Ch. 51: Management of Patients with Immunodeficiency

The cardinal symptoms of immunodeficiency are:

-chronic diarrhea -chronic or recurrent severe infections -poor response to treatment of infections

More than 50% of individuals with which disease develop pernicious anemia?

Common variable immunodeficiency (CVID)

List 5 disorders of common, primary immunodeficiencies:

humoral immunity, T-cell defects, combined B- and T-cell defects, phagocytic disorders, and complement production

The most frequent presenting sign in patients with DiGeorge syndrome is:

hypocalcemia

The nitroblue tetrazolium reductase (NTR) test is used to diagnose immunodeficiency disorders related to:

phagocytic cells

Primary immunodeficiencies predispose people to three conditions:

severe infections, autoimmunity, and cancer

The most prevalent cause of immunodeficiency worldwide is:

severe malnutrition

The recommmended dose of intravenous gamma globulin for a 60-kg man, given monthly, is :

30 g

DiGeorge syndrome is an example of which immunodeficiency?

Primary T-cell

The two types of inherited B-cell deficiencies result from lack of differentiation of B-cells into:

mature B cells and plasma cells

The nurse knows to stop an infusion of gamma globulin if the patient experiences:

-flank pain -shaking chills -tightness in the chest

Immundeficiency disorders are caused by defects or deficiencies in:

-the complement system -B and T lymphocytes -phagocytic cells

When gamma globulin is infused intravenously, the rate should not exceed:

3 mL/min.

The most common secondary immunodeficiency disorder is:

AIDS

More than 50% of patients with CVID develop which disorder?

Pernicious anemia

The primary cause of death for individuals with ataxia-telangiectasia is:

overwhelming infection