Melatonin

(C-aid) contraceptives, anticoagulants (blood-thinning medications), immunosuppresants, diabetes drugs,

Don't take melatonin if you take...

increased CNS depression(major)

Melatonin combined with fluvoxamine can cause

(WN F) warfarin (increased risk of bleeding), nifedipine (minor risk)(increased blood pressure), fluovoxamine(major risk)(increased CNS depression)

Melatonin drug drug interactions

sleep aid

Melatonin is a ____

pineal gland

Melatonin is a hormone made by the ____

(CJ chemo) cancer, jet lag, chemotherapy toxicity

Melatonin non-FDA uses

ethanol

Melatonin with ____ will reduce melatonin efficacy

increased blood pressure

Melatonin/nifedipine can cause...

increased risk of bleeding

Melatonin/warfarin combo can cause...

galactose/glucose/lactose intolerance or malabsorption

Metabolic precaution: Melatonin should not be used in those with...

T

T/F: Large melatonin doses (80 mg) can substantially increase prolactin secretion, and hyperprolactinemia is associated with both male and female infertility (Arendt, 1997). Larger doses (100 mg daily in the evening) potentiate the suppression of luteinizing hormone by testosterone in men (Arendt, 1997). 2) When used as a combination contraceptive (melatonin 75 mg plus norethindrone 0.5 mg) daily for months to years, reported adverse effects have been abnormal bleeding (11.1% to 36.9%) and breast complaints (3.17% to 17.7%) (Arendt, 1997). 3) Chronic ingestion of 1 g/day in humans resulted in depression of serum luteinizing hormone (LH) [61].

T

T/F: Melatonin should not be used in patients with hepatic/renal failure

T

T/F: People use melatonin when they have insomnia -- trouble falling asleep and staying asleep.

at night

Your body makes more melatonin when?

ethanol(alcohol)

______ can reduce melatonin efficacy

pineal gland

part of the brain that controls sleep