Ch 11

Which of the following is not an antiphospholipid antibody? A Lupus anticoagulant B Anticardiolipin antibody C Anti-β2 glycoprotein 1 antibody D Antinuclear antibody

Antinuclear antibody

What protein is the target of "antiphospholipid" antibodies? A β2 Glycoprotein 1 B Cardiolipin C Phosphatidylserine D Phosphatidylinositol

β2 Glycoprotein 1

The effect of which of the following drugs markedly affects the results of a platelet aggregation test? A Dabigatran B Apixaban C Rivaroxaban D Aspirin

Aspirin

Which of the following drugs is least often associated with drug-induced thrombocytopenia? A Quinidine B Heparin C Sulfonamides D Aspirin

Aspirin

Which of the following pairs listing a platelet inhibitor with its mechanism of inhibitory action is incorrect? A Clopidogrel/Block of platelet ADP receptor B Aspirin/Block of platelet thromboxane receptor C Eptifibatide/Block of platelet fibrinogen receptor D Ibuprofen/Block of platelet cyclooxygenase

Aspirin/Block of platelet thromboxane receptor

A patient with a decreased functional platelet glycoprotein Ib/IX/V complex is most likely to have which diagnosis below? A Glanzmann thrombasthenia B Bernard-Soulier disease C Platelet storage pool disease D Cyclooxygenase deficiency

Bernard-Soulier disease

Which of the following statements about immune thrombocytopenia (ITP) is not true? A The destruction of platelets in ITP is antibody mediated. B Acute ITP usually presents as a childhood illness. C Chronic ITP occurs most commonly in patients between ages 20 and 50. D Chronic ITP is much more prevalent in males than in females.

Chronic ITP is much more prevalent in males than in females.

Which of the following coagulation abnormalities is not likely to be present in a patient suffering from severe liver disease associated with cirrhosis? A Decreased production of coagulation factors B Hyperactive platelet function C Thrombocytopenia D Increased D-dimer levels in the circulation

Hyperactive platelet function

With regard to acute disseminated intravascular coagulation (DIC), which of the following statements is true? A DIC commonly presents clinically as a bleeding disorder. B DIC commonly presents as a thrombotic disorder. C Approximately half of patients with DIC present with bleeding, and approximately half present with thrombosis. D Even patients with very severe DIC rarely experience bleeding or thrombosis.

DIC commonly presents clinically as a bleeding disorder.

Which of the following disorders of coagulation or conditions is associated with thrombosis rather than bleeding? A von Willebrand disease B Factor V deficiency C Factor V Leiden mutation D Immune thrombocytopenic purpura

Factor V Leiden mutation

Which of the following heritable thrombotic disorders is the most commonly encountered among Caucasians? A Protein C deficiency B Antithrombin deficiency C Factor V Leiden mutation D Protein S deficiency

Factor V Leiden mutation

A patient is known to have a congenital deficiency of a coagulation factor. The patient presents with a normal prothrombin time (PT) and a markedly elevated partial thromboplastin time (PTT). Which of the following factors is most likely to show a deficiency? A Factor VII B Factor XI C Factor XIII D Fibrinogen

Factor XI

Which of the following factors, even when markedly deficient and associated with a markedly prolonged PTT, does not predispose the patient to bleeding? A Factor VIII B Factor IX C Factor XII D Factor V

Factor XII

Of the choices below, three represent quantitative platelet disorders and one represents a qualitative platelet disorder. Identify the qualitative platelet disorder characterized by defective binding of platelets to Fibrinogen. A Glanzmann thrombasthenia B Immune thrombocytopenic purpura C Hypersplenism D Essential thrombocythemia

Glanzmann thrombasthenia

Which of the following conditions or disorders is not associated with deficiencies of multiple coagulation factors? A Hemophilia A B Vitamin K deficiency C Liver disease D Disseminated intravascular coagulation (DIC)

Hemophilia A

Vitamin K deficiency most often occurs secondary to disease or drug therapy rather than reduced dietary intake. Which of the following conditions does not predispose to vitamin K deficiency? A Warfarin therapy B Malabsorption associated with cystic fibrosis C Antibiotic therapy D Hepatitis A

Hepatitis A

All of the following are quantitative platelet disorders. One of them is immune mediated, that is, involves an antibody that binds to platelets. Identify the immune-mediated thrombocytopenia. A Disseminated intravascular coagulation (DIC) B Hemolytic uremic syndrome (HUS) C Posttransfusion purpura D Thrombotic thrombocytopenic purpura

Posttransfusion purpura

Which of the following tests for hypercoagulability does not yield reliable results for the baseline level in the presence of warfarin? A Antithrombin B Factor V Leiden mutation C Protein C D Prothrombin 20210 mutation

Protein C

Which of the following conditions is not a well-established cause of disseminated intravascular coagulation? A Malignancy B Pulmonary fibrosis C Obstetrical complications such as fetal death in utero D Severe infection

Pulmonary fibrosis

Which of the following anticoagulants below selectively inhibits coagulation factor X? A Warfarin B Heparin C Dabigatran D Rivaroxaban

Rivaroxaban

A patient with von Willebrand disease is being evaluated to determine the subtype of the disorder. It has been shown that the patient's platelets have been coated with von Willebrand factor derived from the pool of circulating von Willebrand factor. It was also found that the patient's platelets aggregated to an extremely low dose of ristocetin added as an agonist in standard platelet-rich plasma aggregometry. What is the most likely subtype of von Willebrand disease in this patient? A Type 1 B Type 2A C Type 2B D Type 3

Type 2B

Individuals with which of the following blood type have a lower baseline level of von Willebrand factor? A Type O B Type A C Type B D Type AB

Type O

Which of the following anticoagulants is monitored with the international normalized ratio (INR)? A Low-molecular-weight heparin B Apixaban C Unfractionated heparin D Warfarin

Warfarin

Which of the following tests is least likely to be informative in the evaluation of the patient for von Willebrand disease? A Factor VIII B Ristocetin cofactor (an assessment for von Willebrand factor activity) C von Willebrand factor antigen D White blood cell count

White blood cell count

Which of the following coagulation disorders has the highest incidence in the population? A von Willebrand disease B Factor V deficiency C Essential thrombocythemia D Platelet storage pool deficiency

von Willebrand disease