Diabetes Mellitus
Two days after a self-managed hypoglycemic episode at home, the patient tells the nurse that his blood glucose levels since the episode have been between 80 and 90 mg/dL. Which is the best response by the nurse? a. "That is a good range for you glucose levels." b. "You should call your HCP because you need to have your insulin increased." c. "That level is too low in view of your recent hypoglycemia and you should increase your food intake." d. "You should take only half your insulin dosage for the next few days to get your glucose level back to normal."
a Blood glucose levels of 80 to 90 mg/dL are within the normal range and are desired in the patient with diabetes, even following a recent hypoglycemic episode. Hypoglycemia is often caused by a single event, such as skipping a meal, taking too much insulin, or vigorous exercise. Once corrected, normal glucose control should be maintained.
The patient with diabetes has a blood glucose level of 248 mg/dL. Which assessment findings would be related to this blood glucose level? SATA a. headache b. unsteady gait c. abdominal cramps d. emotional changes e. increase in urination f. weakness and fatigue
a, c, e, f Manifestations of hyperglycemia include abdominal cramps, polyuria, weakness, fatigue, and headache. The headache may also be seen with hypoglycemia that is manifested by the remaining options.
The patient with type 2 diabetes is being put on acarbose (Precose) and wants to know about taking it. What should the nurse include in this patient's teaching? SATA. a. Take it with the first bite of each meal. b. It is not used in patients with heart failure. c. Endogenous glucose production is decreased. d. Effectiveness is measured by 2-hr postprandial glucose. e. It delays glucose absorption from the GI tract.
a, d, e Acarbose (Precose) is an alpha-glucosidase inhibitor that is taken with the first bite of each meal. The effectiveness is measured with 2-hr postprandial blood glucose testing, as it delays glucose absorption from the GI tract. The other options describe rarely used thiazolidinediones.
What assessment findings occur with diabetic ketoacidosis (DKA)? SATA a. thirst b. ketonuria c. dehydration d. metabolic acidosis e. Kussmaul respirations f. sweet, fruity breath odor
a, b, c, d, e, f In DKA, thirst occurs to replace fluid used to eliminate ketones in the urine in trying to decrease the blood glucose and ketonemia. The metabolic acidosis lead to the Kussmaul respirations trying to decrease the acid in the system. The sweet, fruity breath odor is from acetone. Thirst and dehydration are found with both DKA and hyperosmolar hyperglycemic syndrome (HHS).
What characterizes type 2 diabetes? SATA a. Beta cell exhaustion b. insulin resistance c. genetic predisposition d. altered production of adipokines e. inherited defect and insulin receptors f. inappropriate glucose production by the liver
a, b, c, d, e, f Type 2 diabetes is characterized by beta-cell exhaustion, insulin resistance, genetic predisposition, altered production of adipokines, inherited defect in insulin receptors , and inappropriate glucose production by the liver. The roles the brain, kidneys, and gut in type 2 diabetes development are being studied.
The nurse is teaching the patient with prediabetes ways to prevent or delay the development of type 2 diabetes what information should be included? SATA a. Exercise regularly b. maintain a healthy weight c. have BP checked regularly d. assess for visual changes on a monthly basis e. monitor for polyurea, polyphagia, and polydipsia
a, b, e To reduce the risk of developing diabetes, the patient with prediabetes should maintain a healthy weight, learn to monitor for symptoms of diabetes, have blood glucose and glycosylated hemoglobin (A1C) tested regularly, exercise regularly, and eat a healthy diet.
The patient with diabetes has been diagnosed with autonomic neuropathy. What problems should the nurse assess for in this patient? SATA a. painless foot ulcers b. erectile dysfunction c. burning foot pain at night d. loss of fine motor control e. vomiting undigested food f. painless myocardial infarction
b, e, f Autonomic neuropathy affects most body systems. Manifestations of autonomic neuropathy include erectile dysfunction in men and decreased libido, gastroparesis (nausea, vomiting, gastroesophageal reflux and feeling full), painless myocardial infarction, postural hypotension, and resting tachycardia. The remaining options would occur with sensory neuropathy.
Following the teaching of foot care to a patient with diabetes, the nurse determines that additional instruction is needed when the patient makes which statement? a. "I should wash my feet daily with soap and warm water." b. "I should always wear shoes to protect my feet from injury." c. "If my feet are cold, I should wear socks instead of using a heating pad." d. "I'll know if I have sores or lesions on my feet because they will be painful."
d Complete or partial loss of protective sensation of the feet is common with peripheral neuropathy of diabetes, and patients with diabetes may suffer foot injury and ulceration without ever having pain. Feet must be inspected during daily care for any cuts, blisters, swelling, or reddened areas.
A 72 y/o woman is diagnosed with diabetes. What does the nurse recognize about managing diabetes in the older adult? a. It is harder to achieve strict glucose control than in younger patients. b. Treatment is not warranted unless the patient develops severe hyperglycemia. c. It does not include treatment with insulin because of limited dexterity and vision. d. It usually requires that a younger family member be responsible for care of the patient.
a Older adults have more conditions that may be treated with medications that impair insulin action. Hypoglycemic unawareness is more common, so these patients are more likely to suffer adverse consequences from blood glucose-lowering therapy. Manifestations of long-term complications of diabetes take 10 to 20 years to develop, so the goals for glycemic control are not as rigid as in the younger population. Treatment is indicated and insulin may be used if the patient does not respond to oral agents. The patient's needs rather than age determine the responsibility of others in care.
In type one diabetes, glucose hasn't osmotic effect when insulin deficiency prevents the use of glucose for energy. Which classic symptom is caused by the osmotic effect of glucose? a. Fatigue b. polydipsia c. polyphagia d. recurrent infections
b Polydipsia is caused by fluid loss from polyuria when high glucose levels cause osmotic diuresis. Cellular starvation from lack of glucose and the use of body fat and protein for energy contribute to fatigue, weight loss, and polyphasic in type 1 diabetes.
A patient taking insulin has recorded fasting glucose levels above 200 mg/dL on awakening for the last 5 mornings. What should the nurse have the patient do first? a. Increase the evening insulin dose to prevent the dawn phenomenon. b. Use a single-dose insulin regimen with an intermediate-acting insulin. c. Monitor the glucose level at bedtime, between 2:00 am and 4:00 am, and on arising. d. Decrease the evening insulin dosage to prevent night hypoglycemia and the Somogyi effect.
c The patient's high glucose on arising may be the result of either dawn phenomenon or Somogyi effect. The best way to determine whether the patient needs more or less insulin is by monitoring the glucose at bedtime, between 2:00 am and 4:00 am, an on arising. If the 2:00 am to 4:00 am blood glucose levels are below 60 mg/dL, the insulin dose should be reduced to prevent Somogyi effect; if it is high, the insulin should be increased to prevent dawn phenomenon.
Which tissues require insulin to enable movement of glucose into the tissue cells? SATA a. Liver b. brain c. adipose d. blood cells e. skeletal muscle
c, e Adipose tissue and skeletal muscle require insulin to allow the transport of glucose into the cells. Brain, liver, and blood cells require adequate glucose supply for normal function but do not depend directly on insulin for glucose transport.
The patient with diabetes is brought to the emergency department by his family members, who say that he has had an infection, is not acting like himself, and he is more tired than usual. Number the nursing actions in the order of priority for this patient. a. Establish IV access b. Check blood glucose c. Ensure patent airway d. Begin continuous regular insulin drip e. Administer 0.9% NaCl solution at 1 L/hr f. Establish time of last food and medication(s)
1 = c. Ensure patent airway 2 = b. Check blood glucose 3 = a. Establish IV access 4 = e. Administer 0.9% NaCl solution at 1 L/hr 5 = d. Begin continuous regular insulin drip 6 = f. Establish time of last food and medication(s)
A patient with diabetes calls the clinic because she has nausea and flu-like symptoms. Which advice from the nurse will be the best for this patient? a. Administer the usual insulin dosage b. Hold fluid intake until the nausea subsides. c. Come to the clinic immediately for evaluation and treatment. d. Monitor the blood glucose every 1 to 2 hours and call if it rises over 150 mg/dL
a During minor illness, the patient with diabetes should continue drug therapy and fluid and food intake. Insulin is important because counter regulatory hormones may increase blood glucose during the stress of illness. Food or a carbohydrate liquid substitution is important because during illness the body requires extra energy to deal with the stress of the illness. Blood glucose monitoring should be done every 4 hours, and the HCP should be notified if the level is > 240 mg/dL or if fever, ketonuria, or nausea and vomiting occur.
When teaching a patient with type 1 diabetes, what should the nurse emphasize as the major advantage of using an insulin pump? a. Tight glycemic control can be maintained. b. Errors in insulin dosing are less likely to occur. c. Complications of insulin therapy are prevented. d. Frequent blood glucose monitoring is unnecessary.
a Insulin pumps provide tight glycemic control by continuous subcutaneous insulin infusion based on the patient's basal profile, with bolus doses at mealtime at the patient's discretion and related to blood glucose monitoring. Errors in insulin dosing and complications of insulin therapy are still potential risks with insulin pumps.
When caring for a patient with metabolic syndrome, the nurse should give the highest priority to teaching the patient about which treatment plan? a. Achieving a normal weight b. performing daily aerobic exercise c. eliminating red meat from the diet d. monitoring the blood glucose periodically
a Metabolic syndrome is a cluster of abnormalities that include elevated glucose levels, abdominal obesity, elevated BP, high levels of triglycerides, and low levels of high-density lipoproteins (HDLs). Overweight persons with metabolic syndrome can prevent or delay the onset of diabetes through a program of weight loss. Regular physical activity is also important, but normal weight is most important.
Individualized nutrition therapy for patients using conventional, fixed insulin regimens should include teaching the patient to a. eat regular meals at regular times b. restrict calories to promote moderate weight loss c. eliminate sucrose and other simple sugars from the diet d. limit saturated fat intake to 30% of dietary calorie intake
a The body needs food at regular spaced intervals throughout the day. Omission or deal of meals can result in hypoglycemia, especially for the patient using conventional insulin therapy or OAs. Weight oss may be recommended in type 2 diabetes if the person is overweight, but many patients with type 1 diabetes are thin and do not require a decrease in caloric intake. Fewer simple sugar should be limited, but moderate amounts can be used if counted as a part of total carbohydrate intake.
To prevent hyperglycemia or hypoglycemia related to exercise, what should the nurse teach the patient using glucose-lowering agents about the best time for exercise? a. Plan activity and food intake related to blood glucose levels b. When blood glucose is greater than 250 mg/dL and ketones are present c. When glucose monitoring reveals that the blood glucose is in the normal range d. When blood glucose levels are high, because exercise always has a hypoglycemic effect
a To plan for exercise, a person with diabetes must monitor blood glucose and make adjustments to insulin dose (if taken) and food intake to prevent exercise-induced hypoglycemia. Exercise is delayed if blood glucose is > 250 mg/dL with ketones. Before exercise if blood glucose is < 100 a 15-g carbohydrate snack is eaten. Blood glucose levels should be monitored before, during, and after exercise to determine the effect of exercise on the levels.
A patient with diabetes is learning to mix regular insulin and NPH insulin in the same syringe. The nurse determines that additional teaching is needed when the patient does what? a. Withdraws the NPH dose into the syringe at first b. injects air equal to the NPH dose into the NPH vial first c. removes any air bubbles after withdrawing the first insulin d. add air equal to the insulin dose into the regular vial and withdraws the dose
a When mixing regular and intermediate-acting insulin, regular insulin should always be drawn into the syringe first to prevent contamination of the regular insulin vial with intermediate-acting insulin additives. Air is added to the NPH vial first. Then air is added to the regular vial and the regular insulin is withdrawn, bubbles are removed, and then the dose of NPH is withdrawn.
A patient with type one diabetes is 20 units of Novolin 70/30 (NPH/regular) In the morning and at 6:00 o'clock PM. When teaching the patient about this regimen, what should the nurse emphasize? a. Hypoglycemia is most likely to occur before the noon meal. b. The set meal pattern with a bedtime snack is necessary to prevent hypoglycemia. c. Flexibility in food intake as possible because insulin is available 24 hours a day. d. Free meal glucose checks are required to determine needed changes in daily dosing.
b A split-mixed dose of insulin requires that the patient adhere to a set meal pattern to provide glucose for the peak action of the insulin, and a bedtime snack is usually required when patients take an intermediate-acting insulin late in the day to prevent nocturnal hypoglycemia. Hypoglycemia is most likely to occur with this dose late in the afternoon and during the night. When premixed formulas are used, flexible dosing based on glucose levels is not recommended.
A patient with a newly diagnosed type 2 diabetes has been given a prescription to start an oral hypoglycemic medication. The patient tells the nurse she would rather control her blood sugar with herbal therapy. Which action should the nurse take? a. Teach the patient that herbal therapy is not safe and should not be used. b. Advise the patient to discuss using herbal therapy with her HCP before using it. c. Encourage the patient to give the prescriptive medication time to work before using herbal therapy. d. Teach the patient that if she takes herbal therapy, she will have to monitor her blood sugar more often.
b Advise the patient to seek the guidance of the HCP regarding the safety, efficacy, and specifics of using herbal therapy rather than or with the medication prescribed. Not all herbal therapy is unsafe, but dosages are not universal.
Which class of oral glucose-lowering agents (OA) is most commonly used for people with type 2 diabetes because it reduces hepatic glucose production and enhances tissue uptake of glucose? a. Insulin b. Biguanide c. Meglitinide d. Sulfonylurea
b Biguanides (e.g., metformin [Glucophage]) are most commonly used with type 2 diabetes. They reduce glucose production by the liver and increase insulin sensitivity at the tissue level that improves glucose transport into the cells. Insulin is not taken orally, as it is ineffective. Meglitinides and sulfonylureas increase insulin production from the pancreas.
the following interventions are planned for a patient with diabetes. Which intervention can the nurse delegate to unlicensed assistive personnel? a. Discuss complications of diabetes. b. Check the that the bath water is not too hot. c. check the patient's technique for drawing up insulin. d. Teach the patient to use a meter for self-monitoring a blood glucose
b Checking the temperature of the bath water is part of assisting the ADL and within the scope of care for the UAP. This is important for the patient with neuropathy. Discussing complications, teaching, and assessing learning are appropriate for RNs.
When teaching the patient with diabetes about insulin administration, the nurse should include which instruction? a. Pull back on the plunger after inserting a needle to check for blood. b. Consistently use the same size of insulin syringe to avoid dosing errors. c. Clean the skin at the injection site with an alcohol swab before each injection. d. Rotate injection sites from arms to thighs to abdomen with each injection to prevent lipodystrophies.
b Patients should consistently use the same size of insulin syringe to avoid dosing errors. Errors can be made if patients switch back and forth between different sizes of syringes. Aspiration before injection of the insulin is no longer recommended, nor is the use of alcohol to clean the skin. Because the rate of peak serum concentration varies with the site selected for injection, injections should be rotated within a particular area, such as the abdomen, before changing to another area. Lipodystrophies are rare with the use of human insulin.
The nurse is assessing a newly admitted patient with diabetes. Which observation should be addressed as the priority by the nurse? a. Bilateral numbness of both hands b. Rapid respirations with deep inspiration c. Stage II pressure injury on the right heel d. Areas of lumps and dents on the abdomen
b Rapid deep respirations are symptoms of diabetic ketoacidosis (DKA), so this is the priority of care. Stage II pressure injuries and bilateral numbness are chronic complications of diabetes. The lumps and dents on the abdomen indicate the patient has lipodystrophy and may need to learn about site rotation of insulin injections.
A nurse working in an outpatient clinic plans a screening program for diabetes. What recommendations for screening should included? a. OGTT for all minority populations every year. b. FPG for all persons at age 45 years and then every 3 years. c. Testing people under the age of 21 years for islet cell antibodies d. Testing for type 2 diabetes in all overweight or obese persons
b The American Diabetes Association recommends that testing for type 2 diabetes with a FPG, A1C, or 2-hour OGTT should be considered for all persons at the age of 45 years and above and, if normal, repeated every 3 years. Testing for immune markers of type 1 diabetes is not recommended. Testing at a younger age or more frequently should be done for members of a high-risk ethnic population, including blacks, Hispanics, Native Americans, Asian Americans, and Pacific Islanders. Overweight adults with additional risk factors should be tested.
Cortisol, glucagon, epinephrine, and growth hormones are referred to as counterregulatory hormones because they a. Decrease glucose production b. stimulate glucose output by the liver c. increased glucose transport into the cells d. independently regulate glucose level in the blood
b The counter regulatory hormones have the opposite effect of insulin by stimulating glucose production and output by the liver and by decreasing glucose transport into the cells. The counter regulatory hormones and insulin together regulate the blood glucose level.
Which statement best describes atherosclerotic disease affecting the cerebrovascular, cardiovascular, and peripheral vascular systems in patients with diabetes? a. It can be prevented by tight glucose control. b. It occurs with a higher frequency and earlier onset than in the non diabetic population. c. It is caused by hyperinsulinemia related to insulin resistance common in type 2 diabetes. d. It cannot be modified by reducing risk factors, such as smoking, obesity, and high fat intake.
b The development of atherosclerotic vessel disease seems to be promoted by the altered lipid metabolism common in diabetes. Although tight glucose control may help delay the process, it does not prevent it completely. Atherosclerosis in patients with diabetes does respond somewhat to a reduction in general risk factors, at it does in non diabetics, and reduction in fat intake, control of hypertension, abstention from smoking, maintenance of normal weight, and regular exercise should be carried out by all patients.
What should the goals of nutrition therapy for the patient with type 2 diabetes include? a. Ideal body weight b. Normal serum glucose and lipid levels c. A special diabetic diet using dietetic foods d. Five small meals per day with a bedtime snack
b The specific goals of nutrition therapy for people with diabetes include maintaining near-normal blood glucose levels and achievement of optimal serum lipid levels and BP. Dietary modifications are believed to be important factors in preventing both short- and long-term complications of diabetes. Loss of weight, which may or may not be ideal body weight, may improve insulin resistance. There is no longer a specific "diabetic diet," and use of dietetic foods is not necessary for glucose control. Most patients with diabetes eat 3 meals a day, and some require a bedtime snack for control of nighttime hypoglycemia. The other goals of nutrition therapy include prevention of chronic complications of diabetes, attention to individual needs, and maintenance of the pleasure of eating.
What disorders and diseases are related to macrovascular complications of diabetes? SATA a. chronic kidney disease b. coronary artery disease c. micro aneurysms and destruction of retinal vessels d. ulceration and amputation of the lower extremities e. capillary and arteriole membrane thickening specific to diabetes
b, d Macrovascular disease causes coronary artery disease and ulceration and results in amputation of the lower extremities. However, neuropathy may contribute to not feeling ulcerations. The remaining options are related to microvascular complications of diabetes.
The nurse assesses the technique of the patient with diabetes for self-monitoring of blood glucose (SMBG) 3 months after initial instruction. Which error in the performance of SMBG noted by the nurse requires intervention? a. Doing the SMBG before and after exercising b. Puncturing the finger on the side of the finger pad c. Cleaning the puncture site with alcohol before the puncture d. Holding the hand down for a few minutes before the puncture
c Cleaning the puncture site with alcohol is not necessary and may interfere with test results and lead to drying and splitting of the fingertips. Washing the hands with warm water is adequate cleaning and promotes blood flow to the fingers. Blood flow is also increased by holding the hand down. Punctures on the side of the finger pad are less painful. Self-monitored blood glucose (SMBG) should be performed before and after exercise.
What describes the primary difference in treatment for diabetic ketoacidosis (DKA) and hyperosmolar hyperglycemic syndrome (HHS)? a. DKA requires administration of bicarbonate to correct acidosis b. Potassium replacement is not necessary in management of HHS c. HHS requires greater fluid replacement to correct the dehydration d. Glucose is withheld in HHS until the blood glucose reaches a normal level
c The management of DKA is similar to that of HHS except that HHS requires greater fluid replacement because of the severe hyperosmolar state. Bicarbonate is not usually given in DKA to correct acidosis unless the pH is < 7.0 because administration of insulin will reverse the abnormal fat metabolism. Total body potassium deficit is possible in both conditions, requiring monitoring and possibly potassium administration, and in both conditions glucose is added to IV fluids when blood glucose levels fall to 250 mg/dL.
Which patients should the nurse plan to teach how to prevent or delay the development of diabetes? a. An obese 40-year-old Hispanic woman b. a 20-year-old man whose father has type one diabetes c. a 34-year-old woman whose parents both have type 2 diabetes d. a 12-year-old boy whose father has maturity onset diabetes of the young
c Type 2 diabetes has a strong genetic influence (8% to 14% risk for offspring) and offspring for parents who both have type 2 diabetes have an increased chance of developing it. In contrast, type 1 diabetes is associated with a genetic susceptibility that is related to human antigens. Offspring of a mother with type 1 diabetes have a 1% to 4% chance of developing the disease, while offspring of a father with diabetes have 5% to 6% risk. Other risk factors for type 2 diabetes include obesity; Native American, Hispanic, or African ancestry; and age of 55 years or older. Although 50% of people of people with a parent with maturity-onset diabetes of the young (MODY) will develop MODY, it is autosomal dominant, and treatment depends on which genetic mutation caused it. It is not associated with obesity or hypertension and is not currently considered preventable.
The nurse should observe the patient for symptoms of ketoacidosis when a. illnesses causing nausea and vomiting lead to bicarbonate loss with body fluids b. glucose levels become so high that osmotic diuresis promotes fluid and electrolyte loss c. an insulin deficit causes the body to metabolize large amounts of fatty acids rather than glucose for energy d. the patient skips meals after taking insulin, leading to rapid metabolism of glucose and breakdown of fats for energy
c When insulin is insufficient and glucose cannot be used for cellular energy, the body uses stored fats to meet energy needs. Free fatty acids from stored triglycerides are metabolized in the liver in such large quantities that ketones are formed. Ketones are acidic and alter the pH of the blood, causing acidosis. Osmotic diuresis from the elimination of both glucose and ketones in the urine causes dehydration, not ketosis. The loss of bicarbonate and skipping a meal after insulin administration do not cause ketosis.
A patient with diabetes is found unconscious at home, and a family member calls the clinic. After determining that a glucometer is not available, what should the nurse advise the family member to do? a. Have the patient dirnk some orange juice b. Administer 10 U of regular insulin subcutaneously c. Call for an ambulance to transport the patient to a medical facility d. Administer glucagon 1 mg intramuscularly or subcutaneously
d If a patient with diabetes is unconscious, immediate treatment for hypoglycemia must be given to prevent brain damage, and IM or subcutaneous administration of 1 mg of glucagon should be done. If the unconsciousness has another cause, such as ketosis, the rise in glucose caused by the glucagon is not as dangerous as the low glucose level. Following administration of the glucagon, the patient should be transported to a medical facility for further treatment and evaluation. Oral carbohydrates cannot be given when patients are unconscious, and insulin is contraindicated without knowledge of the patient's glucose level.
The home care nurse should intervene to correct a patient whose insulin administration includes a. warming a prefilled refrigerated syringe in the hands before administration. b. storing syringes profiled with NPH and regular insulin needle-up in the refrigerator. c. placing the insulin bottle currently in use in a small container on the bathroom countertop. d. mixing an evening dose of regular insulin with insulin glargine in 1 syringe for administration.
d Insulin glargine (Lantus), a long-acting insulin that is continuously released with no peak of action, cannot be diluted or mixed with any other insulin or solution. Mixed insulins should be stored needle-up in the refrigerator and warmed before administration. Currently used bottles of insulin may be kept at room temperature out of sunlight for 4 weeks.
In addition to promoting the transport of glucose from the blood into the cell what does insulin do? a. Enhances the breakdown of adipose tissue for energy b. stimulates hepatic glycogenolysis and gluconeogenesis c. prevents the transport of triglycerides into adipose tissue d. increases amino acid transport into cells and protein synthesis
d Insulin is an anabolic hormone that is responsible for growth, repair, and storage. It facilitates movement of amino acid into cells, synthesis of protein
Lispro insulin (Humalog) with NPH (Humulin N) insulin is ordered for a patient with newly diagnosed type one diabetes. When should the nurse administer lispro insulin? a. Only once a day b. one hour before meals c. 30 to 45 minutes before meals d. at meal time or within 15 minutes of meals you are missing
d Lispro is a rapid-acting insulin that has an onset of action of approximately 15 minutes and should be injected at the time of meal to within 15 minutes of eating. Regular insulin is short acting with an onset of action in 30 to 60 minutes following administration and should be given 30 to 45 minus before meals.
Which laboratory results indicate the patient has prediabetes? a. Glucose tolerance results of 132 b. glucose tolerance results up 240 c. fasting blood glucose result of 80 d. fasting blood glucose result of 120
d Prediabetes is defined as impaired glucose tolerance and impaired fasting glucose or both. Fasting blood glucose results between 100 mg/dL and 125 mg/dL indicates prediabetes. A diagnosis of impaired glucose tolerance is made if the 2-hour oral glucose tolerance test (OGTT) results are between 140 mg/dL and 199 mg/dL.
The patient with type 2 diabetes has had trouble controlling his blood glucose with several OAs but wants to avoid the risks of insulin. The HCP told him a medication will be prescribed that will increase insulin synthesis and release from the pancreas, inhibit glucagon secretion, and slow gastric emptying. Which medication will have to be injected? a. Dopamine receptor agonist, bromocriptine (Cycloset) b. Dipeptidyl peptidase-4 (DPP-4) inhibitor, sitagliptin (Januvia) c. Sodium-glucose co-transporter 2 (SGLT2) inhibitor, canagliflozin (Invokana) d. Glucagon-like peptide-1 receptor, eventide extended release (Bydureon)
d This glucagon-like peptide-1 (GLP-1) receptor agonist stimulates GLP-1 to increase insulin synthesis and release from the pancreas, inhibit glucagon secretion, slow gastric emptying, and must be injected subcutaneously once every 7 days. The other medications are oral agents. The mechanism of action for glycemic control for the dopamine receptor agonist is unknown. DPP-4 inhibitors block the action of DPP-4 enzyme that inactivates incretin so there is increased insulin release, decreased glucagon secretion, and decreased hepatic glucose production. Sodium-glucose co-transporter 2 inhibitors block the reabsorption of glucose by the kidney and increase urinary glucose excretion.
