Hema test 4 CSI

Pataasin ang iyong marka sa homework at exams ngayon gamit ang Quizwiz!

Several hours after birth, a newborn develops symptoms of petechiae, purpura, and hemorrhage, and laboratory results show a platelet count of 18.0 × 109/L. The most likely explanation is

Isoimmune neonatal thrombocytopenia.

A man with hemophilia A and an unaffected female can produce a

Female carrier

A man with hemophilia A and an unaffected woman can produce a

Female carrier.

Which factor is involved in contact activation?

Fitzgerald factor

Platelet aggregation cannot occur if _______ is absent.

GP IIb/IIIa

The autoantibody generated in ITP is directed against

GP IIb/IIIa and GPIb-IX.

Which the following test results is normal in a patient with classic von Willebrand's disease?

GP IIb/IIIa, GP Ib/IX

Which test will be abnormal in a factor X deficiency?

PT/ APTT

Which of the following is not a component of the fibrinolytic system?

thrombin

One of the main differences between TTP and HUS is

Neurologic involvement.

All of the following can affect the platelet count except:

Not using a tourniquet

Which of the following drugs would put an individual at risk for thrombosis?

Oral contraceptives

What is the primary purpose of the fibrinolytic system?

To restore blood flow at the local level

The vitamin K-dependent factors are

VII, VII, IX, and X.

If a patient has a prolonged PT, the patient most likely is deficient in factor

VII.

. The only clotting factor not synthesized exclusively by the liver is factor:

VIII

If a patient has a prolonged APTT only, the patient may be deficient in the following factors:

VIII, IX, XI, and XII

Long-term antibiotic therapy is a cause of bleeding because it disrupts:

Vitamin K synthesis

The following laboratory results have been obtained for a 40-year-old woman with infrequent bleeding: PT = 20 seconds (reference range is 11 to 15 seconds), APTT = 50 seconds (reference range is 22 to 40 seconds). What factor deficiency is most likely?

X

The factor that is responsible for stabilizing a soluble fibrin monomer into an insoluble clot is

XIII.

Thrombin-thrombomodulin complex is necessary for

activation of protein C.

The vasoconstrictor substance released from the platelets at the site of injury is:

adenosine diphosphate

Heparin-induced thrombocytopenia is caused by

antibody to heparin-platelet factor 4 complex.

The primary inhibitor of the fibrinolytic system is

antiplasmin.

Immune drug-induced thrombocytopenia is a result of all of the following drugs except:

Aspirin

Which of the following is a defect of platelet adhesion?

Bernard-Soulier syndrome

The prothrombin group of factors consists of factors:

II, VII, IX, X

Alpha granules are found in

Organelles.

Protein C and its cofactor protein S inactivate factors

Va and VIIIa

The main substrate of the coagulation system is:

fibrinogen

Which of the following is not a vitamin K-dependent factor?

. Factor VIII

The factor with the longest half-life is

. I.

Which of the following statements regarding warfarin (Coumadin) is correct?

. It inactivates factors IIa, VIIa, IXa, and Xa.

Which of the following assays will be abnormal with hemophilia A?

. aPTT

. The lupus anticoagulant is directed against

. phospholipid-dependent coagulation tests.

Clotting factors must be present at a minimum of which percentage for hemostasis to be achieved?

30%

The life span of a platelet is

7 to 10 day

Patients with hemophilia A or B have abnormal results in which coagulation assay?

APTT

All of the following are functions of thrombin except:

Activating thromboplastin

Treatment of patients with factor II, VII, or X deficiency consists of:

Administration of prothrombin complex concentrate

A primary inhibitor of the fibrinolytic system is

Alpha-2-antiplasmin.

Factor VIII is also known as which?

Antihemophilic globulin

Which of the following causes irreversible inactivation of platelets?

Aspirin

The presence of thrombocytopenia and giant platelets on the peripheral smear of a patient is characteristic of:

Bernard-Soulier syndrome

The presence of thrombocytopenia and giant platelets best describes

Bernard-Soulier syndrome.

All of the following may lead to deficiencies of clotting factors except:

Cardiovascular disease

The autoantibody generated in ITP is directed against

Collagen

Which of the following is one of the key roles of thrombin with respect to fibrinogen?

Converts fibrinogen into fibrin

All of the following are associated with platelet disorders except:

Deep muscle hemorrhages

D-dimers may be elevated in which of the following conditions?

Deep vein thrombosis

Increased platelets are seen in which of the following disorders?

ET

Keloid scar formation is most commonly associated with:

Factor IX

The following laboratory results have been obtained for a 40-year-old woman: PT 20 seconds (reference 11 to 15 seconds), APTT 50 seconds (reference 22 to 40 seconds). What is the most probable diagnosis?

Factor X deficiency

Which clotting factor deficiency is associated with poor wound healing?

Factor XIII

Which of the clotting factors is not a protease?

Factor XIII

Which of the following is the most useful in differentiating hemophilia A from hemophilia B?

Factor assays

Factor assays measure the percentage of activity of a given factor by mixing the patient's plasma with:

Factor-deficient plasma

What is a new treatment alternative for hemophilia patients?

Gene therapy

A platelet aggregation defect in which there is a deficiency of GP IIb/IIIa is known as:

Glanzmann's thrombasthenia

Receptors found on the platelets are called

Glycoproteins.

Thrombocytosis is defined as a platelet count that is:

Greater than 450 × 109/L

Decreased platelets in combination with bloody diarrhea, vomiting, and abdominal pain is seen in which of the following?

HUS

Christmas disease is another name for:

Hemophilia B

A prolonged thrombin time and a normal reptilase time are indicative of

Heparin therapy.

A prolonged APTT is corrected with factor VIII-deficient plasma but not with factor IX-deficient plasma. What factor is deficient?

IX

A 2-year-old boy develops the following symptoms: petechiae, purpura, and nosebleeds. The platelet count is 18,000. The most likely explanation is:

Idiopathic thrombocytopenic purpura

Which of the following laboratory assays is normal in a patient with dysfibrinogenemia?

Immunologic assay for fibrinogen

Which result is normal in a patient with dysfibrinogenemia?

Immunologic fibrinogen level

A fatal bleed in a patient with hemophilia involves

Intracranial bleeding.

Chronic idiopathic thrombocytopenia purpura (ITP)

Involves the immune destruction of platelets.

In thrombotic thrombocytopenic purpura, which of the following statements is the most accurate?

It is associated with fever, renal failure, and neurological complications.

A patient with 8% factor VIII activity has which form of hemophilia?

Mild

Which the following test results is normal in a patient with classic von Willebrand disease?

Platelet count

Nose bleeding, deep bruising, and gum bleeding are usually manifestations of which type of coagulation disorder?

Platelet defect

Which of the following results regarding lupus inhibitors are correct?

Prolonged APTT on undiluted plasma and 1:1 mix of patient plasma with platelet-poor normal plasma

Aspirin therapy irreversibly inhibits the synthesis of:

Prostaglandins

The treatment of choice for hemophilia A individuals is

Recombinant factor VIII

The purest treatment product for patients with hemophilia A is

Recombinant factor VIII.

Which of the following is the best possible treatment for a patient with DIC?

Resolve the underlying cause of DIC

Which one of the following conditions would produce a thrombocytopenia resulting from an altered distribution of platelets?

Splenomegaly

Which bacterial cell product would precipitate a DIC event?

Streptokinase

Aspirin prevents platelet aggregation by inhibiting the action of

TXA2.

In hemolytic uremic syndrome (HUS), which of the following statements is the most accurate?

The toxin responsible for this syndrome is produced by E. coli O157:H7.

Red cell morphology such as the one at the tip of the pointer are associated with:

Thrombotic thrombocytopenic purpura

Vasoconstriction is caused by several regulatory molecules, which include

Thromboxane A2 and serotonin.

Platelet aggregation is dependent on the presence of:

calcium ion

A decreased platelet count is most often anticipated when a patient demonstrates:

epistakis

The process of fibrin degradation is called ________ and is controlled by the enzyme ________.

fibrinolysis, plasmin

The anticoagulant known as heparin:

inhibits thrombin activity

Which of the following statements regarding protein C is correct?

it is a co-factor to protein S/ it is a physiological inhibitor of coagulation

Dilute Russell's viper venom test (DRVVT) is helpful in the diagnosis of

lupus anticoagulant.

Factor V Leiden is associated with

mutation of factor V.

A decreased platelet count is most often anticipated when a patient demonstrates:

petechiae

1. Factor II is also known as which of the following?

prothrombin

Which organ is responsible for sheltering 20% of the total platelet volume in the circulation?

spleen

Which of the following is the most prevalent inherited bleeding disorder?

von Willebrand Disease

Which of the following is the most prevalent inherited bleeding disorder?

von Willebrand disease

Platelets from patients with which two disorders will not aggregate with ristocetin?

von Willebrand's disease and Bernard-Soulier

Which of the following are platelet adhesion disorders?

von Willebrand's disease and Bernard-Soulier syndrome

An inhibitor of plasmin activity is

α2AP.


Kaugnay na mga set ng pag-aaral

CH 14 ~ PRINCIPLES OF HAIR DESIGN 3

View Set

Connecticut Life and Health Insurance Exam

View Set