Hemopoeisis

functions of macrophages in the bone marrow

- eliminate old RBCs and malformed cells - regulates differentiation of hemopoetic cells - deliver iron to developing RBC for heme formation

functions of adventitial reticular cells

- produce and surround reticular fiber (type III collagen) - prevent clot formation - provide support for sinusoids - can become adipocytes

nucleus may remain as a Howell-Jolly body a. metarubricyte b. rubricyte c. rubiblast d. prorubricyte e. mature erythrocyte f. reticulocyte

e.

organelles degenerate a. metarubricyte b. rubricyte c. rubiblast d. prorubricyte e. mature erythrocyte f. reticulocyte

e.

promotes CFU-M mitosis and differentiation a. G-CSF b. erythropoietin c. stem cell factor d. GM-CSF e. M-CSF f. thrombopoietin

e.

erythropoeisis is stimulated by what that's released from the kidney?

erythropoeitin

production of myeloid elements at sites other than bone marrow; hemopoesis that occurs outside of bone marrow

extramedullary hemopoesis

has no nucleus a. metarubricyte b. rubricyte c. rubiblast d. prorubricyte e. mature erythrocyte f. reticulocyte

f.

proliferation and differentiation of CFU-meg and megakaryocytes a. G-CSF b. erythropoietin c. stem cell factor d. GM-CSF e. M-CSF f. thrombopoietin

f.

seen in peripheral blood a. metarubricyte b. rubricyte c. rubiblast d. prorubricyte e. mature erythrocyte f. reticulocyte

f.

site of origin: kidney/liver a. G-CSF b. erythropoietin c. stem cell factor d. GM-CSF e. M-CSF f. thrombopoietin

f.

adventitial reticular cells can eventually become

fat cells

the formation of blood cells

hemopoiesis

the primary cell of origin (undifferentiated) for all blood cells

pluripotent hemopoetic stem cell

hemopoesis occurs in the yellow/red bone marrow

red

all tissue not directly involved in hematopoesis is the:

stroma

production of megakaryocytes

thrombopoesis

t or f: adults have more yellow marrow than red marrow

true

t or f: granulocytes develop from the same pluripotent stem cell

true

t or f: yellow marrow can be reactivated into red marrow

true

promotes CFU-G mitosis and differentiation; facilitates neutrophil activity a. G-CSF b. erythropoietin c. stem cell factor d. GM-CSF e. M-CSF f. thrombopoietin

a.

site of origin: macrophages; endothelial cells a. G-CSF b. erythropoietin c. stem cell factor d. GM-CSF e. M-CSF f. thrombopoietin

a. and e.

where are macrophages found in the bone marrow?

along the outer wall of sinusoids

CFU-E differentiation; BFU-E mitosis a. G-CSF b. erythropoietin c. stem cell factor d. GM-CSF e. M-CSF f. thrombopoietin

b.

in the third trimester, hemopoesis occurs in the: a. spleen b. bone marrow c. liver

b.

site of origin: endothelial cells of the peritubular capillary network of the kidney; hepatocytes a. G-CSF b. erythropoietin c. stem cell factor d. GM-CSF e. M-CSF f. thrombopoietin

b.

what's the primary site of hemopoesis in adult mammals?

bone marrow

distinguished by its negative golgi a. metarubricyte b. rubricyte c. rubiblast d. prorubricyte e. mature erythrocyte f. reticulocyte

c.

formed by CFU-E a. metarubricyte b. rubricyte c. rubiblast d. prorubricyte e. mature erythrocyte f. reticulocyte

c.

in the first trimester, hemopoesis occurs in the: a. spleen b. bone marrow c. liver

c.

promotes hemopoesis a. G-CSF b. erythropoietin c. stem cell factor d. GM-CSF e. M-CSF f. thrombopoietin

c.

site of origin: stromal cells of bone marrow a. G-CSF b. erythropoietin c. stem cell factor d. GM-CSF e. M-CSF f. thrombopoietin

c.

which of the following is not a cellular change in granulopoeisis a. synthesis of azurophilic granules b. decrease in cell size c. nucleus becomes more regular d. synthesis of specific granules

c. - the nucleus becomes more irregular

hemoglobin production starts here a. metarubricyte b. rubricyte c. rubiblast d. prorubricyte e. mature erythrocyte f. reticulocyte

d.

promotoes CFU-GM mitosis and differentiation; facilitates granulocyte activity a. G-CSF b. erythropoietin c. stem cell factor d. GM-CSF e. M-CSF f. thrombopoietin

d.

site of origin: T-cells; endothelial cells a. G-CSF b. erythropoietin c. stem cell factor d. GM-CSF e. M-CSF f. thrombopoietin

d.

has pyknotic nucleus a. metarubricyte b. rubricyte c. rubiblast d. prorubricyte e. mature erythrocyte f. reticulocyte

a.

in the second trimester, hemopoesis occurs in the: a. spleen b. bone marrow c. liver

a.

as a red blood cell matures, there will be more/less polyribosomes

less

the embryological site of origin is the:

mesoderm of yolk sac (blood islands)

production of marrow or blood cells derived from marrow

myelopoesis