Cluster of Differentiation (CD) Antigens
CD5
Marker on B-1 cells that produce IgM and can be found in the peritoneal and pleural cavities.
CD43
Marker on stem cells, pro-B cells, and pre-B cells, but not immature B cells.
CD7
Marker on the outside of T cells. Plays a role in B-cell/T-cell interactions.
CD47
self antigen on red blood cells recognized by macrophages ("don't eat me" signal)
CD8
A surface protein, present on most cytotoxic T cells, that binds to class I MHC molecules, enhancing the interaction between the T cell and a target cell.
CD25
ALPHA chain of the IL-2 receptor (expressed on activated T cells, on Tregs, and also expressed early in T cell development in the thymus)
CD30
Activated B cells, T cells, and monocytes; Reed-Sternberg cells and variants
CD23
Activated mature B cells
CD35
Aka CR1, expressed on the outside of B cells. On other immune cells (like FDCs), aids in the phagocytosis of C4b and C3b coated pathogens. C5a is also required for phagocytosis when a pathogen is bound to the CR1 receptor (but the C5a receptor is different).
CD49f
Alpha-6 integrin receptor
CD11
An α integrin that associates with CD18 to form different receptors, there are different _____ molecules (a, b, c & d) on Lymphocytes, granulocytes, monocytes and macrophages
CD1
Antigen-presenting molecules found on antigen-presenting and thymus cells. Present lipid antigens like mycobacterium and tuberculosis
CD20
B cell marker
CD21
B cells, follicular dendritic cells
CD40
Cell surface marker found on activated helper T cells
CD27
Cell surface marker present on memory B cells and absent on memory T cells
CD3
Expressed on all T cells and is needed as a signal transducer for the T cell receptor
CD32
Fc receptor on the outside of B cells and macrophages aka Fc gamma RII, feedback inhibition for B cells.
CD18
Functions: Cell adhesion molecule (missing in leukocyte adhesion deficiency) Cell expression: Leukocytes
CD15
Granulocytes (e.g. neutrophils); Reed-Sternberg cells and variants
CD4
Helper T cells
CD34
Hematopoietic stem cell surface protein
CD22
Inhibitory B-cell coreceptor, upon activation (ITIM gets phosphorylated) it activates a deactivating phosphatase that de-phosphorylates ITAMs and leads to decreased B-cell signaling
CD13
Myeloid marker
CD19
Used clinically to count B cells in blood
CD28
a costimulatory molecule in T cell activation
CD2
adhesion molecule on T cells that binds to the LFA-3 adhesion molecule on antigen-presenting cells
CD45
all leukocytes
CD10
antigen expressed by early B-lymphocytes which is also expressed by B-cell leukemias and lymphomas; low levels normal, elevated may indicate cancer
CD46
expression is widely distributed (including non-immune cells)
CD39
inhibits platelet aggregation
CD14
macrophages
CD41
megakaryocytes
CD44
metastasis enhancer; involved in cell adhesion, migration, and proliferation.
CD6
monocytes in dermis
CD31
monocytes, granulocytes, T cell subsets and endothelial cells
CD33
myeloid cells
CD16
neutrophils, NK cells, macrophages
CD38
plasma cells
