Chapter 8

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) Match the glial cell to the nervous system division in which it is found. A. central nervous system B. peripheral nervous system 87) Schwann cells

: B Section Title: Cells of the Nervous System Learning Outcome: 8.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) Match the term with its description (answers may be used more than once). A. ependymal cells B. astrocytes C. satellite cells D. Schwann cells E. oligodendrocytes F. microglia 93) highly branched cells that transfer nutrients between blood vessels and neurons

: B Section Title: Cells of the Nervous System Learning Outcome: 8.1

: Level II: Reviewing Concepts (Bloom's Taxonomy: Application) 138) A home satellite dish receives signals from a satellite, allowing your television to display TV shows. Which part of a neuron is analogous to the satellite dish? A) cell body B) dendrites C) axon D) varicosities E) collaterals

: B Section Title: Cells of the Nervous System Learning Outcome: 8.1

Human Physiology: An Integrated Approach, 6e (Silverthorn) Chapter 8 Neurons: Cellular and Network Properties 1) The portions of a neuron that extend off of the roughly spherical cell body are usually collectively called A) protrusions. B) processes. C) prostheses. D) projections.

: B Section Title: Cells of the Nervous System Learning Outcome: 8.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 109) location of voltage-gated ion channels

: B Section Title: Cells of the Nervous System Learning Outcome: 8.4

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 29) What does the Goldman-Hodgkin-Katz equation take into account that the Nernst equation does NOT? A) the electrical charges of the ions B) the permeabilities of the ions C) the solubilities of the ions D) the sizes of the ions E) the temperature

: B Section Title: Electrical Signals in Neurons Learning Outcome: 8.2

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 47) When voltage-gated K+ channels of a resting neuron open, A) K+ enters the neuron. B) K+ leaves the neuron. C) the neuron depolarizes. D) K+ enters the neuron and the neuron depolarizes. E) K+ leaves the neuron and the neuron depolarizes.

: B Section Title: Electrical Signals in Neurons Learning Outcome: 8.2

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 114) require(s) a minimum stimulus to occur

: B Section Title: Electrical Signals in Neurons Learning Outcome: 8.3

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 41) In order to signal a stronger stimulus, action potentials become A) higher in amplitude only. B) more frequent only. C) longer-lasting only. D) higher in amplitude and more frequent. E) higher in amplitude and longer-lasting.

: B Section Title: Electrical Signals in Neurons Learning Outcome: 8.4

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 45) The all-or-none principle states that A) all stimuli will produce identical action potentials. B) all stimuli great enough to bring the membrane to threshold will produce action potentials of identical magnitude. C) the greater the magnitude of the stimuli, the greater the intensity of the action potential. D) only sensory stimuli can activate action potentials. E) only motor stimuli can activate action potentials.

: B Section Title: Electrical Signals in Neurons Learning Outcome: 8.4

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 148) The inactivation gate A) quickly opens and closes after depolarization. B) is coupled to the movement of the activation gate, but is much slower. C) depends on a change of +100 mV from rest to be signaled to close. D) depends on a loss of Na+ permeability to be triggered. E) depends on a loss of K+ permeability to be triggered.

: B Section Title: Electrical Signals in Neurons Learning Outcome: 8.4

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 150) The following are the main steps in the generation of an action potential: 1. sodium channels are inactivated 2. more voltage-regulated potassium channels open and potassium moves out of the cell, initiating repolarization 3. sodium channels regain their normal properties 4. a graded depolarization brings an area of an excitable membrane to threshold 5. a temporary hyperpolarization occurs 6. sodium channel activation occurs 7. sodium ions enter the cell and further depolarization occurs The proper sequence of these events is A) 4, 6, 7, 3, 2, 5, 1. B) 4, 6, 7, 1, 2, 5, 3. C) 6, 7, 4, 1, 2, 3, 5. D) 2, 4, 6, 7, 1, 3, 5. E) 4, 2, 5, 6, 7, 3, 1.

: B Section Title: Electrical Signals in Neurons Learning Outcome: 8.4

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 146) In the first phase of triggering an action potential in a neuron, Na+ ions flow in and A) only trigger a negative feedback loop. B) only trigger a positive feedback loop. C) only activate the sodium/potassium pump. D) trigger a negative feedback loop and activate the sodium/potassium pump. E) trigger a positive feedback loop and activate the sodium/potassium pump.

: B Section Title: Electrical Signals in Neurons Learning Outcome: 8.4

: Level II: Reviewing Concepts (Bloom's Taxonomy: Application) 155) Conduction occurs along an axon because A) outflow of K+ triggers the adjacent channels to open. B) inflow of Na+ triggers the adjacent channels to open. C) once Na+ enters the cell, the entire membrane depolarizes simultaneously. D) axonal transport "walks" voltage changes along the membrane.

: B Section Title: Electrical Signals in Neurons Learning Outcome: 8.5

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 81) The pattern of synaptic connectivity where a large number of presynaptic neurons provide input to a single postsynaptic neuron, is known as A) divergence. B) convergence. C) integration. D) saltatory conduction. E) potentiation.

: B Section Title: Integration of Neuronal Information Transfer Learning Outcome: 8.9

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 78) If a hyperpolarizing graded potential and a depolarizing graded potential of similar magnitudes arrive at the trigger zone at the same time, what is most likely to occur? A) An action potential is fired off more quickly than usual. B) Nothing. They will cancel each other out. C) The cell becomes hyperpolarized. D) The cell becomes easier to excite. E) The cell dies.

: B Section Title: Integration of Neuronal Information Transfer Learning Outcome: 8.9

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 77) Spatial summation refers to A) electrical signals reaching neurons from outer space. B) multiple graded potentials arriving at one location simultaneously. C) repeated graded potentials reaching the trigger zone one after the other. D) suprathreshold potentials triggering action potentials that are extra large. E) All of the answers are correct.

: B Section Title: Integration of Neuronal Information Transfer Learning Outcome: 8.9

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 80) When a second EPSP arrives at a single synapse before the effects of the first have disappeared, what occurs? A) spatial summation B) temporal summation C) inhibition of the impulse D) hyperpolarization E) decrease in speed of impulse transmission

: B Section Title: Integration of Neuronal Information Transfer Learning Outcome: 8.9

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 7) Exocrine glands, smooth muscles, and cardiac muscles are controlled by the A) central nervous system. B) autonomic nervous system. C) somatic motor division. D) peripheral nervous system. E) enteric nervous system.

: B Section Title: Organization of the Nervous System Learning Outcome: 8.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 8) Autonomic motor neurons are subdivided into the A) visceral and somatic divisions. B) sympathetic and parasympathetic divisions. C) central and peripheral divisions. D) visceral and enteric divisions. E) somatic and enteric divisions.

: B Section Title: Organization of the Nervous System Learning Outcome: 8.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 9) The enteric nervous system is a network of neurons that function in controlling A) reproduction. B) digestion. C) excretion, particularly urination. D) the skeletal system. E) the endocrine system.

: B Section Title: Organization of the Nervous System Learning Outcome: 8.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 83) The rearrangement of connections at synapses, which occurs throughout life, is termed A) elasticity. B) intelligence. C) plasticity. D) senility. E) synchronicity.

: C Section Title: Integration of Neuronal Information Transfer Learning Outcome: 8.10

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 73) An excitatory postsynaptic potential (EPSP) A) depolarizes a neuron, decreasing the likelihood of an action potential. B) hyperpolarizes a neuron, decreasing the likelihood of an action potential. C) depolarizes a neuron, increasing the likelihood of an action potential. D) hyperpolarizes a neuron, increasing the likelihood of an action potential.

: C Section Title: Integration of Neuronal Information Transfer Learning Outcome: 8.6

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 72) Identify the FALSE statement. A) EPSPs that reach threshold can initiate an action potential. B) The trigger zone is the integrating center of the neuron. C) IPSPs depolarize the membrane. D) All of the statements are true.

: C Section Title: Integration of Neuronal Information Transfer Learning Outcome: 8.6

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 79) When multiple, possibly even conflicting signals reach a neuron, the neuron evaluates the signals and may respond or not. This property is called A) temporal summation. B) spatial summation. C) postsynaptic integration. D) graded potentials. E) EPSPs.

: C Section Title: Integration of Neuronal Information Transfer Learning Outcome: 8.9

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 67) Once the action potential reaches the axon terminal, what happens next? A) exocytosis of a neurocrine B) release of the neurotransmitter into the synaptic cleft C) release of a neurohormone into the blood D) Any of the above could happen next.

: D Section Title: Cell-to-Cell Communication in the Nervous System Learning Outcome: 8.6

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 24) Myelin is formed by A) axons only. B) Schwann cells only. C) oligodendrocytes only. D) Schwann cells and oligodendrocytes.

: D Section Title: Cells of the Nervous System Learning Outcome: 8.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 85) Repair of damaged neurons can be assisted by certain neurotrophic factors secreted by the A) cell body only. B) axon only. C) dendrites only. D) Schwann cells only. E) axon and dendrites.

: D Section Title: Cells of the Nervous System Learning Outcome: 8.10

: Level II: Reviewing Concepts (Bloom's Taxonomy: Knowledge) 165) Tom's father suffers a stroke that leaves him partially paralyzed on his right side. What type of glial cell would you expect to find in increased numbers in the damaged area of the brain that is affected by the stroke? A) astrocytes B) Schwann cells C) oligodendrocytes D) microglia

: D Section Title: Cells of the Nervous System Learning Outcome: 8.10

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 162) How would blocking retrograde transport in an axon affect the activity of a neuron? A) The neuron would not be able to produce neurotransmitters. B) The neuron would not be able to produce action potentials. C) The cell body would not be able to export products to the axon terminals. D) The cell body would not be able to respond to changes in the distal end of the axon. E) The neuron would be unable to depolarize when stimulated.

: D Section Title: Electrical Signals in Neurons Learning Outcome: 8.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 27) The Nernst equation predicts A) intracellular ion concentrations. B) extracellular ion concentrations C) the membrane potential resulting from all permeable ions. D) the membrane potential resulting from permeability to a single ion. E) the threshold membrane potential.

: D Section Title: Electrical Signals in Neurons Learning Outcome: 8.2

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 30) The resting membrane potential results from A) uneven distribution of ions across the cell membrane only. B) differences in membrane permeability to Na+ and K+ only. C) activity of the sodium/potassium pump only. D) uneven distribution of ions across the cell membrane and differences in membrane permeability to Na+ and K+. E) None of the answers are correct.

: D Section Title: Electrical Signals in Neurons Learning Outcome: 8.2

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 159) Graded potentials can A) only act as signals over short distances. B) only act as signals over long distances. C) only cause or prevent an action potential. D) act as signals over short distances and cause or prevent an action potential. E) act as signals over long distances and cause or prevent an action potential.

: D Section Title: Electrical Signals in Neurons Learning Outcome: 8.3

: Level II: Reviewing Concepts (Bloom's Taxonomy: Application) 166) Tetrodotoxin is a toxin that blocks voltage-gated sodium channels. What effect does this substance have on the function of neurons? A) Neurons depolarize more rapidly. B) Action potentials lack a repolarization phase. C) The absolute refractory period is shorter than normal. D) The neuron is not able to propagate action potentials. E) The toxin does not interfere with neuron function because the voltage-regulated sodium channels would still function.

: D Section Title: Electrical Signals in Neurons Learning Outcome: 8.4

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 154) If a stimulating electrode is placed in the middle of a resting axon and an above-threshold voltage is applied to the electrode action potentials A) will not occur. B) will start at that point and proceed only toward the axon terminal. C) will start at that point and proceed only toward the cell body. D) will start at that point and travel in both directions in the axon.

: D Section Title: Electrical Signals in Neurons Learning Outcome: 8.5

: Level II: Reviewing Concepts (Bloom's Taxonomy: Knowledge) 168) Presynaptic facilitation occurs when A) extracellular concentration of sodium increases. B) extracellular concentration of potassium increases. C) calcium channels in the presynaptic membrane are inhibited. D) calcium channels in the presynaptic membrane remain open longer. E) temporal summation occurs.

: D Section Title: Integration of Neuronal Information Transfer Learning Outcome: 8.9

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 184) How does the function of dendritic spines in the CNS differ from dendrites in the PNS?

: Dendritic spines have polyribosomes to make their own proteins, send signals to other neurons, and are involved in learning, memory, and various pathologies. PNS dendrites receive external information and transfer it within the neuron. Section Title: Cells of the Nervous System Learning Outcome: 8.1

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 193) The text states "all action potentials are identical to one another." There is an exception, however, where an action potential can have a smaller than normal amplitude. When does this occur and how?

: During the relative refractory period, a smaller than normal action potential can occur. During this period potassium channels are still open causing repolarization. If a wave of depolarization occurs, Na+ can enter the cells through the newly reopened Na+ channels, but this depolarization is offset by the K+ efflux. Section Title: Electrical Signals in Neurons Learning Outcome: 8.4

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 122) The ________ principle states that the properties of the action potential are independent of the relative strength of the depolarizing stimulus.

: all-or-none Section Title: Electrical Signals in Neurons Learning Outcome: 8.4

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 126) In a(n) ________ synapse, there is a direct physical connection between cells.

: electrical Section Title: Cell-to-Cell Communication in the Nervous System Learning Outcome: 8.6

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 124) The period of time during which an excitable membrane can respond again, but only if the stimulus is greater than the initial stimulus is the ________.

: relative refractory period Section Title: Electrical Signals in Neurons Learning Outcome: 8.4

: Level II: Reviewing Concepts (Bloom's Taxonomy: Knowledge) 171) A change in the conditions in the axon terminal can cause a change in the environment of the cell body as a result of ________.

: retrograde transport Section Title: Cells of the Nervous System Learning Outcome: 8.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 128) The addition of stimuli arriving in rapid succession to produce an action potential is called ________.

: temporal summation Section Title: Integration of Neuronal Information Transfer Learning Outcome: 8.9

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 58) Which type of synapse is most prevalent in the nervous system? A) chemical B) electrical C) mechanical D) processing E) radiative

: A Section Title: Cell-to-Cell Communication in the Nervous System Learning Outcome: 8.6

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 88) oligodendrocytes

: A Section Title: Cells of the Nervous System Learning Outcome: 8.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 84) A damaged neuron has a better chance of survival and repair if the ________ is/are undamaged. A) cell body B) axon C) dendrites D) Schwann cells E) axon and dendrites

: A Section Title: Cells of the Nervous System Learning Outcome: 8.10

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 108) where most graded potentials originate

: A Section Title: Cells of the Nervous System Learning Outcome: 8.3

: Level III: Problem Solving (Bloom's Taxonomy: Analysis) 207) Explain the processes that lead to the exocytosis of neurotransmitter from a presynaptic cell. Which components are recycled? Which ion is important in triggering exocytosis?

: Action potential arrives in synaptic terminal, and stimulates opening of voltage-regulated calcium channels. The resulting calcium influx triggers exocytosis of synaptic vesicle contents. The phospholipids of the vesicle membranes are recycled, either from fusion of vesicles then later formation of new vesicles from the same molecules; or from the kiss-and-run model, in which the vesicle phospholipids are not incorporated into the membrane at all, but remain as vesicles that can be refilled with neurotransmitter. Section Title: Cell-to-Cell Communication in the Nervous System Learning Outcome: 8.6

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 164) Caffeine, nicotine, and alcohol all have effects on A) action potential conduction. B) long-term potentiation. C) synaptic activity. D) neurotransmitter degradation. E) neurotransmitter reuptake.

: C Section Title: Integration of Neuronal Information Transfer Learning Outcome: 8.6

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 98) cells in the PNS that form myelin

: D Section Title: Cells of the Nervous System Learning Outcome: 8.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 101) cells that myelinate only one axon each; multiple cells per axon

: D Section Title: Cells of the Nervous System Learning Outcome: 8.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 46) When voltage-gated Na+ channels of a resting neuron open, A) Na+ enters the neuron. B) Na+ leaves the neuron. C) the neuron depolarizes. D) Na+ enters the neuron and the neuron depolarizes. E) Na+ leaves the neuron and the neuron depolarizes.

: D Section Title: Electrical Signals in Neurons Learning Outcome: 8.4

: Level II: Reviewing Concepts (Bloom's Taxonomy: Knowledge) 169) Learning and memory are thought to be due to a synaptic phenomenon known as A) inhibition. B) excitation. C) modulation. D) facilitation. E) long-term potentiation.

: E Section Title: Integration of Neuronal Information Transfer Learning Outcome: 8.9

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 135) If the graded potential increases in amplitude, then the frequency of the action potentials fired also increases.

: True Section Title: Electrical Signals in Neurons Learning Outcome: 8.3

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 125) At a(n) ________ synapse, a neurotransmitter is released to affect the postsynaptic cell.

: chemical Section Title: Cell-to-Cell Communication in the Nervous System Learning Outcome: 8.6

: Level IV: Quantitative Problems (Bloom's Taxonomy: Application) 224) The amplitude of an action potential depends in part on the amount of sodium in the extracellular fluid. Stanley Student has carefully impaled a neuron with an intracellular electrode. He tests the role of extracellular sodium by changing the concentration in the bathing fluid and recording an action potential after each change. The data he generated are shown in the table, where amplitude listed is the peak amplitude of the action potential; make an appropriate graph. Conc. Sodium (mOsM) Amp. (mV) 100 90 120 91 140 92 160 94 180 96 200 100

: Section Title: Electrical Signals in Neurons Learning Outcome: 8.4

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 189) Name two ways a cell changes its membrane permeability to ions. (Hint: One way is relatively slow.)

: 1. opens or closes existing channels 2. inserts or removes membrane channels Section Title: Electrical Signals in Neurons Learning Outcome: 8.2

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 130) Name the two factors that influence the membrane potential.

: 1. the concentration gradients of ions across the membrane 2. the membrane permeability to those ions Section Title: Electrical Signals in Neurons Learning Outcome: 8.2

: Level II: Reviewing Concepts (Bloom's Taxonomy: Knowledge) 170) Products from the cell body of a neuron are transported to the axon terminals by ________.

: (anterograde) axoplasmic transport Section Title: Cells of the Nervous System Learning Outcome: 8.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 63) Excitatory neurotransmitters of the CNS usually act by opening ________ channels. A) Na+ B) K+ C) Cl- D) H+ E) Ca2+

: A Section Title: Cell-to-Cell Communication in the Nervous System Learning Outcome: 8.6

: Level II: Reviewing Concepts (Bloom's Taxonomy: Knowledge) 152) When more action potentials arrive at the axon terminal, how are neurotransmitters affected? A) More molecules are released into the synapse. B) Different molecules are released into the synapse. C) Fewer molecules are released into the synapse. D) There is no effect-all signals are identical.

: A Section Title: Cell-to-Cell Communication in the Nervous System Learning Outcome: 8.6

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 96) cells that create a selectively permeable epithelial layer to separate fluid compartments of the CNS

: A Section Title: Cells of the Nervous System Learning Outcome: 8.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 103) receive(s) most of the incoming synapses

: A Section Title: Cells of the Nervous System Learning Outcome: 8.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 28) Which is the correctly written Nernst equation? A) 61/z × log [ion]out / [ion]in B) 61/z × log [ion]in / [ion]out C) log 61/z × [ion]in / [ion]out D) log 61/z × [ion]out / [ion]in

: A Section Title: Electrical Signals in Neurons Learning Outcome: 8.2

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 112) originate(s) on dendrites and cell bodies

: A Section Title: Electrical Signals in Neurons Learning Outcome: 8.3

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 90) satellite cells

: B Section Title: Cells of the Nervous System Learning Outcome: 8.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 111) originate(s) at the trigger zone

: B Section Title: Electrical Signals in Neurons Learning Outcome: 8.3

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 33) Ion channel inactivation is A) closing of the channel in response to decrease in the stimulus. B) closing of the channel even when the stimulus continues. C) any type of channel closing. D) None of the answers are correct.

: B Section Title: Electrical Signals in Neurons Learning Outcome: 8.4

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 71) In order for a synapse to be an effective means of cellular communication, slow removal or inactivation of neurotransmitter molecules from the synapse is important. A) True B) False

: B Section Title: Integration of Neuronal Information Transfer Learning Outcome: 8.6

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 74) Inhibitory postsynaptic potentials (IPSPs ) A) result in local depolarizations. B) result in local hyperpolarizations. C) increase membrane permeability to sodium ions. D) prevent the escape of potassium ions. E) prevent the escape of calcium ions.

: B Section Title: Integration of Neuronal Information Transfer Learning Outcome: 8.6

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 59) The ion necessary to initiate the release of acetylcholine into the synaptic cleft is A) sodium. B) potassium. C) calcium. D) chloride. E) zinc.

: C Section Title: Cell-to-Cell Communication in the Nervous System Learning Outcome: 8.6

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 60) To increase the amount of neurotransmitter released onto a postsynaptic cell, the presynaptic cell would have to A) send action potentials with higher voltage (higher amplitude). B) send action potentials with longer durations. C) send action potentials with higher frequency. D) do nothing; no change is possible since the all-or-none law is in effect.

: C Section Title: Cell-to-Cell Communication in the Nervous System Learning Outcome: 8.6

: Level III: Problem Solving (Bloom's Taxonomy: Application) 209) The disease rabies is caused by a virus that attacks the central nervous system. The virus is normally introduced when an infected animal bites another, breaking the surface of the skin and allowing the entry of saliva containing the virus. Since the virus cannot move by itself, how does it get to neurons in the central nervous system?

: Circulation of the lymph may spread the virus throughout the body. Retrograde axonal transport brings the viral particles to the nerve cell bodies in the spinal cord. Section Title: Electrical Signals in Neurons Learning Outcome: 8.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 66) Once the stimulus alters the receptor on the cell's membrane, what happens next? A) Ion channels open, allowing ions to enter or exit. B) The membrane permeability is altered. C) A second messenger is activated on the inside of the cell. D) Any of these actions could happen next.

: D Section Title: Cell-to-Cell Communication in the Nervous System Learning Outcome: 8.6

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 21) Clusters of nerve cell bodies in the peripheral nervous system are called A) microglia. B) neuroglia. C) glia. D) ganglia. E) nodes.

: D Section Title: Cells of the Nervous System Learning Outcome: 8.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 5) The afferent and efferent axons together form the A) central nervous system. B) autonomic division system. C) somatic motor division of the nervous system. D) peripheral nervous system. E) visceral nervous system.

: D Section Title: Cells of the Nervous System Learning Outcome: 8.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 16) The axon is connected to the cell body by the A) myelin sheath. B) axon terminal. C) collaterals. D) axon hillock. E) synapse.

: D Section Title: Cells of the Nervous System Learning Outcome: 8.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 49) Ion concentrations are first significantly affected after ________ action potential(s). A) one B) a few dozen C) a few hundred D) a few thousand E) a few million

: D Section Title: Electrical Signals in Neurons Learning Outcome: 8.2

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 38) The point during an action potential when the inside of the cell has become more positive than the outside is known as the A) depolarization. B) rising phase. C) falling phase. D) overshoot. E) peak.

: D Section Title: Electrical Signals in Neurons Learning Outcome: 8.4

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 145) When the neuron is at rest, which statement is true? A) The activation gate is closed. B) The inactivation gate is open. C) No Na+ crosses the membrane is the only observation. D) The activation gate is closed and the inactivation gate is open. E) The activation gate is closed and no Na+ crosses the membrane.

: D Section Title: Electrical Signals in Neurons Learning Outcome: 8.4

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 142) If the sodium-potassium pumps in the cell membrane of a neuron fail to function, over time A) the extracellular concentration of potassium ion will increase. B) the intracellular concentration of sodium ion will increase. C) the membrane resting potential will become more positive than normal. D) All of the answers are correct.

: D Section Title: Electrical Signals in Neurons Learning Outcome: 8.4

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 100) cells that myelinate several axons

: E Section Title: Cells of the Nervous System Learning Outcome: 8.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 82) During childhood, growth and development of the brain PRIMARILY occurs by increasing A) neuron numbers only. B) neuron size only. C) number of dendrites and synapses only. D) neuron numbers and neuron size. E) neuron size and number of dendrites and synapses.

: E Section Title: Cells of the Nervous System Learning Outcome: 8.10

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 43) Voltage-regulated channels are located A) within the cytosol only. B) in the membranes of dendrites only. C) in the membranes of axons only. D) on the neuron cell body only. E) in the membranes of dendrites, in the membranes of axons, and on the neuron cell body.

: E Section Title: Electrical Signals in Neurons Learning Outcome: 8.4

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 40) The absolute refractory period of an action potential A) only ensures one-way travel down an axon. B) only allows a neuron to ignore a second signal sent that closely follows the first. C) only prevents summation of action potentials. D) ensures one-way travel down an axon and allows a neuron to ignore a second signal sent that closely follows the first. E) ensures one-way travel down an axon, allows a neuron to ignore a second signal sent that closely follows the first, and prevents summation of action potentials.

: E Section Title: Electrical Signals in Neurons Learning Outcome: 8.4

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 44) The sodium-potassium exchange pump A) must re-establish ion concentrations after each action potential. B) transports sodium ions into the cell during depolarization. C) transports potassium ions out of the cell during repolarization. D) moves sodium and potassium in the direction of their chemical gradients. E) requires ATP to function.

: E Section Title: Electrical Signals in Neurons Learning Outcome: 8.4

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 52) Which of the following does NOT influence the time necessary for a nerve impulse to be conveyed by a particular neuron? A) length of the axon B) presence or absence of a myelin sheath C) diameter of the axon D) presence or absence of nodes of Ranvier E) whether axon is sensory or motor

: E Section Title: Electrical Signals in Neurons Learning Outcome: 8.5

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 156) Conduction speed is (or can be) enhanced by A) myelin. B) altering extracellular sodium concentration. C) increasing the temperature. D) altering extracellular potassium concentration. E) myelin and increasing the temperature.

: E Section Title: Electrical Signals in Neurons Learning Outcome: 8.5

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 136) In spatial summation the same stimulus is repeated until a threshold level of depolarization is reached.

: False, temporal summation Section Title: Integration of Neuronal Information Transfer Learning Outcome: 8.3

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 183) Compare and contrast fast and slow synaptic potentials, including detailed mechanisms used and what kinds of cells they occur in.

: Fast synaptic potentials begin quickly and last only a few milliseconds; this category includes EPSPs and IPSPs. Slow synaptic potentials take longer to begin and last longer commonly involve G-protein coupled receptors; this type of response is important in growth, development, and long-term memory. Section Title: Integration of Neuronal Information Transfer Learning Outcome: 8.7

: Level IV: Quantitative Problems (Bloom's Taxonomy: Analysis) 221) Draw and label an action potential, in the form of a graph.

: Graph should be similar to Figure 8.9 in the chapter. Section Title: Electrical Signals in Neurons Learning Outcome: 8.4

: Level IV: Quantitative Problems (Bloom's Taxonomy: Application) 226) In the graphs below, identify normokalemia, hyperkalemia, and hypokalemia .

: See Figure 8.17 in the chapter. Section Title: Electrical Signals in Neurons Learning Outcome: 8.4

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 133) An influx of Na+ ions depolarizes the membrane of an axon.

: True Section Title: Electrical Signals in Neurons Learning Outcome: 8.2

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 194) Explain the kiss-and-run model of synaptic vesicle exocytosis, and how it differs from the classic model.

: With the kiss-and-run model the synaptic vesicles fuse to the presynaptic membrane at a fusion complex. When the neurotransmitter is released through the fusion complex into the synaptic cleft the vesicles then pull away from the complex and re-enter the vesicle pool in the cytoplasm. With the classical model the vesicle becomes incorporated into or becomes part of the cell membrane. Section Title: Cell-to-Cell Communication in the Nervous System Learning Outcome: 8.6

: Level IV: Quantitative Problems (Bloom's Taxonomy: Application) 220) If an axon has an absolute refractory period of 2 msec, what is the maximum frequency of action potential (AP) production in that neuron?

: X AP/2 msec × 1000 msec/1 sec = 500 APs per second. Section Title: Electrical Signals in Neurons Learning Outcome: 8.4

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 119) The sum of all of the electrical and chemical forces active across the membrane is known as the ________.

: driving force Section Title: Electrical Signals in Neurons Learning Outcome: 8.2

: Level II: Reviewing Concepts (Bloom's Taxonomy: Knowledge) 173) Graded potentials that arrive at postsynaptic neurons are called ________ if they make that cell more likely to fire.

: excitatory Section Title: Electrical Signals in Neurons Learning Outcome: 8.3

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 120) The two types of electrical signals in neurons are ________.

: graded potentials and action potentials Section Title: Electrical Signals in Neurons Learning Outcome: 8.3

: Level II: Reviewing Concepts (Bloom's Taxonomy: Knowledge) 174) Graded potentials that arrive at postsynaptic neurons are called ________ if they make that cell less likely to fire.

: inhibitory Section Title: Electrical Signals in Neurons Learning Outcome: 8.3

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 117) The gaps between adjacent Schwann cells on an axon are called ________.

: nodes of Ranvier Section Title: Electrical Signals in Neurons Learning Outcome: 8.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 129) The addition of several stimuli arriving from different locations on the same cell to produce an action potential is called ________.

: spatial summation Section Title: Integration of Neuronal Information Transfer Learning Outcome: 8.9

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 118) The potential difference across a membrane or other barrier is a measure of the ________ across the barrier.

: voltage Section Title: Electrical Signals in Neurons Learning Outcome: 8.2

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 89) microglia

: A Section Title: Cells of the Nervous System Learning Outcome: 8.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) Match the type of signal to its description (answers may be used more than once). A. graded potential B. action potential C. both 110) may be hyperpolarizing

: A Section Title: Electrical Signals in Neurons Learning Outcome: 8.3

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 113) can involve ion channels regulated by chemicals

: A Section Title: Electrical Signals in Neurons Learning Outcome: 8.3

: Level III: Problem Solving (Bloom's Taxonomy: Comprehension) 198) Explain the two reasons why graded potentials lose strength as they move through the cell. Why don't action potentials lose strength?

: As a depolarization wave moves through the cell, some of the positive charge is lost to the extracellular fluid through leak channels. Additionally there is cytoplasmic resistance. Action potentials do not lose strength because they are regenerated in each patch of membrane. Section Title: Electrical Signals in Neurons Learning Outcome: 8.3

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 68) Calcium is important in the synapse because it A) is necessary for acetylcholine synthesis. B) signals the exocytosis of the neurotransmitter. C) binds to receptors on the postsynaptic cell, opening ion channels, and triggering graded potentials. D) leaves the axon terminal, hyperpolarizing the cell.

: B Section Title: Cell-to-Cell Communication in the Nervous System Learning Outcome: 8.6

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 62) The inhibitory neurotransmitters of the CNS, GABA and glycine, act by opening ________ channels. A) only Na+ B) only Cl- C) only K+ D) only Ca2+ E) Na+ and K+

: B Section Title: Cell-to-Cell Communication in the Nervous System Learning Outcome: 8.6

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 137) Microvilli are present on cells that, because of their function, benefit from an increased membrane surface area. Which structure(s) on a neuron provide a comparable benefit? A) cell body B) dendrites C) axon D) varicosities E) collaterals

: B Section Title: Cells of the Nervous System Learning Outcome: 8.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 18) Neurotransmitters are released from the A) dendrites. B) axon terminals. C) collaterals. D) axon hillock. E) synapse.

: B Section Title: Cells of the Nervous System Learning Outcome: 8.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 23) Glial cells communicate primarily using A) electrical signals only. B) chemical signals only. C) neurotransmitters only. D) neuromodulators only. E) electrical signals and chemical signals.

: B Section Title: Cells of the Nervous System Learning Outcome: 8.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 51) Which of the following will best increase the conduction rate of action potentials? A) Increase the diameter of the axon, decrease the resistance of the axon membrane to ion leakage. B) Increase the diameter of the axon, increase the resistance of the axon membrane to ion leakage. C) Decrease the diameter of the axon, decrease the resistance of the axon membrane to ion leakage. D) Decrease the diameter of the axon, increase the resistance of the axon membrane to ion leakage.

: B Section Title: Electrical Signals in Neurons Learning Outcome: 8.5

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 161) Arrange the following events in the proper sequence: 1. Efferent neuron reaches threshold and fires an action potential. 2. Afferent neuron reaches threshold and fires an action potential. 3. Effector organ responds by performing output. 4. Integrating center reaches decision about response. 5. Sensory organ detects change in the environment. A) 2, 3, 5, 1, 4 B) 5, 2, 4, 1, 3 C) 5, 1, 4, 2, 3 D) 5, 3, 4, 2, 1 E) 3, 1, 4, 2, 5

: B Section Title: Integration of Neuronal Information Transfer Learning Outcome: 8.9

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 2) Detailed understanding of the cellular basis of signaling in the nervous system has led to good understanding of consciousness, intelligence, and emotion. A) True B) False

: B Section Title: Organization of the Nervous System Learning Outcome: 8.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 19) The term axonal transport refers to A) the release of neurotransmitter molecules from the axon. B) the transport of microtubules to the axon for structural support. C) vesicle transport of proteins and organelles down the axon. D) the movement of the axon terminal to synapse with a new postsynaptic cell. E) None of the answers are correct.

: C Section Title: Cells of the Nervous System Learning Outcome: 8.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 95) cells that form supportive capsules around cell bodies

: C Section Title: Cells of the Nervous System Learning Outcome: 8.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 107) supported by satellite cells

: C Section Title: Cells of the Nervous System Learning Outcome: 8.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 26) These glial cells may contribute to Lou Gehrig's disease. A) Schwann cells B) astrocytes C) microglia D) oligodendrocytes E) ependymal cells

: C Section Title: Cells of the Nervous System Learning Outcome: 8.10

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 86) The tip of an embryonic nerve cell's axon is called a A) kissing cone. B) stem tip. C) growth cone. D) growth tip. E) None of the answers are correct.

: C Section Title: Cells of the Nervous System Learning Outcome: 8.10

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 116) result(s) from influx of sodium

: C Section Title: Electrical Signals in Neurons Learning Outcome: 8.3

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 50) Action potentials are primarily associated with the membranes of A) dendrites only. B) cell bodies only. C) axons only. D) dendrites and axons. E) cell bodies and axons.

: C Section Title: Electrical Signals in Neurons Learning Outcome: 8.4

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 141) If the resting axon's membrane becomes more permeable to potassium ions, A) the inside of the membrane will become more positively charged. B) the membrane will depolarize more rapidly. C) it will take a stimulus of larger magnitude to initiate an action potential. D) the hyperpolarization at the end of the action potential will not occur.

: C Section Title: Electrical Signals in Neurons Learning Outcome: 8.4

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 147) What stops the rising phase of the action potential? A) The K+ gate closes. B) The Na+ activation gate opens. C) The Na+ inactivation gate closes. D) The Na+ inactivation gate opens. E) The sodium activation gate closes.

: C Section Title: Electrical Signals in Neurons Learning Outcome: 8.4

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 144) Identify the FALSE statement. A) Under normal conditions, all action potentials in a given cell are identical. B) Between nodes of Ranvier, signal conduction is decremental. C) The amplitude of the action potential depends on the amplitude of the graded potential that precedes it. D) The voltage-gated sodium and potassium channels begin to open during the depolarization.

: C Section Title: Electrical Signals in Neurons Learning Outcome: 8.5

: Level II: Reviewing Concepts (Bloom's Taxonomy: Knowledge) 188) What causes a graded potential to degrade?

: Current leakage across the membrane and resistance of the cytoplasm are two factors. Section Title: Electrical Signals in Neurons Learning Outcome: 8.3

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 4) Information coming into the central nervous system is transmitted along ________ neurons. A) afferent B) sensory C) efferent D) afferent and sensory E) sensory and efferent

: D Section Title: Cells of the Nervous System Learning Outcome: 8.1

: Level II: Reviewing Concepts (Bloom's Taxonomy: Knowledge) 140) In terms of embryonic origin, neurons are most closely related to ________ cells. A) skeletal muscle B) cardiac muscle C) connective tissue D) epithelial

: D Section Title: Cells of the Nervous System Learning Outcome: 8.10

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 151) When comparing action potentials to graded potentials, an/two important distinguishing characteristic/s is/are A) graded potentials can undergo summation. B) action potentials can undergo summation. C) that the rate of action potentials is limited by the refractory period. D) graded potentials can undergo summation and the rate of action potentials is limited by the refractory period. E) action potentials can undergo summation and the rate of action potentials is limited by the refractory period.

: D Section Title: Electrical Signals in Neurons Learning Outcome: 8.3

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 39) Choose all of the items that are incorrectly matched. A) inactivation gate — closed at rest B) activation gate — open at rest C) inactivation gate — closed during repolarization D) activation gate — opens during depolarization E) All of the answers are incorrectly matched.

: D Section Title: Electrical Signals in Neurons Learning Outcome: 8.4

: Level II: Reviewing Concepts (Bloom's Taxonomy: Knowledge) 157) When sodium channels open during an action potential, the opening is caused by A) binding of sodium ions. B) binding of potassium ions. C) presence of calcium. D) presence of positive charge.

: D Section Title: Electrical Signals in Neurons Learning Outcome: 8.4

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 64) Which of the following is NOT a known drug effect on synaptic function? A) interfere with neurotransmitter synthesis B) alter the rate of neurotransmitter release C) prevent neurotransmitter inactivation D) prevent neurotransmitter binding to receptors E) change the type of neurotransmitter found in the synaptic vesicle

: E Section Title: Cell-to-Cell Communication in the Nervous System Learning Outcome: 8.6

: Level IV: Quantitative Problems (Bloom's Taxonomy: Comprehension) 222) Draw a graph showing change in membrane permeability (don't worry about including the units of permeability) to sodium and potassium during the course of an action potential. For reference, superimpose a graph of the action potential.

: Graph should resemble Figure 8.9 in the chapter. Section Title: Electrical Signals in Neurons Learning Outcome: 8.4

: Level IV: Quantitative Problems (Bloom's Taxonomy: Application) 225) Draw graphs showing the effects of hypokalemia and hyperkalemia on action potential production. Don't worry about exact millivolt values - the point is to show that you understand the effects of these conditions relative to normal.

: Graphs should resemble Figure 8.17 in the chapter. Section Title: Electrical Signals in Neurons Learning Outcome: 8.4

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 179) Draw a motor neuron, being sure to include and label the following parts: axon(s), dendrite(s), cell body, axon collateral(s), axon terminal(s), myelin sheath, and other components as applicable.

: See Figure 8.2 in the chapter Section Title: Cells of the Nervous System Learning Outcome: 8.1

: Level II: Reviewing Concepts (Bloom's Taxonomy: Knowledge) 187) What is a channelopathy, and what are some examples?

: See the first "Clinical Focus" box in the chapter. Section Title: Electrical Signals in Neurons Learning Outcome: 8.10

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 134) The absolute refractory period is important in unidirectional propagation of action potentials.

: True Section Title: Electrical Signals in Neurons Learning Outcome: 8.4

: Level II: Reviewing Concepts (Bloom's Taxonomy: Knowledge) 172) Graded potentials that increase the likelihood of an action potential bring the ________ closer to threshold.

: membrane potential Section Title: Electrical Signals in Neurons Learning Outcome: 8.3

: Level II: Reviewing Concepts (Bloom's Taxonomy: Knowledge) 177) Receptors that work through second messenger systems are called ________ receptors.

: metabotropic Section Title: Cell-to-Cell Communication in the Nervous System Learning Outcome: 8.8

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 127) A ________ is a compound that influences a postsynaptic cell's response to a neurotransmitter.

: neuromodulator Section Title: Cell-to-Cell Communication in the Nervous System Learning Outcome: 8.7

: Level II: Reviewing Concepts (Bloom's Taxonomy: Knowledge) 175) For ________ to occur, a second potential must arrive before a previous one has been completed.

: summation Section Title: Integration of Neuronal Information Transfer Learning Outcome: 8.9

: Level II: Reviewing Concepts (Bloom's Taxonomy: Knowledge) 176) When two or more graded potentials arrive at the trigger zone within a short period of time, their effects are additive and ________ occurs.

: summation Section Title: Integration of Neuronal Information Transfer Learning Outcome: 8.9

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 121) The minimum amount of stimulus required to depolarize an excitable membrane and generate an action potential is known as the ________.

: threshold Section Title: Electrical Signals in Neurons Learning Outcome: 8.4

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 106) contribute(s) most to membrane surface area of cell

: A Section Title: Cells of the Nervous System Learning Outcome: 8.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 91) ependymal cells

: A Section Title: Cells of the Nervous System Learning Outcome: 8.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 70) The neurotransmitter thought to be involved in learning and memory is A) norepinephrine. B) glutamate. C) acetylcholine. D) GABA. E) glycine.

: B Section Title: Integration of Neuronal Information Transfer Learning Outcome: 8.7

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 25) These glial cells act as scavengers. A) Schwann cells B) astrocytes C) microglia D) oligodendrocytes E) ependymal cells

: C Section Title: Cells of the Nervous System Learning Outcome: 8.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 61) Which is/are the most common inhibitory neurotransmitter(s) of the CNS? A) GABA only B) glycine only C) glutamate only D) GABA and glycine E) All of the answers are correct.

: D Section Title: Cell-to-Cell Communication in the Nervous System Learning Outcome: 8.6

: Level IV: Quantitative Problems (Bloom's Taxonomy: Analysis) 219) Use the Nernst equation to predict the membrane potential for each ion.

: EK+ = 61 log 150/5 = 90.10 mV, ENa+ = 61 log 175/15 = 65.08 mV, ECl- = -61 log 40/40 = 0 mV Section Title: Electrical Signals in Neurons Learning Outcome: 8.2

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 123) The time during which an excitable membrane cannot respond to further stimulation regardless of the stimulus strength is the ________.

: absolute refractory period Section Title: Electrical Signals in Neurons Learning Outcome: 8.4

: Level IV: Quantitative Problems (Bloom's Taxonomy: Comprehension) 227) Draw graphs showing the effect on action potentials in a cell following effective doses of each of the listed neurotoxins. Assume that the cell is normally brought to threshold by an electrical stimulus applied to it, so that any abnormality is due to the toxin. Precise values for voltage and duration are not important, just a general trend in how the action potential may be different from normal. 1. puffer fish poison (blocks voltage-gated sodium channel activation) 2. tetraethylammonium (blocks voltage-gated potassium channels) 3. ouabain (blocks sodium-potassium pumps) 4. sea anemone toxin (blocks voltage-gated sodium channel inactivation)

: 1. no action potential; membrane potential would show a stimulus pulse that reaches threshold, however 2. prolonged action potential, as repolarization is slowed in absence of potassium efflux; peak may be higher as well 3. normal action potential 4. prolonged action potential, as sodium influx lasts longer; peak may be higher as well Section Title: Cell-to-Cell Communication in the Nervous System Learning Outcome: 8.4

: Level III: Problem Solving (Bloom's Taxonomy: Application) 217) Create diagrams (of the cells) and graphs (of the potentials) to illustrate the two different situations described below in a multipolar neuron with a threshold voltage of 15 mV above resting potential. In each, indicate decrement of graded potentials (by drawing the same GP at different points as it spreads along the neuron), as well as summation. Situation 1: There are three simultaneously active synapses on the multipolar neuron, two producing EPSPs and one an IPSP. At least one of the EPSPs is larger than 15 mV at the synapse. The neuron does NOT generate an action potential. Situation 2: There are two simultaneously active synapses, one producing an EPSP and the other an IPSP. The neuron generates an action potential.

: (Note to instructor: It is best to have demonstrated this in class or on a handout at some time prior to the exam.) Diagrams and graphs should resemble those in Figure 8.7 in the chapter, except that the number of synaptic inputs shown will be greater (see Fig. 8.24), and a set of graphs should be drawn for each input. Diagrams of a multipolar neuron with the different synapses indicated should be produced. There should be a total of three to five synapses, depending on whether or not the student assumes the three synapses described for situation 1 are different from those for situation 2. The graph of summation should resemble Figure 8.24c,d. In situation 1, the student should choose amplitudes that sum to a value below +15 mV (the PSP that was 15 mV at the synapse is smaller when it reaches the trigger zone). In situation 2, the student should choose amplitudes that sum to a value equal to or above +15 mV. Section Title: Integration of Neuronal Information Transfer Learning Outcome: 8.9

: Level III: Problem Solving (Bloom's Taxonomy: Knowledge) 213) Compare and contrast the communication mechanisms between the nervous and endocrine systems. In other words, how do neurons and neurotransmitters signal to their postsynaptic cells, compared to the way endocrine glands and hormones communicate with their target cells?

: (Note to instructor: Students must have already completed the endocrine chapter(s) in order to answer this.) Neurotransmitters usually do not enter the cell, thus must combine with receptors on the membrane, using mechanisms similar to the amino acid-derivative hormones. Similarities include opening channels in the postsynaptic cell membrane, leading to depolarization of the neuron. In endocrine target cells, the arrival of the stimulus begins a different sequence of events, such as triggering an enzyme cascade, and second messenger systems. Section Title: Cell-to-Cell Communication in the Nervous System Learning Outcome: 8.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 92) astrocytes

: A Section Title: Cells of the Nervous System Learning Outcome: 8.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 99) cells that are a source of neural stem cells

: A Section Title: Cells of the Nervous System Learning Outcome: 8.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 20) Anterograde and retrograde axonal transport are forms of ________ transport. A) fast B) slow C) Neither of these

: A Section Title: Cells of the Nervous System Learning Outcome: 8.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 31) Which ion(s) is/are higher in concentration inside the cell compared to outside? A) potassium B) sodium C) chloride D) calcium E) More than one of the answers is correct.

: A Section Title: Electrical Signals in Neurons Learning Outcome: 8.2

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 48) In the membrane of a resting nerve cell, when chemically gated Cl- channels open, A) Cl- ions enter the cell. B) Cl- ions leave the cell. C) the cell becomes depolarized. D) Cl- ions enter the cell and the cell becomes depolarized. E) Cl- ions leave the cell and the cell becomes depolarized.

: A Section Title: Electrical Signals in Neurons Learning Outcome: 8.2

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 115) size increases if stimulus strength increases

: A Section Title: Electrical Signals in Neurons Learning Outcome: 8.3

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 56) The term hyperkalemia specifically indicates too much potassium in which fluid compartment? A) blood B) intracellular C) interstitial D) extracellular E) All of the answers are correct.

: A Section Title: Electrical Signals in Neurons Learning Outcome: 8.3

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 42) All of the following must occur before a second action potential can begin, EXCEPT A) the Na+ and K+ ions that moved in/out of the cell must move back to their original compartments. B) the Na+ inactivation gate must open and the Na+ activation gate must close. C) the absolute refractory period must occur. D) the Na+ and K+ ions that moved in/out of the cell must move back to their original compartments; the Na+ inactivation gate must open; and the Na+ activation gate must close. E) None of the answers are correct.

: A Section Title: Electrical Signals in Neurons Learning Outcome: 8.4

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 36) The rising phase of the action potential is due to A) Na+ flow into the cell only. B) Na+ flow out of the cell only. C) K+ flow out of the cell only. D) K+ flow into the cell only. E) Na+ flow out of the cell and K+ flow into the cell.

: A Section Title: Electrical Signals in Neurons Learning Outcome: 8.4

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 143) How would the absolute refractory period be affected if voltage-gated sodium channels remained inactivated? A) It would be longer than normal. B) It would be shorter than normal. C) It would be the same whether the channels remained inactivated or not. D) None of the answers are correct.

: A Section Title: Electrical Signals in Neurons Learning Outcome: 8.4

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 163) The basis of neural integration is A) addition of postsynaptic potentials overlapping in time and space. B) command signals from central pattern generators. C) spontaneous activity in pacemaker neurons. D) the area under the curve of postsynaptic potentials overlapping in time and space.

: A Section Title: Integration of Neuronal Information Transfer Learning Outcome: 8.9

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 6) The brain and spinal cord together compose the A) central nervous system. B) autonomic division system. C) somatic motor division of the nervous system. D) peripheral nervous system. E) visceral nervous system.

: A Section Title: Organization of the Nervous System Learning Outcome: 8.1

: Level III: Problem Solving (Bloom's Taxonomy: Application) 206) A compound action potential is recorded using electrodes on a nerve. How does a nerve differ from an axon? Amplitude and duration of a compound action potential vary according to the stimulus intensity applied to the nerve. Given that there is no such variation in the action potential of a single axon, how can you explain this?

: A nerve consists of many axons. A regular action potential is produced by a single axon, whereas a compound action potential is recorded by equipment from a nerve when multiple axons are producing action potentials, and the voltages add together. Increasing stimulus intensity increases the number of axons contributing to the compound action potential. This is because different axons have different threshold voltages, so increasing the voltage stimulates a larger number of axons. Section Title: Electrical Signals in Neurons Learning Outcome: 8.3

: Level II: Reviewing Concepts (Bloom's Taxonomy: Knowledge) 160) The following are steps involved in transmission at the cholinergic synapse: 1. Chemically regulated ion channels on the postsynaptic membrane are activated. 2. Calcium ions enter the axon terminal. 3. An action potential depolarizes the axon terminal at the presynaptic membrane. 4. Acetylcholine is released from storage vesicles by exocytosis. 5. Acetylcholine binds to receptors on the postsynaptic membrane. The correct sequence for these events is A) 4, 2, 1, 5, 3 B) 3, 2, 4, 5, 1 C) 2, 4, 1, 3, 5 D) 2, 5, 4, 1, 3 E) 1, 2, 3, 4, 5

: B Section Title: Cell-to-Cell Communication in the Nervous System Learning Outcome: 8.6

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 182) Compare and contrast action and graded potentials. Your answer should include a definition of each, types, characteristics, ionic basis, functions, and anything else necessary to answer the question.

: Action potentials are stereotyped changes in axon membrane potential that function in long-distance communication between neurons and their target cells. Graded potentials are variable membrane potential changes, usually in dendrites of multipolar neurons, that function in either short-distance communication or changing the probability of an action potential. Action potentials result from opening of voltage-regulated ion channels, which occurs at or above a threshold voltage. Graded potentials are not regenerative and result from the opening of ion channels in response to neurotransmitter or a specific stimulus such as sound or odor, in the case of sensory receptors. The rising phase results from influx of sodium, and the falling phase from efflux of potassium. Other characteristics include the after-hyperpolarization, all-or-none nature, conduction without decrement, independence of amplitude and duration from stimulus strength, refractory period, faster velocity in larger diameter or in myelinated axons. Graded potentials can be depolarizing, if the ion channel is a sodium channel, or hyperpolarizing in the case of potassium or chloride channels. Depolarizations increase the probability that threshold voltage will be attained and an action potential will result. Hyperpolarizations decrease the probability of a resulting action potential. Amplitude and duration are proportional to stimulus intensity, and graded potentials are conducted with decrement. Section Title: Electrical Signals in Neurons Learning Outcome: 8.3

: Level III: Problem Solving (Bloom's Taxonomy: Analysis) 203) In a laboratory situation, a nerve can be stimulated by applying voltage from a stimulator. If a stimulus was applied in the middle of a nerve roughly halfway between the cell bodies and the axon terminals, would resulting action potentials travel only from the stimulus point to the axon terminal? Why or why not? How is this similar to or different from the basic characteristics of an action potential discussed in this chapter? What does this tell you about the nature of the axon?

: Action potentials would travel in both directions from the stimulus point, simultaneously toward the cell bodies and toward the axon terminals. This is because the axon segments on each side of the stimulus point are presumably not refractory when the stimulus is delivered, thus there is nothing to prevent the action potentials from traveling in both directions. In normal transmission, the action potential begins where the axon starts, and travels only away from that point, not toward, because the membrane becomes refractory for a period of time after the action potential occurs. Thus, the axon is quite capable of transmitting action potentials in either direction, even though normally it is prevented from doing so. Section Title: Electrical Signals in Neurons Learning Outcome: 8.5

: Level II: Reviewing Concepts (Bloom's Taxonomy: Knowledge) 190) If both Na+ and K+ channels are activated by depolarization, why do we see more Na+ flux during the rising phase of an action potential?

: Although both channels are activated by depolarization, the Na+ channels open quickly allowing rapid Na+ entry into the cell. The peak of Na+ permeability coincides with the peak of the action potential, while the K+ channels open more slowly and don't reach their peak ion permeability until the falling phase of the action potential. Section Title: Electrical Signals in Neurons Learning Outcome: 8.4

: Level II: Reviewing Concepts (Bloom's Taxonomy: Knowledge) 178) Briefly explain the gross organization of the nervous system in either paragraph form or using a concept map. Be sure to discuss the central, peripheral, and enteric nervous system and the divisions and branches discussed in the text.

: Answers will vary.There are three divisions: the central nervous system (CNS), the peripheral nervous system (PNS), and the enteric nervous system. The CNS consists of the brain and spinal cord and acts as the integrating center for neural reflexes. The brain is also where thoughts and consciousness are formed. The PNS includes the afferent branch, which monitors the internal and external environment and sends signals to the CNS, and the efferent branch, which carries signals from the CNS to effector cells throughout the body. Within the efferent branch, there is the somatic motor division, which controls skeletal muscle, and the autonomic division. The autonomic division, or visceral nervous system, controls the smooth and cardiac muscles and exo- and endocrine glands. It is further divided into the sympathetic and parasympathetic branches. Section Title: Organization of the Nervous System Learning Outcome: 8.1

: Level III: Problem Solving (Bloom's Taxonomy: Comprehension) 196) If potassium channels in a neuron were blocked, would it be possible to produce an action potential? If so, describe the probable appearance of these components of a graph: threshold, rising phase, peak, falling phase, undershoot. If not, explain.

: Assuming sodium channels are functioning normally, there would still be an action potential. Threshold would be unaffected, because it is a property of sodium channels. A peak voltage will be reached when the sodium channels become inactivated; this voltage may be higher than normal since usually there is a partial canceling of the rising voltage as potassium exits. Without a potassium current, the falling phase would be much slower, being dependent on the sodium-potassium pump removing the sodium ions that came in. The undershoot would be absent because it is a result of potassium current. Section Title: Electrical Signals in Neurons Learning Outcome: 8.4

: Level III: Problem Solving (Bloom's Taxonomy: Comprehension) 215) A lab technician has inadvertently substituted lithium for sodium in a solution of saline for use by students in neurophysiology labs. If a frog nerve was bathed in this solution, what would happen upon stimulation of the nerve?

: Assuming the specificity of the voltage-regulated sodium and potassium channels is absolute, the axons will be unable to generate action potentials. The sodium channels will open and close, but there will be no ionic current through them. The students will still see hyperpolarization, as the potassium efflux should be unaffected by lithium. Section Title: Electrical Signals in Neurons Learning Outcome: 8.4

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 57) A chemical synapse ALWAYS includes ________. 1. axon terminal 2. presynaptic cell 3. synaptic cleft 4. postsynaptic cell 5. dendrite A) 1, 2, 3, 4, 5 B) 1, 2, 3, 4 C) 2, 3, 4 D) 2, 3, 4, 5 E) 1, 3, 4

: B Section Title: Cell-to-Cell Communication in the Nervous System Learning Outcome: 8.6

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) Match the part of the neuron to its description (answers may be used more than once). A. dendrites B. axon C. cell body 102) may be covered with myelin

: B Section Title: Cells of the Nervous System Learning Outcome: 8.1

: Level IV: Quantitative Problems (Bloom's Taxonomy: Application) 229) Explain the roles that the AMPA and NMDA receptors play in long-term potentiation.

: Both AMPA and NMDA receptors are located on the postsynaptic cells (dendrites) and require binding of the excitatory neurotransmitter glutamate for activation. When glutamate binds to the AMPA receptor, the channel opens and Na enters the cell. This causes depolarization of the immediate postsynaptic cell or dendrite. This depolarization causes Mg2+ ions to be "kicked out" of the NMDA receptor channel; hence, Mg2+ is no longer acting as a channel blocker. If at the same time glutamate is bound to the NMDA receptor then the channel gate is open and Ca2+ enters the cell. The entry of Ca2+ triggers 2nd messenger pathways that results in an increase in the number of glutamate receptors inserted into the post-synaptic membrane. This increases the probability of an increase in the postsynaptic response or depolarization to glutamate that is referred to as long-term potentiation. Section Title: Integration of Neuronal Information Transfer Learning Outcome: 8.9

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 185) Compare and contrast Schwann cells and oligodendrocytes.

: Both insulate axons by creating myelin. Schwann cells, found in the PNS, are associated with a single axon. One axon may have many Schwann cells wrapped around it leaving small gaps of unmyelinated areas called nodes of Ranvier. Oligodendrocytes are found in the CNS and form myelin around portions of several axons. Section Title: Cells of the Nervous System Learning Outcome: 8.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 34) The total amount of neurotransmitter released at the axon terminal is directly related to A) the amplitude of the action potential. B) the length of the axon. C) the total number of action potentials. D) the amplitude of the graded potential.

: C Section Title: Cell-to-Cell Communication in the Nervous System Learning Outcome: 8.6

: Level II: Reviewing Concepts (Bloom's Taxonomy: Application) 167) Inhibition of neural activity can result from A) presynaptic events only. B) postsynaptic events only. C) presynaptic events and postsynaptic events.

: C Section Title: Cell-to-Cell Communication in the Nervous System Learning Outcome: 8.6

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 153) When more action potentials arrive at the axon terminal, how is the postsynaptic cell affected? A) Neurotransmitter release increases, but does not change the graded potentials that follow. B) Neurotransmitter release does not change, thus the postsynaptic cell behaves the same way it always behaves. C) Neurotransmitter release increases, thereby increasing the frequency or magnitude of graded potentials in the postsynaptic cell. D) Neurotransmitter release does not change, but voltages applied to the postsynaptic cell increase.

: C Section Title: Cell-to-Cell Communication in the Nervous System Learning Outcome: 8.6

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 65) The site of information integration in the nervous system is the A) chemical synapse. B) electrical synapse. C) trigger zone. D) dendritic membrane. E) axon terminal.

: C Section Title: Cell-to-Cell Communication in the Nervous System Learning Outcome: 8.9

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 13) The multiple thin, branched structures on a neuron whose main function is to receive incoming signals are the A) cell bodies. B) axons. C) dendrites. D) somata. E) None of the answers are correct.

: C Section Title: Cells of the Nervous System Learning Outcome: 8.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 17) Branches that sometimes occur along the length of an axon are called A) dendrites. B) axon terminals. C) collaterals. D) axon hillocks. E) synapses.

: C Section Title: Cells of the Nervous System Learning Outcome: 8.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 10) In general, the nervous system is composed of which two types of cells? 1. motor 2. neurons 3. sensory 4. glial 5. associative A) 1 and 2 B) 1 and 3 C) 2 and 4 D) 3 and 4 E) 3 and 5

: C Section Title: Cells of the Nervous System Learning Outcome: 8.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 104) occupy(ies) the least amount of cell volume

: C Section Title: Cells of the Nervous System Learning Outcome: 8.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 105) make(s) proteins necessary for repair of damaged neuron

: C Section Title: Cells of the Nervous System Learning Outcome: 8.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 11) The cell body of neurons is generally A) 90% of the cell volume. B) 50% of the cell volume. C) 10% of the cell volume. D) found in the same position on every neuron.

: C Section Title: Cells of the Nervous System Learning Outcome: 8.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 15) The region where the axon terminal meets its target cell is called the A) collateral. B) hillock. C) synapse. D) nerve. E) dendrites.

: C Section Title: Cells of the Nervous System Learning Outcome: 8.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 12) Interneurons are found A) only in the brain. B) only in the spinal cord. C) only in the CNS. D) throughout the nervous system. E) only in spinal nerves.

: C Section Title: Cells of the Nervous System Learning Outcome: 8.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 35) Which of the following is the most common location where action potentials originate? A) dendrites B) cell body C) axon hillock D) synaptic cleft E) synaptic bouton

: C Section Title: Cells of the Nervous System Learning Outcome: 8.3

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 55) The major determinant of the resting potential of all cells is A) Ca2+ concentration in the blood and interstitial fluid. B) Na+ concentration in the blood and interstitial fluid. C) K+ gradient between the blood and interstitial fluid. D) K+ concentration inside cells. E) Na+ concentration inside cells.

: C Section Title: Electrical Signals in Neurons Learning Outcome: 8.2

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 37) The falling phase of the action potential is due primarily to A) Na+ flow in the cell only. B) Na+ flow out of the cell only. C) K+ flow out of the cell only. D) K+ flow into the cell only. E) Na+ flow out of the cell and K+ flow into the cell.

: C Section Title: Electrical Signals in Neurons Learning Outcome: 8.4

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 69) In response to binding a neurotransmitter, a postsynaptic cell can A) only open chemically gated ion channels, causing graded potentials known as fast synaptic potentials. B) only close ion channels via G proteins and second messenger systems, producing slow responses. C) only regulate protein synthesis and affect the metabolic activities of the postsynaptic cell. D) open chemically gated ion channels, causing graded potentials known as fast synaptic potentials and regulate protein synthesis and affect the metabolic activities of the postsynaptic cell. E) open chemically gated ion channels, causing graded potentials known as fast synaptic potentials, close ion channels via G proteins and second messenger systems, producing slow responses, and regulate protein synthesis and affect the metabolic activities of the postsynaptic cell.

: E Section Title: Cell-to-Cell Communication in the Nervous System Learning Outcome: 8.8

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 14) The collection of axons that carries information between the central nervous system and the peripheral effectors is called the A) axon hillock. B) varicosity. C) axon. D) dendrite. E) nerve.

: E Section Title: Cells of the Nervous System Learning Outcome: 8.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 22) Glial cells A) only provide structural and metabolic support. B) only guide neurons during growth and repair. C) only help maintain homeostasis of the brain's extracellular fluid. D) provide structural and metabolic support and help maintain homeostasis of the brain's extracellular fluid. E) All of the answers are correct.

: E Section Title: Cells of the Nervous System Learning Outcome: 8.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 3) Neurotransmitter is stored and released from A) axon terminals only. B) axon varicosities only. C) dendritic spines only. D) cell bodies only. E) axon terminals and axon varicosities.

: E Section Title: Cells of the Nervous System Learning Outcome: 8.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 97) cells in the CNS that form myelin

: E Section Title: Cells of the Nervous System Learning Outcome: 8.1

: Level II: Reviewing Concepts (Bloom's Taxonomy: Application) 139) These CNS glial cells may be a source of treatment for neural degenerative disorders. A) Schwann cells B) astrocytes C) microglia D) oligodendrocytes E) ependymal cells

: E Section Title: Cells of the Nervous System Learning Outcome: 8.10

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 32) The channelopathy known as QT syndrome is a result of mutation in ________ channels. A) sodium B) potassium C) calcium D) chloride E) sodium, potassium, or calcium

: E Section Title: Electrical Signals in Neurons Learning Outcome: 8.2

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 53) Graded potentials may A) initiate an action potential. B) depolarize the membrane to the threshold voltage. C) hyperpolarize the membrane. D) be called EPSPs or IPSPs. E) All of the statements are true.

: E Section Title: Electrical Signals in Neurons Learning Outcome: 8.3

: Level II: Reviewing Concepts (Bloom's Taxonomy: Knowledge) 158) The primary problem in hyperkalemia is A) that neurons are harder to excite because their resting potential is hyperpolarized. B) that neurons are hyperexcitable because their resting potential is closer to threshold. C) that neurons respond too quickly to smaller graded potentials. D) neurons are harder to excite because their resting potential is hyperpolarized and neurons respond too quickly to smaller graded potentials. E) neurons are hyperexcitable because their resting potential is closer to threshold and neurons respond too quickly to smaller graded potentials.

: E Section Title: Electrical Signals in Neurons Learning Outcome: 8.3

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 149) During the relative refractory period, an initial threshold-level depolarization is usually not sufficient to trigger an action potential. Why? A) Only some Na+ channels have returned to their resting position. B) Only K+ channels are still open, so Na+ entry is offset by K+ loss. C) Only a few K+ channels have returned to their resting position. D) The statement is incorrect; a threshold-level depolarization always triggers an action potential. E) Some Na+ channels have returned to their resting position and K+ channels are still open, so Na+ entry is offset by K+ loss.

: E Section Title: Electrical Signals in Neurons Learning Outcome: 8.4

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 54) Some neurotoxins work essentially the same way as some local anesthetics, which is to A) inactivate the enzyme that destroys the neurotransmitter only. B) bind to Na+ channels and inactivate them only. C) prevent depolarization by blocking Na+ entry into the cell only. D) inactivate the enzyme that destroys the neurotransmitter and bind to Na+ channels and inactivate them. E) bind to Na+ channels and inactivate them and prevent depolarization by blocking Na+ entry into the cell.

: E Section Title: Electrical Signals in Neurons Learning Outcome: 8.5

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Comprehension) 76) Presynaptic facilitation makes a pathway A) less likely to be in use, just through hyperpolarization of selected neurons. B) more likely to be in use, just through depolarization of selected neurons. C) capable of alteration, just through training and conditioning. D) less likely to be in use, just through hyperpolarization of selected neurons and capable of alteration, just through training and conditioning. E) more likely to be in use, just through depolarization of selected neurons and capable of alteration, just through training and conditioning.

: E Section Title: Integration of Neuronal Information Transfer Learning Outcome: 8.9

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 75) When two or more graded potentials arrive at the trigger zone, which of the following could happen? A) An excitatory and inhibitory signal can cancel each other out. B) Two excitatory stimuli may be additive, and summation could occur. C) Two inhibitory stimuli may be additive, resulting in lower excitability. D) An excitatory and inhibitory signal can cancel each other out and two excitatory stimuli may be additive, and summation could occur. E) An excitatory and inhibitory signal can cancel each other out; two excitatory stimuli may be additive, and summation could occur; and two inhibitory stimuli may be additive, resulting in lower excitability.

: E Section Title: Integration of Neuronal Information Transfer Learning Outcome: 8.9

: Level III: Problem Solving (Bloom's Taxonomy: Comprehension) 199) Compare and contrast the EPSP, IPSP, and action potential as to ions involved, all-or-none law application, specific cellular locations, and specific cell types involved.

: EPSPs and IPSPs are graded potentials in postsynaptic cells resulting from the action of neurotransmitters at synapses, which are usually on dendrites of multipolar neurons, but could also be on the synaptic region of any target cell. EPSPs increase the probability that a postsynaptic action potential will result, because they involve an influx of sodium, which depolarizes the membrane potential, bringing it closer to threshold. IPSPs decrease the probability that a postsynaptic action potential will result, because they involve either an influx of chloride or an efflux of potassium, either of which hyperpolarizes the membrane potential, moving it farther from threshold. Action potentials occur in axons of neurons, or in muscle cell membranes. They may result from PSPs or in the case of sensory neurons, specific stimuli such as sound or odor, which cause a type of graded potential called a receptor potential. Action potentials begin when graded potentials depolarize the membrane potential to threshold. The rising phase of an action potential results from sodium influx, and the falling phase from potassium efflux. Action potentials, but not graded potentials, are an all-or-none phenomenon. Section Title: Integration of Neuronal Information Transfer Learning Outcome: 8.6

: Level II: Reviewing Concepts (Bloom's Taxonomy: Knowledge) 180) Why are mitochondria necessary at axon terminals?

: Energy is required in order to move synaptic vesicles to the cell membrane. Section Title: Cells of the Nervous System Learning Outcome: 8.6

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 94) specialized immune cells that are confined to the CNS

: F Section Title: Cells of the Nervous System Learning Outcome: 8.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) 132) The gaps between Schwann cells are called synapses.

: False, nodes of Ranvier Section Title: Cells of the Nervous System Learning Outcome: 8.1

: Level I: Reviewing Facts and Terms (Bloom's Taxonomy: Knowledge) Indicate true or false. If FALSE, substitute a word or phrase for the boldfaced word(s) that will make the statement TRUE. 131) Schwann cells are the primary type of glial cell associated with the central nervous system.

: False, peripheral nervous system Section Title: Cells of the Nervous System Learning Outcome: 8.1

: Level II: Reviewing Concepts (Bloom's Taxonomy: Knowledge) 192) "A refractory period occurs following all types of potentials." Is this statement TRUE or FALSE? What structures are actually refractory? Why or why not?

: False. The refractory period occurs after action potentials and is a distinguishing characteristic, and results from properties of the voltage-gated sodium channels. Graded potentials do not involve channels that have refractory periods. Two stimuli that reach a dendrite at nearly the same time will increase the graded potential produced, whereas if two suprathreshold depolarizations reach the trigger zone at nearly the same time, the first will cause an action potential and the second will be ignored, because of the refractory period. Section Title: Electrical Signals in Neurons Learning Outcome: 8.4

: Level III: Problem Solving (Bloom's Taxonomy: Analysis) 202) Polio is an uncommon disease in most developed countries, but prior to widespread use of the polio vaccine, it was very common. Polio is caused by a virus that infects somatic motor neurons and destroys them. From this information, would you expect a polio victim to lose sensation, motor control, other organ function, and/or cognitive function? Explain. While most victims of polio survive, some do not. What is the most likely cause of death?

: If only motor neurons are affected, the primary result should be paralysis or inability to control skeletal muscles. Because respiration involves skeletal muscles, some victims die of suffocation. Section Title: Cells of the Nervous System Learning Outcome: 8.1

: Level IV: Quantitative Problems (Bloom's Taxonomy: Application) 228) Draw graphs showing the effects on action potentials in a postsynaptic cell of effective doses for each of the listed toxins. Assume that the cell is normally brought to threshold by the stimuli applied to its inputs, so that any abnormality is due to the toxin. 1. curare (prevents receptor from binding neurotransmitter) 2. botulinum toxin (prevents neurotransmitter release)

: In both cases, action potential is prevented, because the postsynaptic potential is blocked. Membrane potential would remain at resting potential, because even a subthreshold postsynaptic potential fails to appear in the absence of neurotransmitter action. Section Title: Cell-to-Cell Communication in the Nervous System Learning Outcome: 8.6

: Level IV: Quantitative Problems (Bloom's Taxonomy: Comprehension) 223) Draw a graph showing what would happen to resting membrane potential over time, if the sodium/potassium pump were not functioning. How would this affect a neuron's ability to produce action potentials? What does this imply about the quantity of ions that normally cross the membrane during the course of an action potential?

: It would be appropriate for the student to draw action potentials on the graph beginning at the point where the resting potential drifts up to threshold, and decreasing in frequency as the resting potential approaches. Very gradually, a cell's resting membrane potential would increase until it reached and stabilized there. At that point the ions would be in equilibrium, and no further net flow of charge would occur. There would be no effect on ability to generate action potentials initially, but with the disappearance of the differential distribution of sodium and potassium upon which the action potential depends, action potentials would gradually come to a stop. This points out the fact that during any single action potential, so few ions cross the membrane that there is no significant change in ion concentrations. Thousands of action potentials would be required before the absence of the sodium-potassium pumps would be noticeable. Section Title: Electrical Signals in Neurons Learning Outcome: 8.4

: Level III: Problem Solving (Bloom's Taxonomy: Application) 205) Your study partner in your physiology class insists that axons conduct graded potentials, and that they play a vital role in production of the action potential. Do you agree or disagree? Defend your answer.

: Your study partner is correct. This is easiest to explain in the context of the myelinated axon. Voltage-regulated ion channels, which produce the action potential, are located only at nodes of Ranvier. This means that the intervening regions do not generate action potentials. After an action potential is produced at one node, the ions diffuse from this node to the next in a decremental manner, but produce sufficient depolarization at the next node to produce an action potential there. Section Title: Cells of the Nervous System Learning Outcome: 8.3

: Level IV: Quantitative Problems (Bloom's Taxonomy: Application) 218) We have finally discovered life on Venus. NASA scientists are investigating a newly discovered life form: a single-celled organism found in the swampy canals. You have been contracted by NASA to perform an electrophysiology study. Using intracellular electrodes to measure the electrical charge inside the cell, you find it has a resting membrane potential of -45 mV when the outside fluid is arbitrarily set to 0 mV. Additionally, you have determined ion concentrations and listed them below. [ ] in mOsm/L Cell Swamp K+ 5 150 Na+ 15 175 Cl- 40 40 For fun, you have used new molecular biology techniques to insert protein channels into the cell membrane that allow only Na+ and Cl- to pass. Predict which ion(s) will move. Tell what direction it (they) will move and what force(s) is/are acting on it (them).

: K+ cannot move because, without potassium channels, the membrane is not permeable to it. Na+ will move into the cell because both its chemical and electrical gradients favor movement in. Cl- leaves the cell due to the electrical gradient (the negative resting potential repels it). Section Title: Electrical Signals in Neurons Learning Outcome: 8.2

: Level III: Problem Solving (Bloom's Taxonomy: Application) 210) In multiple sclerosis, there is progressive and intermittent damage to the myelin sheath of central axons. One symptom is poor motor control of the affected area. Why does destruction of the myelin sheath affect motor control?

: Loss of myelin slows or stops impulse conduction, preventing descending tracts from regulating spinal motor neurons, and leading to loss of coordination and the ability to correct for gravity, movement, and so on. Section Title: Electrical Signals in Neurons Learning Outcome: 8.5

: Level III: Problem Solving (Bloom's Taxonomy: Application) 212) What factors determine the maximum frequency of action potentials conducted by an axon?

: Maximum frequency is mostly dependent upon the duration of the absolute refractory period, which determines the upper limit. The diameter of the axon, amount of myelination present, and the magnitude of the Na+ and K+ gradients across the axonal membrane all affect action potential velocity may also play a secondary role. Section Title: Electrical Signals in Neurons Learning Outcome: 8.4

: Level III: Problem Solving (Bloom's Taxonomy: Analysis) 216) Explain the differences in axon regeneration in the CNS and PNS, and the implications for recovery from injury. What experiments might scientists try based on these differences?

: Schwann cells, present in the PNS but not the CNS, facilitate regrowth of severed axons. This means that people do not recover as well from CNS injury compared to PNS injury. It is possible that there is something fundamentally different in CNS axons compared to PNS axons that accounts for this effect. To test for this, Schwann cells could be transplanted into the spinal cord or brain and CNS axons observed for regrowth. Such experiments have been done, and it is the case that CNS axons are capable of regrowth in the presence of Schwann cells. Identification of chemical or physical factors in the Schwann cells would advance this field of research. Section Title: Electrical Signals in Neurons Learning Outcome: 8.1

: Level III: Problem Solving (Bloom's Taxonomy: Comprehension) 200) Define temporal and spatial summation. Where does the summation occur? Are these processes mutually exclusive, or can they occur at the same time in a typical multipolar neuron? What key property of neurons do these forms of summation demonstrate?

: See Figs. 8.24 and 8.25 in the chapter. Temporal summation is the addition of graded potentials that overlap in time; that is, a second potential arrives before the first one from that source has finished. Spatial summation occurs when there is simultaneous arrival of graded potentials originating from more than one synaptic input. Summation occurs at the trigger zone. Typically a multipolar neuron has many active synapses at a given time, with multiple potentials being produced at each. Summation demonstrates postsynaptic integration. Section Title: Integration of Neuronal Information Transfer Learning Outcome: 8.9

: Level III: Problem Solving (Bloom's Taxonomy: Comprehension) 211) Multiple sclerosis (MS) is one of the better known diseases resulting from demyelination of axons (in MS, only CNS axons are affected). Some of the earliest symptoms of the disease are difficulty in focusing the eyes, such as in reading, and difficulty in maintaining balance, and frequently not being able to make adjustments in posture to avoid falling. How do these symptoms "fit" with what you know about nerve impulses, myelin sheaths, and the location of gated ion channels in the membranes of axons?

: Symptoms listed all involve loss of motor control. The CNS axons involved in initiating and controlling movement are generally myelinated, thus loss of myelination slows or eliminates conduction of action potentials in these cells. Early on, many signals arrive normally at spinal motor neurons to produce movement, but enough signals are missing to cause noticeable alterations in motor control. In other words, loss of myelin slows or stops impulse conduction and leads to loss of coordination and the ability to correct for gravity, movement, and so on. Gated ion channels should be intact at the nodes of Ranvier, but missing elsewhere along the axon. Nodes are generally far enough apart that without myelin, sufficient positive current from one active node does not arrive at the next node to bring it to threshold as quickly as normal or at all, and impulse conduction slows or stops. Section Title: Electrical Signals in Neurons Learning Outcome: 8.5

: Level III: Problem Solving (Bloom's Taxonomy: Comprehension) 208) How do the following relate to nervous system development and/or healing? Synaptic plasticity, neuroglia, neurotrophic factors.

: Synaptic plasticity is the changeability of synapses, necessary for development and continued learning in the nervous system. Neuroglia play an important role in healing of damaged neural tissue. Schwann cells in the PNS facilitate regrowth of severed axons. CNS glia seal off and scar a damaged region. Neurotrophic factors are important in maintaining active synapses. Section Title: Cells of the Nervous System Learning Outcome: 8.6

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 195) Discuss the membrane permeabilities of major ions and how they contribute to the overall resting membrane potential of neurons.

: The average resting membrane potential is -70 mV. It is primarily determined by the concentration gradient of K+ and the membrane permeabilities of K+, Na+, and Cl-. The equilibrium potential for K+ predicted by the Nernst equation is -90 mV. The resting membrane potential is more permeable to K than Na. However, because the cell's resting potential is more positive than -90mV there must be another contributing ion, and it is the Na+ leak channels that allow positive Na+ ions into the cell which cause the resting potential to be slightly more positive. Section Title: Electrical Signals in Neurons Learning Outcome: 8.2

: Level III: Problem Solving (Bloom's Taxonomy: Comprehension) 197) Explain why the voltage-gated Na+ channels can close while the cell is depolarized even though the depolarization was the initial stimulus for the channel opening. Include a discussion on refractory periods and explain why action potentials travel in only one direction.

: The channels have two gates: activation and inactivation gates. (See Fig. 8.10.) At rest, the activation gate is closed and the inactivation gate is open. Upon depolarization both gates move: the activation gate opens allowing Na+ to enter the cell and the inactivation gate (with a delay of 0.5 msec) closes stopping the influx of Na+. At this point during the action potential, the peak has been reached and repolarization occurs due to the K+ ions leaving the cell. During this time, even if another wave of depolarization occurred, the Na+ channels cannot be opened because the activation gate is already open and the inactivation gate is closed. This is the absolute refractory period, when another action potential absolutely cannot occur because the Na+ channels have not reset to their original positions. The relative refractory period occurs after some of the Na+ channels have reset, but a higher than normal depolarizing graded potential is necessary to cause another action potential. Refractory periods also explain why action potentials cannot move backward. (See Fig. 8.15.) The part of the axon experiencing the action potential has open Na+ channels. An increase in Na+ inside the cell causes depolarization and perpetuates the action potential toward the axon terminal due to local current flow. The area of the axon toward the trigger zone, where the action potential (AP) occurred a moment earlier, is in the absolute refractory period and will not experience another action potential even with a depolarization. Section Title: Electrical Signals in Neurons Learning Outcome: 8.4

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 181) Why is it necessary for fast axonal transport to go both forward and backward?

: The organelles and cellular components transported to the axon terminal must also be returned to the cell body for recycling. Fast retrograde recycling may also be used for nerve growth factor transport to the cell body. Section Title: Cells of the Nervous System Learning Outcome: 8.10

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 191) What is the trigger zone? Where is the trigger zone found in efferent, afferent, and interneurons? Do the terms trigger zone and axon hillock have the same meaning? Explain.

: The trigger zone is an area of the neuron that contains a high membrane concentration of voltage-gated Na+ channels and is near an area that lacks these. In order for action potentials to occur, graded potentials reaching the trigger zone must depolarize the membrane to the threshold voltage. In efferent and interneurons, the trigger zone is the axon hillock (also called the initial segment). In afferent neurons, the trigger zone is located where the dendrites join the axon (immediately adjacent to the receptor), rather than at the axon hillock. The axon hillock is an anatomical region, whereas the trigger zone is defined by its function rather than its location. Section Title: Electrical Signals in Neurons Learning Outcome: 8.4

: Level II: Reviewing Concepts (Bloom's Taxonomy: Comprehension) 186) Write out the Nernst and GHK equations, and explain the significance of each. Define equilibrium potential.

: This is discussed in the "Electrical Signals in Neurons" section of the chapter. The Nernst equation is used to calculate the equilibrium potential for individual ions, while the GHK equation calculates the predicted resting membrane potential of a cell. The equilibrium potential is the voltage at which there is no net movement of a particular ion across the membrane, because the force of the concentration gradient is exactly balanced by the force of the electrical gradient. Section Title: Electrical Signals in Neurons Learning Outcome: 8.2

: Level III: Problem Solving (Bloom's Taxonomy: Comprehension) 201) Your study partner has concluded that a single action potential, once initiated, spreads down the length of an axon, non-decrementally; similarly, a single graded potential spreads down the length of a dendrite, but with decrement. Is she completely correct? Explain. How can the mechanism of decremental and non-decremental conduction help her sort this out? How is the process different in myelinated vs. unmyelinated neurons? How may the dominoes analogy help her to understand signal propagation?

: While she is correct about graded potentials, she is incorrect about action potentials. A GP is initiated at a synapse, for example, and spreads in all directions but loses strength as the ions diffuse; no additional ions are crossing the membrane to boost this signal. An AP is initiated at a trigger zone, then a second, identical AP is triggered in the next patch of membrane as more ions enter the cell; thus, there was no decrement of the AP. Between membrane patches, the signal is decremental for the same reasons that GPs decrease with spread, but sufficient to stimulate the next AP. In myelinated axons, the subsequent APs are farther apart than in unmyelinated axons. A row of dominoes, if spaced appropriately, can be felled by pushing on just the first one. That domino falls and does not spread to the end of the row, but it causes its neighboring, identical domino to fall, and so on. Section Title: Electrical Signals in Neurons Learning Outcome: 8.5

: Level III: Problem Solving (Bloom's Taxonomy: Application) 204) Dr. Zoydburger has discovered a toxin produced in the venom of a poisonous marine invertebrate. Tests on lab mammals indicate that this toxin prevents sodium channel inactivation. How would this affect the action potentials produced in the neurons of a poisoned mammal?

: Without sodium channel inactivation, the action potential would not repolarize as quickly, thus any function dependent upon the action potential would be prolonged, including neurotransmitter release and postsynaptic response. Also, the refractory period would not exist, thus action potentials would travel back up the axon, and down again, repeatedly. Section Title: Electrical Signals in Neurons Learning Outcome: 8.4

: Level III: Problem Solving (Bloom's Taxonomy: Application) 214) You and your lab partner have prepared a frog nerve for gathering data on action potentials. You connect an electronic stimulator to the nerve and ask your partner to gradually increase the voltage until you see an action potential. Your partner says that the voltage knob is stuck, that is, it will not increase the voltage. Is there another way to trigger action potentials using this stimulator? If so, what do you tell your partner to do?

: Your lab partner can increase the stimulus frequency instead. A higher frequency of stimuli can result in temporal summation of graded potentials such that the lower voltages sum to threshold. Section Title: Integration of Neuronal Information Transfer Learning Outcome: 8.9