MLT1362 Test 6 Final Exam Review

Abnormal secondary aggregation is associated with _________ ___________ disease which is a qualitative platelet disorder.

Abnormal secondary aggregation is associated with *Wiskott-Aldrich* disease which is a qualitative platelet disorder.

Why is the bleeding time normal in individuals with hemophilia A? A. Because of an increase in factor XIII B. Because the clotting problem is a factor VIII problem C. Because vWF is normal D. Because the clotting problem is a factor IX problem

B. Because the clotting problem is a factor VIII problem

PT test requires that the patient's citrated plasma be combined with _______ and ___________.

PT test requires that the patient's citrated plasma be combined with *Ca++* and *thromboplastin*.

Liquid portion of a clotted specimen.

Serum (Crossword)

The life span of a platelet is A. 5 to 8 days B. 7 to 10 days C. 6 to 9 days D. 9 to 12 days

B. 7 to 10 days

Ratio of blood to anticoagulant.

Nine to one (Crossword)

Refers to the platelet parameter of variation in cell size.

PDW (Crossword)

Test used to monitor oral anticoagulant (coumadin,warfarin) therapy

PT (Crossword)

Use _________ _________ for reversal of a heparin overdose.

Use *protamine sulfate* for reversal of a heparin overdose.

Use recombinant factor _______ as the purest treatment for hemophilia A patients.

Use recombinant factor *VIII* as the purest treatment for hemophilia A patients.

Von Willebrand factor is a component of platelet ________ granules.

Von Willebrand factor is a component of platelet *alpha* granules.

Most common laboratory test to monitor heparin therapy.

aPTT (Crossword)

_________ (over the counter drug) affects platelet function.

*Aspirin* affects platelet function.

___________ is required in the common, intrinsic, and extrinsic pathways.

*Calcium* is required in the common, intrinsic, and extrinsic pathways.

One of the main differences between TTP and HUS is A. Neurologic involvement B. Kidney failure C. Thrombocytopenia D. Microangiopathic hemolytic anemia

A. Neurologic involvement

__________ ____________ is the anticoagulant of choice for routine coagulation procedures.

*Sodium citrate* is the anticoagulant of choice for routine coagulation procedures.

Which of the following is the most prevalent inherited bleeding disorder? A. von Willebrand's disease B. Hemophilia A C. Factor VII deficiency D. Factor XII deficiency

A. von Willebrand's disease

A factor XII deficiency is associated with an ________________ or ________________ presentation.

A factor XII deficiency is associated with an *asymptomatic* or *thrombotic* presentation.

In storage pool diseases, platelets are primarily deficient in this?

ADP (Crossword)

A man with hemophilia A and an unaffected woman can produce a: A. Female carrier B. Male carrier C. Male with hemophilia A D. Normal female

A. Female carrier

Receptors found on the platelets are called A. Glycoproteins B. Vwf C. Fibrinogen D. Beta-Thromboglobulin

A. Glycoproteins

The factor with the longest half-life is A. I B. V C. VII D. X

A. I

A prolonged aPTT is corrected with factor VIII-deficient plasma but not with factor IX-deficient plasma. What factor is deficient? A. IX B. VIII C. V D. X

A. IX

A fatal bleed in a hemophilia patient involves A. Intracranial bleeding B. Mucosal bleeding C. Joint bleeding D. Epistaxis

A. Intracranial bleeding

The vitamin K-dependent factors are A. I, II, V, & X B. II, VII, IX, & X C. I, VII, V, & VIII D. II, IX, XI, & X

B. II, VII, IX, & X

Nose bleeding, deep bruising, and gum bleeding are usually manifestations of which type of coagulation disorder? A. Clotting factor disorder B. Platelet defect C. Thrombosis D. Vascular disorder

B. Platelet defect

If a patient has a prolonged aPTT only, the patient may be deficient in the following factors: A. VIII, X, II, & I B. VIII, IX, XI, & XII C. VIII, X, XI, & XII D. VIII, XI, II, & XII

B. VIII, IX, XI, & XII

Protein C and its cofactor protein S inactivate factors A. VIIa and Xa B. Va and VIIIa C. IXa and VIIa D. VIIIa and XIIa

B. Va and VIIIa

Prolonged bleeding time, thrombocytopenia and giant platelets best describe this syndrome, defect of platelet adhesion.

Bernard-Soulier Syndrome (Crossword)

An inhibitor of plasmin activity is A. tPA B. PAI-1 C. Alpha-2-antiplasmin D. Plasminogen

C. Alpha-2-antiplasmin

Which of the following are defects of platelet adhesion? A. Hermansky-Pudlak syndrome B. Glanzmann's thrombasthenia C. Bernard-Soulier syndrome D. Wiskott-Aldrich syndrome

C. Bernard-Soulier syndrome

The following laboratory results have been obtained for a 40-yr-old-woman: PT 20 seconds (reference 11-15), aPTT 50 seconds (reference 22-40). What is the most probable diagnosis? A. Factor VII deficiency B. Factor VIII deficiency C. Factor X deficiency D. Factor XIII deficiency

C. Factor X deficiency

Which of the following clotting factors is not a protease? A. Factor II B. Factor VII C. Factor XIII D. Factor IX

C. Factor XIII

The autoantibody generated in ITP is directed against A. vWF B. Collagen C. GP IIb/IIIa and GPIb-IX D. Fibrinopeptides A and B

C. GP IIb/IIIa and GPIb-IX

Which result is normal in a patient with dysfibrinogenemia? A. Thrombin time B. Activated partial thromboplastin time C. Immunologic fibrinogen level D. Protein electrophoresis

C. Immunologic fibrinogen level

Several hours after birth, a newborn develops symptoms of petechiae, purpura, and hemorrhage, and laboratory results show a platelet count of 18.0 x 10^9/L. The most likely explanation is A. Drug-induced thrombocytopenia B. Secondary thrombocytopenia C. Isoimmune neonatal thrombocytopenia D. Neonatal DIC

C. Isoimmune neonatal thrombocytopenia

Alpha granules are found in A. The peripheral zone B. The sol gel zone C. Organelles D. Membranes

C. Organelles

Which of the following test results is normal in a patient with classic von Willebrand's disease? A. Bleeding time B. Activated partial thromboplastin time C. Platelet count D. Factor VIII:C and vWF levels

C. Platelet count

Which one of the following conditions would produce a thrombocytopenia due to an altered distribution of platelets? A. Platelet satellitism B. Iron deficiency anemia C. Splenomegaly D. Chemotherapy

C. Splenomegaly

Aspirin prevents platelet aggregation by inhibiting the action of A. PF 3 B. GPII C. TXA2 D. GPIb

C. TXA2

Vasoconstriction is caused by several regulatory molecules, which include A. Fibrinogen and vWF B. ADP and EPI C. Throboxane A2 and serotonin D. Collagen and actomyosin

C. Throboxane A2 and serotonin

If a patient has a prolonged PT, the patient most likely is deficient in factor A. VIII B. II C. VII D. X

C. VII

Required in the extrinsic, intrinsic, and common pathways.

Calcium (Crossword)

D-Dimers are degradation products of cross-linked _______.

D-Dimers are degradation products of cross-linked *fibrin*.

The presence of thrombocytopenia and giant platelets best describes A. Classic von Willebrand's disease B. Wiskott-Aldrich syndrome C. Glanzmann's thrombasthenia D. Bernard-Soulier syndrome

D. Bernard-Soulier syndrome

Which clotting factor deficiency is associated with poor wound healing? A. Factor II B. Factor X C. Factor XII D. Factor XIII

D. Factor XIII

Chronic idiopathic thrombocytopenia purpura (ITP) A. Is found in children B. Usually remits spontaneously within several weeks C. Affects males more commonly than females D. Involves the immune destruction of platelets

D. Involves the immune destruction of platelets

The purest treatment for hemophilia A patients is A. Cryoprecipitate B. Fresh frozen plasma C. Prothrombin complex concentrate D. Recombinant factor VIII

D. Recombinant factor VIII

The factor that is responsible for stabilizing a soluble fibrin monomer into an insoluble clot is A. II B. X C. XII D. XIII

D. XIII

Dense granules of platelets release _________, ___________, & ADP.

Dense granules of platelets release *calcium*, *serotonin*, & ADP.

The factor deficiency that prothrombin time is most sensitive to is which factor? If a patient has a prolonged PT, most likely the patient is deficient in this factor.

Factor VII (Crossword)

Factor VII deficiency causes a(n) _____________ PT but ______ affect the aPTT.

Factor VII deficiency causes an *abnormal* PT but *does not* affect the aPTT (aPTT would be normal results).

Patients with Bernard-Soulier syndrome have?

Giant platelets (Crossword)

Glanzmann's disease is associated with abnormal primary ________________.

Glanzmann's disease is associated with abnormal primary *aggregation*.

Most likely cause of an elevated potassium level in a normal individual.

Hemolysis (Crossword)

Antithrombin III is enhanced by this?

Heparin (Crossword)

Heparin acts by inhibiting _____________.

Heparin acts by inhibiting *thrombin*.

Heparin acts by?

Inhibiting thrombin (Crossword)

Most if not all of the coagulant factors are produced in the?

Liver (Crossword)

Plasmin enzymatically degrades the stabilized _____ _____.

Plasmin enzymatically degrades the stabilized *fibrin clot*.

Requires the presence of von Willebrand factor to work.

Platelet adhesion (Crossword)

Platelets carry platelet factors, coagulation factors ___ & ___.

Platelets carry platelet factors, coagulation factors *V* & *VIII*.

Is not prolonged in G6PD deficiency, also dependent on vitamin K synthesis.

Prothrombin time (Crossword)

The anticoagulant of choice for routine coagulation procedures.

Sodium citrate (Crossword)

The activated partial thromboplastin time "aPTT" screens for abnormalities in the _____________ pathway.

The activated partial thromboplastin time "aPTT" screens for abnormalities in the *intrinsic* pathway.

The clotting factor ________ is not a protease (class of enzymes that breaks down peptide bonds)

The clotting factor *XIII* is not a protease (class of enzymes that breaks down peptide bonds)