Vanders Ch 13

Which of the following drugs, administered as an aerosol spray, would be most likely to help an infant with respiratory distress syndrome of the newborn? A. pulmonary surfactant B. a beta-adrenergic agonist C. a muscarinic agonist D. histamine E. a beta-adrenergic antagonist

a

Which of the following is NOT a function of the respiratory system? A. net uptake of carbon dioxide from the air and removal of oxygen from the blood B. regulation of blood H+ concentration C. trapping of blood clots D. phonation E. defense against microbes

a

Which of the following is NOT true regarding ventilation-perfusion inequality? A. No inequality exists in normal lungs. B. It may result from increased alveolar dead space. C. It is increased from normal in patients with emphysema. D. It is caused by too little or too much blood flow relative to ventilation. E. It is caused by too little or too much ventilation relative to blood flow.

a

Which of the following statements regarding hypoxia is correct? A. Exposure to high altitude is a form of hypoxic hypoxia. B. "Anemic hypoxia" refers to the condition of lower than normal arterial PO2. C. Carbon monoxide poisoning is an example of hypoxic hypoxia. D. Carbon monoxide poisoning is an example of ischemic hypoxia. E. Cyanide poisoning is an example of hypoxic hypoxia.

a

29. Which of the following would cause a decrease in the binding affinity of hemoglobin for oxygen? A. increased pH of the blood B. increased temperature of the blood C. decreased DPG levels in erythrocytes D. the presence of carbon monoxide E. decreased concentration of H+ in the blood

b

Carbonic anhydrase catalyzes a reaction that combines which of the following? A. H2O and O2 B. H2O and CO2 C. H2O and CO D. H+ and HCO3- E. CO2 and O2

b

During a physical examination, Joe learns that his resting tidal volume is 550 ml; his average resting respiratory rate is 15 breaths per minute; his total lung capacity is 6000 ml; and his anatomic dead space is 150 ml. Joe's resting alveolar ventilation is A. 72.0 L/min B. 6.0 L/min C. 4.2 L/min D. 1.8 L/min E. 0.5 L/min

b

During an unforced exhalation/expiration, which would NOT be true? A. alveolar pressure is greater than atmospheric pressure B. intrapleural pressure is greater than alveolar pressure C. intrapleural pressure becomes less negative D. the diaphragm relaxes E. lung volume decreases

b

The volume of air flowing into the alveoli during inhalation/inspiration is increased when there is an increase in which of these? A. airway resistance B. the pressure gradient from the atmosphere to the alveoli C. the pressure in the intrapleural space D. the curvature of the diaphragm E. the volume of air in the intrapleural space

b

When lying down, a subject's respiratory rate is 12 breaths per minute, his anatomical dead space is 150 ml, and his minute ventilation is 7 L/min. Which of these is closest to his alveolar ventilation in liters per minute? A. 6.0 B. 5.2 C. 4.2 D. 3.0 E. 0.583

b

Which is TRUE about the pleural sac? A. It is continuous with the atmosphere and protects the lungs from infection. B. It is a closed sac surrounding each lung that contains only a tiny volume of lubricating fluid. C. It is a closed sac surrounding each lung and contains a large volume of surfactant. D. It is a closed, air-filled space surrounding both lungs that has a negative pressure compared to atmospheric pressure. E. It is bounded by pleural membranes that are very thin, which allows for abundant gas exchange.

b

Which is a proposed benefit of hemoglobin's ability to bind and transport nitric oxide? A. It allows hemoglobin to resist the effects of small pH changes as a buffer molecule. B. By circulating into peripheral vessels, it will trigger vasodilation to improve local blood flow. C. As it circulates it promotes smooth muscle of arteries and arterioles to contract, to increase blood pressure as needed. D. It acts as an enzyme cofactor necessary to maintaining a "clean and smooth" endothelial lining within blood vessels. E. It provides a carrier upon which additional electrolytes can be transported to deficient tissues in the body.

b

Which is characteristic of a person chronically suffering from hypoxic hypoxia? A. higher-than-normal alveolar PO2 B. higher-than-normal hematocrit C. higher-than-normal arterial PO2 D. lower-than-normal lactic acid production E. lower-than-normal blood flow through tissues

b

Which of the following are chemoreceptors? A. hair cells in the cochlea B. receptors in the aortic and carotid bodies C. baroreceptors in the aortic and carotid arch D. receptors that mediate the Hering-Breuer reflex

b

Which of the following drugs, administered as an aerosol spray, would be most likely to help a victim of an asthmatic attack? A. pulmonary surfactant B. a beta-2 adrenergic agonist C. a muscarinic agonist D. histamine E. a beta-2 adrenergic antagonist

b

Which of the following is a cause of asthma? A. loss of alveoli B. inflammation of the bronchioles C. elevation of intrapleural pressure to equal atmospheric pressure D. environmental chemicals that stimulate beta-2 adrenergic receptors E. lack of pulmonary surfactant

b

Which of the following is most responsible for detecting an increase in systemic arterial H+ concentration? A. the medulla of the brainstem B. the peripheral chemoreceptors C. the central chemoreceptors D. the diaphragm E. the dorsal respiratory group

b

Which of the following statements regarding pulmonary surfactant is TRUE? A. It is secreted by type I alveolar cells. B. It increases the compliance of the lungs. C. It increases airway resistance. D. It is secreted into the intrapleural space. E. It can only interact with other lipid molecules.

b

Which of these does NOT increase during heavy exercise? A. minute ventilation B. arterial PCO2 C. oxygen delivery to muscles D. oxygen extraction from the blood by muscles E. body heat production

b

Which of these is demonstrated by the oxygen-hemoglobin dissociation curve? A. The greater the PO2 of the blood, the greater the dissociation of O2 from hemoglobin. B. At normal resting systemic arterial PO2 , hemoglobin is almost 100% saturated with oxygen. C. At normal resting systemic venous PO2 , only about 75% of the hemoglobin is in the form of deoxyhemoglobin. D. More additional oxygen binds to hemoglobin when going from a PO2 of 60 to 100 mmHg, than is added when going from a PO2 of 40 to 60 mmHg. E. As PO2 increases, the saturation of hemoglobin with oxygen increases linearly.

b

Curve B below represents the oxygen-hemoglobin dissociation curve for normal body temperature, arterial hydrogen ion concentration, and DPG concentration. A. Curve A may represent the dissociation at higher than normal arterial H+ concentration. B. Curve C may represent the dissociation at lower than normal body temperature. C. Curve A may represent the dissociation at very low 2,3 diphosphoglycerate levels. D. Curve C may represent the dissociation at lower than normal arterial H+ concentration. E. Curve A may represent the dissociation at higher than normal body temperature.

c

Regarding the partial pressures of O2 and CO2, which of the following statements is NOT true in a normal person at rest? A. Atmospheric PO2 is greater than alveolar PO2. B. The PCO2 in air is less than alveolar PCO2. C. The PO2 in systemic arteries is typically greater than the alveolar PO2. D. PCO2 in the systemic veins is greater than systemic arterial PCO2. E. PCO2 in the pulmonary arteries is greater than pulmonary venous PCO2.

c

What brain center has neurons that fire mainly during inspiration and have input to the spinal motor neurons that activate the diaphragm and inspiratory intercostal muscles? A. the ventral respiratory group of the medulla oblongata B. the pre-Botzinger complex C. the dorsal respiratory group of the medulla oblongata D. the pneumotaxic center of the pons E. the apneustic center of the pons

c

The rhythmic contractions and relaxations of the inspiratory muscles are dependent upon spontaneous depolarizations of the diaphragm. True False

f

The most important signal for regulating normal ventilation is hydrogen ions in the blood generated by lactic acid production. True False

f

Which is TRUE regarding how gasses dissolve in liquids? A. The concentration of a particular gas in a liquid equilibrates to match the concentration of that gas in the air to which the liquid is exposed. B. Different gasses have the same solubility in liquids. C. The partial pressure of a gas in a liquid is equal to the amount freely diffusing in the liquid plus the amount bound to large molecules within the liquid.

D. The partial pressure of a particular gas in a liquid equilibrates to match the partial pressure of that gas in the air to which the liquid is exposed. E. As the partial pressure of a particular gas in an air sample increases, the concentration of that gas in a liquid exposed to that air sample decreases. d

The process of ventilation includes both the transport of gases by bulk flow and the diffusion of gases into and out of the blood. True False

f

If the nerves from the carotid and aortic bodies are cut, which of these would occur? A. A decrease in arterial PO2 will no longer increase ventilation. B. An increase in arterial PCO2 will no longer increase ventilation. C. An increase in arterial lactic acid will inhibit ventilation. D. An increase in arterial PCO2 will inhibit ventilation. E. A decrease in arterial PO2 will inhibit ventilation.

a

In which form is most of the oxygen carried in arterial blood? A. bound to hemoglobin B. dissolved in the plasma C. dissolved in the cytosol of erythrocytes D. converted to HCO3- E. bound to myoglobin

a

Under normal circumstances, which of the following would result from an increase in transpulmonary pressure? A. inhalation/inspiration B. exhalation/expiration C. a collapsed lung D. pneumothorax E. emphysema

a

What is one function of the type II alveolar cells? A. production of surfactant B. secretion of mucus C. phagocytizing bacteria and other foreign particles D. make up the majority of the epithelial wall of the alveoli E. lining the pleural space

a

What is the primary regulator of the magnitude of alveolar ventilation under normal circumstances? A. the H+ concentration in the brain extracellular fluid, which is monitored by central chemoreceptors B. The PO2 of the arterial blood, which is monitored by central chemoreceptors C. The PO2 of the arterial blood, which is monitored by peripheral chemoreceptors D. the H+ concentration in the arterial blood, which is monitored by central chemoreceptors E. stretch receptors in the lung

a

Which is a result of hyperventilation? A. respiratory alkalosis B. respiratory acidosis C. increased blood PCO2 D. metabolic acidosis E. metabolic alkalosis

a

Which is normally TRUE about the intrapleural pressure? A. It is lower than alveolar pressure. B. It is between +5 and +10 mm Hg above atmospheric pressure at functional residual capacity. C. It alternates between being less than, and greater than, atmospheric pressure. D. During a passive exhale, it increases to a value above atmospheric pressure. E. It is always the same as atmospheric pressure during a passive exhale.

a

Which of the following conditions would result in a systemic arterial PO2 lower than is typical of a healthy person at sea level? A. traveling to high altitude B. breathing 100% oxygen C. having iron-deficiency anemia D. breathing regular air in a hyperbaric chamber (higher that normal atmospheric pressure) E. maintaining alveolar ventilation constant while decreasing metabolic rate

a

The majority of hydrogen ions generated in the formation of carbonic acid in the tissues are carried as freely dissolved H+ in the venous blood. True False

f

Which correctly describes the cause of the increase in alveolar ventilation that occurs when a person ascends to high altitude? A. The decrease in PCO2 of inspired air decreases alveolar PCO2, stimulating the peripheral chemoreceptors. B. The decrease in PCO2 of inspired air decreases alveolar PCO2, stimulating the central chemoreceptors. C. The decrease in PO2 of inspired air decreases alveolar and arterial PO2, stimulating the peripheral chemoreceptors. D. The decrease in total atmospheric pressure causes a greater negative pressure in the intrapleural space, resulting in deeper and more frequent breathing. E. The decrease in the total barometric pressure at high altitude causes hypocapnea, which stimulates peripheral chemoreceptors.

c

Which occurs as a result of hypoventilation? A. the pH of the blood increases B. levels of blood O2 increase C. levels of blood H+ ions increase D. alveolar CO2 decreases to near atmospheric levels E. alveolar oxygen increases toward atmospheric levels

c

Which of the following statements about the response of arteriolar smooth muscle to changing oxygen partial pressures is TRUE? A. Both systemic and pulmonary arterioles respond to a decrease in PO2 by constricting. B. Both systemic and pulmonary arterioles respond to a decrease in PO2 by dilating. C. Systemic arterioles respond to a decrease in PO2 by dilating but pulmonary arterioles constrict in response to decreased PO2. D. Systemic arterioles respond to a decrease in PO2 by constricting but pulmonary arterioles dilate in response to decreased PO2. E. Changes in PO2 do not affect arteriolar smooth muscle in the pulmonary system.

c

Which of the following statements regarding control of respiration is correct? A. A slight decrease in arterial PO2 is a stronger stimulus for increased ventilation than is a comparable decrease in arterial PCO2. B. The most important signal for regulating ventilation is the H+ concentration of arterial blood. C. Increased concentrations of lactic acid stimulate ventilation primarily by acting on peripheral chemoreceptors. D. An increase in the HCO3- concentration in blood stimulates ventilation. E. At high altitude, a decrease in PCO2 of the blood stimulates an increase in ventilation.

c

Which of these causes inhalation/inspiration? A. increase in the curvature (upward movement) of the diaphragm B. movement of the ribs closer together due to contraction of the internal intercostal muscles C. flattening (downward movement) of the diaphragm D. contraction of the abdominal muscles E. alveolar pressure increasing above atmospheric pressure

c

Which of these correctly describes the chloride shift? A. In the lungs, chloride enters red blood cells in exchange for bicarbonate ions. B. In the tissues, chloride exits red blood cells in exchange for carbonic acid. C. In the tissues, chloride enters red blood cells in exchange for bicarbonate ions. D. In the lungs, chloride enters red blood cells in exchange for CO2. E. In the tissues, chloride enters red blood cells in exchange for CO2.

c

Which of these results from hyperventilation? A. increased alveolar PCO2 and decreased alveolar PO2 B. an increase in both alveolar PCO2 and PO2 C. decreased alveolar PCO2 and increased alveolar PO2 D. a decrease in both alveolar PCO2 and PO2 E. the same alveolar PCO2 as under normal conditions

c

Action potentials in neurons in the inspiratory center of the medulla result in action potentials in the ________ nerves to the diaphragm, which in turn cause ________ of the muscle, resulting in a/an ________ in the volume of the thoracic cage. A. motor; contraction; decrease B. parasympathetic; contraction; decrease C. sympathetic; contraction; increase D. motor; contraction; increase E. sympathetic; relaxation; increase

d

After CO2 is produced by tissues, in what form is most of that carbon transported to the lungs for removal from the body? A. as dissolved CO2 B. bound to hemoglobin C. as H2CO3 D. as dissolved HCO3- E. as carbonic anhydrase

d

If all other factors remain the same, which of these results in an increase in the amount of oxygen bound to hemoglobin? A. increased plasma [H+] B. increased plasma temperature C. increased plasma [2,3 diphosphoglycerate] D. increased plasma PO2 E. increased plasma [carbon monoxide]

d

Regarding the relationships between the rates of oxygen consumption/carbon dioxide production and alveolar ventilation, which of these statements is TRUE? A. Increased ventilation without a similar increase in metabolism is called hypoventilation. B. In hypoventilation, alveolar PCO2 decreases below resting levels. C. In hyperventilation, alveolar PCO2 can decrease to zero. D. A decrease in metabolism without a similar decrease in alveolar ventilation would result in hyperventilation. E. An increase in ventilation with a matching increase in metabolism is called hyperventilation.

d

Under what conditions is lung compliance increased? A. respiratory distress syndrome of the newborn B. prolonged shallow breathing C. cystic fibrosis D. emphysema E. asthma

d

Which of the following is most responsible for keeping the lung surface and the thoracic wall from separating? A. the presence of surfactant B. the negative pressure in the alveolar space C. the force exerted by the external intercostal muscles D. the surface tension of the intrapleural fluid E. alveolar pressure is higher than atmospheric pressure

d

Which structure is NOT part of the "anatomical dead space?" A. bronchiole B. trachea C. bronchus D. respiratory bronchiole E. terminal bronchiole

d

A respiratory physiologist has measured ventilation parameters for each of three subjects: Tidal volume (TV); Respiratory rate (RR), and Anatomic dead space volume (ADSV). Which of the following statements accurately compares the alveolar ventilation in the three men? A. Tom's is the largest; Dick's and Harry's are the same. B. Tom's is the smallest; Dick's and Harry's are the same. C. Tom's is greater than Dick's, which is greater than Harry's. D. Dick's is greater than Harry's, which is greater than Tom's. E. Harry's is greater than Dick's, which is greater than Tom's.

e

Following strenuous exercise, blood levels of lactic acid are ________ compared to pre-exercise levels. This change in acid concentration causes a reflex ________ in ventilation by activating ________. A. decreased; decrease; peripheral chemoreceptors B. decreased; decrease; central chemoreceptors C. increased; increase; baroreceptors in the aortic arch D. increased; increase; central chemoreceptors E. increased; increase; peripheral chemoreceptors

e

Which of the following statements regarding the transport of CO2 in blood is FALSE? A. Some of the CO2 in blood is dissolved in plasma. B. Some of the CO2 in blood is dissolved in the cytosol of erythrocytes. C. Some of the CO2 in blood is bound to hemoglobin. D. Most of the CO2 in blood is converted to another molecule. E. Some of the CO2 in blood is converted to chloride.

e

Which of these would tend to increase ventilation? A. lower than normal blood PCO2 B. higher than normal blood pH C. breathing carbon monoxide D. iron-deficiency anemia E. breathing air with increased PCO2

e

61. Emphysema is a disease characterized by low lung compliance, obstructed airways, and ventilation-perfusion inequality. True False

f

At sea level PO2 is about 760 mm Hg. True False

f

Decreased alveolar PO2 causes reflex vasodilation of the pulmonary arterioles. True False

f

Deoxyhemoglobin binds bicarbonate ion better than oxyhemoglobin does. True False

f

Doubling the frequency of breathing will cause a greater increase in alveolar ventilation than will doubling the depth of inspiration. True False

f

During inhalation/inspiration, the total alveolar volume decreases. True False

f

During moderate exercise, arterial PCO2 and H+ concentration increase and arterial PO2 decreases, and these are the main stimuli causing increased ventilation. True False

f

Exhalation/expiration of air from the lungs requires contraction of the exhalatory/expiratory intercostal muscles. True False

f

Exposure to high altitude is a form of ischemic hypoxia. True False

f

If lung disease results in an arterial PO2 of 80 mm Hg, the total amount of oxygen carried by the blood is 20% below normal. True False

f

If the parietal pleura is cut during surgery, the lung on the side of the cut will expand and the chest wall will be compressed. True False

f

In a normal person at rest, the part of the respiratory cycle in which no air is flowing through the airways and the respiratory muscles are relaxed is at the end of inhalation/inspiration, prior to exhalation/expiration. True False

f

Increased plasma concentration of lactic acid stimulates increased ventilation primarily by means of central chemoreceptors. True False

f

Infants born prematurely frequently develop respiratory distress syndrome of the newborn because they have too few alveoli to exchange O2 and CO2 efficiently. True False

f

Most of the O2 carried in the blood is dissolved in plasma. True False

f

Of the CO2 returning from the tissues in venous blood, more is dissolved in plasma as CO2 than is bound to hemoglobin. True False

f

The diaphragm is a large sheet of smooth muscle that separates the thoracic cavity from the abdomen. True False

f

The key difference between fetal hemoglobin and adult hemoglobin is that fetal hemoglobin has a lower affinity for oxygen, because the levels of oxygen in placental blood is 2 to 3 times higher than other systemic arteries. True False

f

63. The total dead space in the lungs includes anatomic dead space and any portion of the alveoli that has little or no blood supply. True False

t

69. When blood flows into the systemic capillaries, the PO2 of the erythrocytes is greater than the PO2 of the plasma, causing a shift from oxyhemoglobin to deoxyhemoglobin. True False

t

A clinical sign of obstructive lung disease would be a reduced FEV1/FVC ratio. True False

t

A decrease in arterial PO2 stimulates increased ventilation by causing increased firing of action potentials in the afferent neurons from the carotid and aortic body chemoreceptors. True False

t

A slight fall in arterial PCO2 is a much stronger stimulus for increasing ventilation than a comparable fall in arterial PO2. True False

t

A small amount of carbon monoxide in the air would not significantly alter the PO2 of inspired air nor the PO2 of the arterial blood. True False

t

According to Boyle's law, the pressure exerted by a constant number of gas molecules in a container is inversely proportional to the volume of the container. Therefore, increasing the volume of the container will cause a decrease in its pressure. True False

t

During inhalation/inspiration, the diaphragm contracts and the alveolar pressure is less than atmospheric pressure; during exhalation/expiration, the diaphragm relaxes and the alveolar pressure is greater than atmospheric pressure. True False

t

In the systemic circulation, the PO2 of arterial blood exceeds the PO2 of venous blood, while the reverse is true for the pulmonary circulation. True False

t

Mixed venous blood in a resting individual still contains more than double the amount of oxygen extracted by the tissues as the blood passed through them. True False

t

Nonrespiratory functions of the lungs include acting as "filters" for removing certain chemicals and blood clots. True False

t

Normally, all the H+ ions generated from CO2 in tissue capillaries recombine with bicarbonate in pulmonary capillaries and are removed from the body as CO2. True False

t

One cause of hypoxic hypoxia in disease is diffusion impairment of O2 resulting from decreased alveolar surface area. True False

t

The affinity of hemoglobin for O2 is decreased in rapidly metabolizing tissues. True False

t

The control of respiration by centers in the brainstem can be over-ridden by higher brain centers when speaking, breath-holding, undergoing emotional reactions, and experiencing pain. True False

t

The diameter of the airways in normal lungs is generally great enough that little resistance is offered to airflow. True False

t

The medullary inspiratory neurons receive inhibitory neural input from the pons and also from pulmonary stretch receptors. True False

t

The neurons responsible for the cyclic nature of respiratory muscle function are located in the brain stem. True False

t

When a person hyperventilates, there are lower than normal levels of PCO2 and hydrogen ion in arterial blood, a condition called respiratory alkalosis. True False

t