PrEP and PEP
How many drugs are used for PEP? What is the duration of PEP?
3 drugs for 28 days For example, Truvada + Isentress x 28 days
How often do patients using PrEP need HIV testing?
Every 3 months
RT is a 24 yo MSM pt and HIV negative. He is in a relationship with a HIV+ male. They last had anal sex 2 weeks ago and the condom broke. He is just now presenting to the doctor. What type of prophylaxis is warranted?
HIV testing is needed and then PrEP could be initiated. NOT PEP because PEP must be started within 72 hours of exposure (and this pt's was 2 weeks ago). Can't do anything about this exposure now-- the patient waited too long. Since pt is at high risk (serodiscordant), PrEP is more appropriate to prevent future exposures.
See script below: What type of prevention is this likely -- PEP or PrEP? Truvada 1 tab po daily + Isentress 1 tab po BID QS for 28 days, no refills.
PEP This is a complete 3 drug regimen for 28 days -- PEP
_______________________ is Medication given to HIV(-) patients soon AFTER HIV exposure to ↓ risk of HIV transmission
Post-Exposure Prophylaxis (PEP)
See prescription below: What type of prevention is this likely -- PEP or PrEP? Truvada 1 tablet po daily to prevent infection #30, 1 refill.
PrEP Why is it not PEP? 1. PEP would not have refills (duration = 28 days) 2. PEP requires a 3-drug regimen (typically Truvada + Isentress)
TY is a 28 yo WF who is a self-proclaimed prostitute. She never uses condoms with her clients. She recently fell and broke her ankle so she has not been with a client or had any sex in the past week. Which type of prophylaxis should be considered in this patient?
PrEP (after HIV testing is completed to confirm pt is negative) Last possible exposure was >72 hours ago, so PEP is not appropriate.
________________ is Medication given to high-risk HIV(-) patients BEFORE exposure to HIV to ↓ risk of HIV transmission
Preexposure prophylaxis (PrEP)
What is the only drug approved for PrEP?
Truvada (Tenofovir DF+Emtricitabine)
How soon after a HIV exposure should PEP be started?
within 72 hours (the sooner the better) *remember: PEP has only been shown to be effective if used within 72 hours; therefore, if the patient's last exposure was a week ago PEP is not appropriate
