Morphine Sulfate

Morphine Sulfate

(Roxanol, MS Contin)

Morphine Sulfate Dosage and administration

...

Morphine Sulfate Pediatric:

0.1—0.2 mg/kg/dose I V, IO, IM, SC. Maximum dose: 5 mg.

Morphine Sulfate How supplied

2 mg/mL, 4 mg/mL, 8 mg/mL, 10 mg/mL ampules, vials, and Tubex syringe.

Morphine Sulfate Mechanism of action

Alleviates pain through CNS action. Suppresses fear and anxiety centers in the brain. Depresses brainstem respiratory centers. Increases peripheral venous capacitance and decreases venous return. Decreases preload and afterload, which decreases myocardial oxygen demand.

Morphine Sulfate Adverse reactions/side effects

Confusion, sedation, headache, CNS depression, respiratory depression, apnea, bronchospasm, dyspnea, hypotension, orthostatic hypotension, syncope, bradycardia, t.achycardia, nausea, vomiting, dry mouth.

Morphine Sulfate Contraindications

Head injury, exacerbated COPD, depressed respiratory drive, hypotension, undiagnosed abdominal pain, decreased level of consciousness, suspected hypovolemia, patients who have taken with MAOls within 14 days.

Morphine Sulfate Duration of action

Onset: Immediate. Peak effect: 20 minutes. Duration: 2-7 hours.

Morphine Sulfate Class

Opioid analgesic (schedule ll narcotic).

Morphine Sulfate Drug interactions

Potentiates sedative effects of phenothiazines. CNS depressants may potentiate effects of morphine. MAOIs may cause paradoxical excitation.

Morphine Sulfate Special considerations

Pregnancy safety: Category C. Morphine rapidly crosses the placenta. Safety in neonates has not been established. Use with caution in the elderly, those with asthma, and in those susceptible to central nervous system depression. Vagotonic effect in patients with acute inferior MI (bradycardia, heart block), Naloxone hydrochloride (Narcan) should be readily available as an antidote.

Morphine Sulfate Indications

Severe CHF, acute cardiogenic pulmonary edema, chest pain associated with acute myocardial infarction, analgesia for moderate to severe acute and chronic pain.

Morphine Sulfate Adult: STEMI:

lnitial dose: 2-4 mg slow IV (over 1-5 minutes). Repeat dose: 2-8 mg at 5-15 minute intervals. NSTEMI/Unstable angina. 1-5 mg IV push if symptoms not relieved by nitrates, use with caution.