmed cell death is true except

adaptor proteins stimulate the P13K-Akt pathway

which of the following types of utation cannot give rise to an oncogene

addition of deletion of a base producing a nonsense message and an inactive protein product

in the cell cycle, mitotic CDK is present during

all of the phases of the cell cycle

deletion of CARD domain from Apaf-1

apoptosis is less likely

loss of function mutation in Bax

apoptosis is less likely

FAS dead receptors can cluster without the need for the FAS ligand

apoptosis is more likely

inactivating mutation of Bcl-2

apoptosis is more likely

procaspase 9 can self proteolytically cleave

apoptosisis more likely

what role in regulating the intrinsic pathway a apoptosis is played by the bcl-2 protein family members Bax and Bcl-2

bax stimulates apoptosis while Bcl-2 inhibits apoptosis

which of the following is false about caspases

caspases cleave proteins after arginines

which of the following proteins is a death receptor which triggers the extrinsic pathway of apoptosis

cd95/fas

epigenetic changes in gene expression that can lead to cancer by silencing tumor suppressor genes are mediated by

changes in normal DNA methylation

individuals can inherit a defective APC gene on chromosome 5 from one parent that makes them susceptible to developing familial adenomatous polyposis coli. in which cells is this deletion present in affected individuals

colon epithelial cells

have a gain of function in a proto-oncogene

decrease the probability of cancer

have a gain of function in a tumor suppressor gene

decrease the probability of cancer

organ transplant patients often develop cancers at rates higher than normal. this observation supports the idea that cancer formation is dependent on

evasion of immune surveillance

true or false: APC/C-Cdc20 degrades securin which holds the sister chromatids together, leading to the metaphase to anaphase transition

false

have a loss of function in a proto-oncogene

increase the probability of cancer

each of the following would inhibit cell progression through the cell cycle except

kinase phosphorylation of mitotic Cdk

TRK oncogene

local dna rearrangment

cancer cells secrete an activator of the enzyme _______to degrade basal lamina and extracellular matrix

matrix metalloproteinase

which property of p53 enables it to prevent the development of cancer

p53 prevents the replication of cells with DNA damage

the enzyme_____breaks down the extracellular matrix to facilitate angiogenesis

plasmin

rous sarcoma virus

point mutation

src

proto-oncogene

in which of the following situations would cells die by necrosis not apoptosis

removal of heart muscle cells damaged by oxygen depletion following cardiac infarction

most hereditary forms of breast and ovarian cancer arise in women who inherit a mutant copy of wither the BRCA1 or BRCA2 gene, each of which encodes proteins involved directly in

repairing dna double-strand breaks

which one of the following is true of the G2/M phase transition

requires the destruction of S-cyclins by polyubiquitination and degradation by the proteasome

the first demonstration that cancer could be caused by a virus involved

rous sarcoma virus in chickens

each of the following occurs during apoptosis of a cell except

rupture of the cell membrane releasing cytoplasmic contents for phagocytosis

some cancer cells produce the enzyme ________ which protects the ends of chromosomes during multiple rounds of cell division

telomerase

look closely at the figure and identify the stages of mitosis in the figure. which of the following is the correct listing of stages of mitosis in the figure from A through to D

telophase, prophase, anaphase, prometaphase

mitogens are added to the medium of cultured human cells, with an activating mutation in RAS and that are synchronized in mitosis. the mitogen is washed way after these cells have passed START in the cell cycle.these cells will progress through the cell cycle then arrest in which phase?

the cell cycling just keeps repeating

True or False: Sic1 is polyubiquitinated and targeted for degradation at S-phase by the SCF rather than APC/C which functions during mitosis

true

phosphorylated AKT protein phosphorylates bad proteinsmaking them inactive and preventsapoptosis

true

BRCA1

tumor suppressor gene

p53

tumor suppressor gene

hereditary cancers typically possess loss-of-heterozygosity in

tumor-suppressor genes