Macrocytic Anemia

Folic acid deficiency results in a type of macrocytic anemia similar to that caused by B12 deficiency or from cytotoxic chemotherapy drugs like methotrexate. True or False

True

Gastrointestinal absorption of vitamin B12 occurs in the small bowel only when it is bound to a protein called intrinsic factor (IF) which is made by specialized cells in the gastric mucosa. True or False

True

Nuclear-cytoplasmic dyssynchrony is the cytopathologic hallmark of the megaloblastic anemias, a subtype of macrocytic anemia. True or False

True

On review of a peripheral blood smear, macroovalocytes and hypersegmented polymorphonuclear leukocytes are characteristic findings of megaloblastic anemia. True or False

True

Deficiency of vitamin B12 or deficiency of iron can cause a macrocytic anemia. True or False

False

Iron deficiency, B12 deficiency, and folic acid deficiency all interfere with DNA synthesis and it is by this mechanism that the hematopoietic cells cannot proliferate appropriately and the result is a megaloblastic anemia, a subtype of macrocytic anemia. True or False

False