Rubella virus infections
T/F. Rubella infection in pregnant women may cause fetal death or congential defects known as congentital rubella syndrome.
T.
What is epidemiolgy of rubella, its transmission?
Transmitted via respiratory route, not as contagious as measles. Peaks in SPRING! epidemics every 6-10yrs and pandemics every 20-25yrs. By 2005 USA rubella cases really very low.
Congenital rubella syndrome can cause what to infants?
affects all organs, death, premature delivery, deafness, cataracts, heart defects etc. 85% infants affected during 1st trimester.
What are clinical findings of rubella and its complications?
begins with malaise, low grade fever and RASH on FACE 1st than spread in body. COMplications: arthralgia or arthrits in ADULT FEMALE 70%!!! rarely in kids. and you see thrombocytopenic.
What is rubella vaccine efficacy, composition, duration of immunity, schedule?
composed of live virus of RA 27/3 strain. Efficacy is 95% in 1 does. Lifelong immunity. Need at least 1 dose.
What are dx, tx, prevention and control of rubella?
dx: culture, serology, nucleic acid detection. tx: no specific tx indicated. attenuated live rubella vaccine.
What is pathogenesis of rubella?
entry-spread via blood- disease lymphadenopathy-RASH-fetal abnormalities (cataracts, heart and deafness)
When does the postnatal rubella becomes apparent?
on day of birth, catch virus in blood and throat.
What are the 3 structural polypeptides?
two membrane glycoproteins, E1 and E2 and a single nonglycosylated RNA-associated capsid protein, C, within the virion.
What are characteristics of rubella?
Rash and lymphadenopathy, affects childern and young adults, congenital rubella syndrome!
Describe rubella virus RNA?
Its single stranded and spherical.
What is rubella known as and first description and its classification?
Known as german measles, 3 day measles, first described as distinct clinical entitiy in german lit. Classified as single member of genus rubivirus in family togaviridae. UNLIKE OTHER TOGAVIRUSES IT IS A REPIRATORY VIRUS!
