Mesothelioma and related diseases

Is solitary fibrous tumor benign or malignant?

10-30% malignant

What is the latency period between asbestos exposure and development of mesothelioma?

20-40 yr

What is an important risk factor of mesothelioma?

asbestos

What are other names for mesothelioma?

diffuse mesothelioma, malignant mesothelioma

What are the histologic types of mesothelioma?

epithelioid, sarcomatous, biphasic, desmoplastic

What are the possible symptoms of solitary fibrous tumor?

hypoglycemia (IFG-2 secreting tumor), hypertrophic pulmonary osteoarthropathy, chest pain

What are the common routes of spread for mesothelioma?

local infiltration of the pleura, hematogenous

What is solitary fibrous tumor?

localized fibroblastic tumor of the pleura

What is the name for mesothelioma presented with single pulmonary nodule?

localized malignant mesothelioma

Is mesothelioma more common in men or women?

men

Is pleural effusion common in solitary fibrous tumor?

no

Is solitary fibrous tumor associated with asbestos?

no

What is frozen mediastinum sign?

no mediastinal shift despite large effusion due to pleural thickening and mediastinal infiltration

What are the usual symptoms of solitary fibrous tumor?

none (often found incidentally)

What are the radiographic features of mesothelioma?

pleural effusion, concentric/lobulated pleural thickening, thickened major fissure

What are the CT features of mesothelioma?

pleural thickening, pleural effusion, (smooth, irregular, nodular)

What are the CT features of solitary fibrous tumor?

solitary, smooth , sharply defined, contacting with pleural surface, beak/thorn sign

Does mesothelioma have good or poor prognosis?

very poor