heme quiz 3

Iron deficiency anemia is characterized by: A.Decreased plasma iron, decreased % saturation,increased total iron-binding capacity (TIBC) B.Decreased plasma iron, decreased plasma ferritin,normal RBC porphyrin C.Decreased plasma iron, decreased % saturation,decreased TIBC D.Decreased plasma iron, increased % saturation,decreased TIBC

D.Decreased plasma iron, increased % saturation,decreased TIBC

All of the following are usually found in Hgb Cdisease except: A.Hgb C crystals B.Target cells C.Lysine substituted for glutamic acid at the sixthposition of the β-chain D.Fast mobility of Hgb C at pH 8.6

D.Fast mobility of Hgb C at pH 8.6

Which is the major Hgb found in the RBCs ofpatients with sickle cell trait? A.Hgb S B.Hgb F C.Hgb A2 D.Hgb A

D.Hgb A

Which of the following is the primary Hgb inpatients with thalassemia major? A.Hgb D B.Hgb A C.Hgb C D.Hgb F

D.Hgb F

All of the following are associated withsideroblastic anemia except: A.Increased serum iron B.Ringed sideroblasts C.Dimorphic blood picture D.Increased RBC protoporphyrin

D.Increased RBC protoporphyrin

Which morphological classification ischaracteristic of megaloblastic anemia? A.Normocytic, normochromic B.Microcytic, normochromic C.Macrocytic, hypochromic D.Macrocytic, normochromic

D.Macrocytic, normochromic

Which of the following disorders is associated withineffective erythropoiesis? A.G6PD deficiency B.Liver disease C.Hgb C disease D.Megaloblastic anemia

D.Megaloblastic anemia

An autohemolysis test is positive in all thefollowing conditions except :A.Glucose-6-phosphate dehydrogenase (G6PD)deficiency B.Hereditary spherocytosis (HS) C.Pyruvate kinase (PK) deficiency D.Paroxysmal nocturnal hemoglobinuria (PNH)

D.Paroxysmal nocturnal hemoglobinuria (PNH)

Which anemia is characterized by a lack ofintrinsic factor that prevents B12 absorption? A.Tropical sprue B.Transcobalamin deficiency C.Blind loop syndrome D.Pernicious anemia

D.Pernicious anemia

A 50-year-old patient is suffering from perniciousanemia. Which of the following laboratory dataare most likely for this patient? A.RBC = 2.5 × 1012/L; WBC =12,500/μL (12.5 ×109/L); PLT = 250,000/μL (250 × 109/L) B.RBC = 4.5 × 1012/L; WBC = 6,500/μL (6.5 ×109/L); PLT = 150,000/μL (150 × 109/L) C.RBC = 3.0 × 1012/L; WBC = 5,000/μL (5.0 ×109/L); PLT = 750,000/μL (750 × 109/L) D.RBC = 2.5 × 1012/L; WBC = 2,500/μL (2.5 ×109/L); PLT = 50,000/μL (50 × 109/L)

D.RBC = 2.5 × 1012/L; WBC = 2,500/μL (2.5 ×109/L); PLT = 50,000/μL (50 × 109/L)

Reticulocytosis usually indicates: A.Response to inflammation B.Neoplastic process C.Aplastic anemia D.Red cell regeneration

D.Red cell regeneration

Hemolytic uremic syndrome (HUS) ischaracterized by all of the following except: A.Hemorrhage B.Thrombocytopenia C.Hemoglobinuria D.Reticulocytopenia

D.Reticulocytopenia

Microangiopathic hemolytic anemia ischaracterized by: A.Target cells and Cabot rings B.Toxic granulation and Döhle bodies C.Pappenheimer bodies and basophilic stippling D.Schistocytes and nucleated RBCs

D.Schistocytes and nucleated RBCs

Storage iron is usually best determined by: A.Serum transferrin levels B.Hgb values C.Myoglobin values D.Serum ferritin levels

D.Serum ferritin levels

In which of the following conditions willautosplenectomy most likely occur? A.Thalassemia major B.Hgb C disease C.Hgb SC disease D.Sickle cell diseas

D.Sickle cell diseas

Iron deficiency anemia may be distinguished fromanemia of chronic infection by: A.Serum iron level B.Red cell morphology C.Red cell indices D.Total iron-binding capacity

D.Total iron-binding capacity

Autoimmune hemolytic anemia is bestcharacterized by which of the following? A.Increased levels of plasma C3 B.Spherocytic red cells C.Decreased osmotic fragility D.Decreased unconjugated bilirubin

B.Spherocytic red cells

Which anemia has red cell morphology similar tothat seen in iron deficiency anemia? A.Sickle cell anemia B.Thalassemia syndrome C.Pernicious anemia D.Hereditary spherocytosis

B.Thalassemia syndrome

Which of the following is notassociated withhereditary spherocytosis? A.Increased osmotic fragility B.An MCHC greater than 36% C.Intravascular hemolysis D.Extravascular hemolysis

C intravascular hemolysis

The anemia seen in sickle cell disease is usually: A.Microcytic, normochromic B.Microcytic, hypochromic C.Normocytic, normochromic D.Normocytic, hypochromic

C normocytic, normochromic

Spherocytes differ from normal red cells in all ofthe following except: A.Decreased surface to volume B.No central pallor C.Decreased resistance to hypotonic saline D.Increased deformability

D increased deformability

Which of the following may be seen in theperipheral blood smear of a patient withobstructive liver disease?A.Schistocytes B.Macrocytes C.Howell-Jolly bodies D.Microcytes

B.Macrocytes

Congenital dyserythropoietic anemias (CDAs) arecharacterized by: A.Bizarre multinucleated erythroblasts B.Cytogenetic disorders C.Megaloblastic erythropoiesis D.An elevated M:E ratio

A.Bizarre multinucleated erythroblasts

Sickle cell disorders are: A.Hereditary, intracorpuscular RBC defects B.Hereditary, extracorpuscular RBC defects C.Acquired, intracorpuscular RBC defects D.Acquired, extracorpuscular RBC defects

A.Hereditary, intracorpuscular RBC defects

Which of the following is most true of paroxysmalnocturnal hemoglobinuria (PNH)? A.It is a rare acquired stem cell disorder that resultsin hemolysis B.It is inherited as a sex-linked trait C.It is inherited as an autosomal dominant D.It is inherited as an autosomal recessive trait

A.It is a rare acquired stem cell disorder that resultsin hemolysis

All of the following are associated withintravascular hemolysis except: A.Methemoglobinemia B.Hemoglobinuria C.Hemoglobinemia D.Decreased haptoglobin

A.Methemoglobinemia

Which of the following organs is responsible forthe "pitting process" for RBCs? A. Liver B.Spleen C. Kidney D. Limph nodes

B Spleen

A patient has 80 nucleated red blood cells per 100leukocytes. In addition to increased polychromasiaon the peripheral smear, what other finding maybe present on the CBC? A.Increased platelets B.Increased MCV C.Increased Hct D.Increased red blood cell count

B.Increased MCV

A patient with a vitamin B12anemia is given ahigh dosage of folate. Which of the following isexpected as a result of this treatment?A.An improvement in neurological problems B.An improvement in hematological abnormalities C.No expected improvement D.Toxicity of the liver and kidneys

B.An improvement in hematological abnormalities

The osmotic fragility test result in a patient withthalassemia major would most likely be: A.Increased B.Decreased C.Normal D.Decreased after incubation at 37°C

B.Decreased

Which of the following parameters may be similarfor the anemia of inflammation and iron deficiencyanemia? A.Normocytic indices B.Decreased serum iron concentration C.Ringed sideroblasts D.Pappenheimer bodies

B.Decreased serum iron concentration

All of the following are characteristics ofmegaloblastic anemia except: A.Pancytopenia B.Elevated reticulocyte count C.Hypersegmented neutrophils D.Macrocytic erythrocyte indices

B.Elevated reticulocyte count

Which of the following electrophoretic results isconsistent with a diagnosis of sickle cell trait?A.Hgb A: 40%Hgb S: 35%Hgb F: 5% B.Hgb A: 60%Hgb S: 40%Hgb A2: 2% C.Hgb A: 0%Hgb A2: 5%Hgb F: 95% D.Hgb A: 80%Hgb S: 10%Hgb A2: 10%

B.Hgb A: 60%Hgb S: 40%Hgb A2: 2%

What red cell inclusion may be seen in theperipheral blood smear of a patientpostsplenectomy? A.Toxic granulation B.Howell-Jolly bodies C.Malarial parasites D.Siderotic granules

B.Howell-Jolly bodies

Select the amino acid substitution that isresponsible for sickle cell anemia. A.Lysine is substituted for glutamic acid at thesixth position of the α-chain B.Valine is substituted for glutamic acid at thesixth position of the β-chain C.Valine is substituted for glutamic acid at the sixth position of the α-chain D.Glutamine is substituted for glutamic acid at the sixth position of the β-chain

B.Valine is substituted for glutamic acid at thesixth position of the β-chain

What is the basic hematological defect seen inpatients with thalassemia major? A.DNA synthetic defect B.Hgb structure C.β-Chain synthesis D.Hgb phosphorylation

C.β-Chain synthesis

In which of the following conditions is Hgb A2elevated? A.Hgb H B.Hgb SC disease C.β-Thalassemia minor D.Hgb S trait

C.β-Thalassemia minor

Which of the following conditions may producespherocytes in a peripheral smear? A.Pelger-Huët anomaly B.Pernicious anemia C.Autoimmune hemolytic anemia D.Sideroblastic anemia

C.Autoimmune hemolytic anemia

All of the following are characteristic findings in apatient with iron deficiency anemia except: A.Microcytic, hypochromic red cell morphology B.Decreased serum iron and ferritin levels C.Decreased total iron-binding capacity (TIBC) D.Increased RBC protoporphyrin

C.Decreased total iron-binding capacity (TIBC)

"Bite cells" are usually seen in patients with: A.Rh null trait B.Chronic granulomatous disease C.G6PD deficiency D.PK deficiency

C.G6PD deficiency

Which of the following hemoglobins migrates tothe same position as Hgb A2at pH 8.6? A.Hgb H B.Hgb F C.Hgb C D.Hgb S

C.Hgb C

A patient's peripheral smear reveals numerousNRBCs, marked variation of red cell morphology,and pronounced polychromasia. In addition to adecreased Hgb and decreased Hct values, whatother CBC parameters may be anticipated? A.Reduced platelets B.Increased MCHC C.Increased MCV D.Decreased red-cell distribution width (RDW)

C.Increased MCV

Which of the following are most characteristic ofthe red cell indices associated with megaloblasticanemias? A.MCV 99 fl, MCH 28 pg, MCHC 31% B.MCV 62 fL, MCH 27 pg, MCHC 30% C.MCV 125 fL, MCH 36 pg, MCHC 34% D.MCV 78 fL, MCH 23 pg, MCHC 30%

C.MCV 125 fL, MCH 36 pg, MCHC 34%

A patient has an Hct of 30%, a hemoglobin of 8 g/dL, and an RBC count of 4.0 ×1012/L. Whatis the morphological classification of this anemia? A.Normocytic normochromic B.Macrocytic hypochromic C.Microcytic hypochromic D.Normocytic hyperchromic

C.Microcytic hypochromic

Hereditary pyropoikilocytosis (HP) is a red cellmembrane defect characterized by: A.Increased pencil-shaped cells B.Increased oval macrocytes C.Misshapen budding fragmented cells D.Bite cells

C.Misshapen budding fragmented cells

The macrocytes typically seen in megaloblasticprocesses are: A.Crescent-shaped B.Teardrop-shaped C.Ovalocytic D.Pencil-shaped

C.Ovalocytic

Which of the following is a common finding inaplastic anemia? A.A monoclonal disorder B.Tumor infiltration C.Peripheral blood pancytopenia D.Defective DNA synthesis

C.Peripheral blood pancytopenia

The morphological classification of anemias isbased on which of the following? A.M:E (myeloid:erythroid) ratio B.Prussian blue stain C.RBC indices D.Reticulocyte count

C.RBC indices

.Which of the following disorders has an increasein osmotic fragility? A.Iron deficiency anemia B.Hereditary elliptocytosis C.Hereditary stomatocytosis D.Hereditary spherocytosis

D Hereditary spherocytosi

Which antibody is associated with paroxysmal coldhemoglobinuria (PCH)? A.Anti-I B.Anti-i C.Anti-M D.Anti-P

D.Anti-P

Which antibiotic(s) is (are) most often implicatedin the development of aplastic anemia? A.Sulfonamides B.PenicillinC.Tetracycline D.Chloramphenicol

D.Chloramphenicol

Hypersplenism is characterized by: A. Polycythemia B. Pancytosis C. Leukopenia D. Myelodysplasia

c. leukopenia