3313 Quiz CH16

D-cycloserine has been proposed as a treatment for PTSD T or F: D-cycloserine acts by inhibiting the activation of glutamate receptors in the amygdala which would prevent the LTP of the circuit involved in fear expression

False

T or F: In major depressive disorder there is shift in the metabolism of kynurenine towards the astrocyte pathway which results in kynurenine turning into quinolinic acid an NMDA receptor antagonist

False

T or F: In schizophrenia an excess of dopamine in the prefrontal cortex is consistent with the cognitive symptoms while a lack of dopamine in the striatum is consistent with the positive symptoms

False

T or F: The HPA axis is consistently overactive in major depressive disorder, generalized anxiety disorder and PTSD

False

T or F: In the Wisconsin card sorting task patients with schizophrenia are able to learn an initial sorting rule (e.g. sort by color) but have difficulty performing an extra-dimensional shift (e.g. shift from color to number of symbols)

True

T or F: Overactivation of the amygdala is present in major depressive disorder, generalized anxiety disorder and PTSD

True

T or F: PCP (acts as an non-competitive antagonist of the NMDA receptor) and Amphetamine (increases release of dopamine) are both drugs that would intensify (make worse) the positive symptoms present in schizophrenia

True

Which of the following statements is FALSE regarding major depressive disorder (MDD)?

decreased neural activity in cognitive control regions such as the prefrontal cortex are linked with deficits in executive functions in MDD prolonged release of cortisol is present in patients with MDD due to a reduction in the negative feedback loop of the HPA axis long term peripheral immune system activation is a risk factor of MDD *****All the of the choice options are TRUE regarding major depressive disorder**** increased neural activity in emotion generation regions such as the amygdala are linked with a bias toward negatively valanced stimuli in MDD