Chapters 37 and 38

Pataasin ang iyong marka sa homework at exams ngayon gamit ang Quizwiz!

In what is a patient with the following coagulation test results most likely deficient? PT: 17 sec (11-15 sec) PTT: 31 sec (25-37 sec) TT: 16 sec (15-21 sec)

Factor VII

Which of the single-factor inherited deficiencies is most common as the cause for hemophilia?

Factor VIII

What test is useful for detection of a female carrier of hemophilia A?

Factor VIII to vWF ratio

The urea solubility test is used to detect deficiencies on which factor?

Factor XIII

A 67 year old woman arrives at the ER with acute bleeding into the back of the throat. A coagulation screen is ordered with the following results: PT: 12 sec (11-15 sec) PTT: 57 sec (25-37 sec) Fibrinogen: 450 mg/dL (150-400 mg/dL) What would be a reasonable next step to perform?

Incubate the 1:1 mix at 37C for 1 hour and then repeat the PTT

What coagulation screening test is the most sensitive for detecting mild liver disease?

PT

Which of the following is decreased in acute DIC? - fibrinogen - PT - PTT - fibrin degradation products

PTT

Which of the following tests is increased in a patient with severe hemophilia A? - PTT - TT - PT - factor VIII assay

PTT

Which test will detect dysfibrinogenemia?

Reptilase Time

Which of the following therapies actually lyses the clot rather than prevents future clots? - aspirin - heparin - TPA - coumadin

TPA

Which of the following are components of the contact group of factors? - fibrinogen and thrombin - VIII and vWF - XII and prekallikrein - calcium of IX

XII and prekallikrein

All of the following are functions of thrombin EXCEPT: - activates factors V and VIII - activates plasminogen - activated factor XIII - initiates platelet adhesion

activates plasminogen

What is the role of the thrombin-thrombomodulin complex?

activates protein C

What is or are the possible mechanism(s) for bleeding in patients with severe liver disease? - thrombocytopenia - inadequate production of procoagulants - disseminated intravascular coagulation (DIC) - all of the above

all of the above

What protein does heparin work with to inhibit coagulation?

antithrombin

What substance is known to inactivate cyclooxygenase, causing impairment of platelet function?

aspirin

What is the role cofactors play in the procoagulant process?

bind to their specific activated serine pretease to stabilize to protease and increase its activity

Which of the following is part of primary hemostasis? - fibrinolysis - blood vessels - intrinsic system - inhibitors

blood vessels

Absence of D-dimers is useful for ruling out

deep vein thrombosis (DVT)

Which of the following proteins is the best test to distinguish moderate to severe liver disease from vitamin K deficiency? - factor V concentration - factor VII concentration - factor VIII concentration - factor IX concentration

factor V concentration

A 39 year old male patient shows evidence of poor wound healing and a history of joint bleeding. What protein deficiency is most likely present?

factor XIII screening tests that would be normal (plasma): PT, PTT, TT

What plasma protein is important for normal wound healing and stabilization of the fibrin clot?

factor XIIIa

Which of the following is necessary for platelet aggregation? - protein S - kallikrein - vitamin K - fibrinogen

fibrinogen

Two children in the same family have recurrent, chronic bruising in multiple sites, repeated long-lasting epistaxis, and minor bleeding after dental work. Which type of disorder is most likely?

generalized, congenital, systemic initial testing ( PT, PTT, and platelet count)

Clot based mixing studies and Bethesda titers are used to test for

inhibitors (antibodies) against coagulation factors

Where are most of the plasma procoagulant proteins produced?

liver

What are the primary roles of vWF?

mediates platelet adhesion and carrier molecule for factor VIII

What substance digests the fibrin clot after healing?

plasmin

Which of the following aids in preventing excess clotting? - thrombin - factor VII - nitric oxide - protein C

protein C

What is the purest form of factor VIII that is available for treating a bleeding patient with hemophilia A?

recombinant factor VIII concentrate

Patients who have a deficiency of protein C or protein S have which type of disorder?

thrombotic disorder

What is the most common form of von Willebrand disease (vWD)?

type 1

A 21 year old woman has a primary complaint of menorrhagia. Her coagulation screen gives the following results: PT: 12.0 sec (11-15 sec) PTT: 40 sec (25-37 sec) Factor VIII activity: 35% (50-150%) Platelet count: 225 (150-400) What disorder is most likely?

vWD, type 1

Desmopressin acetate (DDAVP) is used to treat?

vWD, type 1

On what does factor VIII depend for stability?

vWF

Which of the following is necessary for platelet adhesion to collagen? - calcium - fibrinogen - vWF - factor XIII

vWF

What vitamin is essential for normal synthesis of prothrombin group proteins, thus enabling the to bind Ca2+?

vitamin K

Common treatment with oral anticoagulation is based on

vitamin K antagonism


Kaugnay na mga set ng pag-aaral

Law - Contracts - Essential Elements for a Contract

View Set

Money, Credit, and Banking Practice Exam

View Set

MGMT 472 Ch. 14 (Social Entrepreneurship)

View Set

Passpoint PrepU - Practice NCLEX #2

View Set