Pharmaceutics Exam 2

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Considering this "secret" formula and procedure, the amount of Acetaminophen (in kg) required to produce 1 million tylenol tablets is: a. 500kg b. 500,000kg c. 50kg d. 5kg e. 0.5kg

a

What is the role or function of iron oxide yellow in the following tablet coating formulation: HMPC, 5 cps, 7.5% w/w PEG, 0.8 %w/w Iron oxide yellow: 0.6% w/w Titanium dioxide: 3.1 %w/w Purified water: 88% w/w a. colorant b. opacifier c. plasticizer/pore forming agent d. main coating material/polymer e. vehicle or solvent

a

Advantages to the manufacturer for tablet film coating when compared to sugar coating include: 1. shorter production times 2. less gross weight 3. lower incidence in coat chipping

all three are correct

Manufacturing variables that would likely affect the dissolution of a prednisone tablet in the body include: 1. the amount and type of binder added 2. the amount and type of disintegrant added 3. the force of compression used during tableting.

all three are correct

which of the following steps are involved in hard gelatin capsule shells production? 1. dipping 2. spinning 3. trimming

all three are correct

which of the following capsule sized has the largest capacity? a. 5 b. 000 c. 0 d. 1 e. 4

b

which of the following statements is NOT TRUE about modified release drug production? a. they are commercially available in various solid dosage forms: ER tablets or capsules. b. advising patients to drink a full glass of alcohol with these medications for better absorption. c. advising patients not to chew on these products during administration. d. advising patients not to crush these products to maintain their physical integrity. e. delayed release products are not bioequivalent to extended release product for the same active ingredient.

b

A pharmacist receives a prescription for 15 mg piroxicam capsules, qty. 48. A #1 capsule filled with piroxicam weighs 245 mg; a capsule filled with lactose weighs 180 mg. How much piroxicam and lactose are required for the prescription? Prepare sufficient powder for 50 capsules (2 extra). a. 750mg piroxicam + 9mg lactose b. 15mg piroxicam + 230mg lactose c. 750mg piroxicam + 8.45mg lactose d. none of the above e. 15mg piroxicam + 165mg lactose

c

If the API of 125 mg tablet decays by zero-order kinetics with a reaction rate constant kinetic of 0.5 mg per hour, what is the amount of intact drug remaining after 3 days (72 hours)? a. 8.9mg b. 0.89mg c. 89mg d. 890mg

c

What is the role or function of Hydroxy Propyl Methyl Cellulose (HPMC) in the following tablet coating formulation: HMPC, 5 cps, 7.5% w/w PEG, 0.8 %w/w Iron oxide yellow: 0.6% w/w Titanium dioxide: 3.1 %w/w Purified water: 88% w/w a. solvent or vehicle b. opacifier c. main coating material/polymer d. pigment or colorant e. plasticizer/pore forming agent

c

What is the role or function of purified water in the following tablet coating formulation: HMPC, 5 cps, 7.5% w/w PEG, 0.8 %w/w Iron oxide yellow: 0.6% w/w Titanium dioxide: 3.1 %w/w Purified water: 88% w/w a. main coating material/polymer b. colorant or pigment c. vehicle or solvent d. pore forming agent/ plasticizer e. opacifier

c

the shells of soft gelatin capsules may be made elastic or plastic by the addition of...? a. povidone b. HPMC c. sorbitol d. polyethylene glycol

c

Drug is bound to a resin and released due to changed in pH is what type of drug release mechanism?

ion-exchange

what is the name of this drug release mechanism: drug is compressed into tablets with an insoluble polymer.

matrix diffusion

what drug release mechanism corresponds to a drug that is compressed into tablets with a slowly soluble polymer

matrix dissolution

High bloom strength gelatin is used in the manufacturing of...? 1. soft gelatin capsules 2. hard gelatin capsules 3. none of the above

one and two are correct

true statements, about the function of excipients used in tablet formulations include: 1. binders promote granulation during the wet granulation process. 2. glidants help to promote the flow of the tablet granulation during manufacturing. 3. lubricants help the patient to swallow the tablets.

only 1 and 2 are correct

agents that might be used to coat enteric-coated tablets include: 1. hydroxypropyl methylcellulose (HPMC) 2. carboxymethylcellulose (CMC) 3. cellulose acetate phtalate (CAP)

only 3 is correct

what is the name of this drug mechanism: drug is compressed into tablets with semipermeable membrane and laser drilled hole through which drug is transported out by connective flow.

osmotic pumping


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