Pharmacology chapter 16

Which of the following is not a route of administration for methotrexate? a. PO b. transdermal c. IV d. IT

b. transdermal

Once a cell has divided more than 40 times, it is now considered a. clinically undetectable b. stage 1 cancer c. a lethal tumor burden d. a curable tumor size

c. a lethal tumor burden

Which of the following agents derived from the Streptomyces bacteria? a. alkylating agents b. antimetabolites c. anthracyclines d. monoclonal antibodies

c. anthracyclines

Atropine is given as an injection for _______ in patients receiving chemotherapy. a. cardiac arrest b. allergic reaction c. diarrhea d. vomiting

c. diarrhea

Vinorelbine and vinca alkaloids are derived from which of the following natural sources? a. needles of yew trees b. fox glove plant c. periwinkle plant d. white willow bark

c. periwinkle plant

Which of the following agents prevents transmission of intracellular signals that stimulate cell proliferation? a. angiogenesis inhibitors b. monoclonal antibodies c. signal transduction inhibitors d. antiandrogens

c. signal transduction inhibitors

What is the term used to describe the font used on the drug name CARBOplatin? a. look-alike b. sound-alike c. tall man lettering d. capital font

c. tall man lettering

Which of the following is not a hormonal drug? a. antiestrogens b. antiandrogens c. LHRH agonists d. antimetabolite

d. antimetabolite

Which of the following agents has the following major side effects of bone marrow suppression, mucositis, alopecia, and nerve toxicity? a. alkylating agents b. antimetabolites c. topoisomerase inhibitors d. antimicrotubule agents

d. antimicrotubule agents

Which of the following is not a source from which monoclonal antibodies are developed? a. mouse b. bacterial c. human cell lines d. canine

d. canine

Which of the drugs can be safely administered directly into the CNS via a lumbar puncture or spinal tap? a. fluorouracil b. methotrexate c. hydroxyurea d. cytarabine

d. cytarabine

When a pharmacy technician mixes chemotherapy agents, when it is necessary to wear PPE? a. if the drug is a pregnancy category X b. if the package insert requires it c. if the drug is red or blue d. every time

d. every time

Which of the following is not an internal factor for abnormal cell growth? a. immune disorder b. hormones c. genetic mutation d. exposure to asbestos

d. exposure to asbestos

Topotecan is commonly used to treat which of the following types of cancer? a. breast b. colon c. prostate d. ovarian

d. ovarian

which of the following is not a factor that affects tumor response to chemotherapy drugs? a. tumor burden b. cell resistance to agent c. amount of chemotherapy administered d. patient's weight

d. patient's weight

Which of the following types of cancer typically cannot be cured with primary chemotherapy? a. Hodgkin's disease b. lymphona c. testicular cancer d. prostate cancer

d. prostate cancer

What is the term used to describe antimicrotubules drugs that are derived from the bark and needles of yew trees? a. vinca alkaloids b. signal transduction inhibitors c. pemethoxed d. taxanes

d. taxanes

Which of the following is not a targeted anticancer therapy? a. angiogenesis inhibitor b. monoclonal antibodies c. signal transduction inhibitors d. topoisomerase inhibitors

d. topoisomerase inhibitors

Which of the following drugs does not interfere with the enzymes that are essential for tumor cell growth? a. methotrexate b. cytarabine c. fluorouracil d. vincristine

d. vincristine

What is the normal dose for methotrexate orally for rheumatoid arthritis? a. 5 mg once a week b. 5 mg daily c. 5 mg once a month d. 5 mg every other day

a. 5 mg once a week

What natural source is etoposide derived from? a. American mayapple plant b. fox glove plant c. white willow bark d. E. coli bacteria

a. American mayapple plant

All individuals who handle or administer chemotherapy must don which of the following? a. PPE b. SDS c. MSDS d. spill kit

a. PPE

Which of the following agents has the following major side effects of bone marrow suppression, alopecia, nausea and vomiting, infertility, and secondary cancers? a. alkylating agents b. antimetabolites c. topoisomerase inhibitors d. antimicrotubule agents

a. alkylating agents

Which of the following agents works by binding to and damaging deoxyribonucleic acid during the cell division process, ultimately preventing cell replication? a. alkylating agents b. antimetabolites c. topoisomerase inhibitors d. antimicrotubule agents

a. alkylating agents

Which of the following is the medical term for hair loss? a. alopecia b. anaphylaxis c. apoptosis d. asparagine

a. alopecia

Which of the following drugs is known to cause hypertension and kidney damage, so blood pressure and urine samples must be evaluated prior to treatment? a. bevacizumab b. cefuximab c. rituximab d. dasatinib

a. bevacizumab

The oncogene ERBB2, also called HER2 is found in which of the following types of cancer? a. breast b. lung c. colon d. prostate

a. breast

Most chemotherapy is administered via a. central line b. peripheral line c. capillary line d. KVO line

a. central line

Antiestrogen therapy increases a women's risk for which of the following? a. endometrial cancer b. MI c. diabetes d. hypothyroidism

a. endometrial cancer

Investigational drugs are made available to patients who meet certain criteria via a. expanded access approval b. orphan drug approval c. palliative care use d. chemotherapy use

a. expanded access approval

Red colored drugs in chemotherapy are called a. intercalating agents b. blood agents c. red agents d. hazardous agents

a. intercalating agents

Atropine may need to be administered to treat diarrhea that occurs during administration of which chemotherapy agent? a. irinotecan b. cisplatin c. methotrexate d. vincristine

a. irinotecan

Irinotecan is most frequently used to treat which of the following types of cancer? a. lung b. breast c. prostate d. ovarian

a. lung

Which of the following drugs is used to treat lung cancer? a. pemetrexed b. danuorubicin c. methotrexate d. cytarabine

a. pemetrexed

Tumors that are localized and cannot be surgically removed are called? a. resected b. palliative c. tumor burden d. vesicants

a. resected

Which of the following methods is used for localized tumors? a. surgery b. chemotherapy c. drug therapy d. palliative therapy

a. surgery

Which of the following is available in the prescription form Vesanoid for the treatment of acute promyelocytic leukemia? a. vitamin A b. vitamin B c. vitamin C d. vitamin D

a. vitamin A

Asparaginase is an enzyme that breaks down asparagine, depriving leukemia cells of which of the following? a. folic acid b. amino acid c. potassium chloride d. 5FTP

b. amino acid

Mesna should be administered with which of the following drugs? a. cisplatin b. ifosfamide c. oxaliplatin d. cytararbine

b. ifosfamide

Which of the following is a method of possible accidental exposure to chemotherapy agents that cannot occur when a pharmacy technician prepares the medication? a. inhalation b. infusion c. injection d. topical absorption

b. infusion

Inflammation and ulceration of the mucous membranes lining the mouth and gastrointestinal tract is know as a. gastritis b. mucositis c. cystiitis d. alopecia

b. mucositis

Which of the following hormones is responsible for stimulating breast tumors in women? a. testosterone b. progesterone c. androgen d. HCG

b. progesterone

According to the American Cancer Society, which of the following cancers is the most common among men? a. colon b. prostate c. lung d. stomach

b. prostate

Which of the following methods would be used to treat a brain tumor? a. surgery b. radiation c. drug therapy d. palliative therapy

b. radiation

To prevent kidney damage from renal crystal in methotrexate therapy, which of the following is added to IV fluids to increase the pH levels of the urine? a. potassium chloride b. sodium bicarbonate c. sodium chloride d. calcium gluconate

b. sodium bicarbonate

Healthcare personnel should have access to which of the following in all areas where hazardous drugs are prepared, administered, or transported? a. crash cart b. spill kit c. panic button d. fire extinguisher

b. spill kit

Which of the following drug classes blocks the effects of estrogen by preventing synthesis of estrogen in the body? a. antimicrotubules agents b. antiandrogens c. aromatase inhibitors d. antiestrogens

c. aromatase inhibitors

Which of the following methods is used to provide systemic exposure to anticancer therapy? a. surgery b. radiation c. chemotherapy d. drug therapy

c. chemotherapy

Which of the following methods is used for the treatment of melanoma? a. surgery b. radiation c. immunotherapy d. palliative therapy

c. immunotherapy

Which of the following would not be used to premedicate a patient on monoclonal antibodies? a. acetaminophen b. diphenhydramine c. loperamide d. corticosteroids

c. loperamide

Luteinizing hormone-releasing hormone stimulates the production of which of the following? a. male hormones b. female hormones c. male and female hormones d. estrogen

c. male and female hormones

Leucovorin rescue should be provided with which of the following chemotherapy agents? a. cisplatin b. cytaribine c. methotrexate

c. methotrexate

Ototoxicity causes damage to which of the following? a. kidney b. liver c. nerves that affect hearing d. nerves that affect smell

c. nerves that affect hearing

Which of the following is a common tumor suppressor gene? a. ERBB2 b. HER2 c. p53 d. CYP 1A2

c. p53

Which of the following is not a common side effect of cytotoxic drug? a. vomiting b. alopecia c. nausea d. increased bone marrow production

d. increased bone marrow production

Which of the following is not a side effect of antiandrogens? a. hot flashes b. breast tenderness c. gynecomastia d. increased libido

d. increased libido

Which of the following is not a side effect of antiestrogen therapy? a. hot flashes b. mood swings c. depression d. insomnia

d. insomnia