Cumulative Prelecture Quizzes

The average healthy adult has a total body iron content of: A. 20-30 mg B. 100-150 mg C. 1000-1500 mg D. 3500-4000 mg

D. 3500-4000 mg

Which of the following is (are) myeloproliferative neoplasm(s) (MPN)? A. Refractory anemia B. Chronic myeloid leukemia (CML) C. 5q- (deletion of 5q) syndrome D. All the above

B. Chronic myeloid leukemia (CML)

Which of the following statements on lymphoma is (are) true? A. Lymphoma is malignant neoplasm of lymphocytes B. Hodgkin lymphoma is more commonly seen than non-Hodgkin lymphoma C. T-cell non-Hodgkin lymphoma is more commonly seen than B-cell nonHodgkin lymphoma D. All of the above

A. Lymphoma is malignant neoplasm of lymphocytes

The principle regulator of body iron metabolism is: A. Hepcidin produced by the liver B. Erythropoietin produced by the kidney C. Heme produced by red cell precursors D. Transferrin produced by the liver

A. Hepcidin produced by the liver

Which of the following statements is true? A. Hereditary spherocytosis (HS) is caused by "vertical" defect in the membraneassociated cytoskeleton network B. Hereditary spherocytosis (HS) is caused by "horizonal" defect in the membrane-associated cytoskeleton network C. Hereditary elliptocytosis (HE) is caused by "vertical" defect in the membraneassociated cytoskeleton network D. Hereditary pyropoikilocytosis (HPP) is caused by "vertical" defect in the membrane-associated cytoskeleton network

A. Hereditary spherocytosis (HS) is caused by "vertical" defect in the membraneassociated cytoskeleton network

Which of the following statements is correct? A. In warm autoimmune hemolytic anemia, the "defect" is extracorpuscular and the hemolysis is usually extravascular B. In cold agglutinin disease, the "defect" is extracorpuscular and the hemolysis is exclusively intravascular C. In warm autoimmune hemolytic anemia, the "defect" is extracorpuscular and the hemolysis is usually intravascular D. In cold agglutinin disease, the "defect" is intracorpuscular and the hemolysis is primarily intravascular

A. In warm autoimmune hemolytic anemia, the "defect" is extracorpuscular and the hemolysis is usually extravascular

Which of the following statements on INR (international normalization ratio) is (are) correct? A. It is calculated based on PT (prothrombin time) B. It is calculated based on PTT (partial thromboplastin time) C. It is used to monitor heparin therapy D. INR values are laboratory-specific, and therefore cannot be compared among different hospitals

A. It is calculated based on PT (prothrombin time)

Which of the following statements on hemoglobin C disease is NOT true? A. It is caused by a point mutation in the alpha (α) globin chain gene B. Numerous target cells present on blood smear C. Associated with mild chronic hemolysis D. Almost exclusively seen in the Black population

A. It is caused by a point mutation in the alpha (α) globin chain gene

What findings distinguishes megaloblastic anemia due to vitamin B12 deficiency from that due to folate deficiency? A. Neuropathy B. Jaundice C. Elevated serum LDH level D. Pancytopenia

A. Neuropathy

Which of the following statements on paroxysmal nocturnal hemoglobinuria (PNH) is true? A. PNH defect is in the complement pathway B. PNH defect affects red blood cells only C. PNH defect affects white blood cells only D. PNH defect affects both red and white blood cells

A. PNH defect is in the complement pathway

Primary hemostasis involves: A. Platelets, vessel wall, von Willebrand factor (vWF) B. Factor XI, factor VIII, factor IX C. Thrombin, fibrinogen, factor XIII D. Plasminogen activator, plasmin

A. Platelets, vessel wall, von Willebrand factor (vWF)

Activated partial thromboplastin time (aPTT) measures the integrity of: A. The intrinsic pathway and the common pathway B. The extrinsic pathway and the common pathway C. The common pathway only D. The fibrinolytic pathway

A. The intrinsic pathway and the common pathway

According to the WHO, acute leukemia is defined as: A. Bone marrow blast count ≥10% B. Bone marrow blast count ≥20% C. Bone marrow blast count ≥30% D. Bone marrow blast count ≥40%

B. Bone marrow blast count ≥20%

Which of the following lymphomas is considered high-grade? A. Chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) B. Burkitt leukemia/lymphoma (BL) C. Marginal zone lymphoma (MZL) D. Lymphoplasmacytic lymphoma/Waldenstrom macroglobulinemia (LPL/WM)

B. Burkitt leukemia/lymphoma (BL)

The pathogenesis of megaloblastic anemia is: A. Defective RNA synthesis and abnormal cytoplasm maturation B. Defective DNA synthesis and abnormal nuclear maturation C. Defective RNA synthesis and abnormal nuclear maturation D. Defective DNA synthesis and abnormal cytoplasm maturation

B. Defective DNA synthesis and abnormal nuclear maturation

Vitamin K-dependent coagulation factors include A. Factors XII, XI, VIII & V B. Factors II, VII, IX & X C. Fibrinogen (factor I) and factor XIII D. Factors III and IV

B. Factors II, VII, IX & X

Aplastic anemia is associated with: A. Marked increase in bone marrow cellularity B. Marked decrease in bone marrow cellularity C. Normal bone marrow cellularity D. Hypersplenism (enlarged spleen)

B. Marked decrease in bone marrow cellularity

Which of the following cell types is associated with increased osmotic fragility? A. Target cells B. Spherocytes C. Hypochromic cells D. Reticulocytes

B. Spherocytes

Reactive lymphocytes seen in blood smear of a young patient diagnosed with infectious mononucleosis represent: A. Epstein Barr virus (EBV)-infected B cells B. T cells responding to EBV infection C. NK cells responding to EBV infection D. Infected B and T lymphocytes

B. T cells responding to EBV infection

Which of the following differentiates DIC (disseminated intravascular coagulation) from TTP (thrombotic thrombocytopenic purpura)? A. Presence of schistocytes on blood smear B. Thrombocytopenia C. Coagulopathy (e.g., prolongation of PT and PTT, decrease in fibrinogen) D. Fever and organ failure

C. Coagulopathy (e.g., prolongation of PT and PTT, decrease in fibrinogen)

Southeast Asian ovalocytosis is caused by: A. Defect in alpha-spectrin B. Defect in ankyrin C. Defect in Band 3 D. Defect in beta-spectrin

C. Defect in Band 3

Assuming there is no "CRAB" (hypercalcemia, renal insufficiency, anemia, bone lesions), what of the following separates myeloma from MGUS (monoclonal gammopathy of undetermined significance)? A. >10% clonal plasma cells in the marrow B. > 3.0 g/dL M-protein in serum (paraprotein) C. Either A or B D. Neither A nor B

C. Either A or B

The average life spans of red cells, neutrophils, and platelets in the blood circulation are: A. 120 days, 7 days, and 10 days B. 30 days, 7 days, and 10 days C. 120 days, 6-10 hours, and 10 days D. 30 days, 6-10 hours, and 10-12 hours

C. 120 days, 6-10 hours, and 10 days

Oxygen-dependent killing of bacteria by neutrophils is dependent on which enzyme(s)? A. NADPH oxidase B. Myeloperoxidase C. Both A & B D. Neither A & B

C. Both A & B

Which of the following associations is NOT correct? A. Hereditary spherocytosis - spherocytes B. Warm autoimmune hemolysis - spherocytes C. Fatal ABO mismatch in blood transfusion - schistocytes D. Microangiopathic hemolysis - schistocytes

C. Fatal ABO mismatch in blood transfusion - schistocytes

Which of the following is not a crucial area of RBC survival and function? A. Integrity of RBC cellular membrane B. Intact metabolic pathways C. Intravascular hemolysis D. Hemoglobin structure & function

C. Intravascular hemolysis

Polycythemia vera (PV) is caused by: A. Bcr-Abl1 fusion B. Calreticulin (CALR) mutation C. Jak2 mutation (i.e., Jak2 V617F) D. MPL mutation

C. Jak2 mutation (i.e., Jak2 V617F)

Which of the following is NOT associated with bleeding in vivo (in the body)? A. Platelet abnormality, including von Willebrand disease B. Deficiency in coagulation factor or presence of factor-specific inhibitor C. Lupus anticoagulant (non-specific inhibitor) D. Increase in fibrinolytic activity

C. Lupus anticoagulant (non-specific inhibitor)

What condition is NOT a cause of anemia? A. Nutritional deficiency B. Decreased RBC production C. Moderate exercise D. Increased RBC destruction or loss

C. Moderate exercise

In hemoglobin S and C diseases, ____ and ____are substituted for glutamic acid in the 6th position from the N-terminal end of the beta chain, respectively. A. Valine and Tyrosine B. Adenine and Leucine C. Valine and Lysine D. Tyrosine and Lysine

C. Valine and Lysine

What percentage of the blood volume represents the formed elements or cells? A. 55% B. 50% C. 60% D. 45%

D. 45%

What is the composition of normal adult hemoglobin (Hb)? A. 92-95% Hb A; 5-8% Hb A2; 1-2% Hb F B. 90-92% Hb A; 2-3% Hb A2; 2-5% Hb F C. 80-85% Hb A; 2-3% Hb A2; 1-2% Hb F D. 95-97% Hb A; 2-3% Hb A2; 1-2% Hb F

D. 95-97% Hb A; 2-3% Hb A2; 1-2% Hb F

What of the following statements on myeloproliferative neoplasms (MPN) is (are) true? A. Clonal hematopoietic stem cell disorders (i.e., malignant/cancerous disorders) B. Hypercellular bone marrow (i.e., increase in bone marrow cellularity) C. Decrease in peripheral cell counts (e.g., decreases in RBC, WBC and/or platelets) D. A & B only

D. A & B only

Chronic myeloid leukemia (CML) is associated with: A. t(9;22) translocation B. Bcr-Abl1 fusion C. Philadelphia chromosome D. All of the above

D. All of the above

Plasma cell myeloma can cause: A. Pancytopenia B. Bone destruction & kidney damage C. Amyloidosis D. All of the above

D. All of the above

What of the following statements on myelodysplastic syndrome (MDS) is (are) true? A. Clonal hematopoietic stem cell disorders (i.e., malignant/cancerous disorders) B. Usually hypercellular bone marrow (i.e., increase in bone marrow cellularity) C. Decrease in peripheral cell counts (e.g., decreases in RBC, WBC and/or platelets) D. All of the above

D. All of the above

Which of the following statements is (are) correct? A. Hemostasis is the process by which the body spontaneously stops bleeding and maintains blood in the fluid state within the vascular compartment B. Hemostasis is divided into two stages: primary and secondary C. Normal vascular endothelial cell surface is thromboresistant (or antithrombotic) D. All of the above

D. All of the above

Which of the following statements is (are) correct? A. Platelet disorder is typically associated with deep soft tissue and/or joint bleeding B. Coagulation factor deficiency is typically associated with mucous membrane and/or skin bleeding C. Increase in fibrinolytic activity causes delayed bleeding D. All of the above

D. All of the above

Which of the following statements on von Willebrand disease (vWD) is (are) correct? A. Predominantly autosomal dominant in inheritance B. Types 1 and 3 are quantitative deficiency in vWF C. Type 2 is qualitative deficiency in vWF D. All of the above

D. All of the above

Which organ(s) is (are) the primary sites(s) for hematopoiesis in the fetus? A. Liver B. Spleen C. Bone Marrow D. All of the above

D. All of the above

Direct antiglobulin test (DAT) (or Direct Coombs test) is positive in: A. Warm autoimmune hemolytic anemia B. Acute hemolytic transfusion reaction C. Drug-induced (e.g., methyldopa) hemolysis D. All the above

D. All the above

Secondary hemostasis in vivo (inside the body) involves: A. Platelets B. Coagulation cascade C. Fibrin formation D. All the above

D. All the above

The pathogenesis of sickle cell anemia involves: A. Vaso-occlusion by sickle cells B. Extravascular hemolysis C. Polymerization of hemoglobin S D. All the above

D. All the above

Which of the following features indicate myeloid differentiation? A. Positive for myeloperoxidase B. Presence of Auer rods C. Expression of CD13 and CD33 D. All the above

D. All the above

Which of the following is associated with a relatively favorable clinical outcome? A. Acute B lymphoblastic leukemia in a 4 year-old girl B. Acute myeloid leukemia with inv(16) in a 45 year-old man C. Acute promyelocytic leukemia with t(15;17) in a 55 year-old woman D. All the above

D. All the above

How is blood hematocrit (Hct, %) measured on most automated hematology instrument? A. Centrifugation (vis built-in small centrifuge) B. Spectrophotometry C. Calculation (Hemoglobin ÷ RBC count) D. Calculation (MCV x RBC count)

D. Calculation (MCV x RBC count)

Reed-Sternberg cells are seen in: A. Diffuse large B-cell lymphoma (DLBCL) B. Mantle cell lymphoma (MCL) C. Follicular lymphoma (FL) D. Classical Hodgkin lymphoma (CHL)

D. Classical Hodgkin lymphoma (CHL)

Which of the following is not associated with hemolysis? A. G6PD deficiency B. Pyruvate kinase deficiency C. Presence of Heinz bodies D. Decrease in 2,3-DPG

D. Decrease in 2,3-DPG

The protein responsible for transporting iron in the bloodstream is: A. Hemoglobin B. Ferritin C. Transcobalamin D. Transferrin

D. Transferrin

Which of the following is NOT a critical membrane-associated protein in red blood cells? A. Spectrin B. Band 3 C. Ankyrin D. β-globin

D. β-globin