Which of the following is true regarding pKa?
How many subunits are in the quaternary protein structure? a. three b. ti depends on the protein c. one d. two e. four
it depends on the protein
What molecule binds to the "donut" hole is R-state Hb? a. 1,3 - BPG b. 2,3 - BPG c. F6P d. FBP - 2 e. G3P
2,3-BPG
Peptide bonds are made of what type of functional group? a. Amine b. Amide c. Ester d.Hydroxyl e. Ether
Amide
Which is true regarding coupled reactions? a. None are true b. They need 2 or mores steps in the reaction mechanism c. The overall Delta G ิ is exergonic d. All are true e. They typically have intermediates
All are true
Which true about weak acids? a. The do not have high pKa's b. All are true c. The can serve as a buffer pair with its conjugate base d. They do not dissociate completely into hydrogen ions and conjugate base ions e. None are ture
All are true
Which of the followeing does NOT contribute to the stabilly of tertiary structure of proteins a. Disulfide bonds b. Carbon-Carbon bonds c. Hydrophobic interactions d. Hydrogen bonds e. Ionic interactions
Carbon- Carbon bonds
Which of the following will not result in denaturation of proteins? a. Strong Acids b. Heavy Metal Ions c. Detergents d. Chaperones e. StrongBases
Chaperones
How many subunits are shown in the protein structure below? If you cannot see the structure well, look it up on the PDB website. PDK ID 1YT9 HIV Protease with oximinoaryisulfonamide bound (a substrate bound in the center shown as balls and sticks) a. four b. three c. two d. one
Have picture on this question four
What type of secondary structure exists in this protein shown below? If you cannot see the structure well, look it up on the PDK website PDB ID 1BMGOVINE BETA2-MICROGLOBULIN a. a-helices b. paraller B-sheets c. B-helices d. antiparallel a-sheets
Have picture on this question and you forget to answer
Which of the following cases favors the formation of products in a reaction? a. Keq = 1, Delta G = 0 b. Keq < 1, Delta G > 0 c. Keq > 1, Delta G < 0 d. Keq > 1, Delta G > 0 e. None
Keq > 1, Delta G < 0
Which of the following is true regarding pKa? a. The pKa = the isolectric point b. A high Ka will indicate a high pKa c. Lower pKa's are more acidic than higher pKa's d. pKa = pH e. Higher pKa's are more acidic than lower pKa's
Lower pKa's are more acidic than higher pKa's
What types of solutions serve as good buffers? a. Strong bases b. Strong acids c. There are no acidic buffers d. There are no basic buffers e. Weak acids
Weak acids
Raising the pH will cause what to occur on the oxygen affinity plot if Hb? a. a shift to the left of the sigmoidal curve b. an decreasein the oxygen affinity c. a shift from a sigmoidal curve to a hyberbolic curve d. a shift to the right of the sigmoidal curve
a shift to the left of the sigmoidal curve
What type of secondary structure does myoglobin have? Use your book or look for structure in the PDB a. antiparallel a-helices b. antiparallel B-sheets c. a-helices d. parallel B-sheets e. B-helices
a-helices
What is the difference between a high pH compared to a low pH? a. the solution is neutral b. the hydrogen ion concentration is high c. the pKa = pH d. the hydrogen ion concentration is low
the hydrogen ion concentration is low
