Tumors of Soft Tissue

Rhabdomyosarcoma is the correct answer. (this has got to be wrong cause the whole explanation is about synovial sarcomas) Synovial sarcomas account for approximately 10% of all soft tissue sarcomas and typically occur in people in their 20s to 40s. Individuals often present with a deep-seated mass that has been present for several years. Synovial sarcomas can be monophasic or biphasic) Monophasic synovial sarcomas consist of uniform spindle cells with scant cytoplasm and dense chromatin arranged in short, tightly packed fascicles.

Question 10 A 38-year-old man presents with pain on his right foot when walking. On examination a 2 x 1 cm firm mass is felt on ankle extension. Biopsy from the lesion was described to have monophasic spindle cells with features of malignancy. The likely diagnosis is Aggressive fibromatosis Rhabdomyosarcoma Synovial sarcoma Osteosarcoma Squamous cell carcinoma

Liposarcoma is the correct answer. Liposarcomas, malignant tumors of adipose tissue, are the most common sarcomas of adulthood) These tumors typically develop in deep soft tissues of the proximal extremities and retroperitoneum of individuals in the sixth and seventh decades of life) Histopathology reveals features of malignancy.

Question 2 1 / 1 pts A 63-year-old man complains of right lower quadrant stomach discomfort. Patient noticed a dull abdominal pain three months back which was not associated with nausea or vomiting. Abdominal CT revealed a 5 x 4 cm mass in the retroperitoneum. Radio guided tissue biopsy was done) The pathologist's report mentions the following: sections reveal cells showing nuclear pleomorphism, and abnormal mitosis. Occasional immature adipocytes are seen. The likely diagnosis is Osteochondroma Liposarcoma Fibroma Renal cell carcinoma Adrenal adenoma

Fibromatosis is the correct answer. Superficial fibromatosis is a benign growth that can cause local deformity but has an innocuous clinical course) It affects males more frequently than females. Tumor is composed of dense fibrocollagenous tissue with no evidence of malignancy.

Question 3 1 / 1 pts A 12-year-old boy presents with a swelling on the dorsum of the left wrist. He says that the swelling began after sustaining a fall while playing soccer. On examination a firm 3 x 3 cm mass is noted on the dorsum of the right wrist without restriction of movement. Tissue biopsy was reported to composed of dense fibrocollagenous tissue with no evidence of cellular atypia). The likely diagnosis is Fibromatosis Leiomyoma Calcinosis cutis Osteosarcoma Rheumatoid nodule

Duputyren contracture is the correct answer. Dupuytren contracture, or palmar fibromatosis, is an irregular or nodular thickening of the palmar fascia that can be unilateral or bilateral. Incidence increases with age) Attachment to overlying skin can cause puckering or dimpling and a slowly progressive flexion contracture).

Question 4 1 / 1 pts A 36-year-old man is referred to an orthopedic surgeon for loss of range of motion of the middle, ring, and little finger of the left hand) Patient mentions that Initially, he noticed tightening of the skin over the palmar aspect of the left hand and later he could not flex the fingers. There is no history of trauma or burns in the affected area). Likely diagnosis is Duputyren contracture Hypertrophic scar Myositis ossificans Desmoid tumor Keloid

Benign fibrous tumor which tends to invade is the correct answer. Deep fibromatoses, also called desmoid tumors, are large, infiltrative masses that frequently recur but do not metastasize) They arise most frequently in the teens to 30s, predominantly in women. Abdominal fibromatosis generally arises in the musculoaponeurotic structures of the anterior abdominal wall.

Question 5 1 / 1 pts A 27-year-old woman complains to her primary care physician about a slowing growing mass in the right lower abdominal wall. Medical history is significant for a laparoscopic resection of an ovarian-cyst last year, and two pregnancies with caesarean section. The mass was excised, and the pathologist reported it as a desmoid tumor. Which one of the following statements is true about desmoid tumor Dense fibrous tissue growth related to skin type Abscess with surrounding fibrosis Malignant tumor arising from ovary Invasive malignant tumor derived from smooth muscle Benign fibrous tumor which tends to invade

Lipoma is the correct answer. Lipoma, a benign tumor of fat, is the most common soft tissue tumor in adults. On microscopy, lipoma shows well-encapsulated mass of mature adipocytes. It usually arises in the subcutis of the proximal extremities and trunk during middle adulthood)

A 45-year-old man presents with a slow growing painless mass on his right forearm. Patient noticed a tiny pea-sized nodule three years ago which gradually enlarged to become a 2 x 2 cm mass which appears soft with normal overlying skin. Mass was excised and the pathologist describes it as an encapsulated lesion composed of mature adipocytes with supporting fibrous tissue framework. Which one of the following is the likely diagnosis? Malignant melanoma Lipoma Neurofibroma Myositis ossificans Granulation tissue

Rhabdomyosarcoma is the correct answer. Rhabdomyosarcoma is a malignant mesenchymal tumor with skeletal muscle differentiation. Alveolar and embryonal subtypes of rhabdomyosarcoma are the most common soft tissue sarcomas a of childhood and adolescence, usually appearing before 20 years of age) Rhabdomyoblasts with visible cross-striations when present helps in diagnosis.

Question 6 1 / 1 pts A 7-year-old boy is seen at a rural clinic for a rapidly enlarging mass over the left wrist. There is no history of trauma at this site) Radiological findings reveal infiltration of the muscles of the hand with entrapment of the tendons. Tissue biopsies show atypical cells with cross striations. The likely diagnosis is Leiomyosarcoma Rhabdomyosarcoma Leiomyoma Fibrosarcoma Aggressive fibromatosis

Sarcoma botryoides is the correct answer. Sarcoma botryoides is an embryonal rhabdomyosarcoma variant that develops in the walls of hollow, mucosal-lined structures, such as the nasopharynx, common bile duct, bladder, and vagina) Rhabdomyosarcoma is a malignant mesenchymal tumor with skeletal muscle differentiation.

Question 7 An 18-month-old female is seen for bleeding per vagina) Investigations reveal a uterine growth. Tissue biopsy is shown. tumors_of_soft_tissue_q7.jpg The likely diagnosis is Cervical carcinoma Endometrial carcinoma Liposarcoma Sarcoma botryoides Leiomyoma

Rhabdomyosarcoma is the correct answer. The image shows rhabdomyoblast with cross striations, these are components of this malignant tumor. These tumor cells will stain positive for myosin and vimentin.

Question 8 1 / 1 pts A 67-year-old man presents with a mass on right shoulder. Tissue biopsy is shown below. Based on this image the likely diagnosis is tumors_of_soft_tissue_q8.jpg Leiomyosarcoma Keloid Rhabdomyosarcoma Fibromatosis Synovial sarcoma

Proliferating fascicles of smooth muscles is the correct answer. Leiomyomas, benign smooth muscle tumors, often arise in the uterus and are the most common neoplasm in women. Depending on their number, size, and location, uterine leiomyomas may cause a variety of symptoms including infertility and menorrhagia)

Question 9 1 / 1 pts A 43-year-old woman complains of dysmenorrhea) Her obstetric history was normal until the lest 3 menstrual cycles were associated with pain and excessive bleed) Medical history is unremarkable) An ultrasound study revealed a bulky uterus with numerous well-demarcated nodules along the uterine wall. Hysterectomy was performed, and the histologic findings shown below. tumors_of_soft_tissue_q9.jpg The histologic description that matches the image is Thickened perineural tissue Proliferating fascicles of smooth muscles Collection of cell debris and neutrophils Hyperplastic endometrial glands with stroma Fibrous tissue forming sheaths