Cell Bio - Test 4

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Mitotic cyclin levels at the ends of mitosis are regulated by which of the following

Degradation of M cyclin by APC/C-Cdh1

T/F People who inherit one copy of the RB gene that is normal and one copy that is mutated- have a greatly increased risk of cancer.

False

T/F Protein kinase B phosphorylate Bad and other anti-apoptotic proteins making them active

False

T/F The release of calcium from the ER is essential for the PKR to produce the second messengers, DAG and IP3 from membrane bound PIP2

False

T/F: APC/C- Cdc20 proteasome degrades securing which holds the sister chromatids together, leading to the metaphase to anaphase transistion

False

The SOS protein has which of the following functions

guanine nucleotide exchange protein

Increased CED-9

no effect on apoptosis

The first demonstration that cancer could be caused by a virus involved

rous sarcoma virus in chickens

Each of the following occurs during apoptosis of a cell except

rupture of a cell, releasing cytoplasmic contents for phagocytosis

During which stages is APC/C-Cdh1 active

second half of mitosis and G1

Myc

Oncogene

Src

Oncogene

The growth factor MightyChick stimulates the proliferation of cultured chicken cells. The receptor that binds MightyChick is a receptor tyrosine kinase (RTK), and many chicken tumor cell lines have mutations in the gene that encodes this receptor. Which of the following types of mutation would be expected to promote uncontrolled cell proliferation?

A mutation that inactivates the phosphatase that normally removes phosphates from tyrosines on the activated receptor

Each of the following statements regarding CD95-stimulated programmed cell death is true except

Adaptor proteins stimulate the P13K-Akt pathway

Tumor cells in the iris of teh eye are actively producing both VEGF and FGF, factors that stimulate angiogenesis, but no new network of blood vessels to the tumor has been established in spite of the fact that blood vessels are nearby. This observation suggests that most likely

Angiostatin, an angiogenesis inhibitor is present in greater concentration

Inactivating mutation of Bim

Apoptosis less likely

Each of the following would inhibit cell progression through the cell cycle except

CAK kinase phosphorylation of the mitotic Cdk/cyclin complex

Cells lacking the ability to produce a functional Caspase 9 protein are cultured in the presence of a growth factor. Expression of a constitutively active version of which of the following proteins could induce apoptosis in these cells?

Caspase 3

The mitotic exit network requires which of the following activations

Cdc14

Mitogens are added to the medium of cultured human cells that are synchronized in mitosis. The mitogen is washed way after these cells have passed START in the cell cycle. These cells will progress through the cell cycle then arrest in which phase?

G0/G1

Raf is to MEK, as MEK is to

MAPK

Individuals can inherit a defective APC gene on chrome 5 from one parent that makes them susceptible to developing familial adenomatous polyposis. In which cells is this deletion present in affected individuals

all cells

Delete CED-3

apoptosis less likely

Deletion of CARD domain from Apaf-1

apoptosis less likely

BCL-2 protein deleted

apoptosis more likely

FAS death receptors can cluster without the need for the FAS ligand

apoptosis more likely

Procaspase 9 can self-proteolytically cleave

apoptosis more likely

What would be the most obvious outcome of repeated cell cycles consisting of S phase and M phase only/

cells produced would get smaller and smaller

Epigenetic changes in gene expression that can lead to cancer by silencing tumor suppressor genes are mediated by

changes in normal DNA methylation

BRCA1

tumor suppressor

P53

tumor suppressor

Hereditary cancers typically possess loss-of-heterozygosity in

tumor-suppressor genes

All of the following statements about destruction of cyclins is (are) true except

ubiquitin targets CDKs

M-cyclin is present from S-phase but is inactive in the cyclin-Cdk complex by which of the following?

wee1


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