Compliment System
how many globulin proteins does the C system consist of?
30 or more.
what do interferons attract
NK cells and macrophages
immune clearance
activated complement binds antigens and antibody complex to a RBC. this complex moves quickly through the blood in the liver and spleen the complex is removed and destroyed, leaving the RBC. The complex assisted but did not do the actual killing
what is an antigen?
any substance that induces an inflammatory response and immune reaction. It is not the same for all of us. The body reacts by producing an antibody
Cytolysis
cellular killing. A group of complement proteins bind together to form a membrane attack complex (MAC) and they drive a hole in the membrane of the microbe. Cytoplasm leaks out and the microbe dies. The complement is the reason the microbe dies. This is direct!
what 3 ways are complements activated?
classic pathway, alternative pathway, and lectin pathway
what is the lectin pathway
complement binds to carbohydrate on the surface of microbial cells.
inflammation
complement stimulated secretions of basophils and mast cells. Activates our basic neutrophils and macrophages it promotes an inflammatory response and we say that this is an indirect killing method.
phagocytosis
complements put a coating on surface of microbes to make them easier to ingest by phagocytes-neutrophils and macrophages. Osponization-coating the microbes. Indirect method of killing.
When do the globulin proteins of the C system function?
during the second and third line of defense.
C system proteins travel where
in an inactive form in the blood
C system proteins are produced where
in the liver
what is the alternative pathway?
it is triggered by the presence of urus, bacteria, yeast, and cancer cells--> activate complex
what is the classic pathway
its very specific. it occurs when an antigen enters the body. It is not the same for all of us. The body reacts by producing an antibody. they join to form a complex. The presence of this complement activates complex
interferons
when cells get infected by viruses they release these chemicals to other neighboring cells. this causes the neighboring cells to produce anti-viral proteins.
