Exam 3 Homework 11

Which of the following types of mutations would NOT be advantageous for the survival of a cancer cell? A. An inactivating mutation in a tumor suppressor gene B. An inactivating mutation in an oncogene C. An inactivating mutation in a gene that promotes apoptosis D. Methylation of the promoter of a tumor suppressor gene E. B and D

B. An inactivating mutation in an oncogene

Which of the following is characteristic of field cancerization? A. A single tumor grows from a single mutant cell. B. Multiple tumors in an organ are separated by normal tissue C. Multiple tumors in an organ share the same germ-line mutation. D. B and C E. A, B, and C

B. Multiple tumors in an organ are separated by normal tissue

A cell representing an intermediate between stem cells and their differentiated descendants is known as a A. Precursor cell B. Transit-amplifying/ progenitor cell C. Self-renewing stem cell D. Post-mitotic cells E. None of the above

B. Transit- amplifying/ progenitor cell

Patients with colon cancer often exhibit loss of heterozygosity at specific chromosomal arms. These chromosomal regions most likely include genes that act as A. Pro-apoptotic genes B. Oncogenes C. Tumor suppressors D. Tumor promoters E. None of the above.

C. Tumor suppressors

Which of the following statements is FALSE? A. Inflammatory cells are often detected in tumor samples. B. Cancer often arises at sites of chronic inflammation C. Use of NSAIDS has been associated with increased mortality from colorectal cancer D. The inflammatory cytokine TNF has been shown to have direct transforming properties. E. None of the above

C. Use of NSAIDs had been associated with increased mortality from colorectal cancer

The ability of cells to form a tumor is usually A. The result of multiple mutations B. influenced by chemicals that are nonmutagenic but act as promoters. C. A quick process D. A and B E. None of the above.

D. A and B

Which of the following is true of "complete carcinogens" A. They are capable of initiating tumorigenesis B. They promote tumorigenesis C. They can induce tumor formation in laboratory animals on their own without the application of additional chemicals D. A, B, and C E. None of the above

D. A,B,and C

When experimental mice are treated with DMBA and TPA to induce the formation of papillomas, TPA A. Serves as the initiating agent B. Serves as the promoting agent C. Must be administered multiple times in order for papillomas to form D. B and C E. None of the above

D. B and C

The rate at which mutations occur in the cells within a tumor is most likely A. The same as in normal cells of that tissue type B. Less frequent than in normal cells of that tissue type. C. Affected by genome instability within the tumor cells. E. C and D

E. C and D

In experiments in which rat embryo fibroblasts were transfected with suspected oncogenes, introduction of which of the following genes transformed the cells? A. Myc alone B. H-Ras alone C. E1A alone D. Both Myc and E1A together E. Both Myc and H-Ras together

E. both Myc and H-Ras together