Sample Questions

Which of the following is not a coating agent used for Rilutek? A. HPMC B. Polyethylene glycol 6000 C. HPMCP D. Titanium dioxide

C

Which of the following is not a function of the lubricant in a tablet formulation? A. Improving flow properties of granules B. Reducing powder adhesion onto the dies and punches C. Improving tablet wetting in the stomach D. Reducing punch and die wear E. Facilitating tablet ejection from the die

C

For each of the tablet processing problem listed below select/match the most likely reason for the condition. A. Excessive moisture in the granulation B. Entrapment of air C. Tablet friability D. Degraded drug E. Tablet hardness 1. Picking ____ 2. Mottling ____ 3. Capping ____ 4. Sticking ____

1. A 2. D 3. B 4. A

Match the lettered formulation design that best describes the mechanism of drug release from each of the following sustained release drug delivery systems A. Encapsulated dissolution B. Ion exchange C. Matrix diffusion D. Matrix dissolution E. Osmotic pumping 1. Drug is bound to a resin and released due to changes in pH ____ 2. Drug is compressed into tablets with a slowly soluble polymer ____ 3. Drug is compressed into tablets with an insoluble polymer ____ 4. Drug is compressed into tablets with semipermeable membrane and a laser drilled hole through which drug is transported out by convective flow ____

1. B 2. D 3. C 4. E

You are asked to prepare 2 sets of twelve 1 g suppositories, Set A and Set B. Set A requires 12 suppositories each containing 50 mg of drug x while set B requires both 50 mg of drug X as well as 300 mg of Drug Y in all 12 suppositories. Cocoa butter or theobroma oil will be used for the base of the suppositories. Note; Displacement values of X and Y are 0.7 and 1.5 respectively. Hint: Make 15 suppositories to account for losses A. What quantity of base is required in each set? B. How much does each individual suppository weight in each set?

A. Set A: 13.9 g; Set B 10.9 g B. Set A 0.98 g; Set B 1.08 g

Dose dumping is a problem in the formulation of A. Compressed tablets B. Modified release drug products C. Hard gelatin capsules D. Soft gelatin capsules E. Suppositories

B

Which of the following is true about the storage conditions of DSUVIA? A. Should be stored at 30 degrees celsius B. Should be stored away from light C. Can be stored in a bathroom cabinet D. Because light only affects color, it does not matter if DSUVIA is protected from light

B

A pharmacist receives a prescription for 15 mg piroxicam capsules, qty 48. A #1 capsule filled with piroxicam weighs 245 mg; a capsule filled with lactose weighs 180 mg. How much piroxicam and lactose are required for the prescription? Prepare sufficient powder for 50 capsules (2 extra). A. 15 mg piroxicam + 165 mg lactose B. 750 mg piroxicam + 9 g lactose C. 750 mg piroxicam +8.45 mg lactose D. 15 mg piroxicam + 230 mg lactose E. None of the above

C

Decadron is a conventional release tablet. Given that Decadron follows first order release kinetics, it can be assumed A. The rate of drug release is independent of time and constant over time B. The rate of drug release is delayed for a predefined period of time C. the rate of drug release declines exponentially over time D. The rate of drug release increases exponentially

C

If the API of 125 mg tablet decays by zero order kinetics with a reaction rate constant kinetic of 0.5 mg per hour, what is the amount of intact drug remaining after 3 days (72 hours)? A. 0.89 mg B. 8.9 mg C. 89 mg D. 890 mg

C

Rx: Zinc oxide 300 mg; cocoa butter qs If the density displacement factor for zinc oxide is exactly 4.44 and the suppository mold holds 2.0 g of cocoa butter, how much cocoa butter would be required to prepare 12 of the suppositories for this prescription? A. ZnO 0.36 g; cocoa butter 2.3 g B. ZnO 3.6 g; cocoa butter 2.3 g C. ZnO 0.36 g; cocoa butter 23 g D. ZnO 3.6 g; cocoa butter 23 g E. ZnO 3.6 g; cocoa butter 24 g

C

The rectal route of administration of a drug may be preferred over the oral route for some systemic-action because A. The drug does not have to be absorbed B. Absorption is predictable and complete C. A portion of the absorbed drug does not pass through the liver before entering the systemic circulation D. Inert binders, diluents, and excipients cannot interfere with absorption E. The dissolution process is voided

C

USP content uniformity test for tablets is used to ensure which of the following qualities? A. Bioequivalency B. Dissolution C. Potency D. Purity E. Toxicity

C

USP tests for ensuring the quality of drug products in tablet form include all of the following EXCEPT A. Disintegration B. Dissolution C. Hardness and friability D. Content uniformity E. Weight variation

C

Viral transduction enanchers are materials used to increase the amount of gene expression in the target tissue. Which of the following ingredients assists in gene transduction efficiency? A. Sodium phosphate dibasic B. Sodium chloride C. Poloxamer 188 D. Sodium phosphate monobasic

C

What is the active form of Nepafenac? A. Diclofenac B. Ibuprofen C. Amfenac D. NAC (acetylcysteine)

C

A satisfactory suppository base must meet all of the following criteria except A. It should have a narrow melting range B. It should be nonirritating and nonsensitizing C. It should dissolve or disintegrate rapidly in the body cavity D. It should melt below 30 degrees C E. It should be inert

D

A sweetener that is widely employed in chewable tablet formulas is A. Aspartame B. Glucose C. Lactose D. Mannitol E. Sucrose

D

Considering this secret formula and procedure, the amount of acetaminophen (in kg) required to produce 1 million tylenol tablets is: A. 0.5 kg B. 5 kg C. 50 kg D. 500 kg E 500,000 kg

D

If a bottle has an expiration date of "Dec 2021", the pharmacist may continue to dispense the product: A. Up to 1 year after the expiration date B. Only through 1/31/2021 C. Only through 12/15/21 D. Only through 12/31/21 E. If the pharmacist informs the patient to discard unused tablets in 6 months

D

In which solubility class can you find ritonavir? A. Class I B. Class II C. Class III D. Class IV

D

Starch is the main disintegrant ingredient in the Decadron tablet formulation. The primary purpose of starch is to A. Promote particle aggregation/cohesion in the liquid state B. Prevent sticking to die and punch C. Facilitate flow of granules from hopper D. Promote break down of particle aggregates

D

What does Luxturna use as a vector to carry a functional gene into the affected eye tissue? A. Poxvirus B. Adenovirus C. Retrovirus D. Adeno-associated virus

D

What is a disadvantage with using direct compression method? A. Fewer steps B. Direct compression excipients possess inherent disintegration properties (microcrystalline cellulose) C. Faster dissolution compared to wet granulation D. Occurrence of unblending due to variability in API and excipients

D

Which of the following is not an available formulation for Norvir? A. Tablet B. Soft gelatin capsules C. Solution D. Suspension

D

Which one of the following statements concerning tablet dissolution is not true? A. Disintegration precedes dissolution B. In vivo disintegration is usually a good predictor of dissolution C. Changing a drug's crystalline state may change dissolution rates D. Increasing tablet compression force will increase dissolution E. Micronization of drug powder will decrease dissolution time

D

Most commercial vaginal suppositories use a base of A. Beeswax B. Cocoa butter C. Glycerin D. Glycerinated gelatin E. Polyethylene glycols

E

What is a reason why rectal suppository formulation of an NSAID would be preferred for a patient? A. Rectal suppositories offer less therapeutic response than other formulations B. Patient is unconscious C. Patient is alert, aware and able to swallow pills or capsules D. Patient is experiencing N/V E. Both B and D

E

Which of the following capsules has the largest capacity? A. 5 B. 4 C. 1 D. 0 E. 000

E

Formulation of ibuprofen involves A. Low shearing mixing B. Pre-formed ingredients C. Wet mixtures D. Explosions E. A and B are correct F. None of the above

F

Which of the following is not an ingredient in ibuprofen? A. Maltose B. Lactose C. Croscarmellose sodium D. Colloidal silicon dioxide E. Hot butter F. A and E G. B and C H. None of the above

F

True statements about the function of excipients used in tablet formulations include I. binder promote granulation during the wet granulation process II. Glidants help to promote the flow of the tablet granulation during manufacture III. Lubricants help the patient to swallow the tablets

I and II

The prime purpose for which of the following types of coating may be to mask the bitter taste of an orally administered drug? I. Enteric II. Film III. Sugar

II and III

Agents that might be used to coat enteric coated tablets include I. Hydroxypropyl methylcellulose (HPMC) II. Carboxymethylcellulose (CMC) III. Cellulose acetate pthalate (CAP)

III

What is the role of propylene glycol in Imvexxy? A. Plasticizer B. Lubricant C. Preservative D. Suppository base

C

Which flavoring is used in ODT Zofran? A. Mint B. Orange C. Strawberry D. Ghost pepper E. Attack helicoptor

C

The shells of soft gelatin capsules may be made elastic or plastic like by the addition of A. Sorbitol B. Povidone C. PEG D. Lactose E. HPMC

A

Under what temperature conditions should Indocin suppositories be stored? A. 2 to 8 degrees C (36 to 46 degrees F) B. 8 to 14 degrees C (46 to 57 degrees F) C. 0 to 6 degrees C (32 to 42 degrees F) D. Below 0 degrees C (32 degrees F)

A

Which of the following is the active ingredient of Methylin? A. Methylphenidate HCl B. Aspartame C. Microcrystalline cellulose D. A and C E. All of the above

A

Which two ingredients serve as both glidants and anti-adherent agents? A. Talc and magnesium stearate B. Polyethylene glycol and titanium dioxide C. Microcrystalline cellulose and lactose monohydrate D. Croscarmellose sodium and providone (PVP)

A

Which of the following statements is not true about Methylin? A. It is a central nervous system stimulant B. It stimulates the reuptake of NE and dopamine C. It is used for the tx of ADHD D. Maltose and aspartame are two ingredients that act as sweeteners E. It is classified as Class I in regards to the biopharmaceutics classification system

B

Advantages to the manufacturer for tablet film coating when compared to sugar coating include I. Shorter production times II. Less gross weight III. Lower incidence in coat chipping

I, II, and III