Non-melanoma Skin Cancers
Sebaceous Carcinoma
-fourth most common skin cancer -tumors as nodules on the head and neck, most occur on eyelids -symptoms of ocular irritation are common and may be confused with inflammatory disease on eyelids -looks like basal cell but is on eyelid
Squamous Cell Carcinoma In Situ (Bowens)
-growing horizontally on the skin, not invasive -most often caused by UVR -untreated can progress to invasive SCC -pink or red in color -can have scaling surface or erosions with a crust
Cutaneous Lymphoma of the skin
-lymphoma arising from CD4 and CD25 T-cells -Present as: -parapsoriasis en plaque (pink scaling and superficial)
Squamous Cell Carcinoma
-malignant tumor of keratinocytes -arises in epidermis -found in sun exposed areas -indurated papule, plaque or nodule; adherent thick keratotic scale or hyperkeratosis
Kaposi Sarcoma
-multifocal systemic tumor of endothelial cell origin -begin as macule evolve to patches, papules, plaques, nodules, and tumors 4 Variants: classic, HIV/AIDs (face is first involved), immunosuppressive *on palate*
Merkel Cell Carcinoma
-rare malignant solid tumor derived from epithelial cell called the Merkel Cell -in basal cell layer of epidermis -in caucasians and 10-30 times more common in immunosuppressed individuals -pink, violet, reddish brown, dome shaped
Angiosarcoma
-rare, highly malignant proliferation of endothelial cells manifesting as purpuric macules and/or papules -bright red, violet, or black
Dermatofribrosarcoma Protuberans
-rare, locally aggressive tumor that presents as a firm indurated plaque, skin colored to red-brown with exophytic nodules
Neurofibrosarcoma
-uncommon tumors -involves thoracic wall almost twice as often
Morphea-Sclerosing Carcinoma
Type of Basal Cell Carcinoma -appears as a small patch of morphed or a superficial scar -skin colored or whitish
Pigmented Basal Cell Carcinoma
Type of Basal Cell Carcinoma -brown, blue, or black color -smooth, glistening, hard firm -pearly border when skin is stretched
Multi-focal superficial Carcinoma
Type of Basal Cell Carcinoma -horizontal growth -does not go grow deep -pink or red
Arsenic Induced
Type of Basal Cell Carcinoma -superficial with multiple lesions -gather history
Nodular Basal Cell
Type of Basal Cell Carcinoma Papule or nodule translucent or Pearly skin colored or reddish smooth surface with telangiectasia well defined and firm
Ulcerating Basal Cell
Type of Basal Cell Carcinoma-covered with crust with a rolled border -translucent, pearly, smooth, firm with telangiectasia
Karatoacanthoma
Type of Squamous Cell Carcinoma -common, rapidly growing, epithelial tumor with potential for tissue destruction and rarely metastasizes -often sun exposed areas -spontaneous regression -dome shaped nodule with central keratotic plug -firm and skin colored
Arsenic Induced Squamous Cell Carcinoma
-appears decades after chronic arsenic ingestion -begin with arsenical keratoses
Metastatic Malignancy to skin
-breast cancer is most common -disorganized and hard as rock lesions
Sezary Syndrome
-form of T cell lymphoma that can present as wide spread psoriasiform dermatitis or borderline exfoliative erythroderm
Basal Cell Carcinoma
* most common cancer in humans* -locally invasive, aggressive, and destructive but slow growing
Gorlin Syndrome
-Autosomal dominant disorder -multiple BCCs and palmoplantar pits -effects multiple skin systems (CNS and endocrine, organs, bone calcifications)
