24-Paneth cells

what happens if paneth cells are lost

increase of bacteria and infections

what happens to intestinal cells during calorie restriction

inhibits mTOR decrease differentiation of enterocytes increases stem cell proliferation

what are the 2 types of stem cells in the gut

quiescent +4 stem cells CBC/Lgr5+

what is the role of paneth cells

secrete antimicrobial peptides that determine gut microbiota composition protect stem cells from infections signal based on nutrients

how do paneth cells regulate CBC cells

signals control oxidative metabolism in CBC

what is the stem cell niche made up of

epithelial cells-PC non-epithelial cells paracrine and autocrine signals

how are CBC cells kept inactivate

Wnt signalling prevents activation

what causes Crohn's disease

abnormal paneth cell function abnormal bacterial adherence increases inflammation

what are the two major defensin peptides

alpha and beta defensins

how do paneth cells control the microbiota

by secreting different defensins

what happens when defensins cannot be made

cannot fight off bacteria infections

how is paneth cell secretion stimulated

triggered by Ca release secretatory granules