Phases of wound healing

• Hemostasis • Inflammatory • Proliferation • Maturation

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Hemostasis: occurs immediately after the initial injury

Involved blood vessels constrict and blood clotting begins through platelet activation and clustering.

Inflammatory Phase: Follows hemostasis and lasts about 4-6 days

White blood cells, predominantly leukocytes and macrophages, move to the wound. Leukocytes arrive first to ingest bacteria and cellular debris. About 24 hours after the injury, macrophages enter the wound area and remain for and extended period.

Proliferation Phase: The proliferation phase is also known as the fibroblastic, regenerative or connective tissue phase.

The proliferation phase lasts for several weeks. New tissue is built to fill the wound space, primarily through the action of fibroblasts.

Maturation Phase: The final stage of healing begins about 3 weeks after the injury, possibly continuing for months or years.

Collagen that was haphazardly deposited in the wound is remodeled, making the healed wound stronger and more like adjacent tissue.